Identification and validation of the VEGF/p38MAPK/HSP27 pro-tumor inflammatory pathway: screening of active components from and evaluation of their drug-likeness.

Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with pro-tumor inflammation playing a critical role in its initiation and progression. Chronic inflammation acts as a major driving force and a distinct mechanism underlying tumorigenesis. Although previous studies have demonstrated the importance of the VEGF/p38MAPK and p38MAPK/HSP27 signaling pathways in CRC-associated inflammation, a comprehensive understanding of the entire pro-tumor inflammatory mechanism remains incomplete.

Hydrophilicity and Zincophilicity Coincorporated Zwitterionic Additives for High-Performance Zinc Metal Batteries.

Despite the potential of Zn metal batteries (ZMBs) due to their low cost, environmental benefits, and favorable Zn/Zn redox potential, challenges such as low Zn utilization and parasitic reactions hinder their performance. These issues arise from the thermodynamic instability of the Zn anode and high-desolvation energy barriers. To overcome these challenges, this study investigates two zwitterionic compounds with hydrophilic and zincophilic functional groups, BES (N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid) and MES (2-(N-morpholino)ethanesulfonic acid), selecting BES as the optimal electrolyte additive.

Structural characteristics of Brassica rapa L. Polysaccharide and its bioactivity on alcoholic liver injury.

The global prevalence of alcoholic liver disease (ALD) has shown a concerning upward trend, with an increasing incidence among younger demographics. In this study, ultrasound-assisted extraction was employed to isolate polysaccharides from Brassica rapa L (BRL). The purified polysaccharide (BRLPP) was structurally characterized, and its protective effects against alcoholic liver disease (ALD) were investigated.

Nomogram based on pan-immune-inflammation value to predict short-term prognosis in spontaneous intracerebral hemorrhage.

Introduction: The aim of this study was to investigate the impact of the Pan-Immune-Inflammation Value (PIV) on the prognosis of spontaneous intracerebral hemorrhage (ICH) and to develop and validate a nomogram for identifying patients with a poor prognosis following ICH.

Methods: We retrospectively collected the clinical data of 742 patients with ICH admitted to the Affiliated Hospital of Xuzhou Medical University from September 2018 to March 2024. A modified Rankin Scale score > 3 at 90 days after discharge was defined as a poor short-term prognosis.

An integrated research strategy based on "compound exogenous chemical substances-endogenous metabolites in disease": To explore the scientific basis of Modified Bazhen Yimu Gao in the treatment of primary dysmenorrhea.

Ethnopharmacological Relevance: Primary dysmenorrhea (PD) is a common gynecological disease in women, which affects about 45 %-95 % of women. It exerts significant negative effects on the quality of life, learning and work efficiency of women. Modified Bazhen Yimu Gao (MBYG), a proprietary Chinese medicine preparation, has a medication history of 15 years.

Robotic gastrointestinal surgery using the weigao surgical robot system: a single-centre prospective analysis.

Background: The Weigao surgical robot system (WG-NST600S) was successfully developed in China. In this study, we presented our single-centre experience and the short-term outcomes of gastrointestinal surgeries performed using the WG-NST600S system.

Materials And Methods: Between April 2024 and February 2025, consecutive gastrointestinal surgeries were performed using the WG-NST600S system at the participating institution.

β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD/SIRT1 signaling pathways.

Background: Alcoholism is a significant contributor to the development of alcoholic liver disease, for which no universally accepted and effective treatment currently exists. A precursor of NAD, β-Nicotinamide mononucleotide (NMN), has revealed potential therapeutic benefits. However, its effectiveness in preventing ethanol-induced liver damage remains uncertain.

The Effect of Iron and Iodine on the Association Between Particular Matter 2.5 and Thyroid Function in the First Trimester of Pregnancy.

The effect of particulate matter 2.5 (PM) on thyroid function has been reported. However, thyroid function can be affected by iron and iodine, which are essential for the synthesis of thyroid hormones.

Significant Reduction of Chenodeoxycholic Acid and Glycochenodeoxycholic Acid in the Elderly with Severe COVID-19.

