Comprehensive transcriptome sequencing and biochemical studies revealed that acrolein induced lung injury in BEAS-2B cells and male rats through the lncRNA MIR155HG/miR-155-5p/CD200R1 and Nrf2/SLC7A11/GPX4 ferroptosis pathways.

Acrolein is a significant high priority hazardous air pollutant. This research explore the relationship of acrolein-induced ferroptosis with the pathogenesis of lung injury by combining cellular, transcriptome, and animal-level studies. The results in vivo and in vitro models indicated that a total of 18,868 differenced lncRNAs and 15,639 differenced mRNAs were obtained after acrolein exposure.

Moderating effects of a healthy lifestyle on the association of pre-metabolic syndrome with multiple chronic disease comorbidities.

Studies have shown that healthy lifestyles reduce the risk of metabolic syndrome (MetS), but their impact on pre-metabolic syndrome (PreMetS) with multiple comorbidities remains unclear. To explore the association of PreMetS and MetS with multiple comorbidities and to assess whether a healthy lifestyle influences these associations. Associations between PreMetS and MetS, lifestyle behaviors and multiple comorbidities were analyzed by univariate and multivariate logistic regression.

Isolation, whole-genome analysis, and anti-biofilm activity of carbapenem-resistant Enterobacteriaceae phage KP-BW9 and its lysin Lys-BW9.

Carbapenem-resistant Enterobacteriaceae (CRE) have been classified as "urgent priority pathogens" due to their high drug resistance and wide spread. Among them, carbapenem-resistant Escherichia coli (CREco) and carbapenem-resistant Klebsiella pneumoniae (CRKP) are the main types. Phages are naturally occurring viruses that can specifically infect and lyse host bacteria, making them an effective alternative to antibiotics.

Continuous noninvasive blood pressure estimation using tissue blood flow measured by diffuse correlation spectroscopy.

Blood pressure (BP) is an important parameter of human health, since hypertension is a major risk factor of the cardiovascular system. Nowadays, the continuous measurement of BP is only possible with an invasive measurement method using catheter as the gold standard. Diffuse correlation spectroscopy (DCS) is a powerful tool for assessing microvascular hemodynamics in deep tissues, which can reliably provide a blood flow index whose changes are proportional to relative changes in tissue blood flow (BF).

Selenized Binary Transition Metals-MXene Composite for High-Performance Asymmetric Hybrid Capacitors.

The exploration of innovative and high-efficiency energy storage materials is crucial for advancing high-performance supercapacitors. In this study, a novel composite material is synthesized, comprising multilayered MXene (TiCT) nanoparticles integrated with porous NiCoSe nanosheets. The accordion-like nanostructure of MXene and its strong interfacial interactions enhance the surface area and cycling stability of the nanocomposite.

Exploring the interaction mechanism between fibrinogen and copper oxide nanoparticles via multi-spectroscopy and computer simulation.

Fibrinogen is a key component of the coagulation cascade, and its structural alterations upon interaction with other substances can impact the function. Copper oxide nanoparticles (CuO NPs) are a widely used nanomaterial that can enter the blood and interact with fibrinogen. In this study, the molecular mechanism for the formation of fibrinogen-CuO NPs complexes was investigated using spectroscopic techniques, molecular docking and dynamics simulations.

Clinical Outcomes and Predictors of Precise Stent Placement in Patients with Isolated Pulsatile Tinnitus.

Purpose: There is no dedicated stent for isolated venous pulsatile tinnitus (IVPT). This retrospective study aimed to evaluate the the clinical outcomes and associated factors of Precise stent (Cordis) implantation in the management of IVPT.

Methods: We analyzed data from IVPT patients treated at our center between December 2009 and August 2024.

Magnetization switching by asymmetric topological surfaces.

The development of spin-orbit-torque (SOT) devices has sparked considerable research interest, particularly in the quest for novel materials that exhibit high spin-to-charge conversion efficiencies for effective magnetic switching. However, optimizing structure and improving efficiency necessitate theoretical insights and material innovations. In this study, we employ first-principles calculations to investigate the persistent spin current in magnetic topological material MnSbTe.

