Effect of liraglutide treatment on mitigation of hearing damage induced by multiday repeated high-intensity blasts.

Exposures to blasts impair hearing, despite the protection of earplugs. Liraglutide showed therapeutic effects against hearing damage induced by single-day blasts. However, the effect of liraglutide on auditory damage caused by multiday repeated blasts remains unknown.

A polymer pillar for the VOPO cathode to retain voltage stability in aqueous zinc batteries.

The HO-pillared VOPO cathode in aqueous Zn batteries suffers phase transition to low-potential VO, causing voltage decay. Replacing interlayer water with poly(3,4-ethylenedioxythiophene) (PEDOT) inhibits this transition strong PEDOT-VOPO interactions, enabling a stable high voltage of 1.41 V.

Interface-Tunable Fluoropolymer Coatings Enabled by Surface-Engineered Recycled Tire Rubber.

Fluoropolymer coatings demonstrate excellent chemical resistance and durability; however, their inherently low surface energy compromises adhesion and structural cohesion, particularly when exposed to aggressive environments. This study presents a scalable interfacial engineering strategy to enhance coating performance by integrating functionalized ground tire rubber (fGTR) into poly(vinylidene fluoride--hexafluoropropylene) (PVDF-HFP). Postconsumer GTR is transformed into high-performance fillers through surface-initiated grafting of poly(acrylic acid), introducing polar groups capable of improving dispersion in an organic bisolvent system and facilitating strong hydrogen bonding with the matrix.

Cloning and functional study of AdOPT1, a gene for synthesizing isoimperatorin from Angelica dahurica var. formosana.

Angelica dahurica var. formosana (ADF) is a perennial medicinal plant in the Apiaceae family. Its dried roots are rich in furanocoumarins, which exhibit significant pharmacological activities and development potential.

Self-Sensing Composites via an Embedded 3D-Printed PVDF-MoS Nanosensor for Structural Health Monitoring.

Carbon fiber (CF)-reinforced epoxy composites are widely used in vehicle applications, where early damage detection is crucial for reliability and safety. To address this need, we developed a self-sensing epoxy/CF composite by embedding a PVDF-MoS nanosensor via an embedded 3D printing method. By harnessing the intrinsic curing kinetics of epoxy, we tailored its rheological properties to optimize the embedded printing process, enabling precise and reliable support for sensor filaments without compromising the composite's structural and functional integrity.

Effect of Continuous Lipopolysaccharide Induction on Oxidative Stress and Heart Injury in Weaned Piglets.

After weaning, piglets no longer consume breast milk, and their immune system is not yet fully developed. At this time, if weaned piglets are infected with , their subsequent growth will be seriously affected. In the present study, 48 healthy 28-day-old weaned piglets (6.

Effects of lipopolysaccharide administration on thymus damage, antioxidant capacity and immune function in weaned piglets.

Introduction: Piglets are vulnerable to stress during weaning because of changes in the feeding environment, nutrients, and other growth-impacting conditions. In this study, stress injury was modelled by continuous intraperitoneal injection of lipopolysaccharide (LPS) and was used to investigate the dynamics of antioxidant indices and immunoinflammatory factors in the piglet thymus.

Material And Methods: Forty-eight weaned piglets were divided into an LPS group and a control group.

Tailored hydrothermal platforms for fluorescent Q-dots with theranostic application.

This study explores the fluorescence properties of the hydrothermal reaction of citric acid and urea under different conditions, as they have attracted considerable attention in recent years. However, so far, the detailed formation process and the precise chemical structure of the resulting fluorescent products remain inadequately understood. The results reveal that under mild conditions, fluorescence is mainly due to organic molecules, identified as citrazinic acid through acid treatment with spectroscopic techniques.

Electrocatalytic reforming of polyethylene terephthalate waste plastics into high-value-added chemicals with green hydrogen generation.

Electrochemical reforming offers a sustainable strategy for converting plastic waste into high-value-added chemicals and hydrogen fuel. Herein, a cost-effective NiFe-filmed electrode with a Tremella-like nanostructure was developed using an ultrasonic immersion etching method. This electrode enabled the electro-reforming of ethylene glycol (EG, a monomer of polyethylene terephthalate (PET)) into valuable commodity chemicals, with coproduction of hydrogen fuel.

Multiscale Finite Element Modeling of Human Ear for Acoustic Wave Transmission Into Cochlea and Hair Cells Fatigue Failure.

Hearing loss is highly related to acoustic injuries and mechanical damage of ear tissues. The mechanical responses and failures of ear tissues are difficult to measure experimentally, especially cochlear hair cells within the organ of Corti (OC) at microscale. Finite element (FE) modeling has become an important tool for simulating acoustic wave transmission and studying cochlear mechanics.

Encapsulation of thyme essential oil in dendritic mesoporous silica nanoparticles: Enhanced antimycotic properties and ROS-mediated inhibition mechanism.

Dendritic mesoporous silica nanoparticles (DMSNs) have emerged as promising nanocarriers due to their unique three-dimensional structure and tunable pore characteristics. This study investigates the potential of DMSNs to deliver thyme essential oil (TEO) for enhanced antifungal activity against Fusarium oxysporum (F. oxysporum), a major plant pathogen.

Comparison of nitrification inhibitors for mitigating cadmium accumulation in pakchoi and their associated microbial mechanisms.

The use of nitrification inhibitors has been suggested as a strategy to decrease cadmium (Cd) accumulation in crops. However, the most efficient nitrification inhibitor for mitigating crop Cd accumulation remains to be elucidated, and whether and how changes in soil microbial structure are involved in this process also remains unclear. To address these questions, this study applied three commercial nitrification inhibitors, namely, dicyandiamide (DCD), 3,4-dimethylpyrazole phosphate (DMPP), and nitrapyrin (NP), to pakchoi.

