The Orofacial Somatosensory Changes of Edentulous Mandible After Full Arch Implant Surgery-A Six-Month Follow Up.

Aims: To evaluate somatosensory function changes and recovery time in patients with mandibular edentulous jaw after full arch flap implant surgery using a standardized quantitative sensory testing (QST) protocol.

Materials And Methods: Fourteen patients with edentulous mandibles underwent full-arch alveolar flap implant surgery, with three to four implants placed in each case. A QST battery including cold detection threshold (CDT), warmth detection threshold (WDT), thermal sensory limen (TSL), paradoxical heat sensation (PHS), cold pain threshold (CPT), heat pain threshold (HPT), mechanical detection threshold (MDT), mechanical pain threshold (MPT), wind-up ratio (WUR), vibration detection threshold (VDT), and pressure pain threshold (PPT) was performed at skin of mental region and keratinized gingiva of right canine.

Early and Stable Mouse Model of Amphotericin B-Induced Acute Kidney Injury: Application of Continuous Non-Invasive GFR Monitoring.

Background: Amphotericin B (AmB) remains a cornerstone in antifungal therapy, but its clinical use is limited by dose-dependent nephrotoxicity. Lipid-based formulations such as amphotericin B cholesterol sulfate complex dispersion (ABCD) were developed to mitigate renal injury, though their comparative renal safety profiles remain incompletely defined.

Objective: This study aimed to establish a pharmacologically relevant mouse model to characterise the nephrotoxicity of conventional AmB (AmB-D) and ABCD formulations, using continuous non-invasive glomerular filtration rate (GFR) monitoring and renal injury biomarkers.

Global trends in Alzheimer's disease and other dementias in adults aged 55 and above (1992-2021): An age-period-cohort analysis based on the GBD 2021.

Background: Alzheimer's disease and other dementias (ADOD) are growing global health challenges. While existing studies primarily focus on dementia prevention and management in individuals aged 65 and older, evidence suggests that cognitive decline and pathological changes begin earlier (≥55 years). This study focuses on this younger group to enable earlier risk identification and preventive interventions.

Peptides as Master Keys to Skin Aging.

Understanding skin aging and developing intervention strategies are fundamental challenges in dermatology. Recent research has revealed complex interactions among cellular senescence, extracellular matrix remodeling, oxidative stress, and inflammatory networks in aging skin. These advances have catalyzed the development of peptide-based therapeutic strategies, including environment-responsive peptides, biomimetic peptides and advanced nano-delivery systems.

Autophagy dictates PHGDH-mediated serine metabolism in a timely manner to support oocyte development.

The metabolic co-dependence of the oocyte and surrounding granulosa cells is crucial for oocyte developmental competence. Previous research has shown that serine-glycine and its key downstream metabolites are significantly involved in the process of oocyte maturation. However, the mechanism of serine metabolism and its influence on oocyte maturation remain unclear.

Urinary 3-methylhistidine as a potential biomarker for sepsis-associated acute kidney injury: multidimensional metabolomics analysis in mice and human.

Background: Sepsis-associated acute kidney injury (SA-AKI) is strongly associated with increased mortality in critical patients. The early detection of SA-AKI is crucial for clinical intervention. This study aims to integrate multiple metabolomics data related to SA-AKI to identify and validate novel metabolic markers.

Exploring the potential of enzymatic hydrolysis combined with glycosylation to modify soy glycinin: Insights into conformational flexibility, interfacial and emulsifying behavior.

This research aimed to improve the conformational flexibility, oil/water interface and emulsifying properties of soy glycinin (11S) by enzymatic hydrolysis and glycosylation with carboxymethyl cellulose (CMC, 0-0.75 %, w/v). Enzymatic hydrolysis increased degree of grafting of 11S to CMC, with a maximum observed at 0.

Inferring causal trajectories from spatial transcriptomics using CASCAT.

Spatial trajectory inference models cell differentiation and state dynamics within tissues by integrating spatial information. Existing spatial trajectory inference methods depend on similarity-based cell graphs constructed from spatial proximity, with less attention to the Markovian property in cell state transitions. In this study, we introduce CASCAT, a tree-shaped structural causal model with the Markovian property integrated to infer a unique cell differentiation trajectory, addressing challenges posed by Markov equivalence in high-dimensional and nonlinear data.

