Multifunctional Cross-Linkable Silane Additive Enables High-Performance Air-Processed Inverted CsPbI Perovskite Solar Cells.

The extreme sensitivity of inorganic CsPbI perovskites to moisture imposes stringent humidity requirements during fabrication, severely limiting their practical applications. Herein, 3-iodopropyltrimethoxysilane (IPTMS) is introduced as a multifunctional additive into the perovskite precursor to address these limitations. During thermal annealing, IPTMS molecules undergo an hydrolysis-driven cross-linking reaction, consuming residual water while constructing a hydrophobic polysiloxane network at grain boundaries, thus effectively shielding films against moisture infiltration.

Surface ligand networking promotes intersystem crossing in the Au(SR) nanocluster.

Understanding the relationships between the structure and optical properties of ligand-protected, atomically precise metal nanoclusters (NCs) is of paramount importance for exploring their applications in photonics, biomedicine and quantum technology. Here, two Au(SR) NCs protected by 2,4-dimethylbenzenethiolate (DMBT) and cyclohexanethiolate (CHT), respectively, are studied using time-resolved absorption and emission spectroscopies. Although the two NCs exhibit similar photoluminescence (PL) quantum yields (QY ∼ 0.

Ionic Liquid-Confined Covalent-Organic Framework Pores as Nanoreactors for CO Photoconversion.

The topological nanopores of covalent organic frameworks (COFs) show promise as spatially confined nanoreactors for solar CO photoconversion. However, simultaneously increasing the electron density, improving the electron transfer, CO capture, and catalytic efficiency within nanopores remains a challenge for optimizing the performance of such nanoreactors. Here, micro- and mesoporous triazine-COFs were in situ grown on amino-modified BiVO nanosheets (BVO), respectively, obtaining two-dimensional heterojunctions.

High Co-Expression of and as a Predictor of Platinum Resistance and Poor Prognosis in Patients with Epithelial Ovarian Cancer.

This study aimed to determine whether the expression levels of and are associated with survival outcomes and platinum resistance in epithelial ovarian cancer (EOC) patients. We analyzed the medical records of EOC patients. EOC samples obtained during surgery were stained for and .

Near-Infrared to Visible Photon Upconversion with Gold Quantum Rods and Aqueous Photo-Driven Polymerization.

Converting near-infrared (NIR) photons into visible light via triplet-triplet annihilation upconversion (TTA-UC) is a promising strategy for advancing energy, biomedical, and materials science. However, the development of efficient NIR sensitizers remains a major challenge. Here, we report an atomically precise gold quantum rod, Au(PET) (PET = 2-phenylethanethiolate), as a high-performance photosensitizer for NIR-to-visible TTA-UC.

Protein kinase A is a dependent factor and therapeutic target in mouse models of fibrous dysplasia.

Fibrous dysplasia is a skeletal disorder caused by activating mutations in Gα, leading to bone fractures, deformities, and pain. Protein kinase A (PKA), the principal effector of Gα, plays critical roles in various biological processes. However, its role in fibrous dysplasia is unknown.

Proteomic analysis of outer membrane vesicles derived from the type A5 Strain of .

(ica) cause mastitis in sheep, acute sepsis in newborn lambs, and co-infections with various pathogens, leading to bovine respiratory disease syndrome (BRDS), these infections have resulted in significant economic losses to both domestic and international farming industries. An in-depth understanding of the pathogenic mechanisms of is crucial for the prevention and control of this disease. Outer membrane vesicles (OMVs) play a vital role in bacterial pathogenesis, serving as key mediators of interactions between Gram-negative bacteria and their hosts.

Evolution of coherent vibrations in atomically precise gold quantum rods with periodic elongation.

The coherent vibrational dynamics of gold nanorods with varying aspect ratios have been extensively studied by time-resolved spectroscopy to reveal their mechanical properties, but quantum-sized rods (transverse diameter < 2 nanometers) remain unexplored. Here, we present a comprehensive study on the coherent vibrations of atomically precise gold quantum rods with distinct energy gaps (0.6 to 1.

Social Isolation Is Associated With the Acceleration of Death and Incident Cardiovascular Disease in Adults With Chronic Kidney Disease.

Background: Individuals with chronic kidney disease are at markedly increased risk of incident cardiovascular diseases (CVDs) and premature death. The impact of social isolation on adverse outcomes in chronic kidney disease remained understudied.

Methods: This prospective cohort study included 13 090 individuals with chronic kidney disease from the UK Biobank.

Achieving transient and reversible optical transparency in live mice with tartrazine.

