Calix[]azanediyldibenzoate: Intramolecular Hydrogen Bond-Assisted Synthesis, Acidichromism, and Oriented Self-Assembly.

Here, intramolecular hydrogen bond (IMHBs)-induced rigidity is used for the first time to synthesize macrocyclic arenes. Calix[]azanediyldibenzoates (C[]A, where = 3, 4, or 5) are synthesized through a one-step condensation reaction between dimethyl 2,2'-azanediyldibenzoate and paraformaldehyde. Compared to the monomer, the macrocycles exhibit a fast and significant acidochromic response due to the intramolecular charge transfer that is boosted by the synergistic effect of their adsorption and protonation.

A bispecific antibody-drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial.

Research on patients with advanced esophageal squamous cell carcinoma (ESCC) who have progressed on immunotherapy remains limited. BL-B01D1 is a first-in-class antibody-drug conjugate consisting of an EGFR-HER3 bispecific antibody bound to a topoisomerase I inhibitor (Ed-04) payload via a cleavable linker. Here, we present safety and efficacy data from a phase 1 study of BL-B01D1, in 82 patients previously treated for ESCC.

The Application of Three-dimensional Measurement and Grayscale Value Measurement Techniques in Lower Eyelid Blepharoplasty.

Background: Lower eyelid blepharoplasty addresses under-eye bags and tear troughs, but traditional evaluations lack objectivity. 3D imaging and grayscale analysis offer a novel, quantitative approach.

Objectives: To objectively assess blepharoplasty outcomes using 3D imaging and grayscale analysis, validating their effectiveness in capturing morphological and skin texture changes.

Facile design and synthesis of boric acid group based fluorescent probes for monitoring mitochondrial ATP fluctuation.

Adenosine 5'-triphosphate (ATP) is a high-energy phosphate compound that provides most of the energy needed for the physiological activities of organisms. The abnormal fluctuation of intracellular ATP level is closely related to a variety of physiological diseases. So, the monitoring of ATP levels is of great significance for the diagnosis and treatment of diseases.

Defective RuO Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway.

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by chronic inflammation, cartilage degeneration, and the formation of osteophytes, which leads to serious economic and social challenges. Previous studies have demonstrated that oxidative stress-driven inflammation plays a crucial role in the pathophysiological progression of OA. In this study, we presented defective RuO (d-RuO) as an effective antioxidant for the treatment of OA.

A Tetradentate Chelator for Reducing Damage Caused by Uranium.

The rapid advancement of the nuclear industry has precipitated significant challenges in nuclear pollution, with radionuclide uranium emerging as a formidable threat to human safety due to its potent chemical toxicity and radioactivity. The development of uranium chelators represents a pivotal strategy in mitigating the internal damage caused by nuclear exposure. While the US Food and Drug Administration has approved certain drugs for this purpose, issues such as low selectivity and high toxicity remain unresolved.

Contribution of multimodal ultrasound in evaluating the efficacy of lumbricus protein fast dissolving tablets against atherosclerotic plaques in ApoE mice.

Introduction: Atherosclerosis (AS), a prevalent cardiovascular condition characterized by cholesterol accumulation, inflammation, and fibrous tissue proliferation within arterial walls, remains a major global health challenge. Traditional Chinese Medicine (TCM) identifies earthworm (Lumbricus) as an effective treatment for blood stasis syndromes. Some studies have identified lumbricus-derived extracts as being rich in collagenase and fibrinolytic enzymes, which has significant effects in dissolving blood clots, improving circulation, and preventing thrombosis.

Ruthenium Oxide Nanozyme for Tendinopathy Treatment via Countering Ferroptosis.

The global prevalence of tendinopathy (TP) is steadily increasing, resulting in functional impairments in tendons across individuals of all ages. Excessive accumulation of reactive oxygen species (ROS) plays a pivotal role in the development of TP, which compromises tendon repair and integrity through oxidative stress. This process is often accompanied by ferroptosis-a newly recognized form of iron-dependent programmed cell death.

A N^N-bidentate ligand modified with tetraphenylethylene derivative for uranium detection and decorporation in vitro and in vivo.

