Effects of immune checkpoint inhibitors on the pulmonary circulation in lung cancer patients.

Immune checkpoint inhibitors (ICIs) are effective anti-tumor agents, but new immune-related side effects (irAEs) are emerging. This retrospective cohort study investigated 461 lung cancer patients treated with ICIs over 2 years, analyzing changes in pulmonary artery diameter (PAD), aortic diameter (AoD), and the pulmonary artery/aortic diameter (PAD/AoD) ratio through chest computed tomography (CT) at baseline, 3 months, 6 months, 1 year, and 2 years post-treatment. The PAD increased from 25.

Plasma metabolites, metabolic risk score and colorectal cancer risk: a prospective cohort study.

The associations of colorectal cancer (CRC) risk with metabolites, lifestyle factors and their joint effects have not been fully elucidated. Therefore, we conducted a prospective cohort study to estimate the associations of CRC risk with metabolites, metabolic risk score (MRS) and its joint associations with lifestyle factors. This study included 82,514 participants with plasma metabolites data in the UK Biobank.

Serum ascites albumin gradient in predicting the severity of hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids.

Aim Of The Study: Hepatic sinusoidal obstruction syndrome induced by pyrrolizidine alkaloids (PA-HSOS) is a form of drug-induced liver injury (DILI) associated with portal hypertension (PH). The serum-ascites albumin gradient (SAAG) is known to be directly related to PH. However, the clinical value of SAAG for predicting the severity of PA-HSOS is unknown.

Intracranial pressure trajectories and functional outcomes in pediatric intracranial hemorrhage: a group-based trajectory modeling analysis.

Unlabelled: Monitoring the dynamic changes in intracranial pressure (ICP) is crucial for assessing clinical outcomes in pediatric intracranial hemorrhage (ICH). However, the ICP trajectory patterns remain unknown. We aim to identify distinct ICP trajectory patterns in pediatric ICH and assess their impact on clinical outcomes.

Research status and trends of drug-coated balloons in coronary artery disease: a bibliometric analysis.

Objective: Drug-coated balloons have emerged as a pivotal alternative to drug-eluting stents in the interventional management of coronary artery disease, particularly showing clinical advantages in the treatment of in-stent restenosis and small-vessel disease. This study provides a systematic bibliometric analysis of publication trends, research hotspots, and future directions in DCB-related CAD research from 2004 to June 2025.

Methods: A total of 1,092 publications indexed in the Web of Science, Scopus, and PubMed databases were analyzed using CiteSpace, VOSviewer, and bibliometrix.

Bibliometric and visual analysis of overlooked fatigue in kidney transplantation: a narrative review.

Background: Fatigue significantly influences and predicts quality of life, social function, and graft survival after kidney transplantation. Accurate assessment and management of fatigue in kidney transplant recipients are vital, especially when planning treatment strategies and potential rehabilitation programs. However, there is no bibliometric report in this area.

Effect of toe box size on basketball-specific movement performance.

Purpose: While an expanded toe box (TB) design offers notable benefits for foot health in basketball players, its impact on movement performance remains insufficiently elucidated. This study aimed to explore this relationship and inform the development of advanced shoe designs.

Methods: We conducted a controlled laboratory study with a within-subject crossover design.

Identification of Double-Chain ZnO Structure on ZrO as a Highly Active Site for CO Hydrogenation to Methanol.

ZnZrO catalysts exhibit excellent performance in the hydrogenation of CO to methanol, yet the structural identification of active sites in the mixed oxide remains elusive. Herein, combining density functional theory calculations, large-scale machine-learning atomic simulations, and microkinetic modeling, we discovered that double-chain ZnO structures supported on monoclinic ZrO(1̅11) surfaces (ZnO-ZrO) are highly active and stable for methanol synthesis. The double-chain ZnO structure, corresponding to 50% ZnO surface coverage and featuring interconnected 8-membered rings, induces a local minimum (0.

Diffusion-QSM: diffusion model with timetravel and resampling refinement for quantitative susceptibility mapping.

Objective: Quantitative susceptibility mapping (QSM) is a useful magnetic resonance imaging technique. We aim to propose a deep learning (DL)-based method for QSM reconstruction that is robust to data perturbations.

