Simple Two-Component CDs/PVA Hydrogels Possess Dynamic High-Definition and Two-Stage Information Encryption Capability.

Ensuring the fidelity and security level of stored information is essential for information carrier materials to safeguard data and prevent counterfeiting. However, low resolution, limited encryption modes, and complex fabrication hinder existing information carriers from meeting evolving technological demands. Herein, a solvent exchange strategy from DMSO to water is employed to stably anchor hydrophobic fluorescent carbon dots (CDs) with multiple emission states onto a 3D framework of poly(vinyl alcohol) (PVA) chains, forming a simple two-component CDs/PVA hydrogel with tunable fluorescent colors and recyclability.

Association of antioxidant markers (SOD, GSH, NO, Catalase) with ischemic stroke severity and recovery outcomes.

Background: This randomised controlled trial aimed to investigate the relationship between antioxidant markers (Superoxide Dismutase [SOD], Glutathione [GSH], Catalase, and Nitric Oxide [NO]) and the severity of ischemic stroke in affected individuals.

Methods: A single-blind randomised controlled trial was conducted from June 2022 to November 2024, including 364 patients aged 45-80 years diagnosed with ischemic stroke. Participants were randomly divided into two groups: Group A (n=193) received standard stroke rehabilitation therapy, while Group B (n=171) received additional antioxidant support.

Deciphering the methylation landscape of long noncoding RNAs in hepatocellular carcinoma: a focus on LINC00942.

Background: Conduct a comprehensive genome-wide methylomic analysis of long noncoding RNA (lncRNA) genes in hepatocellular carcinoma (HCC) and identify specific lncRNAs for subsequent functional validation.

Methods: We conducted a methylation microarray analysis on 11 HCC samples alongside adjacent non-tumor tissue specimens. This analysis was integrated with The Cancer Genome Atlas data and the Gene Expression Omnibus for a comprehensive methylomic evaluation.

Astaxanthin reverses neurodevelopmental impairment by decreasing oxidative stress-induced disruption of Maf/Bcl2 signaling in prenatal alcohol exposure.

Background: Prenatal alcohol exposure (PAE) is recognized as the leading cause of adverse prenatal exposure disorders worldwide. The neurodevelopmental impairments resulting from PAE in offspring are classified under fetal alcohol syndrome (FAS). Nonetheless, the precise underlying pathogenic mechanisms of FAS remain incompletely understood, and effective therapeutic interventions are currently lacking.

Deep learning and digital twin integration for structural damage detection in ancient pagodas.

In recent years, with the rise of digital twin technology in the field of artificial intelligence and the continuous advancement of hardware imaging equipment, significant progress has been made in the detection of structural damage in buildings and sculptures. Structural damage to cultural heritage buildings poses a major threat to their integrity, making accurate detection of such damage crucial for cultural heritage preservation. However, existing deep learning-based object detection technologies face limitations in achieving full coverage of architectural sculptures and enabling multi-angle, free observation, while also exhibiting substantial detection errors.

Machine learning-enhanced flexible metamaterial biosensor for pesticide qualitative and quantitative analysis.

In recent years, Terahertz (THz) biosensors have achieved substantial and rapid development through the exploration of various electromagnetic modes, materials, and the combination of integrated microfluidic designs. However, existing THz biosensors are still mainly focused on the directional detection of single or specific substances, and most ultra-high sensitive sensing accuracies are inseparable from the targeted calibration of analytes. In practical applications, we often face the challenge of detecting multiple substances.

Shanling Jiangzhi Tea treats hyperuricemia by inhibition of COMT/MAOA signaling pathway and p53/SERPINE1/NLRP3 signaling pathway.

Objective: To evaluate the therapeutic efficacy of Shanling Jiangzhi Tea (SLJZ) on hyperuricemia (HUA) mice and to investigate its mechanism.

Methods: A HUA mouse model was established using a combination of uric acid (UA)and potassium oxonate. Following SLJZ intervention, changes in body weight were monitored.

Bisphenol S exacerbates CRC progression through dual mechanisms of immune microenvironment reprogramming and SLC4A2-mediated EMT activation.

Bisphenol S (BPS) is frequently utilized in the domain of food packaging materials as well as in the sphere of industrial plastic manufacturing. Although existing studies suggest potential associations between BPS exposure and the development of various malignancies, the exact biological function of BPS in colorectal cancer (CRC) advancement is still not fully understood. This research intends to thoroughly explore how BPS influences the malignant characteristics of CRC at the molecular level, particularly its impact on the epithelial-mesenchymal transition (EMT) in tumor cells.

