Autophagy dictates PHGDH-mediated serine metabolism in a timely manner to support oocyte development.

The metabolic co-dependence of the oocyte and surrounding granulosa cells is crucial for oocyte developmental competence. Previous research has shown that serine-glycine and its key downstream metabolites are significantly involved in the process of oocyte maturation. However, the mechanism of serine metabolism and its influence on oocyte maturation remain unclear.

Efficacy and safety of Nd: YAG laser vitreolysis in patients with physiological vitreous floaters.

Purpose: To observe the clinical effects of Nd: YAG laser vitreolysis in patients with physiological vitreous floaters by A/B ultrasound and infrared fundus photography., and to evaluate the safety of the treatment by ffERG.

Methods: Thirty eyes diagnosed with physiological vitreous floaters were enrolled.

Chemical tuning of quantum spin-electric coupling in molecular magnets.

Controlling quantum spins using electric rather than magnetic fields promises substantial architectural advantages for developing quantum technologies. In this context, spins in molecular magnets offer tunability of spin-electric couplings (SECs) by rational chemical design. Here we demonstrate systematic control of SECs in a family of Mn(II)-containing molecules by varying the coordination environment of the spin centre.

Combining Observations and Models: A Review of the CARDAMOM Framework for Data-Constrained Terrestrial Ecosystem Modeling.

The rapid increase in the volume and variety of terrestrial biosphere observations (i.e., remote sensing data and in situ measurements) offers a unique opportunity to derive ecological insights, refine process-based models, and improve forecasting for decision support.

Prioritizing odorous VOCs emitted from air filters using machine learning models.

Atmospheric ozone reacts with pollutants accumulated on air filters in mechanical ventilation systems, generating odorous volatile organic compounds (VOCs). As atmospheric pollutants evolve and ozone-driven reactions intensify, new compounds may form, exacerbating odor issues. This study aims to train a machine learning framework for predicting the odor thresholds of VOCs emitted from air filters.

Rhodiola crenulata extract inhibits cell pyroptosis to ameliorate pulmonary vascular remodeling in rats through the regulation of decadienylcarnitine/NLRP3/GSDMD axis.

Ethnopharmacological Relevance: Our previous work verified that decadienyl-L-carnitine (C10:2) biosynthesis has therapeutic-target capacity for RCE inhibiting pulmonary vascular remodeling to modulate experimental pulmonary hypertension(PH). However, the profound molecular mechanism remains incompletely elucidated.

Aim Of Study: This study aims to investigate whether C10:2 biosynthesis regulates pulmonary vascular remodeling by activating cell pyroptosis.

The effect of low-level toluene on working memory maintenance has its own neural network basis rather than the continuation of brain network alterations during encoding.

Working memory (WM) involves different neural network mechanisms that underlie the encoding of external stimuli and the active maintenance of non-external stimulus information. We have demonstrated that short-term exposure to 70-ppb toluene impairs the encoding network. However, its role in the maintenance network remains unclear.

Edible 3D printed emulsion gels: Effects of inulin on sensory characteristics and mechanical properties.

Inulin is a prebiotic and an effective texture modifier for emulsion gels, offering considerable commercial value for consumers whose chewing ability changes. This study evaluated the influence of inulin on print precision, structural integrity, and sensory quality of 3D-printed emulsion gels. An inulin-based emulsion gel with desirable texture and freezing stability across -18 °C to 25 °C was successfully developed.

Assessment Model of Pediatric Bone Age Based on High-Frequency Ultrasound: A Prospective Cohort Study.

Objective: Ultrasound-based assessment of bone age (BA) in pediatric populations remains underutilized and insufficiently validated. The purpose of this study was to develop a simple and accurate model for estimating BA using high-frequency ultrasonography.

Methods: Participants were prospectively stratified into pilot, modeling, and validation groups based on enrollment dates and predefined inclusion criteria.

Pathogenesis, prevention, and therapeutic advances in hepatitis B, C, and D.

