Effects of pectic oligosaccharide on growth performance, organ indexes and intestinal health in broilers exposed to aflatoxin B.

This study aimed at investigating the influences of pectic oligosaccharide (POS) on growth performance, organ indexes and intestinal health in broilers exposed to aflatoxin B (AFB). In vitro experiment was conducted to assess reactive oxygen species (ROS)-scavenging ability of POS. In vivo experiment was then implemented by allocating 320 one-day-old yellow-feathered broilers to 4 groups (8 replicates/group), according to a 2 × 2 factorial arrangement with POS addition (0 or 400 mg/kg) and AFB exposure (with or without) as the two factors.

A native probiotic strain Enterococcus faecalis TMBC 10513 alleviates avian pathogenic Escherichia coli-induced growth impairment and intestinal disruptions in yellow-feathered broilers at the early stage of infection.

This study aimed to probe if a native probiotic Enterococcus faecalis TMBC 10513 could protect the growth and intestinal health of yellow-feathered broilers against avian pathogenic Escherichia coli (APEC) challenge. In vitro bacteriostasis of E. faecalis TMBC 10513 against APEC O1 was initially investigated.

A urinary DNA methylation assay using two genes enables noninvasive detection and prognostic prediction in urothelial carcinoma.

The incidence of urothelial carcinoma (UC) ranks second among all urological cancers, accounting for over 90% of malignant tumors in bladder. Patients diagnosed with UC experience a lower quality of life due to rapid progression of the disease. Early and non-invasive detection is curial for diagnosing UC and improving patient outcomes.

Residues and Dietary Risk of Lambda-Cyhalothrin in Fresh and Dried Panax notoginseng, Lilium, and Lonicera japonica.

In this study, a method for the determination of three medicinal and food homologous crops (fresh and dried Panax notoginseng, Lilium, and Lonicera japonica) was established, which had good linearity (R > 0.9971), accuracy (77%-104%) and precision (intraday RSD of 0.4% to 8.

Medical treatment of acquired uterine arteriovenous fistulae related to pregnancy: 2 case reports and literature review.

Uterine arteriovenous fistula (UAVF) is a rare form of uterine arteriovenous malformation, the most characteristic clinical symptom of which is intermittent vaginal bleeding. Currently, reports on the treatment of UAVF mainly focus on uterine artery embolization (UAE), high-intensity focused ultrasound (HIFU), and surgical treatment, with relatively few reports on medical conservative therapy. This article reports the process and outcomes of medical treatment for two cases of pregnancy-related acquired UAVF and summarizes and analyzes the indications and drug selection for UAVF medical conservative treatment based on the relevant literature.

Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial.

Objectives: To evaluate the effect of lateral versus supine positioning on incidence of hypoxaemia in sedated patients and to provide evidence based recommendations for respiratory strategies.

Design: Prospective, multicentre, randomised controlled trial.

Setting: 14 tertiary hospitals in China, July to November 2024.

Spesolimab Treatment in GPP: Impact of IL-36RN Mutations and Concomitant Plaque Psoriasis.

We present a case series involving five patients with generalized pustular psoriasis (GPP) who received a single intravenous dose of 900 mg spesolimab in our department from September 2023 to January 2024. Spesolimab was effective in three patients, regardless of their IL-36RN gene mutation status. Two patients with concomitant plaque psoriasis, despite initially poor responses to spesolimab, achieved resolution of pustules after switching their therapy to ixekizumab or secukinumab.

Clinical application of flexible and variable transparent endport technology in minimally invasive neuroendoscopic keyhole surgery: a practical new technology.

With the development of endoscopic technology, neuroendoscopy utilizes its advantages such as good illumination, close range observation, and flexible degrees of freedom. Neuroendoscopic surgery can achieve advantages such as minimally invasive, high clearance rate, low incidence of complications, good brain tissue protection, and fewer surgery-related injuries. However, minimally invasive endoscopic surgery also has inherent limitations, since its narrow surgical channels are prone to collapse and require special instrument support.

Antibacterial mechanism of non-thermal treatments against Pseudomonas putida and their application in tilapia fillets.

Pseudomonas putida is a common spoilage organism in food. This study investigated the inhibitory effects of plasma-activated water (PAW), ozone water (OW), and slightly acidic electrolyzed water (SAEW) on P. putida by examining bacterial morphology, membrane structure, redox balance, metabolic activity, and molecular mechanisms.