Thermal and Mechanical Mechanisms of Polymer Wear at the Nanoscale.

Wear is a ubiquitous phenomenon that limits the life of many engineered components with sliding interfaces through the gradual removal of material. The wear of polymers is crucial in many applications, ranging from bearings to orthopedic implants to nanolithography processes. The wear rate of polymers is strongly affected by the stress and temperature at the interface.

Regulates Lignin and Coumarin Biosynthesis in the Roots of var. .

var. (), which belongs to the Umbelliferae family, is one of the original plants of herbal raw material Angelicae Dahuricae Radix. roots represent an enormous biomass resource convertible for disease treatment and bioproducts.

Effect on the splenocyte function of weaned piglets induced by continuous lipopolysaccharide injections.

Introduction: When piglets are exposed to pathogens for a long period, the immune system organs, among them the spleen, play a major role in combating the stress caused by those pathogens. In the present study, the effect on splenocyte function was investigated in a model of weaned piglets in which stress was induced by multiple low doses of lipopolysaccharide (LPS).

Material And Methods: Forty-eight 28-day-old piglets were divided into two groups: the LPS group and the control group.

Sustainable Aerobic Allylic C-H Bond Oxidation with Heterogeneous Iron Catalyst.

Emerging techniques are revolutionizing the realm of chemical synthesis by introducing new avenues for C-H bond functionalization, which have been exploited for the synthesis of pharmaceuticals, natural compounds, and functional materials. Allylic C-H bond oxidation of alkenes serves as possibly the most employed C-H bond functionalization reaction. However, sustainable and selective approaches remain scarce, and the majority of the existing conditions still hinge on hazardous oxidants or costly metal catalysts.

Direct C-C Double Bond Cleavage of Alkenes Enabled by Highly Dispersed Cobalt Catalyst and Hydroxylamine.

The utilization of a single-atom catalyst to break C-C bonds merges the merits of homogeneous and heterogeneous catalysis and presents an intriguing pathway for obtaining high-value-added products. Herein, a mild, selective, and sustainable oxidative cleavage of alkene to form oxime ether or nitrile was achieved by using atomically dispersed cobalt catalyst and hydroxylamine. Diversified substrate patterns, including symmetrical and unsymmetrical alkenes, di- and tri-substituted alkenes, and late-stage functionalization of complex alkenes were demonstrated.

Genome-Wide Identification and Expression Analysis of bZIP Family Genes in .

The basic (region) leucine zippers (bZIPs) are evolutionarily conserved transcription factors widely distributed in eukaryotic organisms. In plants, they are not only involved in growth and development, defense and stress responses and regulation of physiological processes but also play a pivotal role in regulating secondary metabolism. To explore the function related to the bZIP gene family in Bertoni, we identified 105 genes at the genome-wide level and classified them into 12 subfamilies using bioinformation methods.

Discovery of a Natural Hybrid Polyketide Produced by Endophytic for Biocontrol of Phytopathogenic Fungus .

The endophytic fungus WBS017 exhibits broad-spectrum activity against plant pathogens, with particular effectiveness against . Subsequently, a compound is isolated from strain WBS017 as the main active ingredient against using activity-guided separation and identified as hybrid polyketide (namely cladodionen, CLD) using UV, MS, NMR, etc. In vitro and in vivo antifungal activity tests demonstrate that CLD effectively inhibits the mycelial growth and spore germination, with an IC value of 1.

Developing Transparent and Conductive PolyHEMA Gels Using Deep Eutectic Solvents.

Poly(2-hydroxyethyl methacrylate) (polyHEMA) hydrogels are commonly used in biomaterials such as contact lenses. However, water evaporation from these hydrogels can cause discomfort to wearers, and the bulk polymerization method used to synthesize them often results in heterogeneous microstructures, reducing their optical properties and elasticity. In this study, we synthesized polyHEMA gels using a deep eutectic solvent (DES) instead of water and compared their properties to traditional hydrogels.

1,25-Dihydroxyvitamin D inhibits hepatic diacyglycerol accumulation and ameliorates metabolic dysfunction in polycystic ovary syndrome rat models.

We aimed to evaluate the influence of 1,25-dihydroxyvitamin D (1,25(OH)D) on metabolic dysfunction and elucidate its underlying mechanism using a rat model of polycystic ovary syndrome (PCOS). Twenty-four Sprague-Dawley rats were randomly divided into four groups: control group (CON, 2 ml/kg of oral 0.5% CMC), 1,25VD group (oral 0.

1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells.

Purpose: Hyperandrogenism, one of the most frequent causes of anovulation in women, increases the risk of metabolic disorders in patients with polycystic ovary syndrome (PCOS). Ferroptosis, characterized by iron-dependent lipid peroxidation, has provided new insight into the progression of PCOS. 1,25-dihydroxyvitamin D3 (1,25D3) may play a role in reproduction because its receptor, VDR, which contributes to the inhibition of oxidative stress, is primarily located in the nuclei of granulosa cells.

Effects of Continuous LPS Induction on Oxidative Stress and Liver Injury in Weaned Piglets.

Due to imperfections in their immune and digestive systems, weaned piglets are susceptible to invasions of the external environment and diseases, especially bacterial infections, which lead to slow growth, tissue damage, and even the death of piglets. Here, a model of weaned piglets induced by lipopolysaccharide (LPS) was established to explore the effects of continuous low-dose LPS induction on the mechanism of liver injury. A total of forty-eight healthy 28-day-old weaned piglets (weight = 6.