A multifunctional oxidative stress amplifier for synergistic disruption of redox homeostasis and enhanced cancer therapy.

Emerging nanomedicines that target and disrupt redox homeostasis present a compelling yet technically demanding strategy for cancer therapy. Herein, a multifunctional oxidative stress amplifier, denoted as C-COF@MnO-BSA-FA/Ce6 (CMBFC), was engineered to disrupt redox homeostasis through synergistic mechanisms precisely. The nanoplatform was constructed with a core of N-doped carbon nanospheres derived from covalent organic frameworks (C-COF), which was then coated by an in situ mineralized MnO layer.

Research on Crop Classification Using U-Net Integrated with Multimodal Remote Sensing Temporal Features.

Crop classification plays a vital role in acquiring the spatial distribution of agricultural crops, enhancing agricultural management efficiency, and ensuring food security. With the continuous advancement of remote sensing technologies, achieving efficient and accurate crop classification using remote sensing imagery has become a prominent research focus. Conventional approaches largely rely on empirical rules or single-feature selection (e.

Clinical heterogeneity, treatment patterns, and outcomes of advanced-age-onset myasthenia gravis in China: a retrospective cohort study.

Objectives: The clinical characteristics and outcomes of myasthenia gravis (MG) with onset at age 50 years or older, which commonly referred to as late-onset MG (LOMG), in elderly patients remain incompletely understood. This study aimed to address the clinical heterogeneity within LOMG and to clarify whether very-late-onset MG (≥70 years) constitutes a distinct phenotype requiring tailored management approaches.

Methods: We analyzed data from 2783 patients enrolled in the MG Registry between April 1, 2009, and December 31, 2020.

Integrated [F]FAPI-42 PET/MR improves diagnostic accuracy in breast cancer: comparison with simultaneously acquired breast MRI.

Purpose: This study assessed the diagnostic efficacy of fluorine-18-labeled fibroblast activation protein inhibitor 42 ([F]FAPI-42) PET/MR versus simultaneously acquired breast MRI in identifying primary breast lesions and axillary lymph node metastases.

Methods: A prospective study enrolled 64 women with BI-RADS 4 or 5 lesions identified through mammography or ultrasound. All participants underwent contrast-enhanced [F]FAPI PET/MRI scans of the breast.

Complete removal of COD from potato processing wastewater by co-cultivation of Haematococcus pluvialis and Gordonia terrae.

For efficient removal of COD from the potato processing wastewater, the green alga Haematococcus pluvialis and the bacterium Gordonia terrae were co-cultivated in sterilized wastewater. Results showed that co-cultivation of H. pluvialis and G.

Enhanced Landslide Visualization and Trace Identification Using LiDAR-Derived DEM.

In response to the inability of traditional remote sensing technology to accurately capture the micro-topographic features of landslide surfaces in vegetated areas under complex terrain conditions, this paper proposes a method for enhanced landslide terrain display and trace recognition based on airborne LiDAR technology. Firstly, a high-precision LiDAR-DEM is constructed using preprocessed LiDAR point cloud data, and visual images are generated using visualization methods, including hillshade, slope, openness, and Sky View Factor (SVF). Secondly, pixel-level image fusion methods are applied to the visual images to obtain enhanced display images of the landslide terrain.

Signaling Mechanism of Budding, Proliferation, and Tissue Regeneration in Cnidaria.

Phylum Cnidaria occupies an early branching position in the evolution of eukaryotes, establishing both close and distant relationships with most other eukaryotic metazoans. Budding encompasses the complete processes of cell proliferation, differentiation, and tissue regeneration, making it an ideal model for exploring various aspects of cellular function and evolution. Additionally, budding serves as the primary reproductive method for increasing the cnidarian population.

Insights and progress on postoperative analgesia of radical gastrectomy for gastric cancer: a comprehensive review.

Gastric cancer is a common and highly lethal malignancy of the digestive system, with surgical resection as the primary treatment approach. However, postoperative analgesia management remains a major clinical challenge. Postoperative pain not only affects recovery speed but may also lead to complications, thereby influencing prognosis.

Cytokine Storm Induction Linked to Multi-Organ Failure in Fatal Jellyfish Stings.

