Differential placebo effect of sham acupuncture for chronic pain: a network meta-analysis of randomized controlled trials.

Background: The clinical effects of acupuncture are often underestimated due to the placebo effect of sham acupuncture. While multiple sham acupuncture methods have been used in clinical practice, it is challenging to select the appropriate sham acupuncture technique due to the lack of head-to-head trials.

Purpose: The purpose of this study was to compare the differential placebo effects of diverse sham acupuncture interventions, providing evidence-based guidance for selecting optimal placebo controls in clinical practice.

Comparative Safety Analysis of Avastin and Bevacizumab Biosimilars Based on Food and Drug Administration Adverse Event Reporting System.

Objective: This study aimed to compare adverse event (AE) profiles between Avastin and bevacizumab biosimilars to support clinical decision-making, given the limited availability of real-world data.

Methods: A disproportionality analysis was conducted using the FDA Adverse Event Reporting System (FAERS) to identify and compare AE signals. Signals were evaluated at the system organ classes (SOCs) and preferred term (PT) levels, focusing on the Top 20 PTs by report number, key SOCs and outcomes.

Autophagy and glycolysis synergistically mediate Cd²⁺ transport to enhance Cd tolerance in Arabidopsis.

Cadmium (Cd), as a widely investigated heavy metal, demonstrates severe toxicity to plant growth and development. However, the roles of energy metabolism, and protein degradation caused by autophagy in plant Cd tolerance remain poorly characterized. This study reveals that Cd-exposure simultaneously affects both the glycolytic and autophagic in Arabidopsis thaliana.

Potential Benefit with Acupuncture in Functional Gastrointestinal Disorders: A Systematic Review and Meta-analysis.

Background: Many patients with functional gastrointestinal disorders (FGIDs) seek complementary and alternative therapies to improve gastrointestinal (GI) symptoms. Research on the use of acupuncture to improve GI symptoms has been growing, but the results have been inconsistent.

Objective: To provide a systematic review and meta-analysis of the effectiveness of acupuncture-based treatment for FGIDs using the latest data and a rigorous evaluation system.

A lithography-free approach to polaritonic Luneburg lenses.

Planar polaritonic lenses, achieved by precisely controlling interface polaritons, hold significant promise for subwavelength light focusing. While most existing designs rely on polariton interference or refraction, creating gradient-index polaritonic lenses remains a substantial challenge due to the lack of practical and cost-effective fabrication methods. Here, we introduce a lithography-free approach for producing polaritonic lenses with gradient effective refractive indices by engineering the dielectric environment of polaritons.

Epidemiological Study of Childhood Idiopathic Epilepsy from 1990 to 2021 at Global, Regional, and National Scales.

Objective: To address the long-term impact of childhood idiopathic epilepsy on health and families, and to provide epidemiological evidence for developing effective prevention and treatment strategies, this study aimed to explore the trends in incidence, deaths, and disability-adjusted life years (DALYs) of childhood idiopathic epilepsy globally and across regions from 1990 to 2021.

Patients And Methods: This cross-sectional analysis utilized data from the 2021 Global Burden of Disease database, covering idiopathic epilepsy cases among children aged 0-14 years across 204 countries and regions. The study period was from September 15, 2024, to October 31, 2024.

Unraveling Nitrogen Uptake and Metabolism: Gene Families, Expression Dynamics, and Functional Insights in Aspen (Populus tremula).

The influence of nitrogen on wood formation is well established. To gain insight into the underlying molecular mechanism, we first identified genes in fourteen gene families that are involved in nitrogen uptake and metabolism in European aspen (Populus tremula L.) genome annotation.

Nutrition status of hospitalized patients in the first decade of Chinese nutritionDay survey: Assessment using the ESPEN and GLIM criteria.

Background And Objectives: This study aimed to investigate nutritional status of hospitalized Chinese pa-tients according to the Global Leadership Initiative on Malnutrition (GLIM) and the European Society of Clin-ical Nutrition and Metabolism (ESPEN) criteria and to identify the effects of nutritional characteristics and nutritional support on clinical good outcome.

Methods And Study Design: Inpatients participated in Chinese nutritionDay 2010-2020 surveys were included. Malnutrition was defined according to the ESPEN and GLIM criteria after being risk evaluated by Malnutrition Universal Screening Tool (MUST).

