Calix[]azanediyldibenzoate: Intramolecular Hydrogen Bond-Assisted Synthesis, Acidichromism, and Oriented Self-Assembly.

Here, intramolecular hydrogen bond (IMHBs)-induced rigidity is used for the first time to synthesize macrocyclic arenes. Calix[]azanediyldibenzoates (C[]A, where = 3, 4, or 5) are synthesized through a one-step condensation reaction between dimethyl 2,2'-azanediyldibenzoate and paraformaldehyde. Compared to the monomer, the macrocycles exhibit a fast and significant acidochromic response due to the intramolecular charge transfer that is boosted by the synergistic effect of their adsorption and protonation.

Plasma membrane accessible cholesterol is regulated by ACC1 and lipid droplets.

Proper maintenance of plasma membrane (PM) cholesterol is essential for diverse processes ranging from animal development to pathogen evasion. Despite decades of study, the mechanisms governing cellular cholesterol regulation are incomplete. Using genome-wide screens we find that ACC1, the rate-limiting enzyme in fatty acid biosynthesis, regulates PM cholesterol transport.

The GmPRL1b-GmST2-GmAOC3/4 Module Confers Salt Tolerance and Botrytis cinerea Resistance by Inducing Jasmonic Acid Biosynthesis in Soybean.

Abiotic and biotic stress significantly limit crop yields. However, most stress-tolerance genes identified to date provide resistance to either biotic or abiotic stress and inhibit normal plant growth, limiting their application in breeding. We identified the soybean (Glycine max) NAC transcription factor gene GmST2, which is induced by salt and Botrytis cinerea stresses.

Immunological dynamics in orthotopic versus subcutaneous murine models of HPV-positive oropharyngeal cancer.

The necessity of reliable preclinical models for evaluating the efficacy of novel therapeutic strategies is imperative. Nevertheless, the degree to which tumor-bearing murine models represent the immunological characteristics of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) has largely been unexplored. Utilizing single-cell RNA sequencing technology, our research elucidated that subcutaneous (SC) murine models more accurately reflect the early immunogenic phase of human HPV-positive OPSCC, marked by a stage-dependent increase in effector T cell infiltration.

A regioisomer of thiazole orange derivate for selective G-Quadruplex DNA detection and in vivo tumor imaging.

G-Quadruplex (G4) DNA structures play a crucial role in regulating various biological processes, rendering them attractive targets for diagnostic and therapeutic applications. The development of G4-targeted fluorescent probes will significantly enhance our understanding of G4 DNA biology in vivo and improve the precision of diagnosing and treating genetic diseases. Herein, we report on a regioisomer of a thiazole orange derivative (SQ2) as a promising fluorescent dye for G4 DNA structures and demonstrate its application in both cell and tumor tissue imaging.

Prognostic value of left atrial strain analysis using cardiac magnetic resonance feature tracking technology for patients with acute myocarditis.

Background: Acute myocarditis (AM) is induced by multiple factors, and its clinical symptoms and prognosis vary significantly. Existing diagnostic and prognostic assessment methods have certain limitations. Myocardial strain analysis based on cardiac magnetic resonance feature tracking (CMR-FT) can detect myocardial damage in the subclinical stage, but studies on the correlation between left atrial (LA) strain and the prognosis of AM are relatively limited.

Integrating multiple machine learning approaches with Mendelian randomization to unveil the effects of BMI-mediated matrix metalloproteinase 3 levels on hearing.

This study aimed to investigate the genetic mechanism of the levels of matrix metalloproteinase 3 (MMP-3)-induced hearing impairment and whether BMI mediates their causal relationship by using Mendelian randomization (MR) and machine learning. This research employed aggregated GWAS data from the IEU (Integrative Epidemiology Unit) database for MR and Bayesian Weighted Mendelian Randomization (BWMR) analysis, to uncover the causal association between MMP-3 levels and hearing, along with a potential mediating factor BMI. Inverse variance weighted (IVW), MR Egger, Weighted median, simple mode, and Weighted mode approaches were utilized, and multi-effect testing and heterogeneity testing were conducted.

Dielectric strength weakening of hexagonal boron nitride nanosheets under mechanical stress.

