Association of Blood Cell-Derived Inflammatory Markers with Symptoms and Short-Term Treatment Response in Late-Life Depression.

Objective: The aim of this study was to explore the relationship between whole blood cell-derived inflammatory markers and clinical symptoms in patients with late-life depression (LLD). It also aimed to explore the predictive value of whole blood cell-derived inflammatory markers on the efficacy of short-term medication.

Methods: Eighty-three patients with LLD were included, and their baseline demographics, routine blood test results and clinical characteristics before and after 2 weeks of treatment were collected.

Construction of S, O-Doped g-CN QDs Encapsulated in Eu-MOF with Dual-Emission for Ratiometric Fluorescence Detection of Hg²⁺.

Mercury ions (Hg) are categorized as environmental pollutants, which distributed in water, soil, and food systems due to environmental contamination. Hence, designing a sensitive assay for the convenient determination of Hg is of great importance. Herein, S and O-doped graphite phase nitrogenized carbon quantum dots (S, O-CNQDs) was encapsulated within a europium -based metal-organic framework (Eu-MOF) to construct a novel ratiometric fluorescent nanoprobe for the quantitative detection of Hg.

Long-term outcomes of ventriculoperitoneal shunt in HIV-negative Cryptococcal meningitis.

Cryptococcal meningitis (CM) is a life-threatening fungal infection of the central nervous system, with intracranial hypertension being a major contributor to mortality. Ventriculoperitoneal (VP) shunting has been established as a crucial intervention for managing elevated intracranial pressure; however, comprehensive long-term prognostic data for CM patients undergoing VP shunt placement remain limited. This study aimed to evaluate the long-term outcomes of VP shunting in patients with CM through a retrospective analysis.

Distinct characteristics of lymphoid and myeloid clonal hematopoiesis in World Trade Center first responders.

Clonal hematopoiesis of indeterminate potential (CHIP) represents the presence of clonal somatic mutations in blood cells in otherwise healthy individuals. While CHIP is known to increase risk for hematologic malignancies and cardiovascular disease, its association with airborne carcinogens remains largely unknown. We investigated CHIP mutations in 9/11 World Trade Center (WTC) disaster responders (n=350), who experienced substantial exposure to a complex mix of airborne carcinogens.

SMARCA1-NPFF axis inhibits colorectal cancer metastasis by blocking epithelial-mesenchymal transition and macrophage-dependent immune reprogramming.

Dysregulation of chromatin remodeling represents an essential driving factor for cancer development and progression. Our previous work demonstrated that increased inclusion of exon 13 during alternative splicing functionally inactivates SMARCA1, the catalytic subunit of the ISWI chromatin remodeling complex, to promote colorectal cancer (CRC) metastasis, but the precise mechanism underlying SMARCA1-mediated metastasis suppression remains elusive. In this study, through ATAC-seq and RNA-seq analyses, we established an inverse correlation between SMARCA1 activity and neuropeptide FF (NPFF) transcriptional output in CRC cell lines and clinical specimens.

Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic manner.

The medial preoptic area (MPOA) of the hypothalamus is essential for metabolic adaptation to environmental challenges, though the molecular mechanisms underlying this process remain poorly understood. Here, we investigate the role of Forkhead transcription factor O1 (FoxO1), a key mediator of stress adaptation, in MPOA-dependent metabolic responses to temperature and nutritional changes. Our findings reveal sex-specific responses to both nutritional and temperature challenges.

SA9: A Novel Strategy to Alleviate Type 2 Diabetes.

: Probiotics have recently emerged as promising agents in the prevention and treatment of various human diseases. This study investigates the therapeutic potential of SA9 in the management of type 2 diabetes mellitus (T2DM). : The in vitro antidiabetic activity of SA9 was primarily assessed via its α-glucosidase inhibitory capacity, complemented by metabolomic profiling to identify putative bioactive metabolites.

Perspectives in transvaginal sonography for the diagnosis of adenomyosis.

