Association and mechanism of Ligusticum chuanxiong alleviating itch: A combination of experimental and network pharmacology study.

Ethnopharmacological Relevance: Ligusticum chuanxiong (CX) is a traditional Chinese medicine with diverse effects, such as anti-inflammatory, antioxidant, neuroprotective, anti-nociceptive, and anticancer properties. It has been used in clinical applications with satisfying therapeutic effects. However, the underlying mechanism that contributes to the anti-pruritic effects remains to be comprehensively investigated.

Design and Fabrication of Microsphere-Based Micro/Nano Structures for Efficient Electromagnetic Modulation and Absorption.

The development of high-performance electromagnetic (EM) absorption materials is pivotal in addressing EM pollution. Such absorption materials enable flexible modulation of EM performance, which has become an important focal point of recent research. Among various EM absorption materials, microsphere-based micro/nano materials exhibit extremely high stability and remarkable attributes for modulating their EM performance.

Safety and Diagnostic Yield of Transbronchial Cryobiopsy by Flexible Bronchoscopy Under Conscious Sedation Without Intubation in Diffuse Parenchymal Lung Disease.

Background: Transbronchial cryobiopsy (TBCB) is generally recommended under intubation or rigid bronchoscopy with general anesthesia. However, some patients with diffuse parenchymal lung disease (DPLD) are unable to tolerate general anesthesia, which limits the widespread adoption of TBCB.

Methods: A total of 37 patients with DPLD who underwent TBCB under conscious sedation without intubation were included in this study.

Genome-transcriptome co-analysis identifies members and molecular characteristics of the TRAF gene family in Siberian sturgeon (Acipenser baerii).

Tumor necrosis factor receptor-associated factors (TRAFs), as key signal transducers, play a crucial role in both innate and adaptive immune responses. However, current research on the systematic identification of the TRAF family and its functional role in Siberian sturgeon (Acipenser baerii) is relatively unexplored. In this study, TRAF family members were first identified in A.

Role of Active Video Games in Blood Pressure Management Among Children and Young Adults: Systematic Review and Meta-Analysis.

Background: The significant association between blood pressure (BP) in children and young adulthood and risks of cardiovascular diseases in adulthood highlights the critical need for early BP control. While lifestyle modifications such as increased physical exercise have proven effective, traditional exercise forms always suffer from low motivation and adherence. Active video games (AVGs), combining exercise with engaging gameplay, may present a promising alternative for managing BP in children and young adults.

Improved Hypoxic Microenvironment By Nanoformulation For Effective T Cell Therapy In Mice Model.

Introduction: Adoptive cell therapy (ACT) has emerged as a powerful strategy for eliciting tumor regression. However, its efficacy in solid tumors remains limited, primarily due to the immunosuppressive tumor microenvironment (TME). We developed a tumor microenvironment-responsive mesoporous silica nanosphere (MSN) formulation co-loaded with the immunostimulant imiquimod (R837), zinc peroxide (ZnO), and manganese peroxide (MnO) to alleviate hypoxia and enhance dendritic cell (DC)-mediated antitumor immunity.

Development of synthetic chloride transporters using high-throughput screening and machine learning.

The development of synthetic compounds capable of transporting chloride anions across biological membranes has become an intensive research field in the last two decades. Progress is driven by the desire to develop treatments for chloride transport related diseases (, cystic fibrosis), cancer or bacterial infections. In this manuscript, we use high-throughput screening and machine learning to identify novel scaffolds, and to find the molecular features needed to achieve potent chloride transport that can be generalized across diverse chemotypes.

Ageing-Dependent Thyroid Hormone Receptor α Reduction Activates IP3R1-Meditated Ca Transfer in MAM and Exacerbates Skeletal Muscle Atrophy in Mice.

Sarcopenia profoundly impacts the quality of life and longevity in elderly populations. Notably, alterations in thyroid hormone (TH) levels during ageing are intricately linked to the development of sarcopenia. In skeletal muscle, the primary action of TH is mediated through the thyroid hormone receptor alpha (TRα).

Nanoplastics Toxicity Is a Subset of Nanotoxicology, Not a Separate Field.

Nanoplastics toxicity has been framed as an emerging, distinct research area, purportedly addressing a new threat. While this focus has heightened public awareness and influenced the regulation of plastics, isolating nanoplastics toxicity risks inefficiently allocating research resources and hindering sustainable management strategies. Here, using data mining and machine learning, we show that research on nanoplastics toxicity closely mirrors that of engineered nanoparticles, a well-established domain of nanotoxicology.

Pseudo Label Learning for Partial Point Cloud Registration.