Exploring the protective mechanism of Lentinus edodes mycelia polysaccharide against AGEs-induced HUVECs damage: Insights from whole transcriptome sequencing and cell biology techniques.

A novel Lentinus edodes mycelia polysaccharide (LMP) prepared in laboratory could effectively inhibit the generation of advanced glycosylation end products (AGEs), but the inhibitory mechanism of LMP on AGEs-induced human umbilical vein endothelial cells (HUVECs) damage is still unclear. Whole transcriptome sequencing technology combined with cell-level verification were used to reveal the inhibition mechanism of LMP on AGEs-induced HUVECs damage in the research. Whole transcriptome sequencing data demonstrated the differential expressions of multiple lncRNAs, CircRNAs, miRNAs, and mRNAs among different groups.

Phase Diagram Mapping of a Moiré System Using Surface Acoustic Waves.

Taking advantage of interfacial electron-phonon interactions, surface acoustic waves (SAWs) have emerged as a sensitive and contact-free technique for investigating low-dimensional materials. This noninvasive technique proves especially valuable for probing low-conductivity states and provides crucial radio-frequency conductivity information. In this work, for the first time, we extend SAW measurements to moiré systems to explore the correlated quantum phases.

Dysregulated homocysteine metabolism and cardiovascular disease and clinical treatments.

Elevated homocysteine (Hcy) levels, known as hyperhomocysteinemia (HHcy), are recognized as a separate risk factor for cardiovascular disease. Mutations in methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta synthase (CBS)-enzymes pivotal at the juncture of the trans-sulfuration and remethylation pathways-underlie the pathogenesis of HHcy. Although vitamin supplementation has been proven to effectively decrease Hcy levels, there is still uncertainty about whether this reduction translates to a decrease in the incidence rates from cardiovascular diseases (CVDs).

Prospective multicenter comparison of the diagnostic value of IgG and IgGAM antibodies for heparin-induced thrombocytopenia.

Background And Aims: Heparin-induced thrombocytopenia (HIT) is a critical complication of heparin therapy. Immune antibodies are involved in the development of HIT. The purpose of this study was to explore the diagnostic value of IgGAM and IgG antibodies.

Multifunctional chitosan-based indicator films containing composite pigments stabilized by extracellular and cell wall polysaccharides from Auricularia cornea var. Li. waste for visualization of salmon freshness.

Smart packaging can indicate the meat freshness through color variations of natural pigments within the films, whose instability have hindered their industrial application. This study developed multifunctional indicator films (CS-ACPS-CB) that possessed ultraviolet resistance, antioxidant properties, and pH sensitivity by incorporating extracellular and cell wall polysaccharides from Auricularia cornea var. Li waste (ACPS) into chitosan (CS) matrix with curcumin/betalain as indicators.

MSTNet: Multi-scale spatial-aware transformer with multi-instance learning for diabetic retinopathy classification.

Diabetic retinopathy (DR), the leading cause of vision loss among diabetic adults worldwide, underscores the importance of early detection and timely treatment using fundus images to prevent vision loss. However, existing deep learning methods struggle to capture the correlation and contextual information of subtle lesion features with the current scale of dataset. To this end, we propose a novel Multi-scale Spatial-aware Transformer Network (MSTNet) for DR classification.

Baicalein Inhibited Amino-modified Polystyrene Nanoplastics Induced Human Umbilical Vein Endothelial Cells Pyroptosis by Reducing the Expression of NLRP3/Caspase-1/Gasdermin D Pathway-related Proteins.

Amino-modified polystyrene nanoplastics (NH-NPs), generated through ultraviolet aging and photocatalytic processes, can lead to vascular damage. Baicalein is a flavonoid compound with anti-inflammatory properties that exerts a protective effect on blood vessels. However, whether baicalein can inhibit vascular damage induced by NH-NPs remains to be investigated.

Cryptotanshinone Inhibits Obesity-Related Cervical Cancer by Downregulating CXCL8 Expression in Hela Cells.

