Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer.

While epithelial-mesenchymal plasticity (EMP) drives cancer metastasis, its regulation by redox dynamics remains poorly understood. Herein, we identified an oxidative stress-responsive CBP/SIRT1 axis that coordinated ZEB1 acetylation at K1108 to promote lung metastasis in triple-negative breast cancer (TNBC). Mechanistically, the biochemical and functional analyses revealed that the dual-acetyltransferase CBP, through stabilization and autoacetylation by oxidative stress, formed a dynamic partnership with SIRT1 to execute precision lysine modification.

Multi-omics integration reveals the impact of mediterranean diet on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease.

Objective: To investigate the effects of the Mediterranean diet (MD) on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: C57BL/6 mice were fed a high-fat diet for 12 weeks to induce MASLD, with normal chow (NC)-fed mice as controls. Post-modeling, MASLD mice were randomized into three groups: HF (continued high-fat diet), HF-NC (switched to normal chow), and HF-MD (switched to MD).

Ginsenoside Rg1 mitigates the prolonged isoflurane anesthesia-induced neuroimmune disruptions.

Ethnopharmacological Relevance: Ginsenoside Rg1, a primary bioactive component of Panax ginseng, has been historically used in traditional Chinese medicine to replenish qi, nourish vitality, and restore cognitive function. Its neuroprotective properties have been documented in conditions involving neurological exhaustion and immune dysregulation.

Aim Of The Study: This study investigated the therapeutic potential and mechanisms of ginsenoside Rg1 in mitigating neurobehavioral and systemic immune dysfunction induced by prolonged general anesthesia.

Amphoteric coplanar conjugated molecules enabling efficient and stable perovskite/silicon tandem solar cells.

The perovskite/silicon tandem solar cells (TSCs) offers a state-of-the-art solution for achieving unparalleled efficiency and cost-effectiveness in solar energy conversion. However, the fabrication of high-quality wide-bandgap perovskite films with a thickness of 1 μm on nano-textured silicon substrates remains a formidable challenge. Herein, we designed an amphoteric coplanar conjugated molecule (ACCM) guided by the principles of density functional theory and Brønsted acid-base chemistry.

Three-dimensional energy-controllable focal spot array with extended depth of focus created by pure phase modulation.

To produce a three-dimensional (3D) energy-controllable focal spot array with an extended depth of focus (EDOF), we propose a pure phase modulation that combines a two-dimensional (2D) pure phase sinusoidal grating (2D PSG) and a light sword optical element (LSOE). The intensity distribution in the 3D focal field is achieved by both simulation and experiment, exhibiting high energy controllability and EDOF. Additionally, the position of the maximum intensity value of any focusing spot exhibits a rotation characteristic, further indicating that the EDOF can be continuously extended.

Gap of women leadership in global obesity research.

Objective: This study aims to evaluate and summarize the current state of gender equality for female scientists in obesity research.

Methods: We conducted a comprehensive analysis of governmental funding, high-impact publications/citations, and awards received by female and male scientists engaged in obesity research worldwide. Median citations were compared by sex and year, with group differences assessed using the nonparametric Mann-Whitney U test.

Development of cardiovascular and all-cause mortality risk prediction models for maintenance hemodialysis patients based on metabolomics.

Introduction: The outcome of maintenance hemodialysis (MHD) remains poor, with cardiovascular death accounting for more than half of all-cause death cases. In this study, cardiovascular mortality and all-cause mortality prediction models were developed to investigate the predictive role of metabolites in MHD patients.

Methods: Clinical and metabolomics data of 135 hemodialysis patients from a single center were collected with a 6-year follow-up.

From shock to strategy: Adversity experiences and Environmental, Social, and Governance investment.

This study investigates the association between individuals' personal experiences and their decisions regarding Environmental, Social, and Governance (ESG) investments. We surveyed 10,000 representative respondents living in 47 prefectures of Japan using quota sampling and analyzed both the extensive and intensive margins of ESG investment decisions, as well as investors' willingness to forgo financial returns. Using data retrieved from an online survey conducted in December 2024, we show via regression analyses that personal experiences linked to ESG component - especially those related to environmental (E) issues - are significantly associated with an increased likelihood of ESG investment.

Nonlinear Imaging Detection of Organ Fibrosis in Minute Samples for Early Stage Utilizing Dual-Channel Two-Photon and Second-Harmonic Excitation.