Methods: We developed Diffusion-QSM, a diffusion model-based method with a time-travel and resampling refinement module for high-quality QSM reconstruction.

Unraveling the complexity of neurodegeneration: heterogeneous damage patterns of locus coeruleus and substantia nigra in Alzheimer's disease.

Introduction: Alzheimer's disease (AD) involves complex neurodegeneration in the locus coeruleus (LC) and substantia nigra (SN), critical brain regions affecting cognitive and emotional processes.

Methods: Using the National Alzheimer's Coordinating Center dataset of 11,583 participants, we conducted a multimodal analysis involving descriptive statistics, multifactorial regression, mediation analysis, and receiver operating characteristic curve assessment.

Results: LC degenerative changes (18.

Tumor-activated nanocomplex reprograms cancer and macrophage metabolism in opposite directions to overcome immune suppression.

Immunotherapy efficacy is hindered by the immunosuppressive metabolism of cancer cells and tumor-associated macrophages (TAMs), yet their opposite metabolic programs complicate synchronized modulation of tumor microenvironment. Here, we report an acid-activated Fe-Zn nanocomplex (FZNC) that transforms into spiky FeOOH nanoparticles within the tumor microenvironment. This transformation enhances cellular uptake and enables selective scavenging of hydrogen sulfide (HS)-a metabolite that promotes glycolysis in cancer cells and oxidative phosphorylation (OXPHOS) in TAMs.

Fto-mediated mA modification is essential for cerebellar development through regulating epigenetic reprogramming.

Background: Growing evidence highlights the importance of epitranscriptomic regulation in cerebellar development and function, especially through mA methylation. Nevertheless, the precise function of the RNA demethylase Fto in the cerebellum is still uncertain.

Methods: An Fto knockout (Fto) mouse model was generated to investigate the role of Fto in cerebellar development.

Enhanced enzyme stability at the interphase of water-oil for continuous-flow olefin epoxidation.

The practical applications of enzymes often require their immobilization for multiple recycling or long-term running. However, practically efficient enzyme immobilization methods are lacking. Herein, we present an enzyme immobilization approach by engineering a porous "interphase" between water and oil around the surfaces of Pickering emulsion droplets.

Transcriptomic and Lipidomic Analysis Reveals the Regulatory Network of Lipid Metabolism in .

Hemp possesses significant healthcare value due to its rich composition of unsaturated fatty acids and a distinctive golden ratio of linoleic acid to α-linolenic acid. As a promising special-oil crop, it holds substantial potential for development and utilization. However, the regulatory mechanisms underlying its lipid metabolic pathways remain poorly understood.

Supplement C18:1 in Culture Medium to Improve Survival Rate and Fermentation Activity of Lyophilization of L9.

This study explored the impact of C18:1 fatty acid supplementation in culture medium on the survival rate, fermentation activity, and membrane stability of L9 during freeze-drying. Cells cultured in medium supplemented with C18:1 (0.2 mg/ml) exhibited a higher survival rate (95.

An Antibody Cocktail-Based Immunoaffinity-LC-MS Method Enabled Ultra-Sensitive and Robust Quantification of Circulating Proinsulin Proteoforms and C-Peptide.

Accurately measuring circulating proinsulin proteoforms is crucial for clinical investigation of diabetes, but was previously not feasible owing to limited assay specificity/sensitivity. Here we devised a highly sensitive LC-MS-based strategy to quantify intact proinsulin, des-31,32 and des-64,65 proinsulin, and C-peptide in circulation. The method involves: (i) quantitative, robust affinity capture using an optimized antibody cocktail, eliminating the severe quantitative bias across multiple proteoforms typically introduced when using a single antibody; (ii) Lys-C digestion producing unique signature peptides for each proteoform, and (iii) trapping-nano-LC coupled with FAIMS/dCV-MS for an ultrasensitive analysis.

Artificial intelligence-assisted quality control circles led by clinical pharmacists to improve the rational use of parenteral proton pump inhibitors among hospitalised patients.

Proton pump inhibitors (PPIs) are a class of drugs that inhibit gastric acid secretion and are commonly overused in clinical practice. We developed a quality control circle (QCC) assisted by artificial intelligence (AI) and led by clinical pharmacists to improve rational PPI use among patients in our hospital. A QCC team was established to follow QCC procedures.

