Visualization of Total Synthesis from Au to Au Nanoclusters.

The emergence of geometrically related Au and Au nanoclusters (NCs), both possessing a valence electron count of 8e, has substantiated the feasibility of chemically preparing reduced metal nanoclusters. Nevertheless, a significant challenge remains: the dynamic transformation pathways governing their structural evolution have remained elusive, severely impeding precise atomic-level control in NCs synthesis. Herein, we present a large conjugated quinoline thiol ligand with protonatable sites, which enables the systematic construction of seven structurally related Au NCs.

Pregnancy-associated fulminant type 1 diabetes mellitus: Two case reports and literature review.

Pregnancy-associated fulminant type 1 diabetes mellitus (PFT1DM) occurs during pregnancy or within 2 weeks after delivery. Despite the low incidence of PFT1DM in obstetrics, it poses a great threat to the lives of mothers and infants. The present study reported the management of 2 cases with PFT1DM, emphasizing the importance of early diagnosis and appropriate treatments to improve pregnancy outcomes.

Integrative network toxicology, molecular dynamics and transcriptional analysis elucidate DEHP-induced cardiovascular dysfunction.

Diethylhexyl phthalate (DEHP), a ubiquitous environmental pollutant, has been linked to cardiovascular diseases (CVDs), though the molecular mechanisms driving this association remain poorly understood. This study employed an integrated approach combining network toxicology, molecular docking, and molecular dynamics simulations to identify critical gene targets and elucidate their roles in DEHP-induced CVD pathogenesis. Potential clinical targets were screened using public databases (STITCH, ChEMBL, GeneCards, and OMIM), revealing ten core candidates: , , , , MAPK family members ( and ), and cytochrome P450 enzymes (, , , and ).

Discovery of an unconventional quantum echo by interference of Higgs coherence.

Detecting photon echoes from superconducting Higgs modes is challenging due to the necessity of preserving and retrieving phase coherence encoded in multiple Higgs and quasiparticle (QP) excitations. Here, we demonstrate the emergence of a Higgs echo in niobium superconductors. This approach disentangles unique quantum pathways involving the Higgs mode and QP excitations.

Polygonatum Odoratum (Mill.) Druce Alleviates Lipopolysaccharide-Induced Inflammation and Improves the Ovarian Function in Polycystic Ovary Syndrome Rats.

Problem: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligoovulation or anovulation, and the morphology of polycystic ovaries. Polygonatum odoratum (Mill.) Druce (POD), a key component of the traditional Chinese herb Polygonatum odoratum, has uncertain effects on improving ovarian function and inflammation in patients with PCOS.

An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial.

Adolescents with obesity face numerous health risks and encounter barriers that lead to physical inactivity. We developed a virtual reality sports system, named REVERIE (Real-World Exercise and VR-Based Exercise Research in Education), which used deep reinforcement learning to train transformer-based virtual coaching agents, offering immersive and effective sports guidance, with biomechanical performance comparable to real-world physical sports. We integrated REVERIE into a randomized controlled trial involving an 8-week intervention in adolescents with excess body weight (n = 227).

PADI1 aggravates endoplasmic reticulum stress in trophoblast cells by inhibiting the FAK-ERK signaling pathway.

Preeclampsia (PE) is a multisystemic syndrome of pregnancy that seriously affects maternal and infant healthcare. Here, we identified PADI1 as an abnormally highly expressed gene in PE and investigated its effect on trophoblast cells. According to the analysis results from GEO datasets GSE186257 and GSE143953, PADI1 is highly expressed in the placental samples of PE patients.

The Effect of AMH on Folliculogenesis.

Polycystic ovary syndrome (PCOS) is a common and frequent disease and always leads to endocrine and metabolic disorders among women of reproductive age. In most PCOS patients, the serum level of anti-mullerian hormone (AMH) is significantly higher than that of normal women of childbearing age. AMH is an important auxiliary diagnostic method for PCOS.