Adenomyosis is a common gynecological condition affecting women of reproductive age, posing significant diagnostic challenges due to its diverse clinical presentations. This extended opinion study critically reviews the diagnostic methods for adenomyosis, with a focus on transvaginal sonography (TVS), a widely used non-invasive imaging technique. The study evaluates the effectiveness, limitations, and clinical applicability of TVS, while exploring the role of histopathological confirmation when non-invasive methods are insufficient.

An interpretable machine learning model for predicting early liver metastasis after pancreatic cancer surgery.

Background: Liver metastasis is the most frequent site of distant metastasis in pancreatic ductal adenocarcinoma (PDAC), significantly contributing to poor prognosis. This study aims to develop and validate a machine learning (ML) model for predicting early liver metastasis (ELM) following pancreatic cancer surgery.

Method: This retrospective study included 407 pancreatic cancer patients who underwent surgery at the First Affiliated Hospital of Soochow University between January 2015 and December 2023, aiming to develop and validate a predictive model.

Increased Aβ40 in plasma is associated with severity of exposure to airborne pollutants at the World Trade Center: a cross-sectional study of neurological biomarkers.

World Trade Center (WTC) responders who were more severely exposed to the airborne pollution while working in rescue and recovery work would have heightened circulating levels of β-Amyloid (Aβ) levels in plasma. Plasma for 905 WTC responders was retrieved in 2019 and flash frozen and assayed using single molecule analysis to measure circulating levels of two subtypes of Aβ (Aβ40, Aβ42), alongside phosphorylated tau-181, glial fibrillary acidic protein (GFAP), and neurofilament-light. Plasma data were linked to demographics, blood volume, apolipoprotein-ε4 status, and medical outcomes as well as, in a subsample, with neuroimaging-based measures of cortical thickness.

RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation.

The capacity of cells to sense and respond to nutrient availability is essential for metabolic homeostasis. Failure in this process may cause cell death and associated diseases. While nutrient sensing in metabolic pathways is well understood, the mechanisms linking nutrient signals to cell death remain unclear.

A Nematode Effector, MiMSP8, Targets U2AF, a Subunit of a Splicing Factor Involved in Host pre-mRNA Splicing, Thereby Promoting Parasitism.

Root-knot nematodes secrete effectors into plant cells to facilitate parasitism. A candidate effector, MiMSP8, of Meloidogyne incognita has been shown to localise within the nucleus when transiently expressed in Nicotiana benthamiana leaf cells, but its role is still unknown. We demonstrate that the MiMSP8 protein is expressed in the dorsal gland of M.

Charting unknown metabolic reactions by mass spectrometry-resolved stable-isotope tracing metabolomics.

Metabolic reactions play important roles in organisms such as providing energy, transmitting signals, and synthesizing biomacromolecules. Charting unknown metabolic reactions in cells is hindered by limited technologies, restricting the holistic understanding of cellular metabolism. Using mass spectrometry-resolved stable-isotope tracing metabolomics, we develop an isotopologue similarity networking strategy, namely IsoNet, to effectively deduce previously unknown metabolic reactions.

A nematode effector hijacks a host RBR-type E3 ubiquitin ligase to regulate NRC4 receptor-mediated plant immunity and facilitate parasitism.

The root-knot nematode Meloidogyne incognita is an obligate biotrophic pathogen that causes extensive losses to agriculture worldwide. Effectors secreted by the parasite play an essential role during nematode infection through suppressing plant innate immunity. Here, we identify and characterize a M.

Guillain-Barré Syndrome During the Outbreak of Omicron in Southern China: A Multicenter Case-Control Study.

Purpose: The largest nationwide outbreak of Omicron, a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variant, occurred between December 2022 and February 2023 in China. This multicenter case-control study investigated the clinical features of GBS during this period.

Methods: The clinical characteristics of patients diagnosed with GBS associated with SARS-CoV-2 were assessed during an Omicron outbreak at 14 referral hospitals in Hubei Province, Southern China.

S-adenosylmethionine metabolism shapes CD8 T cell functions in colorectal cancer.