Atherogenic index of plasma and its 5-year changes associated with type 2 diabetes risk: a 10-Year cohort study.

Background: The global burden of type 2 diabetes mellitus (T2DM) is increasing, particularly in resource-limited settings like rural China. Although traditional blood glucose remains an essential measurement for diabetes screening, Atherogenic Index of Plasma (AIP) is emerging as a complementary predictor of T2DM risk. Over time, however, the association between AIP and T2DM risk remains insufficiently understood.

Precision and Accuracy in Quantitative Measurement of Gene Expression from Single-cell/nuclei RNA Sequencing Data.

Single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) have become essential tools for profiling gene expression across different cell types in biomedical research. While factors like RNA integrity, cell count, and sequencing depth are known to influence data quality, quantitative benchmarks and actionable guidelines are lacking. This gap contributes to variability in study designs and inconsistencies in downstream analyses.

Characterization of cis-regulatory elements and functional variants in colorectal cancer using epigenomics and CRISPRi screenings.

Genetic variants associated with colorectal cancer (CRC) are primarily noncoding and reside in cis-regulatory elements (CREs), yet their underlying mechanisms remain elusive. Here we established a dynamic epigenetic atlas using multiomics data from 533 colorectal tissues spanning normal to advanced adenoma to cancer, identifying 7,492 differential CREs linked to 5,490 target genes. High-throughput CRISPR interference screening revealed 265 functional CREs involved in CRC cell proliferation.

Flexible wearable medical devices: from material innovations and data processing to intelligent healthcare applications.

Background: Flexible wearable medical devices drive healthcare transformation via non-invasive, real-time physiological monitoring and personalized management. Traditional rigid devices lack long-term comfort, while chronic disease care and telemedicine demand reliable, patient-centered solutions. Advances in materials (carbon nanomaterials, liquid metals, hydrogels) enable stretchable, biocompatible substrates adapting to bodily movements.

Characteristics and associated cognitive indicators of decision-making decline over time in older people with mild cognitive impairment.

Background: Impaired decision-making (DM) under uncertainty in mild cognitive impairment (MCI) increases financial vulnerability and suboptimal medical decision-making OBJECTIVE: This two-year longitudinal study characterized DM changes in MCI and identified modifiable cognitive correlates for functional preservation.

Methods: Fifty-two MCI and 49 cognitively normal (CN) participants underwent annual Iowa Gambling Task (IGT), modeled via Outcome-Representation Learning (ORL) to quantify reward/punishment learning rates (A/A), memory decay (K), and win/deck perseverance (β/β). Concurrent neuropsychological assessments measured six domains.

The intricate dance of RNA-binding proteins: unveiling the mechanisms behind male infertility.

Background: RNA-binding proteins (RBPs) are indispensable for transcriptional and post-transcriptional processes during spermatogenesis, orchestrating germ cell proliferation, differentiation, and maturation. Despite their established importance, the contributions of RBPs in male infertility remain underexplored. Recently, a seminal Science publication reported an RBP atlas of 1744 murine testicular RBPs, 22 loss-of-function variants, and 137 deleterious missense variants identified in 1046 infertile patients, providing unprecedented opportunities to investigate their molecular and clinical relevance.

Ginsenoside Rh2 ameliorates pulmonary fibrosis via HSP70-dependent autophagic flux regulation and senescence arrest.

Ethnopharmacological Relevance: Panax ginseng C.A. Meyer, a prominent Qi-tonifying herb in Traditional Chinese Medicine (TCM), has been traditionally used to enhance spleen and pulmonary functions through Qi regulation, consistent with the TCM doctrine of "fortifying vital qi while dispelling pathogens".

Driving pressure-guided dynamic PEEP titration reduces atelectasis and improves oxygenation in pediatric laparoscopy: a randomized trial on personalized ventilation strategies.

Background: Pediatric laparoscopic surgery often induces atelectasis due to pneumoperitoneum, postural changes, and immature respiratory physiology, increasing postoperative pulmonary complications (PPCs). Fixed PEEP may fail to address perioperative variability. This study evaluated whether dynamic PEEP adjustment reduces atelectasis and improves oxygenation.