Proteomic subtypes enrich current acute myeloid leukemia nomenclature and reflect intrinsic pathogenesis alongside aging.

Acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy that increasingly affects the elderly population, with its post-transcriptional landscape remaining largely elusive. Establishing a stable proteomics-based classification system and systematically screening age-related proteins and regulatory networks are crucial for understanding the pathogenesis and outcomes of AML. In this study, we leveraged a multi-omics cohort of 374 newly diagnosed AML patients, integrating proteome, phosphoproteome, genome, transcriptome, and drug screening data.

Dynamical variations, impact factors, and prediction of echinoco-ccosis in Xinjiang by ARIMA-Random Forest Hybrid Model.

Background: Xinjiang is the second largest pastoral areas, and the main arid and semi-arid regions in China. The echinococcosis in Xinjiang has been brought serious challenge and large pressure for the disease control and prevention.

Methods: We comprehensively investigated the echinococcosis temporal variations at multiple time scales in Xinjiang during the period of 2004-2020.

Individual and combined effects of maternal per- and polyfluoroalkyl substances exposure on preterm birth: a nested case-control study in China.

Background: Per- and polyfluoroalkyl substances (PFAS) are a large class of synthetic chemicals with ubiquitous human exposure. Maternal PFAS exposure has been linked with adverse birth outcomes, but their associations with preterm birth (PTB) remained ambiguous.

Methods: To assess the associations of individual and mixed PFAS exposure with preterm birth (PTB) and its subtypes (spontaneous and iatrogenic), a nested case-control study involving 177 PTB cases and 531 controls was conducted in Shanghai, China.

Drug-Coated Balloon Versus Plain Balloon Angioplasty for the Treatment of Dysfunctional Dialysis Access: A Systematic Review and Meta-analysis.

Background: The optimal treatment for dysfunctional dialysis access between drug-coated balloon angioplasty (DCBA) and plain balloon angioplasty (PBA), including standard balloon angioplasty (SBA) and high-pressure balloon angioplasty (HPBA), remains unclear. This study aims to compare the efficacy and safety of DCBA and PBA.

Materials And Methods: A systematic review was conducted to identify randomized controlled trials (RCTs) comparing DCBA and PBA.

A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants.

Pseudorabies virus (PRV) causes an acute febrile infectious disease of pigs. Since 2011, PRV variants have appeared and spread nationwide in China. mRNA vaccines present a safe alternative and can stimulate humoral and cellular immunity.

Single-cell RNA sequencing reveals palmitoylation-driven cellular heterogeneity and prognostic biomarkers in lung adenocarcinoma.

Background: Lung adenocarcinoma (LUAD) is marked by significant variation within tumor cells and continues to be a major global cause of cancer deaths. Palmitoylation is a dynamic lipid-based modification that occurs after protein synthesis and influences the behavior and lifespan of various cancer-related proteins. However, its role in shaping cellular complexity and predicting outcomes in LUAD patients is not yet fully clarified.

Solid-State Packing Controls Exciton Delocalization and Photophysics in Nonfullerene Acceptors.

We engineer molecular packing in five derivatives of the nonfullerene acceptor Y6. Using transient absorption spectroscopy, we find evidence of the formation of a delocalized exciton in addition to the local exciton in neat films of the acceptors. Following selective photoexcitation of the acceptors in donor/acceptor blends with D18, we observe anion formation on the same timescale as in neat acceptor films, suggesting that D18 is a bystander to charge generation after photoexcitation of the acceptors.

Construction and validation of a frailty risk prediction model for geriatric hematologic neoplasms patients: A cross-sectional study.

BackgroundWith the increasing incidence of malignant hematological neoplasms in the elderly population, debilitating issues have gradually become an important challenge for patients.ObjectivesTo construct a prediction model, draw a nomogram, and perform internal validation of the model.Methods505 elderly patients with hematological neoplasms were included in the study.

Impact of carbon emission trading on carbon transfers in China's inter-provincial and international trade.