Observation of the magnonic Dicke superradiant phase transition.

Two-level atoms ultrastrongly coupled with single-mode cavity photons are predicted to exhibit a quantum phase transition, entering a phase in which both the atomic polarization and the photonic field are finite even without external driving. However, this phenomenon, the superradiant phase transition (SRPT), is forbidden by a no-go theorem due to the existence of the diamagnetic term. Here, we present spectroscopic evidence for a magnonic SRPT in ErFeO, where the role of the photonic mode (two-level atoms) in the photonic SRPT is played by an Fe magnon mode (Er spins).

Back analysis of mechanical parameters based on GPSO-BP neural network and its application.

Rock mass mechanical parameters are essential for the design and construction of underground engineering projects, but parameters obtained through traditional methods are often unsuitable for direct use in numerical simulations. The back analysis method, based on displacement monitoring, has emerged as a new approach for determining rock mass parameters. In this study, an experimental scheme was developed using orthogonal and uniform experimental designs to obtain training samples for the neural network.

Fibroblast Growth Factor 21 Levels Are Associated With Perception and Neural Responses to Sweetness in Type 2 Diabetes Mellitus.

Backgruound: The relationship between fibroblast growth factor 21 (FGF21) and sweet taste perception and preference in type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate this relationship and examine the neural responses of T2DM patients to high-calorie sweet (HCS) food pictures, further exploring its correlation with FGF21 levels.

Methods: We assessed sweet taste perception and preference in 40 T2DM patients and 41 controls using classical scales.

Cancer-Associated Fibroblasts Foster a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer.

Unlabelled: Perineural invasion (PNI) is a pivotal prognostic factor in pancreatic cancer, associated with aggressive tumor behavior and adverse patient outcomes. The recognized clinical impact of PNI highlights the need to better understand the molecular mechanisms underlying PNI-induced phenotypes. In this study, we isolated PNI-associated cancer-associated fibroblasts (pCAF), which demonstrated a markedly enhanced capacity to promote neural invasion in pancreatic cancer compared with non-PNI-associated CAFs.

Large language models for diabetes training: a prospective study.

Diabetes poses a considerable global health challenge, with varying levels of diabetes knowledge among healthcare professionals, highlighting the importance of diabetes training. Large Language Models (LLMs) provide new insights into diabetes training, but their performance in diabetes-related queries remains uncertain, especially outside the English language like Chinese. We first evaluated the performance of ten LLMs: ChatGPT-3.

Spatially Selective MicroRNA Imaging in Human Colorectal Cancer Tissues Using a Multivariate-Gated Signal Amplification Nanosensor.

MicroRNA (miRNA) is involved in the genesis in viand development of colorectal cancer. The in vivo imaging of miRNA at the tumor sites is essential for understanding its role in colorectal cancer pathology and therapeutic target identification. However, achieving accurate imaging of miRNA at the tumor sites is hindered by the low abundance of miRNAs in tumor cells and nonspecific signal leakage in normal tissues.

Fibroblast growth factor 23 predicts incident diabetic kidney disease: A 4.6-year prospective study.

Aims: Fibroblast growth factor (FGF) 23 is a bone-derived phosphaturic hormone that participates in the regulation of mineral metabolism and the development of chronic kidney disease. This study aimed to investigate the association between FGF23 and diabetic kidney disease (DKD) in a community-based prospective cohort.

Materials And Methods: Of 7230 individuals who completed a 4.

GATA1-mediated macrophage polarization via TrkB/cGMP-PKG signaling pathway to promote the development of preeclampsia.

Background: Preeclampsia (PE) is a severe pregnancy complication characterized by hypertension and proteinuria. PE poses a substantial threat to the health of both mothers and fetuses, and currently, there is no definitive treatment available. Recent studies have indicated that the transcription factor GATA1 may be implicated in the pathological processes of PE, but the underlying mechanism remains elusive.