Comparison of [F]AlF-NOTA-FAPI-04 PET/CT and [F]FDG PET/CT for diagnosing lymph node metastasis in malignant tumors.

Purpose: This study compared the diagnostic performance, semi-quantitative capability, and staging accuracy of [F]AlF-NOTA-FAPI-04 and [F]FDG PET/CT in detecting lymph node metastases.

Methods: This single-center retrospective study included 41 patients with suspected lymph node metastases who received both [F]FDG and [F]AlF-NOTA-FAPI-04 PET/CT. The study compared metastatic lymph node detection, semi-quantitative values, and N staging accuracy.

S-nitros(yl)ation of CaMKIIα and its precision redox regulation by SNOTAC plays a critical role in learning and memory.

Ca/calmodulin-dependent protein kinase II α (CaMKIIα) and nitric oxide (NO) both play vital roles in learning and memory; however, the underlying mechanisms connecting them have remained elusive. To address this question, our study surprisingly observed that during learning and memory tasks, S-nitrosation of CaMKIIα, a key redox-based post-translational modification, significantly increased in mouse hippocampus. We then constructed mice with mutations in the major S-nitrosation sites of CaMKIIα (C280/289V) and found that the mutant mice exhibited remarkable cognitive impairments and attenuated long-term potentiation (LTP).

Controls of reservoir quality for submarine fan of F4 Formation in the Z oilfield, Illizi Basin, Algeria.

Subaqueous fan reservoirs have emerged as a pivotal focus in recent deep-water oil and gas exploration. In the Illizi Basin of Algeria, a series of submarine fan reservoirs are developed within the Devonian F4 Formation of the Z oilfield. Understanding the genesis of high-quality reservoirs (defined as those with porosity exceeding 25% and permeability greater than 1000 mD) is crucial for pinpointing high-productivity wells in deep-water submarine fan settings.

Solriamfetol for the treatment of excessive daytime sleepiness in participants with obstructive sleep apnea with different levels of adherence to primary OSA therapy: Subgroup analysis of a randomized clinical trial.

Background: Solriamfetol is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated for the treatment of excessive daytime sleepiness (EDS) associated with obstructive sleep apnea (OSA). The current study aims to evaluate effects of solriamfetol among participants with different adherence to primary OSA therapy using data from a randomized clinical trial conducted among Chinese participants.

Methods: Participants were 1:1 randomized to placebo or solriamfetol (up to 150 mg/day) for 12 weeks (stratified by adherence to primary OSA therapy).

Xylooligosaccharide Supplementation Mitigates Growth Performance Impairment and Intestinal Injuries in Enterohemorrhagic -Challenged Broilers.

Xylooligosaccharide (XOS) is a typical prebiotic; however, whether it protects chickens from enterohemorrhagic (EHEC) challenge remains unknown. This study investigated the protective effects of XOS on the growth and gut health of EHEC-challenged broilers. A total of 270 1-day-old broilers were divided into three groups (nine replicates per group): negative control (were not challenged), positive control (EHEC-challenged from days 8 to 11), and XOS (EHEC-challenged broilers supplemented with 1.

Chloride leaching and strength development of alkali-activated materials with municipal solid waste incineration fly ash, red mud and carbide slag.

Using as an alkaline activator to produce alkali-activated materials (AAMs) for construction and buildings provides an economic strategy for the treatment of hazardous municipal solid waste incineration fly ash (MSWI FA). In this study, AlO-rich red mud (RM) and CaO-rich carbide slag (CS) were used to tackle the chloride leaching issue of AAMs with MSWI FA arising from the Cl in MSWI FA. The optimal content of RM and CS for achieving higher compressive strength and less chloride leaching was determined.

Plasma-activated water treatment delayed the lipid oxidation and degradation of golden pompano fillets during storage based on lipidomics.

Lipid oxidation and degradation during storage represent key challenges affecting the quality of golden pompano () fillets. This study aimed to investigate the dynamic changes in lipid profiles of plasma-activated water (PAW)-treated fillets over 18 days, using chemical analysis and UHPLC-MS-based lipidomics. The results showed that the PAW-treated group exhibited higher POV and TBARS values within 0-6 days, but significantly delayed their increase within 6-18 days.