Hexagonal boron nitride (hBN) nanosheets have become the most promising candidates as gate dielectric and insulating substrates for two-dimensional (2D) material-based electronic and optoelectronic devices. While mechanical stress in hBN nanosheets is often either intrinsically or intentionally introduced for 2D material-based devices during device fabrication and operation, the dielectric strength of hBN nanosheets under mechanical stress is still elusive. In this work, the dielectric strength of hBN nanosheets in a metal/hBN/metal structure is systematically studied when mechanical stress normal to nanosheets is applied.

Adaptability of Foxtail Millet Varieties Based on Photosynthetic Performance and Agronomic Traits.

As a strategic crop of dry farming in northern China, the photosynthetic characteristics and stress resistance of foxtail millet ( L.) are crucial to yield formation. This study aimed to explore the physiological characteristics of various foxtail millet varieties and screen high-efficiency varieties adapted to semi-arid climates.

Role and mechanism of botanical drugs and their metabolites in osteoporosis: new strategies for clinical application.

Osteoporosis, the most prevalent bone disease worldwide, is characterized by reduced bone mineral density and microarchitectural deterioration. Current pharmacological agents for osteoporosis management include bisphosphonates, calcitonin, estrogen, denosumab, and romosozumab. However, emerging evidence suggests these therapies may increase risks of breast cancer, ovarian cancer, osteonecrosis, and cardiovascular diseases.

Ultrafast Synthesis of MOF-Derived Magnetic Ni@C Catalyst for Efficient Photo-Enhanced Uranium Recovery in Real Nuclear Wastewater.

Photocatalytic reduction of uranium from wastewater containing high concentrations of fluoride is crucial from both environmental and sustainability perspectives. However, the coordination of fluorine and uranyl ions to U(VI)-F complexes with high bond strengths poses challenges for photocatalysts. Electrostatic interactions induced by photocatalysis to dissociate U(VI)-F complexes provide an effective method for the extraction of uranium from wastewater containing fluorine.

Endovascular Therapy Versus Medical Management for Large Ischemic Infarct: 1-Year Outcomes of the ANGEL-ASPECT Trial.

Background: Several trials have shown the benefit and safety of endovascular therapy (EVT) compared with medical management (MM) of patients with a large ischemic core in the 90-day follow-up. However, the 1-year outcome comparison between EVT and MM in Asian patients with a large ischemic core has not been investigated. Our aim was to evaluate the 1-year outcomes of patients in the ANGEL-ASPECT trial (Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core).

Radiomics-Driven Diffusion Model and Monte Carlo Compression Sampling for Reliable Medical Image Synthesis.

Reliable medical image synthesis is crucial for clinical applications and downstream tasks, where high-quality anatomical structure and predictive confidence are essential. Existing studies have made significant progress by embedding prior conditional knowledge, such as conditional images or textual information, to synthesize natural images. However, medical image synthesis remains a challenging task due to: 1) Data scarcity: High-quality medical text prompt are extremely rare and require specialized expertise.

VariMix: A variety-guided data mixing framework for explainable medical image classifications.

Background And Objective: Modern deep neural networks are highly over-parameterized, necessitating the use of data augmentation techniques to prevent overfitting and enhance generalization. Generative adversarial networks (GANs) are popular for synthesizing visually realistic images. However, these synthetic images often lack diversity and may have ambiguous class labels.

A polymer pillar for the VOPO cathode to retain voltage stability in aqueous zinc batteries.

The HO-pillared VOPO cathode in aqueous Zn batteries suffers phase transition to low-potential VO, causing voltage decay. Replacing interlayer water with poly(3,4-ethylenedioxythiophene) (PEDOT) inhibits this transition strong PEDOT-VOPO interactions, enabling a stable high voltage of 1.41 V.

Hygroscopic properties modeling and thermodynamic analysis of a seamless popping capsule.

This study investigated the thermal stability of seamless "popping" capsules at different storage temperatures to address the challenges of adhesion and texture changes affecting shelf life. Storage experiments at different temperatures identified optimal conditions for maintaining product integrity. Moisture adsorption behavior was analyzed using isothermal adsorption curves at 25 °C, 32 °C, and 37 °C, along with sorption kinetics at 68% relative humidity (RH).

Severe Aortic Valve Stenosis During Pregnancy: Role of Multidisciplinary Pregnancy Heart Team to Guide Decision-Making.