Partial point cloud registration plays a crucial role in computer vision and has widespread applications in 3D map construction, pose estimation, and high-precision localization. However, the collected point clouds often contain missing data due to hardware limitations and complex environments. Various partial registration algorithms have been proposed, most of which rely on estimating overlap regions.

Biproximate ellipsoid formula with transrectal ultrasound: a superior method for PSA density in gray zone prostate cancer detection.

Purpose: This study aimed to enhance prostate cancer (PCa) detection in patients with prostate-specific antigen (PSA) levels within the "gray zone" (4-10 ng/mL) by comparing PSA density (PSAD) calculations derived from the traditional ellipsoid formula (TEF) and the biproximate ellipsoid formula (BPEF).

Materials And Methods: A total of 99 patients were enrolled. All participants underwent transrectal ultrasound (TRUS) for prostate volume estimation, followed by PSAD calculation using both the BPEF and TEF methods.

Disulfiram Protects Against Multiorgan Injuries and Cell Pyroptosis via Inhibiting GSDMD in Severe Acute Pancreatitis Mice.

Severe acute pancreatitis (SAP) is distinguished by an uncontrolled systemic pro-inflammatory response caused by the activation of trypsin within the pancreatic tissue, leading to the occurrence of multiple organ failure (MOF). Gasdermin D (GSDMD)-induced pyroptosis represents a form of programmed cell death characterised by robust inflammatory responses. This indicates that directing efforts towards pyroptosis could potentially offer a remedy for SAP and its related MOF.

Effects of different electroacupuncture/ transcutaneous electrical acupoint stimulation parameters on the pregnancy outcomes of in vitro fertilisation-embryo transfer: a systematic review and meta-analysis.

Background: Extensive progress has been made in improving pregnancy outcomes for in vitro fertilisation and embryo transfer (IVF-ET) patients through the use of electroacupuncture (EA) and transcutaneous electrical acupoint stimulation (TEAS). However, a clear and suitable recommendation for the parameter selection scheme of EA/TEAS remains elusive.

Objective: To evaluate evidence-based conclusions of different EA/TEAS parameters on improvement of pregnancy outcomes in patients undergoing IVF-ET and evaluate other factors that may affect pregnancy outcomes.

Gradient-Asymmetric WPU-CNT@BiTe Film for Flexible Tactile Sensor with Decoupled Bending-Thermal Sensing Capacity.

Flexible tactile sensors equipped with multimodal decoupling capabilities are essential for the advancement of intelligent robotics. However, these sensors face challenges related to signal interference and limitations in single-variable detection. Drawing inspiration from the multilayered architecture and perception ability of biological skin, this study presents the development of an asymmetric gradient WPU-CNT@BiTe film via a gravity-induced self-sedimentation strategy, which integrates piezoresistive and thermoelectric effects, facilitating a dual-mode decoupled sensing capacity.

Function of chemokines in embryo implantation.

Embryo implantation centrally involves the maternal immune system's specific acceptance of the semi-allogeneic embryo. Despite advances in assisted reproduction, implantation failure remains a key bottleneck limiting clinical pregnancy rates, with its mechanisms a significant challenge in reproductive immunology. Recent studies reveal that chemokine-mediated dynamic remodeling of the immune microenvironment is central to maintaining maternal-fetal immune homeostasis.

Influence of iron and manganese on nitrogen biotransformation in the vadose zone of red beds following landfill leachate leakage.

Landfill leachate leakage causes nitrogen contamination in the groundwater of red beds with high levels of iron (Fe) and manganese (Mn). However, the influence of Fe and Mn on nitrogen biotransformation in the vadose zone of red beds (VZRB) remains unclear. This study investigates the influences of varying concentrations of Fe and Mn on nitrogen biotransformation following leachate infiltration through batch and column experiments.

Steel slag catalyzed municipal sludge pyrolysis to produce low-pollution gas, biochar, and bio-oil products.

This study examined the influence of steel slag powder as an additive on the pyrolysis characteristics of sludge, including the activation energy of the reactions, in addition to inhibiting the escape of nitrogen-containing and sulfur-containing gases, while improving the bio-oil fraction. There were three methods used to calculate the average activation energy of sludge: Flynn-Wall-Ozawa, Kissinger-Akahira-Sunose, and Friedman. It can be concluded that the addition of steel slag powder accelerated sludge pyrolysis and that the kinetic modeling during the primary pyrolysis stages occurred through a reaction-level mechanism model (Fn).

Long-Term Outcomes of Endoscopic Ultrasound-Guided Coloenterostomy With a Lumen-Apposing Metal Stent for Malignant Small Bowel Obstruction.

