Orbital-Tailoring Strategy via Dual-Defect Engineering in P-FeTe@NC Synergizes Polysulfide Adsorption-Conversion for Lithium-Sulfur Batteries.

The polysulfide shuttling and sluggish sulfur redox kinetics hinder the commercialization of lithium-sulfur (Li-S) batteries. Herein, the fabrication of phosphorus (P)-doped iron telluride (FeTe) nanoparticles with engineered Te vacancies anchored on nitrogen (N)-doped carbon (C) (P-FeTe@NC) is presented as a multifunctional sulfur host. Theoretical and experimental analyses show that Te vacancies create electron-deficient Fe sites, which chemically anchor polysulfides through enhanced Fe─S covalent interactions.

Pharmacological properties and therapeutic potential of berberine: a comprehensive review.

In recent decades, the pharmacological properties of botanical drugs have been investigated with increasing depth, offering novel insights into their potential for enhancing healthcare. Berberine (BBR) is an alkaloid extracted from the roots, rhizomes and stem tubers of plants such as s, , , and several other plants, which is used not only as an anti-inflammatory and antibacterial agent, but also for the treatment of cancer and chronic diseases. BBR has demonstrated remarkable therapeutic efficacy in the management of disorders affecting the nervous, cardiovascular, and endocrine systems, characterized by its high safety profile and minimal adverse effects.

Specificities of chemosensory receptors in the human gut microbiota.

The human gut is rich in metabolites and harbors a complex microbial community, yet surprisingly little is known about the spectrum of chemical signals detected by the large variety of sensory receptors present in the gut microbiome. Here, we systematically mapped the ligand specificities of selected extracytoplasmic sensory domains from twenty members of the human gut microbiota, with a primary focus on the abundant and physiologically important class of Clostridia. Twenty-five metabolites from different chemical classes-including amino acids, nucleobase derivatives, amines, indole, and carboxylates-were identified as specific ligands for fifteen sensory domains from nine bacterial species, which represent all three major functional classes of transmembrane receptors: chemotaxis receptors, histidine kinases, and enzymatic sensors.

Composite Hydrogel Dressing with Drug-Release Capability and Enhanced Mechanical Performance.

Wound care is a critical concern due to the rising prevalence of chronic and infected wounds, which demands improved treatment solutions. Conventional dressings often fall short in delivering effective drug release and mechanical performance, limiting their clinical utility. In this study, we present a composite hydrogel dressing incorporating berberine-loaded silk fibroin microspheres and fibers (CGFs).

Macroporous hydrogel-based mRNA cancer vaccine for in situ recruitment and modulation of dendritic cells.

mRNA-based vaccines have demonstrated tremendous success in the era of covid-19, but their full potential for cancer treatment awaits to be realized. To address the low efficiency of conventional mRNA vaccines to encounter and become taken up by dendritic cells in the body, here we report a macroporous hydrogel-based mRNA vaccine that enables in situ recruitment and modulation of dendritic cells. Upon subcutaneous injection of macroporous hydrogels loaded with chemokines and neoantigen-encoding mRNA lipoplexes, high numbers of dendritic cells can be recruited to the gel, take up and process mRNA, and present mRNA-encoded neoantigens in situ, prior to their migration to draining lymph nodes to prime neoantigen-specific CD8T cells.

Laser-modulated MnBiTe terahertz biosensor for high-sensitivity marine bacterial detection.

The prompt and precise identification of marine bacteria is essential for assessing ecosystem health and mitigating microbial contamination in aquatic environments. In this study, we introduce a terahertz (THz) biosensor that utilizes magneto-topological MnBiTe thin films, capitalizing on their quantum anomalous Hall effect and surface-dominated optoelectronic characteristics for label-free bacterial detection. Through the application of surface engineering and laser modulation techniques, the sensor achieves a detection limit of 9.

Diagnostic and therapeutic challenges of Candida albicans infection post-lumbar surgery in a rheumatoid arthritis patient: A case report and review of the literature.

Rationale: Postoperative Candida albicans infections are exceedingly rare in urban populations, especially among patients on long-term immunosuppressive therapy. To date, there have been no reported cases of rheumatoid arthritis (RA) patients developing C albicans infections following spinal surgery. This report aims to highlight this rare occurrence and share insights on management strategies.

The predictive value of hsCRP/HDL-C ratio for cardiometabolic multimorbidity in middle-aged and elderly people: evidence from a large national cohort study.