Histopathological staining remains the fibrosis diagnostic gold standard yet suffers from staining artifacts and variability. Nonlinear optical techniques (e.g.

Sex Difference of Alcoholic Hypertension: Mechanism and Targeted Therapy.

Purpose Of Review: This review provides a critical examination of the sex-specific impact of alcohol consumption on the development and progression of hypertension. Specifically, it elucidates the differential roles of alcohol metabolism and blood pressure regulatory mechanisms in men and women. Finally, it explores promising sex-specific therapeutic strategies for the management of alcoholic hypertension.

Differences in odor-active compounds and non-volatile precursors between spray-dried and freeze-dried Spirulina platensis revealed by GC×GC-TOFMS-O and UPLC-MS/MS.

The effects of freeze-drying and spray-drying on odorants and precursors in Spirulina platensis (Sp) cultivated in different environments (gj: glass jar; rp: raceway pond; cp: circular pond) were investigated. Ninety-four odorants were identified, and hexanal, (Z)-4-decenal, (E, E)-2,4-decadienal, β-cyclocitral, β-ionone, dimethyl trisulfide exhibited higher flavor dilution factors (≥ 81). Spray-drying increased pyrazines and terpenoids formation, enhancing roasted and seaweed-like odors, whereas freeze-drying retained higher levels of aldehydes and acids, causing fishy and rancid odors.

Mollugin attenuates oxygen-glucose deprivation/reperfusion-induced brain microvascular endothelial cell death and permeability through activation of BDNF/TrkB-modulated Akt pathway.

Brain microvascular endothelial cell injury is an important pathological basis for blood-brain barrier damage in ischemic stroke. Mollugin is a bioactive phytochemical constituent from Rubia cordifolia L., which has a protective potential in some diseases.

Late-Stage Activation of Toll-like receptor 3 Alleviates Cognitive Impairment and Neuropathology in an Alzheimer's Disease Mouse Model.

This study was to investigate the effects of Toll-like receptor-3 (TLR3) activation on cognitive impairment and neuropathology in late-stage of Alzheimer's disease in a mouse model. Amyloid protein precursor (APP)/presenilin-1 (PSEN1) (APP/PSEN1) mice were treated with Poly (I:C), a specific for TLR3. A panel of neurobehavioral tests were conducted to evaluate their cognitive functions.

High-Performance Ratiometric Fluorescence pH Sensor Based on HPTS-IP/TiO@THHM Sensing Film.

A high-performance ratiometric fluorescence pH sensor based on HPTS-IP/TiO@THHM pH sensing film which contains a pH sensing layer and a scattering layer was developed. The pH sensing layer and scattering layer were fabricated by embedding HPTS-IP hydrophobic ion pairs and TiO in TEOS-HTES organic/inorganic hybrid matrix (THHM), respectively. The HPTS-IP hydrophobic ion pairs were excited using pulsed signals from two LEDs with emission peaks of 404 nm and 454 nm, respectively.

A transcriptomic and proteomic analysis and comparison of human brain tissue from patients with and without epilepsy.

The present study was to investigate potential biomarkers and therapeutic targets for epilepsy by conducting a transcriptomic and proteomic analysis of human brain tissue from patients with epileptic lesions. Brain tissue was collected from the epileptic lesions after surgical resection and surgical removed brain tissue from non-epileptic patients. Using RNA sequencing and iTRAQ-based proteomic analysis, The transcriptomic analysis identified 1,604 DEGs, with 584 upregulated and 1,020 downregulated.

Angiotensinogen inhibition concurrently mitigates alcohol-associated hepatic and muscle injury.

Aims: The organ communication mechanisms driven by alcohol-associated liver disease (ALD) remain inadequately understood. This study explores the endocrine roles of the hepatokine angiotensinogen (AGT) and the renin-angiotensin system (RAS) in ALD.

Methods And Results: Hepatokine screening tests revealed that chronic-binge ethanol consumption upregulates hepatic AGT production, triggering downstream RAS activation.

Association of Co-Exposure to Polycyclic Aromatic Hydrocarbons and Metal(loid)s with the Risk of Neural Tube Defects: A Case-Control Study in Northern China.

Objective: Exposure to polycyclic aromatic hydrocarbons (PAHs) or metal(loid)s individually has been associated with neural tube defects (NTDs). However, the impacts of PAH and metal(loid) co-exposure and potential interaction effects on NTD risk remain unclear. We conducted a case-control study in China among population with a high prevalence of NTDs to investigate the combined effects of PAH and metal(loid) exposures on the risk of NTD.

