Targeting HMGB1 modulates cancer-associated fibroblasts and enhances radiotherapy in lung adenocarcinoma.

Radio-resistance remains a major challenge in the effective treatment of lung cancer. Cancer-associated fibroblasts (CAFs), the predominant cellular components in solid tumors, play a crucial role in tumor treatment and resistance. Thus, understanding the interactions between CAFs and tumor cells is key to overcoming radio-resistance in lung cancer.

Steering CO Electroreduction Pathway via Tuning Microenvironment of Cobalt Center in Molecular Catalysts.

Owing to its chemical stability and molecular-level structural tunability, the molecular electrocatalyst cobalt phthalocyanine (CoPc) demonstrates significant potential for the electrochemical reduction of CO (CORR). However, the specific catalytic reaction process of CORR and the dynamic structural evolution mechanisms of CoPc remain a contentious subject. Elucidating the reaction pathways of CO electroreduction to CO and tracking structural evolution pose substantial challenges.

Mobile App-Based Intervention and Cardiovascular Risk Factors in Patients With Uncontrolled Type 2 Diabetes: A Randomized Clinical Trial.

Importance: Controlling modifiable cardiovascular risk factors is important but underused for patients with type 2 diabetes (T2D). Mobile message-based intervention strategies could address this gap but lack evidence of benefit on multiple risk factors.

Objective: To evaluate the effectiveness of a mobile message-based intervention in controlling cardiovascular risk factors in patients with T2D.

Ten thousand hour stable zinc air batteries via Fe and W dual atom sites.

Durable and highly active oxygen electrocatalysts are crucial to the large-scale application of rechargeable zinc-air batteries. Here we utilize the N unit in phthalocyanine molecule to trap the tungsten atoms scratched off from the tungsten carbide milling balls and place the obtained W-N unit adjacent to the Fe-N units from iron (Ⅱ) phthalocyanine, resulting in highly active Fe-N/W-N diatomic sites with well-pronounced 3d-5d hybrid for efficient and durable oxygen electrocatalysis. The electron distribution of the Fe-N site is optimized by the neighboring W-N site, which facilitates the O activation and the desorption of *OH and enhances the catalytic activity of the Fe-N site.

Identification of Salivary Exosome-Derived miRNAs as Potential Biomarkers for Non-Invasive Diagnosis and Proactive Monitoring of Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD), a chronic inflammatory disorder with relapsing/remitting characteristics, lacks reliable non-invasive biomarkers for accurate diagnosis and longitudinal monitoring. This study explored salivary exosomal miRNAs as potential biomarkers to address this unmet clinical need. Using discovery (24 IBD patients [11 active, 13 remission] and 6 healthy controls [HCs]) and validation cohorts (102 IBD patients [53 active, 49 remission] and 18 HCs), we analyzed miRNA profiles via reverse transcription quantitative PCR (RT-qPCR).

Naringenin Inhibits Enterotoxigenic -Induced Ferroptosis via Targeting HSP90 in IPEC-J2 Cells.

Enterotoxigenic (ETEC) leads to severe diarrhea in piglets. Naringenin (Nar), a natural flavonoid compound, is known for its antibacterial and anti-antioxidant properties. However, the protective effects of Nar against ETEC-induced diarrhea have not been reported yet.

Facile Synthesis of High Areal Density and Stable Pt Single-Atom Electrocatalysts by Arc Discharge Atomization and CoNi Trapping.

Pt-group metal single-atom catalysts (SACs) with a large single-atom areal density are highly desirable for efficient electrocatalysis but remain challenging to synthesize. Herein, a facile vacuum direct current arc discharge (DCAD) strategy is reported for the rapid and scalable synthesis of Pt SACs with an unprecedented areal density of 10.6 atoms nm (3.

Effects of yeast culture () on growth performance, serum biochemistry, rumen fermentation and microbiota of intake-restricted multiparous Suffolk sheep.

Introduction: This study evaluated the effects of yeast culture (YC) supplementation on growth performance, nutrient digestibility, serum parameters, rumen fermentation, and bacterial communities in intake-restricted multiparous Suffolk sheep, aiming to provide a theoretical basis for enhancing productivity.

Methods: Thirty multiparous Suffolk sheep (Suffolk♂ × Hu♀), with a mean body weight of 22 ± 0.5 kg, were arbitrarily assigned to three experimental groups: ad libitum feeding (AL), intake restriction (20% reduction, IR), and intake restriction with 30 g/d YC supplementation (20% reduction, IRY) groups ( = 10), and each sheep was housed separately.

RoadDiffBox: Automatic Road Distress Diagnosis through Controlled Image Generation and Semi-Supervised Learning.