Pollution profiles and human health risk assessment of BPA analogues in seafood from a Chinese coastal city.

With the restrictions on bisphenol A (BPA), bisphenol analogues (BPs) have become prevalent in the environment and organisms. Diet is a major route for human exposed to BPs, and seafood is a significant dietary component, particularly for coastal residents. We collected 31 seafood samples from the largest seafood market in Lianyungang and detected 11 BPs.

E9 Regulates Sleep Disorders Through Its Metabolite GABA.

Background: Insomnia, the most prevalent sleep disorder, is clinically defined as difficulty initiating or maintaining sleep. Although many medications are effective for insomnia treatment, they carry risks of drug dependence and abuse. The microbiota-gut-brain axis (MGBA) facilitates bidirectional signaling between the gastrointestinal tract and the central nervous system via gut microbes.

Modulation of Membrane-Disruptive Activity of Melittin via N- and C-Terminal PEGylation Strategies.

Melittin has emerged as a promising therapeutic agent due to its potent antitumor and antimicrobial activities. However, the clinical translation of native Melittin is hindered by substantial challenges, including systemic toxicity and rapid proteolytic degradation, leading to suboptimal pharmacokinetic profiles. Therefore, structure-activity relationship-guided rational design strategies focusing on the molecular determinants of membrane penetration mechanisms are essential for optimizing Melittin's therapeutic index.

Aberrant Development of Hippocampal GABAergic Neurons Arising from Hypothyroidism Contributes to Memory Deficits in Mice Through Maf Suppressing .

Thyroid hormone (TH) deficiency during the pregnancy and lactation periods leads to enduring memory impairments in offspring. However, the mechanisms underlying the cognitive and memory deficits induced by developmental hypothyroidism remain largely unexplored. Mice were exposed to propylthiouracil (PTU) or purified water to detect changes in hippocampal neurogenesis and differentiation of their offspring to explain the pathogenesis of impaired learning and memory.

Polymeric ionic liquid modifier as ion-induced crosslinker and functional enhancer: Facile fabrication of multifunctional gelatin hydrogels for flexible electronics.

Gelatin-based ionic conductive hydrogels (ICHs) are promising materials for flexible electronics due to their favorable intrinsic properties, but achieving superior mechanical performance, high conductivity, multifunctionality, and simple fabrication simultaneously is challenging. Inspired by the ion-induced salting-out effect and the tunability of polymeric ionic liquids, poly(1-vinyl-3-carboxymethyl imidazolium fluoride) (PVCIF) was synthesized as an advanced macromolecular modifier and employed in a one-step soaking method to construct gelatin-based ICHs. The fluoride anions in PVCIF induce a salting-out effect, promoting gelatin aggregation and forming robust protein hydrogels.

Safety and feasibility of prone retroperitoneal robotic-assisted partial nephrectomy (prRAPN): a novel posterior approach and perioperative results - a prospective study.

Purpose: Lateral positioning remains standard for retroperitoneal robotic-assisted partial nephrectomy (rRAPN). Emerging single-port systems have expanded supine positioning applications in rRAPN. This study evaluates the feasibility and safety of novel prone retroperitoneal RAPN (prRAPN).

Regulation of protein translocation through A SiN-CNT stacked nanopore using an embedded gold nanoparticle.

Proteins play a crucial role in the growth, movement, and reproduction of life, and the determination of accurate protein sequences is of great significance in understanding the specific functions of proteins. Nanopore sequencing is currently the most prevalent method due to its speed, cost-effectiveness, and ability to sequence long proteins. However, its accuracy is often compromised by the rapid translocation of the sample, making it challenging to generate effective blocking signals.

Benzotriazole and Poly(vinylidene Fluoride) Synergistically Promote the Selectivity of Carbon Dioxide Reduction on Copper toward C Products.

Electrochemical reduction of carbon dioxide (CORR) to valuable chemicals offers a promising solution to mitigate CO emissions and address the energy crisis. Surface modification of the catalyst surface with small molecules or polymers could modulate the product selectivity of the CORR. If a properly chosen polymer and molecule were combined together, a significant improvement in the CORR might be realized.

Kaempferol inhibits oxidative stress and reduces macrophage pyroptosis by activating the NRF2 signaling pathway.