Real-world effectiveness of single-inhaler fluticasone furoate/umeclidinium bromide/vilanterol in Chinese patients with symptomatic chronic obstructive pulmonary disease (COPD): a post-marketing, prospective, multicenter, observational study.

Objective: To assess the effectiveness of single-inhaler fluticasone furoate/umeclidinium bromide/vilanterol (FF/UMEC/VI) in symptomatic chronic obstructive pulmonary disease (COPD) under real-world settings in China.

Methods: In this single-arm, prospective, observational study, participants received 12 weeks of FF/UMEC/VI treatment. The primary outcome was change from baseline (CFB) in COPD Assessment Test (CAT) score at Week 12.

1D Van Der Waals Superlattices for Polarization-Sensitive Photodetectors.

The ability to detect polarimetric information of light over a broad spectra range is central to practical optoelectronic applications and has been successfully demonstrated with photodetectors of low-symmetry 2D van der Waals materials (vdWMs). However, polarization sensitivity within such a photodetectors remains elusive due to the limited diversity. To address this challenge, an approach is proposed by transforms 2D Lead iodine (PbI) into 1D superlattice microwires (SLMs) through a solution-phase antisolvent diffusion method.

A dynamic molecular landscape in colorectal cancer progression at single-cell resolution.

Background: Precursor lesions like polyps and adenomas in the colon commonly precede colorectal cancer (CRC), advancing through the "normal-polyp-adenoma-carcinoma" sequence towards malignancy. Yet, the cellular heterogeneity and molecular mechanisms involved in CRC development remain inadequately characterized.

Methods: To understand the molecular mechanisms driving the onset and progression of CRC, we conducted a comprehensive analysis of ten clinical colorectal samples representing sequential pathological stages using single-cell RNA sequencing (scRNA-seq).

The Lattice flow diverter for the treatment of intracranial aneurysms: a single center experience in 117 consecutive aneurysms.

Background: Flow diversion has revolutionized the management of intracranial aneurysms. This study aimed to evaluate the preliminary safety and efficacy profile of the novel Lattice flow diverter (LFD) in clinical applications.

Methods: We retrospectively analyzed consecutive patients with intracranial aneurysms who were treated with the LFD between June 2023 and May 2024.

TaSULTR1;2 regulates sulfur and selenium uptake in wheat.

Sulfur (S) and selenium (Se) are essential nutrients for living organisms, playing a critical role in plant growth and development. The sulfate transporter (SULTR) serves as the primary carrier for sulfate uptake, transport and redistribution. However, functions of SULTRs in wheat remain completely unknown.

Machine learning model to predict sepsis in ICU patients with intracerebral hemorrhage.

Patients with intracerebral hemorrhage (ICH) are highly susceptible to sepsis. This study evaluates the efficacy of machine learning (ML) models in predicting sepsis risk in intensive care units (ICUs) patients with ICH. We conducted a retrospective analysis on ICH patients using the MIMIC-IV database, randomly dividing them into training and validation cohorts.

Targeted codelivery of nitric oxide and hydrogen sulfide for enhanced antithrombosis efficacy.

Thrombosis is a leading cause of mortality worldwide. As important gaseous signaling molecules, both nitric oxide (NO) and hydrogen sulfide (HS) demonstrate antiplatelet and anticoagulant functions, but little attention has been given to their synergistic effect and the underlying mechanism. In the present study, we developed an NO/HS codelivery system based on enzyme prodrug therapy (EPT) strategy in which the prodrugs are specifically recognized by the engineered β-galactosidase.

Prevalence and 10-Year Risk of Intracerebral Hemorrhage in Central China Using Estimates From the 1 Million Cross-Sectional Study.

Background And Objectives: Intracerebral hemorrhage (ICH) is a common and fatal type of stroke, especially in central China. However, recent epidemiologic data are scarce. The study aimed to investigate the latest prevalence of ICH in central China and assess the risk of ICH in the next 10 years based on the Resident Health Records (RHR) data.

Gut microbiota-derived tryptophan metabolites improve total parenteral nutrition-associated infections by regulating Group 3 innate lymphoid cells.