During the designed service life, road infrastructures will bear repeated loading conditions from vehicle weights and environmental conditions, resulting in the inevitable occurrence of road distresses including cracks, potholes, etc. The traditional inspection methods by transportation engineers are normally costly and labor-intensive. In recent years, artificial intelligence (AI)-based road distress detection methods have been widely used as convenient and automated approaches, while the AI-based methods heavily depend on a large amount of high-quality images, limiting the real engineering applications.

Sparse regularization inversion method for transient electromagnetic data and high-resolution prospection of subsurface targets.

Transient Electromagnetic Method (TEM) is a geophysical technique with great potential for high-resolution subsurface imaging. However, conventional inversion algorithms for TEM typically employ the L2-norm regularization in the objective function, which assumes a smoothly varying resistivity distribution. This assumption limits the resolution of sharp electrical interfaces.

Pd Single-Atoms Doped CuP Quantum Dots with Moderately Optimized H* Sorption Behaviors for Actualizing the Multifunctional "Formaldehyde-Nitrate" Galvanic System.

Nitrate and formaldehyde, which are substantial wastes in industrial and agricultural effluents, pose significant hazards to the human health and ecosystem. Current purification technologies remain great challenges due to the unsatisfactory energy-intensive, time-consuming and noticeably costly reasons. Herein, a bifunctional electrocatalysts of Pd single-atoms doped CuP quantum dots (Pd-CuP SA-QDs) are reported to moderately optimize the H* sorption behaviors for accelerating the kinetics of nitrate reduction (NORR) and formaldehyde oxidation (FOR) reactions in a dual-directional way, thus realizing the high activity and selectivity for both cathodic ammonia (NH) synthesis and anodic H production concurrently.

Partial replacement of corn silage with sorghum-sudangrass silage improves growth performance and rumen function in Hu sheep via microbial and metabolic modulation.

Background: The rumen hosts a diverse microbial community and serves as a natural bioreactor that efficiently utilizes plant biomass. To explore the potential of silage (SS) as an alternative to whole-plant corn silage (WS), this study evaluated the growth performance, rumen microbiota, serum metabolome, and rumen fermentation characteristics of Hu sheep. The aim was to assess the feasibility of SS as a feed resource and to identify specific rumen bacteria that interact with host metabolism.

Prophylactic pulmonary vein isolation in patients with typical atrial flutter and heart failure.

Background: Heart failure (HF) readmission rates remain a concern in patients with typical atrial flutter (AFL) and HF, even after cavotricuspid isthmus (CTI) ablation.

Objective: This study aimed to explore whether additional prophylactic circumferential pulmonary vein isolation (CPVI) could improve hard outcomes among patients with AFL and HF.

Methods: In this prospective, nonrandomized, controlled study, patients with AFL and HF were consecutively enrolled from 9 centers.

Deciphering the Role of Fluorination in Dual-Halogen Electrolytes for All-Solid-State Batteries: A Case Study of New LiHfClF Solid Electrolytes.

Lithium metal chlorides are promising superionic conductors for all-solid-state batteries (SSBs) due to their favorable mechanical properties, high ionic conductivity, and good oxidative stability (up to >4.2 V versus Li/Li). Nonetheless, chloride solid electrolytes (SEs) still undergo electrochemical degradation when paired with high-voltage cathodes such as LiNiCoMnO.

Mesaconic acid as a key metabolite with anti-inflammatory and anti-aging properties produced by Lactobacillus plantarum 124 from centenarian gut microbiota.

The gut microbiota of centenarians plays a vital role in promoting healthy longevity. We performed a cross-sectional study of 224 people from Jiaoling, China, which is globally recognised for the longevity of its residents. Compared with younger people, centenarians showed significantly increased alpha-diversity, enrichment of the beneficial bacteria Lactobacillus, Akkermansia, and Christensenella, and increased redox capacity in the gut microbiota.

Prognostic value of red cell distribution width-to-albumin ratio in septic patients with malignancies: A retrospective cohort study based on the MIMIC-IV database.

ObjectiveTo investigate the prognostic value of red cell distribution width-to-albumin ratio (RAR) in sepsis patients with malignancies and evaluate its association with in-hospital mortality.MethodsThe retrospective cohort study was conducted using data extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Participants were stratified into quartiles (Q1-Q4) based on RAR levels measured within 24 hours of intensive care unit admission.

Multifunctional Cross-Linkable Silane Additive Enables High-Performance Air-Processed Inverted CsPbI Perovskite Solar Cells.