Optical imaging provides real-time visualization of tissues and cells at high spatial and temporal resolutions through techniques such as fluorescence microscopy, optical coherence tomography and photoacoustic imaging. However, overcoming light scattering, caused by mismatches in the refractive indices of tissue components such as water and lipids, still represents a major challenge, particularly when imaging through the thicker biological tissues of living animals. Despite advances in deep-tissue imaging, many optical methods struggle to achieve diffraction-limited resolution at depth or are unsuitable for use in live animals.

Nanoresonance Cavity and Localized Surface Plasmon Resonance Enhanced Broad-Spectral Photodetector for Versatile Applications.

To overcome the limitations inherent in traditional silicon (Si)-based photodetectors, particularly the low light absorption and complex carrier dynamics, this study proposes and fabricates in situ three-dimensional (3D) graphene/Si Schottky junctions integrated with WS quantum dots (QDs). The introduction of WS QDs enables the heterojunction to realize "double-enhanced absorption" by the synergistic effect of the natural nanoresonant cavity effect and the surface plasmon resonance effect (LSPR) of the WS QDs. Photodetectors constructed from the WS QDs/3D-graphene/Si heterojunction demonstrate a broadband, self-powered response from 440 to 1850 nm, maintaining stable operation at 1550 nm for 4 months.

Multipath-Assisted Ultra-Wideband Vehicle Localization in Underground Parking Environment Using Ray-Tracing.

In complex underground parking scenarios, non-line-of-sight (NLOS) obstructions significantly impede positioning signals, presenting substantial challenges for accurate vehicle localization. While traditional positioning approaches primarily focus on mitigating NLOS effects to enhance accuracy, this research adopts an alternative perspective by leveraging NLOS propagation as valuable information, enabling precise positioning in NLOS-dominated environments. We introduce an innovative NLOS positioning framework based on the generalized source (GS) technique, which employs ray-tracing (RT) to transform NLOS paths into equivalent line-of-sight (LOS) paths.

Resveratrol-mediated NRF2/HO-1 signaling pathway to improve postoperative cognitive dysfunction in elderly rats.

To investigate the effects of resveratrol (RES) on cognitive function and its modulation of the NRF2/HO-1 signaling pathway in a rodent model of postoperative cognitive dysfunction (POCD). A POCD model was established in aged Sprague-Dawley rats using sevoflurane anesthesia and laparotomy. Rats were divided into four groups: control, POCD, RES, and POCD + RES.

Generalizable Organic-to-Aqueous Phase Transfer of a Au Nanocluster with Luminescence Enhancement and Robust Photocatalysis in Water.

For the majority of gold nanoclusters (NCs), their water insolubility, low photoluminescence (PL) intensity, and less understood photostability are three critical factors that limit their application in the biomedical and photocatalysis fields. In this study, we report a polymer wrapping method for phase transfer of organic soluble NCs into aqueous phase without degrading the electronic and optical properties, and such materials are further demonstrated for robust photocatalysis in water. We first synthesized a Au(DMBT) NC (DMBT = 2,4-dimethylbenzenethiolate) and found that the aromatic ligands confer a greatly enhanced antioxidation capability of the NC compared to the Au(CHT) counterpart (CHT = cyclohexanethiolate), with the critical role of aromatic ligand interactions identified by X-ray crystallography.

Analysis of the Influence of the Dynamic Characteristics of an Optical Bench on Optical Mechanical System Imaging Under Vibration Conditions.

The imaging processes of optoelectronic devices are affected by vibration in the transportation platform, which can cause image shaking and blurring. Nowadays, devices often solve problems of image shaking and blurring using motion rotors. However, there is relatively little research on the influence of optical fixtures themselves under vibration conditions.

14-3-3θ phosphorylation exacerbates alpha-synuclein aggregation and toxicity.

Aggregation of alpha-synuclein (αsyn) plays an integral role in Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). 14-3-3θ is a highly expressed brain protein with chaperone-like activity that regulates αsyn folding. 14-3-3θ overexpression reduces αsyn aggregation, transmission between cells, and neuronal loss, while 14-3-3 inhibition promotes αsyn pathology.

A Ray-Tracing-Based Single-Site Localization Method for Non-Line-of-Sight Environments.

Localization accuracy in non-line-of-sight (NLOS) scenarios is often hindered by the complex nature of multipath propagation. Traditional approaches typically focus on NLOS node identification and error mitigation techniques. However, the intricacies of NLOS localization are intrinsically tied to propagation challenges.

Imaging of viral replication in live cells by using split fluorescent protein-tagged reporter flaviviruses.