Uranium, once introduced into the human body, tends to accumulate in the kidneys and femurs. Its potent chemical toxicity and radioactivity can lead to severe damage, posing significant health risks. Consequently, there is an urgent need to develop low-toxicity materials capable of effectively detecting and removing uranium.

Determination of five alkylhydrazines by isotope-coded derivatization combined with ultra-high-performance liquid chromatography-tandem mass spectrometry.

Alkylhydrazines, extensively used in agricultural and military applications, pose notable environmental and health concerns due to their toxicity and potential accumulation in food chains. A novel isotope-coded derivatization (ICD) method was developed using 4-(N-methylphenanthroimidazolyl)-benzaldehyde as the reagent, enabling precise quantification of five alkylhydrazines in environmental and food matrices using ultra-high-performance liquid chromatographytandem mass spectrometry. The detection limits (0.

Red-emitting aggregation-induced emission fluorescent probe for monitoring fluctuation of HClO in mitochondria during ferroptosis.

Background: Ferroptosis is an iron-dependent programmed cell death pathway driven by lipid peroxidation that involves various inflammation-related diseases and even cancer, which is often accompanied by the accumulation of mitochondrial ROS. HClO, as one of the vital ROS in organisms, is mainly derived from the mitochondria of cells. And abnormal levels of HClO can disrupt redox homeostasis in cells and lead to various diseases.

Surface adsorption of methyl blue promotes the electrocatalytic hydrogen evolution on the composite of platinum and rGO.

Electrocatalytic hydrogen evolution reaction (HER) is a promising way to produce clean hydrogen energy. Although a variety of strategies have been developed to improve the performance of HER, it is still necessary to further develop cost-effective and efficient method for further improvement of HER performance. In this work, we proposed a novel method to further improve the HER performance of platinum (Pt) by adsorbing carefully chosen molecules on the composite of Pt and reduced graphene oxide (rGO).

Mutation and Survival Analysis of Tislelizumab in Advanced or Metastatic Esophageal Squamous Cell Carcinoma: A Biomarker Analysis From the Randomized, Phase III, RATIONALE-302 Trial.

Purpose: Although multiple agents targeting PD-1 have been approved as second-line treatment for esophageal squamous cell carcinoma (ESCC), only a fraction of patients derive long-term survival. Hence, reliable predictive biomarkers are urgently needed.

Methods: Comprehensive tumor genomic profiling and transcriptome sequencing were performed on samples from the RATIONALE-302 study.

Application of Orbital Septal Fat Repositioning Combined With SVF-Gel Fillers in Lower Blepharoplasty.

Background: Lower blepharoplasty is a widely used cosmetic surgical procedure to improve under-eye bags and tear trough deformities, aiming to enhance facial aesthetics and achieve a more youthful appearance. The formation of these deformities is often associated with factors such as aging, skin laxity, and fat displacement. Traditional surgical methods include orbital septal fat repositioning and fat grafting, each with its own advantages and limitations.

Albumin Modulated Homodimer as an Efficient Photosensitizer for Long-Term Imaging-Guided Tumor Therapy Directed with Sunlight Irradiation.

The reactive oxygen species (ROS) amplification caused by inevitable plasma albumin encapsulation is still a challenge to circumvent the systemic adverse effects in the photodynamic therapy (PDT) process. Herein, a disulfide bond linked homodimer, Cy1280, which is modulated by albumin to accurately balance the fluorescence and ROS generation and exhibit a weak fluorescence and sealed PDT effect during blood circulation, is exploited. Cy1280 can be specifically internalized and dispersed at the tumor site via Organic Anion Transporter Proteins (OATPs) and thiol-disulfide exchange mediated synergistic uptake and activated after mild sunlight irradiation (100 ± 5 Klx) to sensitize neighboring oxygen in cellular mitochondria to execute direct protein dysfunction effect.

PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial.

