Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial.

Objectives: To evaluate the effect of lateral versus supine positioning on incidence of hypoxaemia in sedated patients and to provide evidence based recommendations for respiratory strategies.

Design: Prospective, multicentre, randomised controlled trial.

Setting: 14 tertiary hospitals in China, July to November 2024.

Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation.

Sepsis, a life-threatening systemic inflammatory response to infection, progresses to multiorgan dysfunction involving the heart, lungs, kidneys, brain, and liver. Its heterogeneous pathogenesis involves intertwined pathways such as inflammationmetabolism imbalance, immune dysregulation, mitochondrial dysfunction, and programmed cell death. While traditional biomarkers such as CRP and PCT lack organ-specific sensitivity, emerging multiomics technologies enable systematic network analysis beyond single-molecule detection.

Malignancy in Idiopathic Inflammatory Myopathies: Recent Insights.

Idiopathic inflammatory myopathies (IIMs) are a group of rare autoimmune diseases in which several subtypes, primarily dermatomyositis (DM), are associated with a high risk of malignancy. Although the relationship between the pathogenesis of IIMs and co-occurring malignancy is poorly understood, there is a growing evidence base for specific risk factors which are associated with cancer-associated myositis (CAM), including myositis-specific or myositis-associated autoantibodies (MSAs/MAAs). In addition, given that patients with different subtypes of IIMs, as classified according to clinical manifestations or serum autoantibody measurement, exhibit heterogeneity in tumorigenesis, further research is urgently needed to explore the pathogenesis of CAM, in order to develop novel biomarkers and therapeutic alternatives for patients.

From binary to gradient: EUS-RFA redefines primary aldosteronism therapy.

EUS-RFA redefines PA treatment, shifting from a binary (surgery or drugs) to a gradient paradigm (ablation, drugs, surgery). Outcomes: EUS-RFA (FABULAS, Argentesi et al., The Lancet 2025): 75% biochemical remission, 43% clinical remission; medical treatment (PAMO criteria[9]): 52.

Superselective Adrenal Artery Embolization as a Novel Alternative Treatment for Aldosterone-Producing Adenomas: A Case of Refractory Hypertension With Concomitant Autonomous Cortisol Secretion.

Primary aldosteronism (PA) is characterized by an overproduction of aldosterone, leading to hypertension and hypokalemia. Although surgery is an effective treatment for unilateral PA, some patients may be unwilling or unable to undergo this invasive procedure. This case report presents a 51-year-old female patient with refractory hypertension, diagnosed with right-sided hypersecretion of aldosterone and concomitant with autonomous cortisol secretion.

Finerenone ameliorates high-fat-induced myocardial lipotoxicity by suppressing ferroptosis through augmenting the system Xc/GSH synthesis pathway.

Obesity cardiomyopathy (OCM) is a distinct clinical entity in cardiovascular disease, yet targeted therapeutic options are scarce. Finerenone, a novel nonsteroidal mineralocorticoid receptor antagonist, has shown cardioprotective effects, but its role in mitigating OCM lipotoxicity is unclear. To elucidate the underlying functions and mechanisms, rats were fed on an HFD for 16 weeks to establish the OCM model.

Correction: Proteomic analysis of silk fibroin reveals diverse biological function of different degumming processing from different origin.

[This corrects the article DOI: 10.3389/fbioe.2021.

Infectious agents in dilated cardiomyopathy: Genetic interactions, autoimmunity, mechanisms, and therapeutic approaches.

Dilated cardiomyopathy (DCM) is a heterogeneous myocardial disorder characterized by left ventricular dilation and systolic dysfunction in the absence of ischemic, hypertensive, or valvular heart disease. Although its precise etiology remains unclear, it is widely recognized as a multifactorial disease arising from complex interactions between genetic predisposition and environmental triggers. Among these, infectious agents have been implicated in the pathogenesis of various subtypes, particularly inflammatory and idiopathic DCM.

Phenotypic Variation of the Invasive Plant and Analysis of Its Competitiveness With the Co-Occurring Indigenous Species .

is a malignant invasive plant in China. In this study, we sought to clarify the phenotypic variation of this plant and its competitive interaction with the indigenous species . Therefore, we established single-species planting groups for each species, with plant densities of one, two, four, or eight individuals.