Background: Cardiovascular disease is associated with inflammation and dysregulated lipid metabolism. This study aimed to investigate the predictive value of high-sensitive C-reactive protein to high-density lipoprotein cholesterol ratio (CHR) in assessing the risk of developing cardiometabolic multi-morbidity (CMM) within the Chinese population.

Methods: A cohort of 8,187 participants were selected from the China Health and Retirement Longitudinal Study (CHARLS) and divided into four groups based on the quartile of CHR.

Genomic landscape and molecular evolutionary trajectories of renal epithelioid angiomyolipoma and benign angiomyolipoma.

Renal angiomyolipoma (AML) encompasses benign variants (lipomatous [L-AML], myomatous [M-AML]) and epithelioid AML (eAML), a potentially malignant subtype associated with aggressive behavior. While TSC1/TSC2 mutations are frequent, the molecular drivers underlying eAML pathogenesis remain unclear. Whole-exome sequencing (WES) was performed on 35 AML samples (15 eAML, 10 L-AML, 10 M-AML) with matched germline controls.

Prehospital blood pressure lowering in patients with ultra-acute presumed stroke: A systematic review and meta-analysis.

Objective: High blood pressure frequently occurs in the setting of acute stroke and is associated with worse prognoses. However, it is still uncertain whether initiating blood pressure-lowering therapy in the prehospital phase after stroke onset can enhance outcomes for patients with undifferentiated acute stroke.

Methods: We conducted a search of the PubMed, Embase, and Cochrane databases to identify randomized controlled trials investigating prehospital blood pressure lowering interventions for presumed ultra-acute stroke (within <6 hours).

Neutrophil to high-density lipoprotein cholesterol ratio predicts deep venous thrombosis in spontaneous intracerebral hemorrhage.

Deep vein thrombosis (DVT) is a common and serious complication of spontaneous intracerebral hemorrhage (ICH). The timely recognition and treatment of DVT can significantly mitigate several negative consequences. To investigate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and the occurrence of DVT in ICH patients.

Integrative network toxicology, molecular dynamics and transcriptional analysis elucidate DEHP-induced cardiovascular dysfunction.

Diethylhexyl phthalate (DEHP), a ubiquitous environmental pollutant, has been linked to cardiovascular diseases (CVDs), though the molecular mechanisms driving this association remain poorly understood. This study employed an integrated approach combining network toxicology, molecular docking, and molecular dynamics simulations to identify critical gene targets and elucidate their roles in DEHP-induced CVD pathogenesis. Potential clinical targets were screened using public databases (STITCH, ChEMBL, GeneCards, and OMIM), revealing ten core candidates: , , , , MAPK family members ( and ), and cytochrome P450 enzymes (, , , and ).

Experimental evolution partially restores functionality of bacterial chemotaxis network with reduced number of components.

The chemotaxis signaling pathway, which enables bacteria to follow chemical gradients in their environment, is highly conserved among motile bacteria. It is assumed that Escherichia coli contains the minimal and non-redundant set of protein activities that are necessary for bacterial chemotaxis and nearly universally conserved among bacterial chemotaxis pathways. These include stimulus sensing, signal transduction towards the flagellar motor, and adaptation-based temporal comparisons of the environment.

The development and evanescence of red blood cell antibodies in a 51-year-old pregnant ovum recipient and her pregnancy outcome.

Management of complications, including hemolytic disease of the fetus and newborn (HDFN) and identifying compatible red blood cell (RBC) for future transfusions, related to multiple RBC alloantibodies in extremely advanced age pregnant donor ovum (DO) recipient is a challenge for transfusion medicine, especially during emergencies when alloantibodies become evanescent. Here we reported a 51-year-old woman underwent three cycles of IVF using embryos from her husband sperm and anonymously DO. She was detected with anti-Ce and anti-Jk alloantibodies during the pregnancy, with anti-Jk becoming evanescent in the third trimester and reinduced after delivery.

Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma.

Tertiary lymphoid structures (TLSs), organized clusters of immune cells within non-lymphoid tissues, significantly influence tumor progression and therapeutic response. However, their prognostic relevance and underlying regulatory mechanisms in clear cell renal cell carcinoma (ccRCC) remain insufficiently characterized. We integrated transcriptomic and clinical data from 928 ccRCC patients to construct a TLS-related prognostic RiskScore using machine learning algorithms.

