Mobile App-Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes: A Randomized Clinical Trial.

Importance: Controlling modifiable cardiovascular risk factors is important but underused for patients with type 2 diabetes (T2D). Mobile message-based intervention strategies could address this gap but lack evidence of benefit on multiple risk factors.

Objective: To evaluate the effectiveness of a mobile message-based intervention in controlling cardiovascular risk factors in patients with T2D.

CircCRIM1 promotes the translation of HIF-1α protein through its interaction with PTBP3 and enhances malignant progression and angiogenesis in glioblastoma.

Glioblastoma (GBM) is the most aggressive type of primary intracranial tumor. Circular RNAs (circRNAs) are closely related to the malignant progression of GBM. Elevated levels of Circular RNA hsa_circ_0002346 (circCRIM1) significantly correlate with tumor growth, metastasis, and poor prognosis, suggesting its potential as a biomarker for cancer diagnosis and treatment response.

Recent Progress on the Research of 3D Printing in Aqueous Zinc-Ion Batteries.

The global transition towards a low-carbon energy system urgently demands efficient and safe energy storage solutions. Aqueous zinc-ion batteries (AZIBs) are considered a promising alternative to lithium-ion batteries due to their inherent safety and environmental friendliness. However, conventional manufacturing methods are costly and labor-intensive, hindering their large-scale production.

Innovations in the meat colloid science: Exploring the future of meat from the perspectives of sustainability, health, and personalization.

Meat is an important food source with rich nutrition. Its distinctive flavor attracts people to enjoy the pleasure of food. However, some problems about sustainability, health, and personalization (high energy consumption in farming, negative effects of high salt/fat in meat on health, and the personalized demand for meat texture and shape) arise with meat consumption.

Latent Profile Analysis of Dyadic Decision Self-Efficacy Among Stroke Patients and Their Caregivers.

Objective: To explore the latent categories and influencing factors of dyadic decision self-efficacy among stroke patients and their caregivers.

Methods: A cross-sectional survey involving 305 patient-caregiver pairs was conducted using standardised questionnaires. Latent profile analysis was used to identify dyadic self-efficacy categories and multinomial logistic regression was employed to analyse influencing factors.

Construction and validation of a frailty risk prediction model for geriatric hematologic neoplasms patients: A cross-sectional study.

BackgroundWith the increasing incidence of malignant hematological neoplasms in the elderly population, debilitating issues have gradually become an important challenge for patients.ObjectivesTo construct a prediction model, draw a nomogram, and perform internal validation of the model.Methods505 elderly patients with hematological neoplasms were included in the study.

[Retracted] Effects of TLR4 gene silencing on the proliferation and apotosis of hepatocarcinoma HEPG2 cells.

[This retracts the article DOI: 10.3892/ol.2016.

Transformer is involved in female sex determination in Bemisia tabaci.

Sex determination is one of the fundamental questions in developmental and evolutionary biology. While the upstream regulatory mechanisms governing somatic sex determination in insects are highly divergent, the downstream transformer (tra) + transformer2 (tra2) → doublesex (dsx) pathway is relatively conserved. In the sweet potato whitefly, Bemisia tabaci, a global invasive pest, tra2 and dsx have been previously characterised, revealing their critical role in male genitalia formation.

Severe hypotension induced by Almonertinib: a case report with literature review and clinical insights.

Lung adenocarcinoma is a common malignancy in clinical practice, but the coexistence of lung and gastric adenocarcinomas in a single patient is rare. This report presents the case of a 70-year-old male with a history of smoking for over 30 years, diagnosed with both lung adenocarcinoma and gastric adenocarcinoma through lung biopsy and gastroscopy. Following comprehensive evaluations and exclusion of treatment contraindications, the patient underwent a therapeutic regimen comprising Sintilimab combined with nab-paclitaxel and cisplatin.

Two DNA-binding One Zinc Finger transcription factors, MdCDOF3 and MdDOF3.6, accelerate leaf senescence by activating in response to sorbitol signaling in apple.

Leaf senescence, an essential component of the plant life cycle, seriously affects the productivity of numerous commercial crops, with cytokinins serving as crucial regulators in delaying this process. Here, we observed that apple () leaves exhibiting deficiencies in sorbitol synthesis due to antisense inhibition of () presented an increase in cytokinin content and exhibited a delay in leaf senescence, in contrast to wild-type (WT) leaves. Transcriptome analysis indicated that the expression of (), encoding a key enzyme in the cytokinin degradation pathway, was significantly downregulated in the antisense lines.

Dynamic Changes in Functional CTL and NK Lymphocyte Subsets in the Early Stage After Renal Transplantation.

Background: Functional lymphocytes play a pivotal role in renal injury and rejection following transplantation. Understanding their dynamic changes is essential for evaluating renal allograft function and predicting rejection. However, the early postoperative dynamics of these subsets and their relationship with renal function remain unclear.

Tislelizumab-induced anaphylactic shock: a case report.

Immune-checkpoint inhibitors (ICIs) have transformed cancer therapy, but immune-related adverse events (irAEs) remain a major concern. Tislelizumab-a humanised anti-PD-1 monoclonal antibody-has a favourable safety profile; thus, severe hypersensitivity reactions are rarely reported. A 61-year-old male patient was admitted in October 2023 with complaints of intermittent cough and dyspnoea for 1 year, aggravation accompanied by fatigue and bloody sputum for more than 20 days.

Discovery of Dual-Acting Biofilm Inhibitors against by the Coupling of 3-Hydroxypyridin-4(1)-ones with -Phenylamide QS Inhibitors.

() is prevalent in hospital infections and strongly complicates the treatment for its propensity to cause biofilm-associated resistance. Herein, a series of novel dual-acting biofilm inhibitors were designed and synthesized by coupling 3-hydroxypyridin-4(1)-ones with -phenylamides quorum sensing inhibitors. The hit compound (IC = 0.

