Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation.

Sepsis, a life-threatening systemic inflammatory response to infection, progresses to multiorgan dysfunction involving the heart, lungs, kidneys, brain, and liver. Its heterogeneous pathogenesis involves intertwined pathways such as inflammationmetabolism imbalance, immune dysregulation, mitochondrial dysfunction, and programmed cell death. While traditional biomarkers such as CRP and PCT lack organ-specific sensitivity, emerging multiomics technologies enable systematic network analysis beyond single-molecule detection.

Malignancy in Idiopathic Inflammatory Myopathies: Recent Insights.

Idiopathic inflammatory myopathies (IIMs) are a group of rare autoimmune diseases in which several subtypes, primarily dermatomyositis (DM), are associated with a high risk of malignancy. Although the relationship between the pathogenesis of IIMs and co-occurring malignancy is poorly understood, there is a growing evidence base for specific risk factors which are associated with cancer-associated myositis (CAM), including myositis-specific or myositis-associated autoantibodies (MSAs/MAAs). In addition, given that patients with different subtypes of IIMs, as classified according to clinical manifestations or serum autoantibody measurement, exhibit heterogeneity in tumorigenesis, further research is urgently needed to explore the pathogenesis of CAM, in order to develop novel biomarkers and therapeutic alternatives for patients.

Infectious agents in dilated cardiomyopathy: Genetic interactions, autoimmunity, mechanisms, and therapeutic approaches.

Dilated cardiomyopathy (DCM) is a heterogeneous myocardial disorder characterized by left ventricular dilation and systolic dysfunction in the absence of ischemic, hypertensive, or valvular heart disease. Although its precise etiology remains unclear, it is widely recognized as a multifactorial disease arising from complex interactions between genetic predisposition and environmental triggers. Among these, infectious agents have been implicated in the pathogenesis of various subtypes, particularly inflammatory and idiopathic DCM.

Single-cell profiling reveals monocyte heterogeneity and association with liver fibrosis in patients with chronic HBV.

Background: Chronic hepatitis B (CHB) infection results in persistent liver inflammation, which ultimately leads to liver fibrosis and increases the risk of cirrhosis. Recruitment of circulating monocytes to the liver is an essential aspect that exacerbates liver fibrosis; however, the mechanism underlying their dysregulation, which contributes to this progression, remains unclear.

Methods: Single-cell RNA sequencing was performed to characterize the landscape of circulating monocytes from patients with CHB and liver fibrosis (CHB group) and healthy controls (HC group).

Bacterial heat shock protein: A new crosstalk between T lymphocyte and macrophage via JAK2/STAT1 pathway in bloodstream infection.

Bloodstream infection (BSI) refers to the infection of blood by pathogens. Severe immune response to BSI can lead to sepsis, a systemic infection leading to multiple organ dysfunction, coupled with drug resistance, mortality, and limited clinical treatment options. This work aims to further investigate the new interplay between bacterial exocrine regulatory protein and host immune cells in the context of highly drug-resistant malignant BSI.

Stable organic polymer anode for high rate and fast charge sodium based dual-ion battery.

Considering the extensive resources, flexible structural designability, and abundant active sites, organic electrodes have been considered as the ideal sodium storage materials. However, organic materials generally face the limitations of unstable and dissolved characteristic, leading to a poor cyclic stability. In this work, we proposed a carbon nanotube (CNT) modified polyimide as the anode for sodium-based dual-ion battery (SDIB).

Ultra-Dispersed α-MoC Embedded in a Plum-Like N-Doped Carbon Framework as a Synergistic Adsorption-Electrocatalysis Interlayer for High-Performance Li-S Batteries.

The shuttle effect and sluggish redox kinetics of lithium polysulfides (LiPSs) severely hinder the scalable application of lithium-sulfurr (Li-S) batteries. Herein, the highly dispersed α-phase molybdenum carbide nano-crystallites embedded in a porous nitrogen-doped carbon framework (α-MoC @NCF) are developed via a simple metal-organic frameworks (MOFs) assisted strategy and proposed as the multifunctional separator interlayer for Li-S batteries. The inlaid MoC nanocrystals and in situ doped nitrogen atoms provide a strong chemisorption and outstanding electrocatalytic conversion toward LiPSs, whereas the unique plum-like carbon framework with hierarchical porosity enables fast electron/Li transfer and can physically suppress LiPSs shuttling.

Novel tumor therapy strategies targeting endoplasmic reticulum-mitochondria signal pathways.

Organelles form tight connections through membrane contact sites, thereby cooperating to regulate homeostasis and cell function. Among them, the contact between endoplasmic reticulum (ER), the main intracellular calcium storage organelles, and mitochondria has been recognized for decades, and its main roles in the ion and lipid transport, ROS signaling, membrane dynamic changes and cellular metabolism are basically determined. At present, many tumor chemotherapeutic drugs rely on ER-mitochondrial calcium signal to function, but the mechanism of targeting resident molecules at the mitochondria-associated endoplasmic reticulum membranes (MAM) to sensitize traditional chemotherapy and the new tumor therapeutic targets identified based on the signal pathways on the MAM have not been thoroughly discussed.

T cells: an emerging cast of roles in bipolar disorder.

Bipolar disorder (BD) is a distinctly heterogeneous and multifactorial disorder with a high individual and social burden. Immune pathway dysregulation is an important pathophysiological feature of BD. Recent studies have suggested a potential role for T lymphocytes in the pathogenesis of BD.

High Discharge Capacity and Ultra-Fast-Charging Sodium Dual-Ion Battery Based on Insoluble Organic Polymer Anode and Concentrated Electrolyte.

Sodium-based dual-ion batteries have shown great promise for large-scale energy storage applications due to their wide operating voltages, environmental friendliness, abundant sodium resources, and low cost, which are widely investigated by researchers. However, the development of high-performance anode materials is a key requirement for the realization of such electrochemical energy storage systems at the practical application level. Carbonaceous anode materials based on intercalation/deintercalation mechanisms typically exhibit low discharge capacities, while metal-based materials based on conversion or alloying reactions show unsatisfactory stability in performance.

Sodium-Based Dual-Ion Battery Based on the Organic Anode and Ionic Liquid Electrolyte.

Combining the advantages of dual-ion batteries (DIBs) and sodium-ion batteries (SIBs), we herein develop a superior sodium-based dual-ion battery (Na-DIB) based on the PTCDA organic anode and ionic liquid (IL) electrolyte. The system shows the highest specific discharge capacity of 177 mAh g at 0.5C and excellent capacity retention over 100% at 2C after 200 cycles.