The extreme sensitivity of inorganic CsPbI perovskites to moisture imposes stringent humidity requirements during fabrication, severely limiting their practical applications. Herein, 3-iodopropyltrimethoxysilane (IPTMS) is introduced as a multifunctional additive into the perovskite precursor to address these limitations. During thermal annealing, IPTMS molecules undergo an hydrolysis-driven cross-linking reaction, consuming residual water while constructing a hydrophobic polysiloxane network at grain boundaries, thus effectively shielding films against moisture infiltration.

Research Progress in Chemical Synthesis and Biosynthesis of Bioactive Pyridine Alkaloids.

Pyridine alkaloids possess important biological activities and are widely used in fields such as medicine and pesticides. This paper comprehensively reviews the research progress in the chemical synthesis and biosynthesis of pyridine alkaloids. In terms of chemical synthesis, there are diverse synthesis methods for arylpyridine compounds.

Primary Adrenal Lymphoma Diagnosed by Endoscopic Ultrasound Fine-Needle Aspiration Biopsy: A Case Report.

BACKGROUND Primary adrenal lesions pose significant diagnostic challenges, as noninvasive imaging often fails to differentiate malignant from benign lesions. Percutaneous fine-needle aspiration (FNA) could be risky and undiagnostic, particularly in patients with hematologic disorders and low platelet counts. Performing surgery risks adrenal dysfunction, potentially resulting in poor prognosis.

Formic acid promotes chemical remediation of carbon tetrachloride contaminated soil during thermal activated persulfate processing via reductive radicals.

Carbon tetrachloride (CT, CCl₄) is one typical persistent organochlorine pollutant, which is refractory to be degraded in environment due to its strong chemical inertness. In this study, organic acids were introduced into the thermal activated persulfate (PS) system, which would react with oxidative radicals to generate reductive radicals, promoting the rapid degradation of CT. The results showed that formic acid (FA) enhanced the degradation rate by 3.

In Situ Adsorption-Reduction of Chromium(VI) with a Self-Regenerated Intelligent Urea-MOF(Fe): Preparation, DFT Simulation and Mechanism.

Environmental pollution caused by hexavalent chromium becomes worse and worse, so it is urgent to develop efficient and stable treatments. In this work, urea-doped iron-based metal-organic framework N/MOF(Fe) was prepared via the solvothermal method, and its microstructure was systematically analyzed using characterization techniques, such as SEM, TEM, BET, XRD, FTIR, XPS and so on. Comparison of FTIR spectra with different urea doping amounts revealed the regulation law of amino functional groups and their influence on the construction of Cr(VI) adsorption active sites.

Predicting Systemic and Liver Bosentan Exposure Using Physiologically-Based Pharmacokinetic Modeling.

Bosentan is the first approved oral medication for pulmonary arterial hypertension, yet the black-box warning on its labeling implies a substantial risk of liver injury associated with bosentan exposure. The risk assessment of bosentan-induced liver injury requires a thorough understanding of the underlying mechanisms, for which there is accumulating evidence. Integrating these mechanisms with clinical liver bosentan concentration would enable a more dynamic and relevant risk assessment.

Analysis of risk factors and nursing care for nonspecific abdominal pain after endoscopic retrograde cholangiopancreatography (ERCP): A case report.

Rationale: Endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic nasobiliary drainage is the standard treatment for common bile duct (CBD) stones. Post-ERCP abdominal pain is typically linked to complications like pancreatitis, perforation, or cholangitis. However, cases of nonspecific abdominal pain caused by duodenal ulcers induced by the nasobiliary drainage tube after ERCP have not been reported to date, highlighting the novelty and clinical relevance of this case.

Solid solvation structure design improves all-solid-state organic batteries.

Organic electrode materials offer a versatile, sustainable approach for next-generation lithium-ion batteries but are limited by low working voltages and poor cycling stability. Here we report a solid-solvation-structure design strategy to improve both the voltage and stability of organic electrode materials in all-solid-state batteries. As a proof of concept, we incorporate halide electrolytes as solid solutes and tetrachloro-o-benzoquinone as a solid solvent to form homogeneous solid cathode solutions.

Protocol for constructing asymmetric triple-atoms supported on nitrogen-doped carbon nanotubes via atomic layer deposition.

The precise construction of highly efficient triple-atom catalysts (TACs) remains a significant challenge. Here, we present a protocol for constructing asymmetric Pt-Ru-Co triple-atoms (TAs) supported on nitrogen-doped carbon nanotubes (NCNTs) via selective atomic layer deposition (ALD) technology. We describe steps for synthesizing the NCNT substrate, deposition of Pt-Ru-Co TAs, and characterizing the materials.