Regulatory B cells promote the immunosuppressive microenvironment and progression of clear cell renal cell carcinoma.

Background: Regulatory B cells (Bregs) are critical mediators of immune modulation and tumor progression. However, their prognostic relevance and mechanistic roles in clear cell renal cell carcinoma (ccRCC) remain insufficiently explored.

Methods: A comprehensive pancancer strategy was implemented to assess the prognostic role of Breg cells.

Light/Copper(I) Synergistically Catalyzes the Three-Component Radical Monofluoroalkyl Arylation of Styrenes.

A three-component radical monofluoroalkyl arylation reaction of styrenes with ethyl bromofluoroacetate and (hetero)arenes catalyzed by light/copper(I) synergy is established herein. In a one-step reaction, two new C-C bonds and 1,1-di(hetero)aryl skeletons can be constructed. This reaction has the characteristics of mild reaction conditions, good yields, a wide range of substrates, and good regioselectivity.

Decreased impulsivity in Schizophrenia: Evidence from self-report and behavioral measures.

Impulsivity contributes to deleterious outcomes among schizophrenia (SZ) patients, and it plays an important role in the diagnostic process. However, impulsivity can be measured in a variety of ways, and previous research has yielded mixed results regarding its relationship with positive and negative symptoms. To address this, we controlled for additional variables (e.

Effect of Diamine Monomers with Varied Backbone Structures on Dielectric and Other Comprehensive Properties of Fluorinated Polyimide Films.

Fluorinated polyimide (FPI), renowned for its exceptional low-dielectric properties, colorless transparency, high-temperature resistance, and flexibility, has emerged as an ideal material for addressing challenges in 5G/6G high-frequency signal transmission and flexible electronic substrates. Nevertheless, the structure-property relationship between molecular architectures and the dielectric characteristics of FPI films remains insufficiently understood, necessitating urgent elucidation of the underlying mechanisms. In this study, a diamine monomer containing bis-amide bonds, 4-amino-N-{4-[(4-aminobenzoyl)amino]phenyl}benzamide (PABA), was synthesized.

Proteogenomic characterization reveals that lipid droplet formation promotes esophageal squamous cell cancer progression.

Esophageal cancer is one of the most common cancers and a leading cause of cancer-related mortality in the world. Here, we have performed comprehensive characterization of genetic, transcriptomic, proteomic, and phosphoproteomic features in 293 patients with esophageal squamous cell carcinoma (ESCC). Chromosome 12q13.

Open-Shell Species Enabled Diverse Deoxygenative Cyanofunctionalization of Aldehydes under Metal-Free Conditions.

The conversion of carbonyl compounds to functionalized nitriles enables both one-carbon homologation and rapid multifunctionalization, especially considering the diverse transformation potential of the cyano group. Herein, by simultaneously introducing a cyano and a suitable C-O activated group into carbonyl compounds, we successfully achieved an efficient deoxygenative cyanofunctionalization of unactivated aliphatic aldehydes via a free radical process. Due to the unique characteristics of the open-shell species, this protocol can readily facilitate a variety of bond formations to install alkyl ketone, alkenyl, allylic, halo, phosphorus, and sulfur groups.

Thermal or Photoinduced Radical Cascade Cyclization to Access CF/SCF-Containing Small- and Medium-Membered-Sized -Heterocycles.

In this report, an efficient copper-catalyzed radical cascade cyclization of aryl aldehyde-derived hydrazones with a Togni reagent or AgSCF in two directions to access a series of trifluoromethylated five/six/seven-membered heterocycles and trifluoromethylthiolated five-membered heterocycles was developed. The model reaction was extrapolated with 74 examples, affording satisfactory yields for desired products. Further transformation and large-scale experiments were conducted and gave positive results, which paved the way to a broad application of the protocol.

Adjustable Upcycling of Polyethylene Terephthalate to Biodegradable Polymer Monomers by Mn-Catalyzed Solvent Switching Strategy.

Waste plastics represent a new resource for the chemical industry. In this study, we demonstrate a solvent-switching strategy to upcycle waste polyethylene terephthalate (PET) into monomer terephthalic acid (TPA) and key bulk feedstocks for biodegradable polymers, such as lactic acid (LA) or glycolic acid (GA). PET undergoes rapid and mild depolymerization into its monomers TPA and ethylene glycol (EG) under the catalysis of a manganese complex.