Elderly individuals infected with SARS-CoV-2 are at higher risk of developing cytokine storms and severe outcomes, yet specific biomarkers remain unclear. In this study, we investigated the alteration of primary bile acid metabolism in elderly patients with severe COVID-19 using untargeted metabolomics ( = 31), followed by targeted metabolomics to compare patients with disease progression ( = 16) to those without ( = 48). Significant reductions in chenodeoxycholic acid (CDCA) and glycochenodeoxycholic acid (GCDCA) levels were identified in severe cases, with GCDCA levels at admission correlating strongly with peak inflammatory markers.

Arsenic trioxide regulates DYNAP through hsa-mir-573 and inhibits the proliferation of laryngeal cancer.

Laryngeal squamous cell carcinoma (LSCC) is a malignant tumor with limited treatment options and poor prognosis in advanced stages. Arsenic trioxide (ATO), a drug well-known for treating acute promyelocytic leukemia, has shown potential antitumor effects in several solid tumors. This study aimed to investigate the role of ATO on LSCC proliferation and its underlying molecular mechanisms.

RFX2-BNIP3 axis-driven adaptive mitophagy promotes resistance to ACK1-targeted therapy in non-small cell lung cancer.

Activated Cdc42-associated kinase 1 (ACK1) is an oncogenic non-receptor kinase that promotes tumor cell survival and impairs T-cell activation. Targeting ACK1 has great promise in cancer control. However, tumor adaptive responses that may limit the anticancer efficacy of ACK1 inhibition (ACK1i) remain unclear.

M6PR upregulation by berberine attenuates hepatic senescence via sorting STING into endosome for degradation.

Background: Cellular senescence is associated with various hepatic diseases. Stimulator of interferon genes (STING) signaling has been identified as a significant driver of cellular senescence and hepatic stellate cells (HSCs) activation. The blockade of STING signaling serves as a potential strategy to halt senescence.

PD-1 Attenuates Neuropathic Pain by Ameliorating NLRP3 Inflammasome-Mediated Microglia Pyroptosis.

Neuropathic pain lacks effective clinical treatments due to its complex pathogenesis. Growing evidence indicates that programmed cell death receptor-1 (PD-1) plays a vital role in reducing neuropathic pain. Recent studies have also implicated the nucleotide-binding oligomerisation domain-like receptor pyrin domain-containing 3 (NLRP3 inflammasome and its associated pyroptosis in the pathophysiology of various pain types.

Rapidly making biodegradable and recyclable paper plastic based on microwave radiation driven dynamic carbamate chemistry.

In response to the looming concerns of plastic pollution, replacing plastic with paper is a very promising way, but its realization seems a long way off due to the poor water resistance and unsatisfied mechanical strength of cellulose fibril-based materials. Herein, we develop a versatile functionalizing material consisting of mainly biobased cyclic carbonate-bearing compounds and amine compound, which can enable the rapid transformation (within 2 min under microwave radiation) of the cellulose paper into plastic-like material (named paper plastic) having an unprecedently high tensile strength of ~126 MPa. Through a systematic experimental and theoretical study, the paper plastic's combination of excellent mechanical properties and water/solvent resistance is attributed to the easy formation of carbamate abundant non-isocyanate polyurethane cooperated with the intermolecular bond exchange mechanism between the dynamic carbamate moiety and hydroxyl of the cellulose.

Soleus H-Reflex Up-Conditioning during Sciatic Nerve Regeneration in Rats Improves Recovery of Locomotion.

Operant conditioning of the spinal stretch reflex or its electrical analog, the H-reflex, induces plasticity in the brain and spinal cord that increases (up-conditioning) or decreases (down-conditioning) the reflex elicited by primary afferent input to the spinal motoneuron. In rats in which the sciatic nerve is transected and repaired, soleus (SOL) H-reflex up-conditioning during regeneration strengthens primary afferent reinnervation of SOL motoneurons and improves recovery of the SOL H-reflex. This suggests that H-reflex up-conditioning could improve functional recovery after nerve injury and repair.

Extratumoral Signs of Malignant Nonspiculate and Noncalcified Masses on Mammography: Are They Associated With Prognostic Factors in Breast Cancer?

To investigate the association between mammographic extratumoral signs, specifically their subclassifications, of nonspiculate and noncalcified masses (NSNCMs) and prognostic factors in breast cancer. This retrospective study analyzed imaging and pathological data from 374 patients, categorizing extratumoral signs into structural abnormalities (parenchymal and trabecular) and halo, while also undergoing subclassification. The focus prognostic factors were achieved through screening.