Associations between multiple metabolic biomarkers with steatotic liver disease subcategories: A 5-year Chinese cohort study.

The effectiveness of established biomarkers for non-alcoholic fatty liver disease (NAFLD) within the updated framework of steatotic liver disease (SLD) remains uncertain. This cohort study examines the association of four metabolic biomarkers-retinol-binding protein 4 (RBP-4), fibroblast growth factor 21 (FGF-21), adiponectin, and osteocalcin-with SLD and its subtypes: metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction with alcohol-related liver disease (MetALD)/alcohol-related liver disease (ALD). Among 3,504 Chinese participants aged 55-70, 938 (26.

Phase I Trial of Upamostat Combined With Gemcitabine in Locally Unresectable or Metastatic Pancreatic Cancer: Safety and Preliminary Efficacy Assessment.

Aim: This study aimed to determine the maximum tolerated dose (MTD) of the urokinase plasminogen activator (uPA) inhibitor upamostat (LH011) in combination with gemcitabine for locally advanced unresectable or metastatic pancreatic cancer.

Method: Seventeen patients were enrolled and received escalating doses of oral LH011 (100, 200, 400, or 600 mg) daily alongside 1000 mg/m of gemcitabine. Safety profiles, tumor response (including response rate and progression-free survival), pharmacokinetics, and changes in CA199 and D-dimer levels were assessed.

Transferrin-targeting pH-responsive and biodegradable mesoporous silica nanohybrid for nitric oxide-sensitized chemotherapy of cancer.

Weakly acidic pH, low oxygen and high glutathione levels are the main characteristics of tumor cells. Taking advantage of the unique acidic microenvironment of tumor cells, acid-responsive mesoporous organosilica nanoparticles (AMON) were designed for nitric oxide (NO)-sensitized chemotherapy of tumors. AMON served as a nanocarrier co-loaded with a nitric oxide donor (NOD) and chemotherapeutic drug doxorubicin (DOX).

Advances and challenges in preparing membrane proteins for native mass spectrometry.

Native mass spectrometry (nMS) is becoming a crucial tool for analyzing membrane proteins (MPs), yet challenges remain in solubilizing and stabilizing their native conformations while resolving and characterizing the heterogeneity introduced by post-translational modifications and ligand binding. This review highlights recent advancements and persistent challenges in preparing MPs for nMS. Optimizing detergents and additives can significantly reduce sample heterogeneity and surface charge, enhancing MP signal quality and structural preservation in nMS.

A novel label-free impedance biosensor for KRAS G12C mutations detection based on PET-RAFT and ROP synergistic signal amplification.

The KRAS G12C mutations, as crucial biomarkers, are closely associated with non-small cell lung cancer. Here, a novel label-free electrochemical biosensor with synergistic signal amplification of photocell energy transfer-reversible addition fragmentation chain transfer (PET-RAFT) and ring-opening polymerization (ROP) was developed for the first time for sensitive detection of KRAS G12C mutations. Specifically, hairpin DNA (hDNA), which act as biomolecular probe, was self-assembled on Au electrode surface by Au-S bond.

Lower-limb inter-joint coordination during balance recovery after trips.

Background: Trips are one of the most common external perturbations that can lead to accidental falls. Knowledge about postural control attributes of balance recovery after trips could help reveal the biomechanical causes for trip-induced falls and provide implications for fall prevention interventions.

Research Question: The objective of the present study was to examine coordinated lower-limb movements during balance recovery after trips.

Effects of microencapsulated plant essential oils on growth performance, immunity, and intestinal health of weaned Tibetan piglets.

Introduction: Plant essential oils (PEOs) have received significant attention in animal production due to their diverse beneficial properties and hold potential to alleviate weaning stress. However, PEOs effectiveness is often compromised by volatility and degradation. Microencapsulation can enhance the stability and control release rate of essential oils.