Osteoimmunology in Osteoarthritis: Unraveling the Interplay of Immunity, Inflammation, and Joint Degeneration.

Osteoarthritis (OA) is a degenerative joint disease influenced by multiple factors, with its etiology arising from intricate interactions among mechanical stress, inflammatory processes, and disruptions in bone metabolism. Recent research in bone immunology indicates that immune-mediated mechanisms significantly contribute to the progression of OA, highlighting the interactions among immune cells, cytokine networks, and bone components. Immune cells interact with osteoclasts, osteoblasts, and chondrocytes in a variety of ways.

Deep learning radiomics for the prediction of epidermal growth factor receptor mutation status based on MRI in brain metastasis from lung adenocarcinoma patients.

Background: Early and accurate identification of epidermal growth factor receptor (EGFR) mutation status in non-small cell lung cancer (NSCLC) patients with brain metastases is critical for guiding targeted therapy. This study aimed to develop a deep learning radiomics model utilizing multi-sequence magnetic resonance imaging (MRI) to differentiate between EGFR mutant type (MT) and wild type (WT).

Methods: In this retrospective study, 288 NSCLC patients with confirmed brain metastases were enrolled, including 106 with EGFR MT and 182 with EGFR WT.

Single-cell RNA-seq reveals the immune response of Co-infection with streptococcus pneumoniae after influenza A virus by a lung-on-chip: The molecular structure and mechanism of tight junction protein ZO-1.

Secondary bacterial infection is the main cause of pneumonia after influenza virus infection. This study aims to explore the impact of co-infection of influenza A virus (IAV) and Streptococcus pneumoniae (SP) on lung immune response using a human lung-on-chip model and single-cell RNA sequencing technology, with a focus on the molecular structure and mechanism of action of the tight junction protein ZO-1 in this process. Research and construct a human lung-on-chip model to simulate the microenvironment of the lungs in vivo.

Slice2Mesh: 3D Surface Reconstruction From Sparse Slices of Images for the Left Ventricle.

Cine MRI is a widely used technique to evaluate left ventricular function and motion, as it captures temporal information. However, due to the limited spatial resolution, cine MRI only provides a few sparse scans at regular positions and orientations, which poses challenges for reconstructing dense 3D cardiac structures, which is essential for better understanding the cardiac structure and motion in a dynamic 3D manner. In this study, we propose a novel learning-based 3D cardiac surface reconstruction method, Slice2Mesh, which directly predicts accurate and high-fidelity 3D meshes from sparse slices of cine MRI images under partial supervision of sparse contour points.

Remote sensing-based maize growth process parameters revel the maize yield: a comparison of field- and regional-scale.

The accurate estimation of regional crop yields holds significant importance for optimizing subsequent resource allocation and maximizing economic returns in agriculture. Crop yield can be effectively estimated by assessing the overall growth status through long-term remote sensing observations. However, most previous studies have relied on remote sensing data from one or a few periods for yield estimation, thus lacking a comprehensive description of entire crop growth.

Liver diseases: epidemiology, causes, trends and predictions.

As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles in metabolism, detoxification, and immune response. Various factors including viruses, alcohol, metabolites, toxins, and other pathogenic agents can compromise liver function, leading to acute or chronic injury that may progress to end-stage liver diseases. While sharing common features, liver diseases exhibit distinct pathophysiological, clinical, and therapeutic profiles.

Ultrasmooth Micromilling of Stainless Steel by Ultrashort Pulsed Laser Ablation Using MHz Bursts.

Ultrashort pulsed (USP) laser burst ablation has attracted numerous interests for its great potential in enhancing ablation efficiency and reducing the heat-affected zone. However, little attention has been paid to the influence of burst ablation on the processed surface quality. To fill this research gap, the present study conducts a comprehensive investigation on the surface processing of stainless steel using ultrashort pulsed laser burst ablation.

ADARp110 promotes hepatocellular carcinoma progression via stabilization of CD24 mRNA.

ADAR is highly expressed and correlated with poor prognosis in hepatocellular carcinoma (HCC), yet the role of its constitutive isoform ADARp110 in tumorigenesis remains elusive. We investigated the role of ADARp110 in HCC and underlying mechanisms using clinical samples, a hepatocyte-specific knock-in mouse model, and engineered cell lines. ADARp110 is overexpressed and associated with poor survival in both human and mouse HCC.