Clinical nutritional support is recognized by Klinefner's Surgery as one of the four pivotal advancements in surgical practice during the 20th century. Surgeons regard clinical nutrition as a "life-saving" discipline, pivotal in preserving the lives of numerous critically ill patients and facilitating the success of many surgical procedures. Parenteral nutrition (PN) support serves as a crucial component of clinical nutritional therapy, while a range of complications associated with total parenteral nutrition (TPN) can significantly undermine the efficacy of patient treatment.

Real-Time Sensor for Measuring the Surface Temperature of Thermal Protection Structures Based on the Full-Time Domain Temperature Inversion Method.

The real-time surface thermal monitoring of thermal protection structures (TPSs) is crucial for hypersonic vehicle safety. This study proposes an effective approach for real-time temperature reconstruction by integrating embedded sensor arrays with an enhanced full-time domain inversion algorithm, utilizing the overlapping sliding window method. An array of three evenly spaced sensors is used for TPS monitoring.

Pipeline embolization device in treating middle cerebral artery aneurysms: a single-center experience in 69 consecutive patients.

Purpose: The pipeline embolization device (PED) has been established as an effective treatment option for aneurysms within its designated indications. Recently, its off-label applications, including treating middle cerebral artery (MCA) aneurysms, have increased. This study augmented the current literature by examining the outcomes of PED utilization for MCA aneurysms.

Higher Time to Peak after Stent Implantation in Symptomatic High-Grade Intracranial Atherosclerotic Stenosis is Related to In-Stent Restenosis.

Little is known about the association between periprocedural hemodynamics and in-stent restenosis (ISR) following stent implantation in patients with symptomatic intracranial atherosclerotic stenosis (ICAS). This study aims to identify periprocedural hemodynamics that may be associated with ISR. Subjects were selected from the NOVA trial (The First-in-man Trial Evaluating the Safety and Efficacy of the NOVA Intracranial Stent Trial).

Tailoring Phonon Polaritons with a Single-Layer Photonics-Empowered Polaritonic Crystal.

Photonic crystals (PhCs) are artificial periodic structures that can compress and control light at the nanoscale. Recently, the emerging van der Waals (vdW) materials with extreme anisotropy exhibit exotic hyperbolic phonon resonances and ray-like propagation. However, localization and manipulation of these hyperbolic phonon polaritons (PhPs) in polaritonic crystals (PoCs) on a scale deeply below the polariton wavelength have remained elusive so far.

Relationship of Apolipoprotein B to Aortic Aneurysm: Frailty Index as a Partial Mediator - a Mendelian Randomization Study.

Aim    Aortic aneurysm is characterized by localized expansion and damage to the vessel wall. While apolipoprotein B (ApoB) has been linked to atherosclerosis, its causal relationship with aortic aneurysm remains unclear. This study used a Mendelian randomization (MR) approach to explore the causal relationships between ApoB, aortic aneurysm, and potential mediators.

Effects of drainage and long-term tillage on greenhouse gas fluxes in a natural wetland: insights from microbial mechanisms.

Background: The conversion of natural wetlands to agricultural land through drainage contributes to 62% of the global wetland loss. Such conversion significantly alters greenhouse gas (GHG) fluxes, yet the underlying mechanisms of GHG fluxes resulting from drainage and long-term tillage practices remain highly uncertain. In this study, we measured GHG fluxes of a natural reed wetland (referred to as "Wetland") and a drained wetland that used as farmland (referred to as "Dryland").

EasyMetagenome: A user-friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research.

Shotgun metagenomics has become a pivotal technology in microbiome research, enabling in-depth analysis of microbial communities at both the high-resolution taxonomic and functional levels. This approach provides valuable insights of microbial diversity, interactions, and their roles in health and disease. However, the complexity of data processing and the need for reproducibility pose significant challenges to researchers.

Analysis of the Influence of the Dynamic Characteristics of an Optical Bench on Optical Mechanical System Imaging Under Vibration Conditions.

The imaging processes of optoelectronic devices are affected by vibration in the transportation platform, which can cause image shaking and blurring. Nowadays, devices often solve problems of image shaking and blurring using motion rotors. However, there is relatively little research on the influence of optical fixtures themselves under vibration conditions.