Targeted codelivery of nitric oxide and hydrogen sulfide for enhanced antithrombosis efficacy.

Thrombosis is a leading cause of mortality worldwide. As important gaseous signaling molecules, both nitric oxide (NO) and hydrogen sulfide (HS) demonstrate antiplatelet and anticoagulant functions, but little attention has been given to their synergistic effect and the underlying mechanism. In the present study, we developed an NO/HS codelivery system based on enzyme prodrug therapy (EPT) strategy in which the prodrugs are specifically recognized by the engineered β-galactosidase.

New biomarkers in IgA nephropathy.

Currently, IgA nephropathy (IgAN) is the most common cause of chronic renal failure in patients with primary glomerulonephritis. However, IgAN diagnosis is usually performed by collecting a renal biopsy as gold standard to visualize pathological changes in the glomeruli. The randomized nature of this invasive procedure in clinical practice, together with the need to exclude patients with contraindications, often results in a limited number of eligible people.

High-voltage and intrinsically safe electrolytes for Li metal batteries.

Current electrolytes of mixing different functional solvents inherit both merits and weaknesses of each solvent, thus cannot simultaneously meet all the requirements of high energy, long cycle life, and high safety for Li metal batteries (LMBs). Here, we design a high voltage and safe electrolyte (VSE) by integrating different functional groups into one molecule. The VSE electrolyte has a wide electrochemical stability window of ~5.

Research on the spatiotemporal evolution characteristics of China's charging stations.

New energy vehicles (NEVs) are pivotal for reducing emissions in the transportation sector, and charging facilities are fundamental to the sustainable growth of the NEV industry. To scientifically plan and optimize the development and layout of China's electric vehicle charging infrastructure, this paper analyzed the growth, spatial distribution and the spatiotemporal evolution characteristics of EV charging station in China from 2009 to 2023 using the geographically weighted regression (GWR) model, geographically and temporally weighted regression (GTWR) model and the STIRPAT model. The main research conclusions are as follows: The growth trend of charging station is generally consistent with the growth trend of NEV, albeit with a certain time lag.

An investigation of γ radiation detection with a CMOS imaging sensor.

In this study, a feasibility of γ radiation detection using complementary metal-oxide semiconductor (CMOS) image sensors with a neural network algorithm to extract the γ rays interacted pixels has been investigated. The responses characteristics of the CMOS imaging sensor to γ-ray is studied by placed in a γ fields produced by standardCo orCs isotope sources. The supported preview frame rate of the CMOS image sensor is 25 fps, establishing the functional relationship between the gray level histograms and the dose rate through the neural network, the high energy γ-ray fromCo andCs source radiation dose rate in µSv/h level can be detected using the CMOS imaging sensor.

Soil microbial community composition and nitrogen enrichment responses to the operation of electric power substation.

The surge in global energy demand mandates a significant expansion of electric power substations. Nevertheless, the ecological consequences of electric power substation operation, particularly concerning the electromagnetic field, on soil microbial communities and nitrogen enrichment remain unexplored. In this study, we collected soil samples from six distinct sites at varying distances from an electric power substation in Xintang village, southeastern China, and investigated the impacts of electromagnetic field on the microbial diversity and community structures employing metagenomic sequencing technique.

Protein Complex Heterogeneity and Topology Revealed by Electron Capture Charge Reduction and Surface Induced Dissociation.

We illustrate the utility of native mass spectrometry (nMS) combined with a fast, tunable gas-phase charge reduction, electron capture charge reduction (ECCR), for the characterization of protein complex topology and glycoprotein heterogeneity. ECCR efficiently reduces the charge states of tetradecameric GroEL, illustrating Orbitrap / measurements to greater than 100,000 /. For pentameric C-reactive protein and tetradecameric GroEL, our novel device combining ECCR with surface induced dissociation (SID) reduces the charge states and yields more topologically informative fragmentation.

Revealing the effect of sea buckthorn oil, fish oil and structured lipid on intestinal microbiota, colonic short chain fatty acid composition and serum lipid profiles in vivo.