Metabolite nutrients within the tumor microenvironment shape both tumor progression and immune cell functionality. It remains elusive how the metabolic interaction between T cells and tumor cells results in different anti-cancer immunotherapeutic responses. Here, we use untargeted metabolomics to investigate the metabolic heterogeneity in patients with colorectal cancer (CRC).

Transcriptome landscape of the adrenal gland and superior cervical ganglion from hypertension-induced left ventricular hypertrophy rat model.

Background: Hypertension-induced left ventricular hypertrophy (LVH) is a cardiac structural remodeling and dysfunction resulting from chronic hypertension and is an independent risk factor for cardiovascular morbidity and mortality. Studies have implicated the involvement of the adrenal gland (AG) and superior cervical ganglion (SCG) in hypertension regulation. However, the molecular mechanisms of AG and SCG during hypertension-induced LVH remain unclear.

Crop management measures to mitigate negative impacts of late sowing on winter wheat production in China: a meta-analysis.

Background: Global warming, extreme weather, and crop rotation disruptions often lead to delayed sowing of winter wheat, impacting yields. Management strategies like fertilization and increased planting density may mitigate these effects, but their efficacy is not well understood. We conducted a meta-analysis using data from 95 studies to assess the impact of late sowing and management practices on winter wheat yield and components in China.

Efficacy and safety of autologous CIK cell therapy plus Toripalimab with or without chemotherapy in advanced NSCLC: A phase II study.

Advanced non-small cell lung cancer (NSCLC) with positive PD-L1 expression requires more effective therapeutic options. This study aims to evaluate the efficacy and safety of autologous cytokine-induced killer (CIK) cell therapy combined with the anti-PD-1 antibody toripalimab, with or without chemotherapy, as a first-line treatment for advanced NSCLC. This phase II trial enrolled 40 patients with PD-L1-positive, driver mutation-negative advanced NSCLC between July 2020 and December 2022.

Meta-Analysis of the Clinical Efficacy of Auricular Acupressure on Patients with Depression.

Objective: A systematic review of evaluating the clinical effects of auricular acupressure on patients with depression.

Methods: A comprehensive literature search was conducted in various electronic databases including PubMed, Web of Science, Cochrane Library, Google Scholar, CNKI, Wanfang, Embase, and VIP. The search time limit was from the establishment of the database to December, 2023.

Oral hygiene is independently associated with early stroke-associated pneumonia in hospitalized patients with ischemic stroke: An observational study.

Stroke-associated pneumonia (SAP) is a major stroke complication. Oral microorganisms are important contributors to SAP. Here, we aimed to investigate whether oral hygiene is associated with early SAP (<72 h of stroke onset) in patients with ischemic stroke.

Fault Root Cause Analysis Based on Liang-Kleeman Information Flow and Graphical Lasso.

Root cause analysis is used to find the specific fault location and cause of a fault during system fault diagnosis. It is an important step in fault diagnosis. The root cause analysis method based on causality starts from the origin of the causal connection between transactions and infers the location and cause of the mechanism failure by analyzing the causal impact of variables between systems, which has methodological advantages.

Temporal transcriptome profiling in the response to Salmonella enterica serovar enteritidis infection in chicken cecum.

Salmonella enterica serovar Enteritidis (S. Enteritidis) is a common zoonotic pathogen that not only causes gastroenteritis or death of livestock and poultry but also poses a serious threat to human health, causing severe economic losses to the poultry industry and society. Herein, RNA-sequencing (RNA-seq) was used to analyze the transcriptome variation of chicken cecum at four different time points (1, 3, 7, and 14 days) following S.

Multiscale Understanding of Anion Exchange Membrane Fuel Cells: Mechanisms, Electrocatalysts, Polymers, and Cell Management.

Anion exchange membrane fuel cells (AEMFCs) are among the most promising sustainable electrochemical technologies to help solve energy challenges. Compared to proton exchange membrane fuel cells (PEMFCs), AEMFCs offer a broader choice of catalyst materials and a less corrosive operating environment for the bipolar plates and the membrane. This can lead to potentially lower costs and longer operational life than PEMFCs.