Glutathionylation-mediated degradation of a cap-binding protein enhances Arabidopsis resistance to Plutella xylostella.

The lepidopteran insect pest diamondback moth (Plutella xylostella) causes severe yield losses in cruciferous plants worldwide; therefore, there is an urgent need to characterize the genes for resistance to P. xylostella in plants and decipher their mechanisms. We previously demonstrated that inactivating NOVEL CAP-BINDING PROTEIN (NCBP), also known as RESISTANCE TO PLUTELLA XYLOSTELLA (RPX1), enhanced Arabidopsis (Arabidopsis thaliana) resistance to P.

Development of an upper limb muscle strength rehabilitation assessment system using particle swarm optimisation.

Purpose: This study develops a particle swarm optimization (PSO)-based assessment system for evaluating upper extremity and shoulder joint muscle strength with potential application to stroke rehabilitation. This study validates the system on healthy adult volunteers using surface electromyography and joint motion data.

Methods: The system comprises a multimodal data acquisition module and a computational analysis pipeline.

Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic manner.

The medial preoptic area (MPOA) of the hypothalamus is essential for metabolic adaptation to environmental challenges, though the molecular mechanisms underlying this process remain poorly understood. Here, we investigate the role of Forkhead transcription factor O1 (FoxO1), a key mediator of stress adaptation, in MPOA-dependent metabolic responses to temperature and nutritional changes. Our findings reveal sex-specific responses to both nutritional and temperature challenges.

[F]AlF-NOTA-FAPI-04 PET/CT improves detection of subcentimeter recurrent lesions in differentiated thyroid cancer.

Purpose: Fibroblast activation protein (FAP)-targeted PET/CT has emerged as a promising tool for visualizing tumor stroma. This study aimed to validate the diagnostic efficacy of [F]AlF-NOTA-FAPI-04 PET/CT in detecting subclinical metastases in recurrent differentiated thyroid cancer (DTC), with direct comparison to [F]FDG PET/CT.

Methods: Twenty-three DTC participants with biochemical recurrence (suppressed thyroglobulin [Tg] ≥ 1 ng/mL or Tg antibodies [Tg-Ab] > 115 IU/mL) underwent [F]AlF-NOTA-FAPI-04 PET/CT, including 16 who underwent paired [F]FDG scans.

Warhead Strategy for Targeted Protein S-Nitrosation.

Protein post-translational modifications (PTMs) are critical factors in disease progression. While progress has been made in regulating disease-associated PTMs such as phosphorylation and acetylation, the approach to achieving targeted S-nitrosation for disease treatment, particularly in vivo, remains largely uncharted. This challenge arises because S-nitrosation is primarily mediated by nitric oxide (NO), a gaseous free radical that complicates efforts to confine the effects of NO to a specific protein.

Liver ERα mediates sex differences in metabolic pattern changes in response to time-restricted feeding.

Time-restricted feeding (TRF) is a dietary strategy used to prevent and treat obesity in both sexes. However, TRF affects liver metabolism differently in males and females, and the mechanisms behind these differences remain unclear. Our study reveals that during TRF, female livers are more likely to break down amino acids (AAs) to synthesize fats, while male livers significantly reduce fatty acid synthesis.

Linking Ecological Stoichiometry to Biomass Allocation in Plants Under Cadmium and Petroleum Stress in the Yellow River Delta.

Cadmium and petroleum are the main pollutants in coastal wetland ecosystems that affect plant nutrient balance and growth. Scholars have discovered how saline plants adapt to single stresses. How plant ecology and physiology correspond to complex cadmium and petroleum pollution, especially regarding the pollution impacts on carbon (C), nitrogen (N), and phosphorus (P) stoichiometry and biomass allocation in coastal wetland plants, remains unclear, limiting their application in regard to pollution remediation.

Magnetic magic: How stimulation alters feeding patterns in Aplysia californica.

Repetitive transcranial magnetic stimulation (rTMS) is emerging as a groundbreaking treatment for eating disorders, such as anorexia and bulimia nervosa, though its underlying neurological mechanisms remain elusive. To shed light on the effects of rTMS on neural control of feeding behavior, we investigated the feeding responses in the marine mollusk Aplysia californica. Using in vitro preparations, we elicited feeding responses and performed dual nerve recordings to identify motor programs associated with rejection and ingestion.