Fatal jellyfish stings often cause multi-organ failure. Until now, these fatal outcomes are attributed to the direct toxic effects of the venom. Here, a mouse model of delayed jellyfish envenomation syndrome (DJES) is established and showed that venom from Nemopilema nomurai jellyfish can trigger a deadly cytokine storm - a severe inflammatory reaction.

Reduced miR-338-3p contributes to polycystic ovarian syndrome by inhibiting proliferation and enhancing apoptosis.

Background: Polycystic ovarian syndrome (PCOS) is a frequently occurring disorder affecting reproductive and metabolic health. miR-338-3p is implicated in early follicular development. We aimed to investigate the expression of miR-338-3p in PCOS patients and its effects on proliferation and apoptosis of ovarian granulosa cells.

Multifunctional silver nanoclusters with hyaluronic acid for dual-targeted tumor imaging and ROS-mediated therapy.

Despite their potential in cancer theranostics, silver nanoparticles (Ag NPs) face significant clinical translation challenges, including polydispersity, weak fluorescence emission, and suboptimal biocompatibility. To overcome these challenges, we introduce Ag@PEG2000-HA nanoclusters (NCs), novel silver-based NCs developed through a sequential functionalization process using polyethylene glycol (PEG) and hyaluronic acid (HA). The HA-induced stabilization enlarges nanocluster cores and promotes ligand-metal charge transfer, synergizing with size-dependent aggregation-induced emission (AIE) effect to amplify fluorescence.

Light/Copper(I) Synergistically Catalyzes the Three-Component Radical Monofluoroalkyl Arylation of Styrenes.

A three-component radical monofluoroalkyl arylation reaction of styrenes with ethyl bromofluoroacetate and (hetero)arenes catalyzed by light/copper(I) synergy is established herein. In a one-step reaction, two new C-C bonds and 1,1-di(hetero)aryl skeletons can be constructed. This reaction has the characteristics of mild reaction conditions, good yields, a wide range of substrates, and good regioselectivity.

Defective RuO Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway.

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by chronic inflammation, cartilage degeneration, and the formation of osteophytes, which leads to serious economic and social challenges. Previous studies have demonstrated that oxidative stress-driven inflammation plays a crucial role in the pathophysiological progression of OA. In this study, we presented defective RuO (d-RuO) as an effective antioxidant for the treatment of OA.

Immunological biomarkers and gene signatures predictive of radiotherapy resistance in non-small cell lung cancer.

Introduction: A significant challenge in treating non-small cell lung cancer (NSCLC) is its inherent resistance to radiation therapy, leading to poor patient prognosis. This study aimed to identify key genes influencing radiotherapy resistance in NSCLC through comprehensive bioinformatics analysis.

Methods: A total of 103 common genes were identified, enriched in critical biological pathways such as coagulation, complement activation, growth factor activity, and cytokine signaling.

Ruthenium Oxide Nanozyme for Tendinopathy Treatment via Countering Ferroptosis.

The global prevalence of tendinopathy (TP) is steadily increasing, resulting in functional impairments in tendons across individuals of all ages. Excessive accumulation of reactive oxygen species (ROS) plays a pivotal role in the development of TP, which compromises tendon repair and integrity through oxidative stress. This process is often accompanied by ferroptosis-a newly recognized form of iron-dependent programmed cell death.

Comparative serum imidazole propionate profiling in colorectal adenoma and cancer by UPLC-MS/MS.

Introduction: The incidence of colorectal cancer (CRC) is increasing with colorectal adenomas recognized as key precancerous lesions. Emerging evidence suggests that Imidazole propionate (ImP), a metabolite of gut microbiota, is elevated in patients, indicating a potential role in tumorigenesis of CRC.

Objectives: This study aimed to validate a novel method for detecting serum ImP using 3-piperazin-1-yl-propionic acid as an internal standard (IS), and to compare ImP levels between patients with colorectal adenomas and colorectal cancer.

Specialized pro-resolving mediators in neutrophil apoptosis regulation: unlocking novel therapeutic potential in kidney diseases.