Combining biomarkers to predict the disease activity of graves' ophthalmopathy: a combinatory model of the NLR, TRAb and FT4.

Purpose: The aim of this study was to identify potential biomarkers associated with active Graves' ophthalmopathy (GO) and develop a model for predicting the occurrence and progression of active GO.

Methods: A retrospective study was conducted on 220 GO patients (n=120 in the active phase, n=100 in the stable phase) and 70 healthy controls. Laboratory and other clinical indicators were compared in GO patients at different stages and healthy controls.

Effect of light therapy and continuous health education on older adults with coronary heart disease and comorbid depressive symptoms: A randomized controlled trial.

This study aimed to assess the efficacy of Light Therapy (LT) along with continuous health education on community-dwelling elderly Coronary Heart Disease (CHD) patients with comorbid Depressive Symptoms (DSs). A stratified whole-cluster random sample of 60 community-dwelling patients aged ≥65 years with CHD and comorbid DSs was selected and randomized. The participants were randomized into control and intervention groups for routine management alone and LT+continuous health education intervention, respectively (N = 30 each).

Pyrrolidinium Fullerenes as YTHDF1 Inhibitors for Targeted Tumor Therapy.

Cancer remains a leading cause of global morbidity and mortality, necessitating the development of novel targeted therapies. This study explores the therapeutic potential of pyrrolidinium fullerenes as YTH N-methyladenosine RNA binding protein 1 (YTHDF1) inhibitors for cancer treatment. A series of functionalized pyrrolidinium fullerenes is synthesized and characterized, including C-(N,N-dimethyl-pyrrolidinium iodide) (NDMPFI), C-(N-methyl-N-benzyl-pyrrolidinium iodide) (NMBPFI), and C-(N-methyl-N-hydroxyethyl-pyrrolidinium iodide) (NMHPFI).

Spillover effects of integrated care: Evidence from the impact of Home- and Community-Based Integrated Care for Older Adults (HCICOA) on spouses' health and well-being in China.

Background: Home- and Community-Based Integrated Care for Older Adults (HCICOA) has been rapidly implemented in China to address aging population needs. While its direct benefits for care recipients are well studied, its spillover effects on spouses remain underexplored. This study examines HCICOA's impact on spouses' health and well-being.

Effect of dapagliflozin on metabolic dysfunction-associated steatohepatitis: multicentre, double blind, randomised, placebo controlled trial.

Objective: To assess the efficacy and safety of the sodium-glucose cotransporter 2 inhibitor dapagliflozin in participants with metabolic dysfunction-associated steatohepatitis (MASH).

Design: Multicentre, double blind, randomised, placebo controlled trial.

Setting: Six tertiary hospitals in China from 23 November 2018 to 28 March 2023.

Development of magnetic particle-based chemiluminescence immunoassay for quantitative determination of hepatitis C virus core antigen.

Objectives: Development of an immunoassay for quantitation detecting the highly conserved hepatitis C core antigen (HCVcAg).

Methods: Anti-HCVcAg monoclonal antibodies (mAbs) were developed and evaluated using enzyme-linked immunosorbent assay (ELISA), and the chemiluminescence enzyme immunoassay (CLEIA) was also proposed. The serum HCVcAg was measured to evaluate and analyze the performance of CLEIA and analysis of the mAb pair was evaluated by sequencing of the antibody variable region.

Venetoclax confers synthetic lethality to chidamide in preclinical models with transformed follicular lymphoma.

Transformed follicular lymphoma (t-FL) is an aggressive and heterogeneous hematological malignancy with limited treatment success; the development of novel therapeutic approaches is urgently needed for patients with t-FL. Here, we conducted high-throughput screening (HTS) and in vitro experiments using t-FL cell lines and primary samples to assess the synergistic effects of the histone deacetylase inhibitor chidamide and the BCL-2 inhibitor venetoclax. In vivo efficacy was further tested in xenograft models.

Latent profile analysis of fear of progression in Chinese hematologic malignancy survivors.

Fear of disease progression (FoP) is a multidimensional concept that refers to the fear or worry about disease progress. Little is known about the distinct FoP profiles and their determinants in culturally specific contexts, especially among hematologic malignancies (HM) patients in China. This study aimed to identify heterogeneous profiles of FoP and their associated predictors among Chinese patients with HM.

Antithrombotic effect and plasma pharmacochemistry of Justicia Procumbens L.

Importance: Justicia procumbens L. contains lignans with remarkable antiplatelet aggregation effects. Its ethyl acetate extract has demonstrated the efficacy of inhibiting platelet aggregation in preliminary tests.

High Diversity and Prevalence of Rickettsial Agents in Ticks from Livestock in Karst Landscapes of Southwest China.

Ticks and tick-borne pathogens pose a significant threat to human and animal health, yet the diversity and prevalence of tick-borne microorganisms in karst regions remains inadequately explored. In October 2023, a total of 274 ticks were collected from livestock in Guizhou Province, which boasts the largest karst area in China. Pathogen identification was subsequently performed using PCR amplification, Sanger sequencing, and phylogenetic analysis.

NKG2D-CAR-targeted iPSC-derived MSCs efficiently target solid tumors expressing NKG2D ligand.

Mesenchymal stem cells (MSCs) hold potential in cancer therapy; however, insufficient tumor homing ability and heterogeneity limit their therapeutic benefits. Obviously, the homogeneous induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) with enhanced ability of tumor targeting could be the solution. In this study, a CAR containing the NKG2D extracellular domain was targeted at the locus of iPSCs to generate NKG2D-CAR-iPSCs, which were subsequently differentiated into NKG2D-CAR-iMSCs.