Defective RuO Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway.

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by chronic inflammation, cartilage degeneration, and the formation of osteophytes, which leads to serious economic and social challenges. Previous studies have demonstrated that oxidative stress-driven inflammation plays a crucial role in the pathophysiological progression of OA. In this study, we presented defective RuO (d-RuO) as an effective antioxidant for the treatment of OA.

Ruthenium Oxide Nanozyme for Tendinopathy Treatment via Countering Ferroptosis.

The global prevalence of tendinopathy (TP) is steadily increasing, resulting in functional impairments in tendons across individuals of all ages. Excessive accumulation of reactive oxygen species (ROS) plays a pivotal role in the development of TP, which compromises tendon repair and integrity through oxidative stress. This process is often accompanied by ferroptosis-a newly recognized form of iron-dependent programmed cell death.

Facile Preparation of Cellulose Beads with Tunable Graded Pores and High Mechanical Strength.

Cellulose-based hierarchical porous beads exhibit significant application potential in adsorption and separation systems due to their degradation and biocompatibility. However, the current fabrications of cellulose beads show poor mechanical properties and a difficult-to-regulate hierarchical porous structure, reducing their lifespan of use and limiting their application in fine separation. Here, we reported the facile creep-drop method to prepare cellulose beads that enabled systemic regulation of the macro-size, micropore structures, and mechanical properties by optimizing injection nozzle diameter, the composition of the coagulation bath, the temperature of the coagulation bath, and cellulose concentration.

Near Infrared Responsive Gold Nanorods Attenuate Osteoarthritis Progression by Targeting TRPV1.

Osteoarthritis (OA) is the most common degenerative joint disease worldwide, with the main pathological manifestation of articular cartilage degeneration. It have been investigated that pharmacological activation of transient receptor potential vanilloid 1 (TRPV1) significantly alleviated cartilage degeneration by abolishing chondrocyte ferroptosis. In this work, in view of the thermal activated feature of TRPV1, Citrate-stabilized gold nanorods (Cit-AuNRs) is conjugated to TRPV1 monoclonal antibody (Cit-AuNRs@Anti-TRPV1) as a photothermal switch for TRPV1 activation in chondrocytes under near infrared (NIR) irradiation.

Template-mediated copper doped porous g-CN for efficient photodegradation of antibiotic contaminants.

Graphite carbon nitride (g-CN) has great potential to treat antibiotic wastewater, but limited by small specific surface area, rapid recombination of photogenerated carriers and narrow visible light absorption range. In order to solve above problems, we designed a simple template-mediated approach by supramolecular self-assembly (Cu-melamine-cyanuric acid) to prepare copper doped porous graphitic carbon nitride (Cu-pCN) photocatalyst. The pre-organized template self-assembly driven by hydrogen bonds and electrostatic interaction, resulted in highly porous structure.

Efficient removal of cationic dyes via activated carbon with ultrahigh specific surface derived from vinasse wastes.

In this work, a simple and feasible approach for converting waste vinasse generated from the alcohol industries into high value-added activated carbon (AC) was proposed. The obtained AC possessed abundant micropores with micropore volume of 0.9613 cm/g and ultrahigh specific surface areas (2015 m/g), indicating prominent adsorption capacity.

Biological properties of sulfanilamide-loaded alginate hydrogel fibers based on ionic and chemical crosslinking for wound dressings.

In this work, alginate hydrogel fibers loading sulfanilamide were proposed using a combination of Ca ions and glutaraldehyde crosslinking to develop an efficient wound dressing. The structure, mechanical properties, absorbency, in vitro drug release and cytotoxicity of the proposed alginate hydrogel fibers were investigated systematically. The results indicated that crosslinking with glutaraldehyde can efficiently enhance the mechanical properties of the alginate hydrogel fibers, and reduce their swelling degree which is beneficial for hydrogel fibers to obtain adjustable fluid adsorption capacity, sustained drug release feature over hydrogel fibers crosslinked only by Ca ions.