AI-based large-scale screening of gastric cancer from noncontrast CT imaging.

Early detection through screening is critical for reducing gastric cancer (GC) mortality. However, in most high-prevalence regions, large-scale screening remains challenging due to limited resources, low compliance and suboptimal detection rate of upper endoscopic screening. Therefore, there is an urgent need for more efficient screening protocols.

Non-hormone replacement therapy to overcome premature ovarian insufficiency: advances in natural products and stem cells targeting autophagy.

Premature ovarian insufficiency (POI) is the most common cause of female infertility. With the increase in people's bad life habits, the causative factors of POI have increased, and its incidence has shown a rising trend year by year. At present, the commonly used clinical treatment for POI is hormonal replacement therapy (HRT), but it is not universally applicable and is prone to cause subsequent complications, posing certain health risks to patients with POI.

Extraction, Structural Analysis, and Bioactivity of a Novel Polysaccharide From Corydalis yanhusuo Residues.

This research extracted and purified polysaccharides from Corydalis yanhusuo residue. The structure of purified polysaccharides of Corydalis yanhusuo (CYP-1) was characterized by methods such as infrared spectroscopy, nuclear magnetic resonance, and monosaccharide composition analysis. In addition, the purified polysaccharides were subjected to preliminary studies in vitro for antioxidant and antitumor activities.

The Single and Combined Effects of Decabromodiphenyl Ethane and Mixed Microplastics on Male Mice Reproductive Toxicity.

The expansive surface area of microplastics (MPs) allow them to retain pollutants, however, the combined toxicity of mixed MPs and organic contaminants remains poorly studied. The semen quality of men worldwide was observed to exhibit downward trends. This study investigates the reproductive toxicity and underlying mechanisms of male mice exposed to MPs and novel brominated flame retardants decabromodiphenyl ethane (DBDPE), individually or combined.

Late-Stage Activation of Toll-like receptor 3 Alleviates Cognitive Impairment and Neuropathology in an Alzheimer's Disease Mouse Model.

This study was to investigate the effects of Toll-like receptor-3 (TLR3) activation on cognitive impairment and neuropathology in late-stage of Alzheimer's disease in a mouse model. Amyloid protein precursor (APP)/presenilin-1 (PSEN1) (APP/PSEN1) mice were treated with Poly (I:C), a specific for TLR3. A panel of neurobehavioral tests were conducted to evaluate their cognitive functions.

Early Immunological and Inflammation Proteomic Changes in Elderly COVID-19 Patients Predict Severe Disease Progression.

Elderly patients infected with SARS-CoV-2 are at higher risk of developing cytokine storm and severe outcomes; however, specific immunological and proteomic biomarkers for early prediction remain unclear in this vulnerable group. We enrolled 182 elderly COVID-19 patients from the Chinese PLA General Hospital between November 2022 and April 2023, categorizing them based on progression to respiratory failure requiring mechanical ventilation (defined as severe progression). Olink proteomic analysis was performed on admission serum from 40 propensity score-matched samples, with differentially expressed proteins (DEPs) validated by cytometric bead array (CBA) in 178 patients.

Mitochondrial metabolism in laryngeal cancer: therapeutic mechanisms and prospects.

Tumours reprogram pathways that regulate nutrient uptake and metabolism to meet the biosynthetic, bioenergetic, and redox requirements of cancer cells. This phenomenon is known as metabolic reprogramming and is edited by the deletion of oncogenes and the activation of proto-oncogenes. This article highlights the pathological mechanisms associated with metabolic reprogramming in laryngeal cancer (LC), including enhanced glycolysis, tricarboxylic acid cycle, nucleotide synthesis, lipid synthesis and metabolism, and amino acid metabolism, with a special emphasis on glutamine, tryptophan, and arginine metabolism.

Bone metastases diminish extraosseous response to checkpoint blockade immunotherapy through osteopontin-producing osteoclasts.

Bone metastatic lesions typically associate with suboptimal responses to immune checkpoint blockade (ICB) therapies. In this study, we observed that across multiple clinical cohorts and a variety of mouse models, the presence of osseous metastases induces ICB resistance in extraosseous tumors. Mechanistically, this long-distance communication is mediated by osseous tumor-conditioned osteoclasts producing osteopontin (OPN).