In this study, the effects of sea buckthorn oil (SBO), fish oil (FO) and an enzymatically synthesized structured lipid (SL) on serum, short-chain fatty acids (SCFAs) and intestinal microbiota in Sprague-Dawley (SD) rats were investigated. The results demonstrated that FO, SBO, and SL effectively reduced the levels of high-density lipoprotein cholesterol and low-density lipoprotein cholesterol in the serum of SD rats. SBO increased serum triglyceride levels, while FO elevated total cholesterol levels.

Cross-Domain Denoising for Low-Dose Multi-Frame Spiral Computed Tomography.

Computed tomography (CT) has been used worldwide as a non-invasive test to assist in diagnosis. However, the ionizing nature of X-ray exposure raises concerns about potential health risks such as cancer. The desire for lower radiation doses has driven researchers to improve reconstruction quality.

Protein complex heterogeneity and topology revealed by electron capture charge reduction and surface induced dissociation.

We illustrate the utility of native mass spectrometry (nMS) combined with a fast, tunable gas-phase charge reduction, electron capture charge reduction (ECCR), for the characterization of protein complex topology and glycoprotein heterogeneity. ECCR efficiently reduces the charge states of tetradecameric GroEL, illustrating Orbitrap measurements to greater than 100,000 . For pentameric C-reactive protein and tetradecameric GroEL, our novel device combining ECCR with surface induced dissociation (SID) reduces the charge states and yields more topologically informative fragmentation.

Taxonomy of the genus Periacma Meyrick (Lepidoptera: Autostichidae) from China, with a checklist of the world species.

Ten new species of the genus Periacma Meyrick, 1894 are described: P. anterosinuata sp. nov.

Reversed domain adaptation for nuclei segmentation-based pathological image classification.

Despite the fact that digital pathology has provided a new paradigm for modern medicine, the insufficiency of annotations for training remains a significant challenge. Due to the weak generalization abilities of deep-learning models, their performance is notably constrained in domains without sufficient annotations. Our research aims to enhance the model's generalization ability through domain adaptation, increasing the prediction ability for the target domain data while only using the source domain labels for training.

The effects of ultrasound-guided QLB and TAPB combined with opioid-free anesthesia (OFA) on clinical efficacy of the patients undergoing abdominal surgery.

Background: Although opioids provide effective analgesia for abdominal surgery, they also present serious unwanted side effects. Ultrasound-guild quadratus lumborum block (QLB) and transversus abdominis plane block (TAPB) have been proven to offer long-lasting and efficient analgesia during abdominal surgery. However, the clinical efficacy of ultrasound-guided QLB and TAPB combined with opioid-free anesthesia (OFA) in abdominal surgery remains unclear.

Comparison of bispectral index and patient state index as measures of sedation depth during surgeries using remimazolam tosilate.

Background: The Bispectral Index (BIS) and the Patient State Index (PSI) are commonly used measures to assess intraoperative sedation depth. However, model differences lead to different results, which in turn interferes with clinicians' judgment on the depth of anesthesia. Remimazolam tosilate (RT) for injection is a new benzodiazepine used in sedation.

Description of eight new species of the genus Irepacma Moriuti, Saito & Lewvanich (Lepidoptera: Autostichidae) from China.

Eight new species of the genus Irepacma Moriuti, Saito & Lewvanich, 1985 are described based on specimens collected in China: I. bispicifera Wang, sp. nov.

Phase Stability and Dual-Mode Photoluminescence Modulation in Er-Doped Lead Zirconate Titanate Antiferroelectrics.

The electric-field-modulation (-modulation) of photoluminescence (PL) properties in bulk ceramics has attracted tremendous interest due to its potential application in optical data storage and communication devices. One promising approach of reversibly and largely modulating the PL intensity has been proposed in rare-earth Er-doped PbLaZrTiO (PLZT) antiferroelectrics (AFEs) based on the unique -dependent antiferroelectric-ferroelectric (AFE-FE) phase transition. However, the AFE phase stability of PLZT doped with various Er contents and their -modulated PL properties have not been systematically investigated.