Background: Pregnant women with underlying cardiovascular disease are at an increased risk of maternal-fetal morbidity and mortality especially in the setting of symptomatic stenotic valvular heart disease.

Case Summary: A 35-year-old female at 17 weeks gestation presented to the emergency department with exertional dyspnea for 3 months and was diagnosed with decompensated heart failure. Echocardiogram demonstrated left ventricular ejection fraction of 45% with severe aortic valve stenosis and moderate aortic regurgitation.

Cerebral network topology and peak width of skeletonized mean diffusivity changes associated with cognitive impairment in patients with obstructive sleep apnea.

Objectives: To characterize the network topology and peak width of skeletonized mean diffusivity (PSMD) and their correlation with cognitive impairment in obstructive sleep apnea (OSA) patients and to assess whether such impairments are reversible after treatment.

Methods: Ninety-one OSA patients and 30 healthy controls (HCs) participated. Patients were classified into mild group (n = 37) and moderate-severe group (n = 54) based on apnea-hypopnea index.

Molecular mechanism of self-activation induced by the intrinsically disordered region in Rac1b: Structural and functional insights.

Rac1b is a splicing variant of the RAC1 gene, characterized by a 19-amino-acid (19AA) insertion between residues 75 and 76. Overexpression of Rac1b has been observed in various cancers, establishing it as a potential target for anticancer therapies. Similar to Rac1, Rac1b functions as a GTPase, cycling between an active GTP-bound state and an inactive GDP-bound state.

Enhanced YOLO and Scanning Portal System for Vehicle Component Detection.

In this paper, a novel online detection system is designed to enhance accuracy and operational efficiency in the outbound logistics of automotive components after production. The system consists of a scanning portal system and an improved YOLOv12-based detection algorithm which captures images of automotive parts passing through the scanning portal in real time. By integrating deep learning, the system enables real-time monitoring and identification, thereby preventing misdetections and missed detections of automotive parts, in this way promoting intelligent automotive part recognition and detection.

Optimizing the Bioprocesses of Bacteriocin Production in HD1.7 by the "Acetate Switch": Novel Insights into the Labor Division Between Energy Metabolism, Quorum Sensing, and Acetate.

Acetate may act as a signaling molecule, regulating Paracin 1.7 production via quorum sensing (QS) in HD1.7.

Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells.

Background: Ovarian cancer (OC) poses a significant challenge for conventional chimeric antigen receptor-engineered T (CAR-T) cell therapy, due to frequent recurrence linked to tumor heterogeneity, platinum resistance, immune evasion, and an immunosuppressive tumor microenvironment (TME).

Methods: Here, we analyze primary OC patient samples and identify a unique opportunity for allogeneic CAR-NKT (CAR-NKT) cells to concurrently attack OC tumor cells and their TME. Leveraging stem cell gene engineering and a clinically guided culture method, we achieve robust generation of CAR-NKT cells at high yield and purity.

Zoned blaze broadband gratings mosaicked using a device made from high-stability special materials.

Broadband gratings are fundamental optical components in broadband spectral instruments. Herein, the complexity and cost of fabrication methods are addressed by zoned blazed broadband grating fabrication via mosaicking technology. A blaze angle calculation method and zoned grating structural parameters are established and designed.

Dual-targeted siRubicon delivery strategy triggers hepatocellular lipophagy for mitigating liver steatosis.

Metabolic dysfunction-associated steatotic liver disease is marked by fat accumulation and inflammation, partly due to impaired lipophagy-a cellular process in which lipid droplets are broken down through autophagy. Rubicon, a protein that inhibits this process, worsens the condition by blocking fat breakdown. Small interfering RNA molecules targeting Rubicon show therapeutic potential but face challenges such as instability and off-target effects.

High-performance gate-all-around phototransistor with a GaO/NiO heterojunction for advanced ultraviolet detection.

Gallium oxide (), with its ultra-wide bandgap of 4.9 eV, excellent thermal stability, and availability in large native substrates, is an ideal material for solar-blind ultraviolet (UV) detection. In this study, we present a high-performance gate-all-around (GAA) phototransistor based on a p-NiO/n- heterojunction, specifically designed for advanced UV detection applications.