This study evaluates the impact of national Emissions Trading Scheme (ETS) in China on inter-provincial and international carbon emission transfers using a multi-regional Computable General Equilibrium (CGE) model, incorporating production- and consumption-based accounting, regional trade linkages, and carbon market mechanisms. Significant regional disparities in emissions reductions and economic impacts are identified, particularly between northern and southern provinces divided by the Qinling-Huaihe Line. Northern provinces achieve greater production-side emission reductions and experience lower marginal abatement costs than southern provinces, reflecting industrial structural differences.

Analysis and verification of potential ferroptosis-related diagnostic markers in the early stage of metabolic dysfunction-associated steatohepatitis.

Metabolic dysfunction-associated steatohepatitis (MASH) is currently the fastest-growing cause of liver-related deaths. Intervention in the early stage of MASH will effectively reverse the condition and avoid huge health and economic burdens. To date, our understanding of MASH remains quite limited.

Development of a novel resistant starch via synergistic triple modification strategy that enables lipid complexation under mild conditions.

To address the limitations of conventional resistant starches (RSs) cannot simultaneously inhibit the absorption of starch and lipids, a novel RS was synthesized via a synergistic enzymatic (combined branching and amylolysis) -physical-chemical triple modification strategy. After enzymatic modification to optimize the amylose content and average degree of polymerization, physical modification to create empty V-type helical cavities, and esterification to increase resistance, the final modified starch (E-P-C) exhibited both a high RS content of 69.7.

Impaired central sensitivity to thyroid hormone is associated with hypertriglyceridemia in euthyroid population.

Background: We aimed to investigate the correlation between central thyroid hormone sensitivity and Hypertriglyceridemia (HTG) in euthyroid population.

Methods: A total of 833 individuals who underwent physical examinations were randomly selected. Biochemical parameters including thyroid hormones (THs), liver and kidney functions, blood glucose, and blood lipids were measured.

Identification of Immune Hub Genes in Obese Postmenopausal Women Using Microarray and Single-Cell RNA Seq Data.

Obesity is characterized by a chronic state of low-grade inflammation. Investigating immune-critical genes and their biological functions in the adipose tissue of postmenopausal obese women is crucial for elucidating the underlying mechanisms of immune dysregulation associated with obesity. In this study, microarray (GSE151839) and single-cell RNA-seq (GSE176171) datasets were obtained from the Gene Expression Omnibus (GEO).

NR4A1 Mediates Bronchopulmonary Dysplasia-Like Lung Injury Induced by Intrauterine Inflammation in Mouse Offspring.

Intrauterine inflammation (IUI) is involved in the development of bronchopulmonary dysplasia (BPD). Previously, we observed BPD-like pathological changes in a mouse model of IUI. This study aimed to identify the key molecules involved in IUI-induced lung injury, focusing on NR4A1.

M6PR upregulation by berberine attenuates hepatic senescence via sorting STING into endosome for degradation.

Background: Cellular senescence is associated with various hepatic diseases. Stimulator of interferon genes (STING) signaling has been identified as a significant driver of cellular senescence and hepatic stellate cells (HSCs) activation. The blockade of STING signaling serves as a potential strategy to halt senescence.

Treatment-Related Decision Fatigue in Patients With Recurrent Papillary Thyroid Cancer: A Qualitative Study.

The purpose of this study was to explore the experience of treatment-related decision fatigue in patients with recurrent papillary thyroid cancer. Patients with recurrent papillary thyroid carcinoma who were followed up in thyroid surgery wards and outpatient clinics of three tertiary hospitals in Jiangsu Province were included in this study. Semi-structured interviews were conducted from January to April 2024.

Molecular mechanisms of unique therapeutic potential of CUDC-907 for MEF2D fusion-driven BCP-ALL.

MEF2D fusions are found in a special subtype of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with poor prognosis. In this study, we conducted high-throughput drug screenings using cell line and ex vivo cell model harboring, respectively, MEF2D::HNRNPUL1(MH) and MEF2D::BCL9(MB), the two major MEF2D fusions. We identified CUDC-907 as a highly potent dual-target inhibitor of PI3K/HDAC, demonstrating remarkable efficacy in inducing robust lethality while maintaining selectivity for MEF2D fusion-expressing cells.