Defective RuO Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway.

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by chronic inflammation, cartilage degeneration, and the formation of osteophytes, which leads to serious economic and social challenges. Previous studies have demonstrated that oxidative stress-driven inflammation plays a crucial role in the pathophysiological progression of OA. In this study, we presented defective RuO (d-RuO) as an effective antioxidant for the treatment of OA.

Ruthenium Oxide Nanozyme for Tendinopathy Treatment via Countering Ferroptosis.

The global prevalence of tendinopathy (TP) is steadily increasing, resulting in functional impairments in tendons across individuals of all ages. Excessive accumulation of reactive oxygen species (ROS) plays a pivotal role in the development of TP, which compromises tendon repair and integrity through oxidative stress. This process is often accompanied by ferroptosis-a newly recognized form of iron-dependent programmed cell death.

Single-nucleus transcriptomics reveals subsets of degenerative myonuclei after rotator cuff tear-induced muscle atrophy.

Rotator cuff tear (RCT) is the primary cause of shoulder pain and disability and frequently trigger muscle degeneration characterised by muscle atrophy, fatty infiltration and fibrosis. Single-nucleus RNA sequencing (snRNA-seq) was used to reveal the transcriptional changes in the supraspinatus muscle after RCT. Supraspinatus muscles were obtained from patients with habitual shoulder dislocation (n = 3) and RCT (n = 3).

Numerical and Experimental Investigation of the Effect of Current Density on the Anomalous Codeposition of Ternary Fe-Co-Ni Alloy Coatings.

Gradient-structured ternary Fe-Co-Ni alloy coatings electrodeposited on steel substrates at various current densities from chloride baths were numerically and experimentally investigated. The electrodeposition process, considering hydrogen evolution and hydrolysis reaction, was modelled using the finite element method (FEM) and was based on the tertiary current distribution. The experimentally tested coating thickness and elemental contents were used to verify the simulation model.