Kaempferol exhibits various biological activities, including antioxidant and anti-inflammatory effects. Its role in modulating lipid metabolism and inhibiting inflammatory responses to suppress the progression of atherosclerosis has been confirmed. However, its impact on macrophage pyroptosis and the underlying mechanisms remain unclear.

Phase Diagram Mapping of a Moiré System Using Surface Acoustic Waves.

Taking advantage of interfacial electron-phonon interactions, surface acoustic waves (SAWs) have emerged as a sensitive and contact-free technique for investigating low-dimensional materials. This noninvasive technique proves especially valuable for probing low-conductivity states and provides crucial radio-frequency conductivity information. In this work, for the first time, we extend SAW measurements to moiré systems to explore the correlated quantum phases.

Promoting the Cobalt Phthalocyanine-Catalyzed Electrochemical Reduction of Carbon Dioxide with the Coadsorption of Melamine.

Electrochemical reduction of carbon dioxide (CORR) is a promising strategy for mitigating global warming and producing value-added products simultaneously. Molecular catalysts, such as cobalt phthalocyanine (CoPc), are known to be effective in converting carbon dioxide (CO) to carbon monoxide (CO). However, it is still challenging to improve the reaction rate and selectivity of this conversion.

Effect of 4-nitrophenol on the reproductive capacity of female mice.

Diesel exhaust particle-derived 4-nitrophenol (PNP) has been demonstrated to exhibit anti-androgenic and estrogenic effects, as well as the potential to disrupt the hypothalamic-pituitary-gonadal axis in male rats. Studies have also confirmed PNP's toxicity in various tissues; however, its harmful effects on the female reproductive system remain unclear. Therefore, this study investigated PNP's reproductive toxicity in female mice.

A Deep Learning-Based Multimodal Fusion Model for Recurrence Prediction in Persistent Atrial Fibrillation Patients.

Background: The long-term success rate of atrial fibrillation (AF) ablation remains a significant clinical challenge, particularly in patients with persistent atrial fibrillation (Persistent AF, PeAF). The recurrence risk in PeAF patients is influenced by various factors, which complicates the prediction of ablation outcomes. While clinical characteristics provide important references for risk assessment, the predictive accuracy of existing methods is limited and they fail to fully leverage the rich information contained in electrocardiogram (ECG) signals.

Visualization of HSP70-regulated mild-photothermal therapy for synergistic tumor treatment: a precise space-time mild-temperature photothermal ablation strategy.

Mild-temperature photothermal therapy (MPTT) advances anticancer management by regulating reactive oxygen species (ROS) and lipid peroxides (LPO) to inhibit the overexpression of heat shock protein 70 (HSP70), thus decreasing the cellular heat resistance and increasing the efficacy of tumor ablation. However, formidable challenge remains on the traditional MPTT without imaging-guided optimal treatment time point, thus inadequate HSP70 blockage would potentially further diminish the effectiveness of MPTT. Herein, a novel biomimetic nanoprobe (Cu-ABTS@CCMs) is developed, based on encapsulating the multifunctional Cu nanoparticles and ROS-responsive 2,2'-azino-bis (3-ethylbenzothiazole-6- sulphonic acid) (ABTS) within cancer cell membranes (CCMs) to ensure second near-infrared photoacoustic (NIR-II PA) imaging-guided precise MPTT time point.

Surface adsorption of methyl blue promotes the electrocatalytic hydrogen evolution on the composite of platinum and rGO.

Electrocatalytic hydrogen evolution reaction (HER) is a promising way to produce clean hydrogen energy. Although a variety of strategies have been developed to improve the performance of HER, it is still necessary to further develop cost-effective and efficient method for further improvement of HER performance. In this work, we proposed a novel method to further improve the HER performance of platinum (Pt) by adsorbing carefully chosen molecules on the composite of Pt and reduced graphene oxide (rGO).

Neixiao-ruanmai decoction No 2 improves carotid atherosclerosis by modulating gut microbiota and inhibiting TLR4/NF-κB pathway activation.

Background: Carotid atherosclerosis(CAs) plaques are challenging to reverse. Neixiao-Ruanmai Decoction No 2(NXRMT No 2), a Traditional Chinese Medicine (TCM) decoction, has shown potential in treating CAs. However, while preliminary clinical trials have confirmed the efficacy of NXRMT No 2 in improving CAs, the comparative effectiveness of long-term versus short-term treatment courses remains unclear, and the underlying mechanisms of this decoction are not yet fully understood.