Kidney diseases represent a diverse group of disorders with pathogenic mechanisms involving multiple pathological processes, including inflammation, immunity, and cell death. Neutrophils, as primary effector cells in inflammatory immune responses, participate in defending against renal infection and injury by releasing reactive oxygen species, proteases, and cytokines. However, persistent neutrophil activation is considered a crucial driver of kidney disease progression.

Novel biodegradable mulch films made from vegetable stalk and sodium alginate.

Biodegradable mulch films are essential for reducing plastic pollution in agriculture; however, current production methods often rely on complex and costly chemical processes. This study presents an innovative, eco-friendly approach to developing fully biodegradable mulch films using untreated vegetable stalks and sodium alginate through a simple blending method. By eliminating the need for pretreatment, this process significantly reduces energy consumption and maximizes agricultural waste utilization.

Efficacy and safety of hydromorphone for postoperative patient-controlled intravenous analgesia for patients undergoing orthopedic surgery: a randomized, double-blinded controlled trial.

Background: The study aimed to evaluate the efficacy and safety of hydromorphone in postoperative patient-controlled intravenous analgesia (PCIA) for orthopedic surgery patients, offering a reference for postoperative pain management in this patient population.

Methods: This was a prospective, randomized, double-blinded, controlled trial involving 80 patients aged 23 to 64 years undergoing elective orthopedic surgery. All participants were randomly assigned to the test group (Group H) and the control group (Group C) by the random number table method.

Low-dose cyclophosphamide combined with chinese herbal medicine Shuli Fenxiao formula for the treatment of intermediate-to-high risk primary membranous nephropathy.

Background: At present, the side effects of hormonal and immunosuppressant therapy for intermediate-to-high risk primary membranous nephropathy (PMN) are relatively large, and the remission rate is limited, so more safe and effective regimens are needed.

Methods: This study is a clinical prospective case series study. 31 patients were finally included.

Association between serum α-klotho levels and the incidence of diabetic kidney disease and mortality in type 2 diabetes: evidence from a Chinese cohort and the NHANES database.

Background: The α-klotho is crucial in diabetes and its related complications. This study seeks to explore the link between α-klotho levels and the risk of diabetic kidney disease (DKD) as well as all-cause and cardiovascular mortality among individuals with type 2 diabetes mellitus (T2DM).

Methods: The investigation involved 126 Chinese T2DM patients and 4,451 individuals from the National Health and Nutrition Examination Survey (NHANES) database.

MiRNA- 1293 Promotes Hepatocellular Carcinoma Cell Proliferation and Invasion by METTL3-Mediated m6 A Modification of Pri-miRNA- 1293.

Hepatocellular carcinoma (HCC) is a highly heterogeneous, proliferative, and aggressive malignancy of the digestive system. MicroRNAs (miRNAs) are expected to be a new target for the treatment of HCC. Crosstalk between N6-methyladenine (m6A) modification and miRNAs are involved in HCC progression.

Diagnostic value of serum TGF-β1 and CysC in type 2 diabetic kidney disease: a cross-sectional study.

Background: Diabetic kidney disease (DKD) is one of the common microvascular complications of diabetes. The exploration of serum biomarkers holds promise for improving the efficiency and accuracy of early DKD diagnosis. This study aims to investigate the diagnostic value of transforming growth factor-β1 (TGF-β1) and cystatin C (CysC) in DKD patients.

Metabolomic Analysis of the Responses of Bryophyte (Hedw.) Limpr. to Cadmium (Cd) Stress.

In recent years, there have been many studies on the response of plants to heavy metal stress, but the metabolic changes in bryophytes, pioneer plants quickly responding to environmental changes, under exogenous cadmium (Cd) stress have yet to be explored. In this indoor experiment, the responses in the metabolome of bryophyte (Hedw.) Limpr.

Primary hyperthyroidism complicated by primary hyperparathyroidism: a case report and literature review.

Background: The clinical occurrence of primary hyperthyroidism (PH) combined with primary hyperparathyroidism (PHPT) is exceedingly rare. There remains considerable debate regarding the necessity of iodine use prior to surgery for hyperthyroidism and whether thyroid function should be normalized before proceeding with the operation. Furthermore, the decision on whether to perform total parathyroidectomy or subtotal parathyroidectomy due to parathyroid hyperplasia must be based on a comprehensive assessment by a multidisciplinary team (MDT).