Alpha-fetoprotein-producing gastric or gastro-esophageal junction (AFP-G/GEJ) cancer, a rare gastric cancer subtype, exhibits increased angiogenesis and more immunosuppression than non-AFP-G/GEJ cancer. The potential benefits of anti-angiogenic agents and immunotherapy for this specific subtype remain unknown. This multi-center, single-arm, phase 2 trial (ClinicalTrials.

Effectiveness, safety, and patterns of use of camrelizumab in advanced esophageal cancer: an individual patient data pooled analysis of 987 patients from three prospective cohort studies.

Background And Aims: This individual patient data pooled analysis aimed to evaluate the effectiveness, safety, and patterns of use of camrelizumab in a large cohort of advanced esophageal cancer (AEC) patients.

Approach And Results: Adult patients (≥ 18 years) who had received camrelizumab as part of AEC treatment were pooled from three independent, prospective observational cohort studies (NCT04616040, ChiCTR1900027275, and ChiCTR2000039499). The main outcomes were patterns of camrelizumab use, progression-free survival (PFS), overall survival (OS), and safety in the overall population and specific subgroups of underrepresented patients.

Medical image segmentation network based on a multisize convolutional kernel association strategy.

Background: Medical image segmentation plays a crucial role in clinical diagnosis and treatment planning by extracting essential information from tissue images.

Purpose: This research aims to address limitations in current medical image segmentation models by proposing a new CKASnet model that enhances adaptability and efficiency while maintaining segmentation accuracy.

Methods: The CKASnet model integrates a novel convolutional kernel association strategy (CKAS), which modifies and updates convolutional kernels to improve their receptive fields and adaptability.

Origin and de novo domestication of sweet orange.

Sweet orange is cultivated worldwide but suffers from various devastating diseases because of its monogenetic background. The elucidation of the origin of a crop facilitates the domestication of new crops that may better cope with new challenges. Here we collected and sequenced 226 citrus accessions and assembled telomere-to-telomere phased diploid genomes of sweet orange and sour orange.

Hawthorn total flavonoids ameliorate hyperlipidemia through AMPK/SREBP1-c and PPARα/PGC-1α/CPT-1A pathway activation and gut microbiota modulation.

Background: The increased prevalence of hyperlipidemia significantly affects human health worldwide. Although drug treatment is very effective, the harm to the human body cannot be ignored. Improvement of lipid metabolism by natural medicinal and food homologous products is an effective approach to ameliorate hyperlipidemia and it has gradually become a research focus.

An integrated prognosis prediction model based on real-word clinical characteristics for immunotherapy in advanced esophageal squamous cell carcinoma.

Introduction: Immune checkpoint inhibitors (ICIs) benefit only a subset of patients in advanced esophageal squamous cell carcinoma (ESCC). Our study aims to develop and validate a clinically accessible model to better identify those who may respond to ICIs.

Methods: This study enrolled advanced ESCC patients treated with ICIs at Peking University Cancer Hospital from January 14, 2016, to January 26, 2024 for the training cohort and at Harbin Medical University Cancer Hospital between January 10, 2019, and July 6, 2022 for the validation cohort.

The transcription factor CitPH4 regulates plant defense-related metabolite biosynthesis in citrus.

Wild citrus (Citrus L.) exhibits high disease resistance accompanied by high-acidity fruit, whereas cultivated citrus produces tastier fruit but is more susceptible to disease. This is a common phenomenon, but the underlying molecular mechanisms remain unknown.

"Candidatus Liberibacter asiaticus" Infection Induces Citric Acid Accumulation and Immune Responses Mediated by the Transcription Factor CitPH4.

Citrus huanglongbing (HLB), caused by "Candidatus Liberibacter" spp., is one of the most disastrous citrus diseases worldwide. HLB-affected citrus fruits are significantly more acidic than healthy fruits.

A multi-scale information fusion medical image segmentation network based on convolutional kernel coupled updata mechanism.

Medical image segmentation is pivotal in disease diagnosis and treatment. This paper presents a novel network architecture for medical image segmentation, termed TransDLNet, which is engineered to enhance the efficiency of multi-scale information utilization. TransDLNet integrates convolutional neural networks and Transformers, facilitating cross-level multi-scale information fusion for complex medical images.