Background And Aims: Endoscopic ultrasound-guided coloenterostomy (EUS-CE) using lumen-apposing metal stents (LAMS) has emerged as a potential alternative for the palliative treatment of malignant small bowel obstruction (MSBO). However, the long-term outcomes of EUS-CE remain unclear. This study aimed to assess the efficacy and safety of EUS-CE, focusing on long-term outcomes.

An Interpretable Machine Learning Model Based on Inflammatory-Nutritional Biomarkers for Predicting Metachronous Liver Metastases After Colorectal Cancer Surgery.

: Tumor progression is regulated by systemic immune status, nutritional metabolism, and the inflammatory microenvironment. This study aims to investigate inflammatory-nutritional biomarkers associated with metachronous liver metastasis (MLM) in colorectal cancer (CRC) and develop a machine learning model for accurate prediction. : This study enrolled 680 patients with CRC who underwent curative resection, randomly allocated into a training set (n = 477) and a validation set (n = 203) in a 7:3 ratio.

Self-sustained biomimetic bioelectronic accelerated metabolic reprogramming of bone regeneration.

Bionic bioelectronics has promising applications in bone defect repair, with current research primarily focusing on the development of electroactive biomaterials and self-powered systems, which can mimic the electrophysiological microenvironment of natural bone tissue, accelerating bone healing by promoting osteoblast proliferation and differentiation through electrical stimulation. However, the biological mechanisms of bionic electrical stimulation in bone defect repair remain incompletely understood. Here, the study developed a self-sustained biomimetic bioelectronic system comprising a triboelectric/piezoelectric hybrid nanogenerator (TP-hNG) and a multifunctional gold-coated polymer internal fixation plate (GP-IFP), which utilizes the natural biomechanical properties of rat heartbeat and respiratory movements to generate bionic electric signals (Bio-SIG) that are closely related to physiological neurofeedback signals.

Physical activity and phubbing behavior in Chinese college students: the mediating role of self-control and the moderating role of gender.

Objective: The prevalent adoption of smartphones has given rise to widespread phubbing behavior among college students, characterized by excessive smartphone use in social settings. However, research investigating behavioral intervention strategies to mitigate phubbing behavior remains notably scarce. In the present study, we examined the mediating mechanism of self-control and the moderating role of gender between physical activity and phubbing behavior in college students.

Chemoprevention of hepatocellular carcinoma using N-acetylgalactosamine-conjugated siRNAs.

The ability to prevent hepatocellular carcinoma (HCC) in patients with chronic liver disease remains an unmet clinical need. We performed a head-to-head comparison of N-acetylgalactosamine (GalNAc)-conjugated small interfering RNA (siRNA)-mediated inhibition of five genes (CDK1, PD-L1, CTNNB1, SMYD3, ANLN) to prevent cancer in four distinct autochthonous HCC mouse models. siRNA targeting Cdk1 and Anln (siCdk1 and siAnln, respectively) increased overall survival in the CTNNB1/MYC hydrodynamic transfection (HDT) model, in which HCC formation is driven by oncogenes.

[Application practice and exploration of artificial intelligence technology in entire industrial chain of traditional Chinese medicine resources].

With the growing awareness of public health, the value and importance of traditional Chinese medicine(TCM) resources have become increasingly prominent. Despite the undeniable significance of TCM in medical treatment and healthcare, the protection, development, and utilization of TCM resources still face numerous challenges. Under the traditional model, the development and utilization of TCM resources heavily rely on manual labor and empirical decision-making, which not only leads to inefficiencies and high costs but also causes serious issues such as unstable drug quality and imbalances in market supply and demand.

Associations between protein intake status and the association of "double burden of malnutrition" in children aged 2-5 years: a health and nutrition survey of selected children in Bengbu City, China.

Background: Protein intake is widely recognized as a reliable marker for assessing malnutrition. The double burden of malnutrition (DBM) is characterized by the coexistence of malnutrition and overweight, obesity, or diet-related noncommunicable diseases in individuals, families, and populations throughout the life course.

Methods: Children were categorized into quartiles based on the protein index.

Association between acupuncture and live birth rates after fresh embryo transfer: A cohort study based on different propensity score methods.

Objective: To explore the association between acupuncture during controlled ovarian hyperstimulation (COH) and the live birth rate (LBR) using different propensity score methods.

Methods: In this retrospective cohort study, eligible women who underwent a COH were divided into acupuncture and non-acupuncture groups. The primary outcome was LBR, as determined by propensity score matching (PSM).