Viral hepatitis poses a considerable risk to public health. Among the five hepatitis viruses, hepatitis B, C, and D virus are of particular concern due to their high rates of chronic infection and significant global disease burden. The World Health Organization's Global Health Sector Strategy, introduced in 2016, seeks to eradicate viral hepatitis as a public health issue by 2030, aiming for a 90% decrease in new infections and a 65% drop in fatality rates.

HVT-delivered chicken IGF-1 improves growth performance in broilers.

The domesticated poultry is invaluable as a global protein source. Growth performance in poultry, particularly broilers, plays a critical role in production efficiency. Insulin-like growth factor-1 (IGF-1) is a multifunctional hormone which shows promotive effects on growth and development.

Obstetric and perinatal outcomes in pregnancies conceived with donor versus partner sperm: a systematic review and meta-analysis.

Background: Male-related factors contribute to 30-40% of infertility cases, with donor sperm serving as a critical solution for severe male infertility or paternally inherited genetic disorders. While cryopreservation ensures virological safety, concerns persist regarding sperm DNA damage, oxidative stress, and epigenetic impacts on embryogenesis. Previous studies have shown inconsistent evidence regarding obstetric and perinatal outcomes using donor versus partner sperm.

Manipulating Competitive Li Coordination of F-Rich Polymer and High Flash Point Glyme Electrolyte Enabling High Rate and Intrinsically Safe Quasi-Solid-State Li Metal Batteries.

Metal-based batteries incorporating quasi-solid gel electrolytes (QSEs) represent a promising approach to attain both high safety and high energy density. Nevertheless, the issues of limited ionic conductivity and insufficient solid-solid contact interfaces significantly impede their practical applications. In this study, an intrinsically safe QSE synthesized by in situ polymerizing trifluoroethyl acrylate (TFEA) in high flash point tetraglyme (G4)-based electrolyte is developed.

Diversity-Oriented Synthesis of Diaza-Polycyclic Aromatic Hydrocarbons Coupled with Virtual Screening for OLED Applications.

The development of organic light-emitting diode (OLED) materials requires precisely engineered molecular architectures with tailored optoelectronic properties. Here, we present a strategy that synergistically integrates diversity-oriented synthesis (DOS) with virtual screening to systematically explore the chemical space of diaza-polycyclic aromatic hydrocarbons (diaza-PAHs) for OLED applications. DOS, originally developed for drug discovery, serves as a powerful tool to generate structurally diverse molecular libraries, granting access to previously unexplored diaza-PAHs with potential OLED functionality.

Near-infrared-triggered copper-doped carbon nitride nanocomposite inducing domino effect for synergistic tumor therapy and immune microenvironment reprogramming.

Multimodal targeted combination therapies harnessing synergistic interactions have emerged as a transformative paradigm in oncology, gradually superseding conventional monotherapies. We herein report a near-infrared (NIR) light-triggered multifunctional nanocomposite based on copper-doped graphitic-phase carbon nitride (named CNCu@HA), which efficiently eliminates tumors by inducing apoptosis, cuproptosis, and immunogenic cell death (ICD) while initiating robust immune responses. Specifically, the incorporation of copper ions enhances NIR photoabsorption and effectively separates the electron-hole pairs.

A Nanomodulator Enhances Radiotherapy-Induced In Situ Cancer Vaccine by Promoting Antigen-Presenting of Tumor-Associated Macrophage.

Radiotherapy (RT) can induce an in situ vaccine effect by promoting the generation of tumor neoantigens, yet this effect is insufficient to elicit robust antitumor immune responses. Although the abundant tumor-associated macrophages (TAMs) in tumor tissue, as members of antigen-presenting cells, have been shown to capture antigens efficiently, the proteomic analysis, that TAMs is demonstrated exhibit up-regulated cysteine protease in lysosomes that leads to tumor antigen degradation. Inhibiting cysteine protease activity can promote the antigen-presenting of TAMs.

Kaposi Sarcoma-Associated Herpesvirus and Kidney Disease.

Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, is a carcinogenic gamma herpesvirus strongly associated with various human malignancies, including Kaposi sarcoma. Compromised immune function is a critical risk factor for the development of Kaposi sarcoma, particularly in individuals with human immunodeficiency virus (HIV) infection or those receiving immunosuppressive therapy. Antiviral therapy and radiotherapy have little role in KS treatment, which consists of chemotherapy and immunobiologicals (besides changing, reducing, or discontinuing immunosuppressants).

Altered Nasal Microbiota-Metabolome Interactions in Allergic Rhinitis: Implications for Inflammatory Dysregulation.

Objective: The aim of this study was to investigate the correlation between nasal microbiome, metabolites, and their potential contribution to the pathogenesis of allergic rhinitis (AR), a widespread chronic inflammatory disorder that poses a considerable healthcare burden worldwide. Immune dysregulation and environmental factors are key in the development of allergic responses, but the importance of host-microbiota interactions in influencing these responses is gaining recognition.

Methods: 32 AR patients and 20 healthy controls underwent 16S rDNA sequencing and untargeted metabolomics analysis.

The dysbiosis of gut microbiota and dysregulation of metabolites in IgA nephropathy and membranous nephropathy.

Introduction: Immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) are among the most common forms of primary glomerular diseases, with a rising global incidence. Despite their clinical importance, the underlying pathogenesis of these diseases and the development of reliable non-invasive diagnostic tools remain inadequately understood. Accumulating evidence suggests that gut microbiota and its associated metabolites may play a crucial role in the development of kidney diseases via the gut-kidney axis.

Phenotypic Diversity Analysis and Integrative Evaluation of Germplasm Resources in Ya'an, Sichuan Province.

As a unique woody oil crop in China, Abel. germplasm resources show significant genetic diversity in Ya'an City. This study measured 60 phenotypic traits (32 quantitative, 28 qualitative) of 302 accessions to analyze phenotypic variation, establish a classification system, and screen high-yield, high-oil germplasms.

Nematode Pheromones as Key Mediators of Behavior, Development, and Ecological Interactions.

Plant parasitic nematodes cause huge economic losses to agriculture and forestry every year, and chemical insecticides destroy the ecological environment. Researching the mechanism by which small-molecule signaling substances regulate nematode behavior and development is important for developing environmentally friendly biological control agents. Nematode pheromones are essential chemicals signaling intraspecies and interspecies communication, regulating development, reproduction, and social behavior.

Machine learning-based dynamic CEA trajectory and prognosis in gastric cancer.

Background: Static carcinoembryonic antigen (CEA) levels are well‑established prognostic markers in patients with gastric cancer, but the significance of their dynamic trajectories over time has rarely been reported.

Methods: We analysed the perioperative CEA levels (presurgery, early postsurgery, and late postsurgery) of 578 gastric cancer patients who underwent curative resection, with a median follow-up of 29 months. We used the entire cohort for k-means clustering.

Reduction in Earth's carbon budget imbalance.

The Global Carbon Project (GCP) compiles an updated global carbon budget each year, synthesizing state‑of‑the‑art estimates of anthropogenic CO emissions, land and ocean sinks, and the atmospheric CO growth rate. The residual between these terms, referred to as the global carbon budget imbalance, reflects the aggregate inaccuracies of the individual component estimates. Growth rates derived from marine boundary layer (MBL) surface flask mixing ratio observations are assumed to be highly accurate.

Impact of music-based interventions on subjective well-being: a meta-analysis of listening, training, and therapy in clinical and nonclinical populations.

Introduction: This meta-analysis aims to systematically evaluate the impacts of three types of Music-based interventions (MBIs)-music listening, music training, and music therapy on the subjective well-being (SWB) of clinical and non-clinical populations.

Methods: The study conducted a systematic search of Web of Science, PubMed, and Scopus (from inception to January 2025) using the PRISMA guidelines, and selected 10 studies with a total of 387 and 326 experimental and control groups, respectively. Study quality was assessed using the Cochrane Risk of Bias Tool for randomized controlled trials.