The knowledge on the life cycle of flaviviruses is still incomplete, and no direct-acting antivirals against their infections are clinically available. Herein, by screening via a Zika virus (ZIKV) replicon assay, we found that the N-terminus of NS2A exhibited great tolerance to the insertions of different split fluorescent proteins (split-FPs). Furthermore, both ZIKV and dengue virus encoding a split-FP-tagged NS2A propagated efficiently, and the split-FP-tagged ZIKVs had good genetic stability.

Toward in vivo bronchoscopic functional CFTR assessment using a short circuit current measurement probe.

The epithelial lining of luminal organs provides an immune barrier against external factors and regulates the transport of nutrients, ions, and water into the body. Several conditions are associated with the breakdown or dysfunction of the epithelial lining. Short circuit current () measurement using a bulky, expensive, and hard-to-deploy system known as the Ussing chamber is the gold standard for evaluation of epithelial transport function but requires tissue excision.

Research on wireless channel model based on improved ray tracing algorithm that considers multiple diffuse scattering and employs pyramid-shaped ray tubes as the carrier.

This paper extensively utilizes fine three dimensional environmental data obtained from laser point clouds. Based on theories such as geometrical optics and effective roughness theory, a deterministic wireless channel model is established, which integrates higher-order diffuse scattering. This model is referred to as the ray tracing fusion with higher-order diffuse scattering model.

Targeting sirtuins for cancer therapy: epigenetics modifications and beyond.

Sirtuins (SIRTs) are well-known as nicotinic adenine dinucleotide(NAD)-dependent histone deacetylases, which are important epigenetic enzymes consisting of seven family members (SIRT1-7). Of note, SIRT1 and SIRT2 are distributed in the nucleus and cytoplasm, while SIRT3, SIRT4 and SIRT5 are localized in the mitochondria. SIRT6 and SIRT7 are distributed in the nucleus.

Transverse dentoalveolar development in Chinese children and adolescents: A cross-sectional study using revised Andrews' Element III analysis.

Introduction: This study investigated the prevalence of maxillary transverse deficiency (MTD) in Chinese children and adolescents using revised Andrews' Element III analysis and studied transverse developmental characteristics of the maxillomandibular complex.

Methods: Plaster or digital casts of 794 participants aged 7-18 years were evaluated. MTD was diagnosed when the maxilla-mandible width difference, represented by the decompensated maxillary and mandibular first molars, exceeded 4 mm.

Raising Near-Infrared Photoluminescence Quantum Yield of Au Quantum Rod to 50% in Solutions and 75% in Films.

Highly emissive gold nanoclusters (NCs) in the near-infrared (NIR) region are of wide interest, but challenges arise from the excessive nonradiative dissipation. Here, we demonstrate an effective suppression of the motions of surface motifs on the Au(PET) rod (PET = 2-phenylethanethiolate) by noncoordinative interactions with amide molecules and accordingly raise the NIR emission (875/1045 nm peaks) quantum yield (QY) from 18% to 50% in deaerated solution at room temperature, which is rare in Au NCs. Cryogenic photoluminescence measurements indicate that amide molecules effectively suppress the vibrations associated with the Au-S staple motifs on Au and also enhance the radiative relaxation, both of which lead to stronger emission.

Self-Assembled Monolayer Suppresses Interfacial Reaction between NiO and Perovskite for Efficient and Stable Inverted Inorganic Perovskite Solar Cells.

Inorganic NiO has attracted tremendous attention in organic-inorganic hybrid perovskite solar cells (PSCs) in recent years but is relatively less used in all-inorganic PSCs. In this study, we have discovered and confirmed the detrimental interfacial reaction between NiO and DMAI-containing CsPbI inorganic perovskites. Thus, a self-assembled monolayer, Br-2PACz, is employed to modify the NiO surface to obstruct the adverse interfacial reaction and further improve the device performance.

Comparative efficacy and safety of ciprofol, propofol, and propofol and etomidate mixture, and ciprofol and etomidate mixture in patients undergoing painless gastroscopy: A randomized, double-blind controlled clinical trial.

Background: To compare the efficacy and safety of ciprofol, propofol, propofol and etomidate mixture or ciprofol and etomidate mixture in patients undergoing painless gastroscopic anesthesia, and to explore the optimal plan to relieve the patient's discomfort.

Methods: A total of 120 patients scheduled for painless gastroscopy were randomly assigned to 4 groups: propofol (Group P), ciprofol (Group C), propofol-etomidate mixture (Group P-E), and ciprofol-etomidate mixture (Group C-E). The success rate of gastroscopy examination, patient satisfaction, incidence of injection pain, hemodynamic parameters, induction time, procedure time, the consumption of drugs, awakening time, and incidence of adverse events were evaluated.