Cervical cancer is one of the cancers commonly found in the female reproductive system and is associated with obesity. However, the exact connection mechanisms remain unclear. Screening of key therapeutic targets and natural products with good antitumor activity has become a crucial strategy for cancer therapy.

Silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysms.

Silent magnetic resonance angiography (S-MRA) is primarily utilized to assess the blood flow in aneurysms and parent vessels of treated intracranial aneurysms. This study aimed to compare the diagnostic value of S-MRA and three-dimensional time of flight (3D-TOF) MRA for unruptured intracranial aneurysms. We included patients diagnosed with unruptured intracranial aneurysms using digital subtraction angiography (DSA) who subsequently underwent S-MRA and 3D-TOF MRA.

Curcumin Regulates Microglia Polarization to Alleviate Ischemic Stroke by Targeting microRNA-205-5p/Kruppel-Like Factor 2 (KLF2)/Activating Transcription Factor 2 (ATF2) Axis.

Ischemic stroke (IS) often causes fearful sequela, even death. Curcumin was beneficial to IS, but its underlying molecular mechanism is unclear. Mice were subjected to middle cerebral artery occlusion (MCAO) surgery, and BV-2 cells were treated with oxygen-glucose deprivation/reoxygenation (OGD/R) induction to establish IS models in vivo and in vitro.

Corrigendum to "Unified calibration of D-dimer can improve the uniformity of different detection systems" [Practical Laboratory Medicine 40 (2024) e00413].

[This corrects the article DOI: 10.1016/j.plabm.

Cadmium exposure induces inflammation, oxidative stress and DNA damage in HUVEC and promotes THP-1 adhesion: A possible mechanism on the formation of atherosclerotic plaque.

Observational studies have shown that cadmium exposure increases the risk of cardiovascular disease, but the underlying mechanism is still unclear. Atherosclerotic plaque can cause vascular obstruction, which is important for the death from cardiovascular disease. Cell damage and monocyte adhesion are two early events in atherosclerotic plaque formation that can be induced by cadmium exposure, but the mechanism remains to be determined.

Tunable Topological Transitions Probed by the Quantum Hall Effect in Twisted Double Bilayer Graphene.

The moiré system provides a tunable platform for investigating exotic quantum phases. Particularly, the displacement field is crucial for tuning the electronic structures and topological properties of twisted double bilayer graphene (TDBG). Here, we present a series of -tunable topological transitions by the evolution of quantum Hall phases (QHPs) in the valence bands of TDBG.

Long-Term Outcomes of Stenting for Pulsatile Tinnitus Caused by Cerebral Venous Sinus Stenosis.

Objective: To investigate the long-term outcomes of stenting for isolated pulsatile tinnitus (PT) caused by cerebral venous sinus stenosis.

Study Design: Retrospective study.

Setting: The First Medical Center, Chinese PLA General Hospital.

Isolation and characterization of Salmonella enteritidis bacteriophage Salmp-p7 isolated from slaughterhouse effluent and its application in food.

Salmonella enteritidis is one of the most common pathogens that cause foodborne disease outbreaks and food spoilage, which seriously threatens human health. Bacteriophages have shown broad application prospects in controlling harmful microorganisms during food processing and preservation due to their ability to specifically infect bacteria. In this study, Salmonella enteritidis bacteriophage Salmp-p7 was isolated and characterized from slaughterhouse wastewater.

Hemodynamic assessment of intracranial atherosclerotic stenosis: comparison between invasive non-hyperemic pressure ratio and angiography-derived quantitative flow ratio.

Objectives: To evaluate the diagnostic accuracy of the quantitative flow ratio (QFR) for hemodynamic exploration of intracranial atherosclerotic stenosis, using the invasive cerebrovascular pressure ratio (CVPR) and resting full-cycle ratio (RFR) as reference standards.

Materials And Methods: Patients with symptomatic unifocal intracranial atherosclerotic stenosis were included. The CVPR was defined as the ratio of the proximal and distal pressures.