An adaptive AI-based virtual reality sports system for adolescents with excess body weight: a randomized controlled trial.

Adolescents with obesity face numerous health risks and encounter barriers that lead to physical inactivity. We developed a virtual reality sports system, named REVERIE (Real-World Exercise and VR-Based Exercise Research in Education), which used deep reinforcement learning to train transformer-based virtual coaching agents, offering immersive and effective sports guidance, with biomechanical performance comparable to real-world physical sports. We integrated REVERIE into a randomized controlled trial involving an 8-week intervention in adolescents with excess body weight (n = 227).

Fibroblast Growth Factor 21 Levels Are Associated With Perception and Neural Responses to Sweetness in Type 2 Diabetes Mellitus.

Backgruound: The relationship between fibroblast growth factor 21 (FGF21) and sweet taste perception and preference in type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate this relationship and examine the neural responses of T2DM patients to high-calorie sweet (HCS) food pictures, further exploring its correlation with FGF21 levels.

Methods: We assessed sweet taste perception and preference in 40 T2DM patients and 41 controls using classical scales.

Exercise-induced improvement of glycemic fluctuation and its relationship with fat and muscle distribution in type 2 diabetes.

Aims: Management of blood glucose fluctuation is essential for diabetes. Exercise is a key therapeutic strategy for diabetes patients, although little is known about determinants of glycemic response to exercise training. We aimed to investigate the effect of combined aerobic and resistance exercise training on blood glucose fluctuation in type 2 diabetes patients and explore the predictors of exercise-induced glycemic response.

Effect of virtual reality-based exercise and physical exercise on adolescents with overweight and obesity: study protocol for a randomised controlled trial.

Introduction: Obesity is a complex and multifactorial disease that has affected many adolescents in recent decades. Clinical practice guidelines recommend exercise as the key treatment option for adolescents with overweight and obesity. However, the effects of virtual reality (VR) exercise on the physical and brain health of adolescents with overweight and obese remain unclear.

Correction of Range-Variant Motion Error and Residual RCM in Sparse Regularization SAR Imaging.

Lq (0 < q ≤ 1) regularization has been confirmed effective when applied to sparse SAR imaging. However, the inaccuracies caused by motion errors in the observation model will lead to various degradations and defocus in the reconstructed image. For high-resolution and light-small SAR systems, the range-variant motion errors will decrease the accuracy of range cell migration correction (RCMC), and residual range cell migration (RCM) will exceed multiple range resolution cells and degrade the image quality substantially.

Chemoenzymatic catalytic synthesis of furfurylamine from hemicellulose in biomasses.

Recently, efficient synthesis of furan-based chemicals from biomacromolecule via chemoenzymatic approaches have been widely recognized. In this work, an efficient conversion of biomacromolecule (e.g.

Significant Enhancement of 5-Hydroxymethylfural Productivity from -Fructose with SG(SiO) in Betaine:Glycerol-Water for Efficient Synthesis of Biobased 5-(Hydroxymethyl)furfurylamine.

5-Hydroxymethyl-2-furfurylamine (5-HMFA) as an important 5-HMF derivative has been widely utilized in the manufacture of diuretics, antihypertensive drugs, preservatives and curing agents. In this work, an efficient chemoenzymatic route was constructed for producing 5-(hydroxymethyl)furfurylamine (5-HMFA) from biobased -fructose in deep eutectic solvent Betaine:Glycerol-water. The introduction of Betaine:Glycerol could greatly promote the dehydration of -fructose to 5-HMF and inhibit the secondary decomposition reactions of 5-HMF, compared with a single aqueous phase.

An MCIA-like complex is required for mitochondrial complex I assembly and seed development in maize.

During adaptive radiation, mitochondria have co-evolved with their hosts, leading to gain or loss of subunits and assembly factors of respiratory complexes. Plant mitochondrial complex I harbors ∼40 nuclear- and 9 mitochondrial-encoded subunits, and is formed by stepwise assembly during which different intermediates are integrated via various assembly factors. In mammals, the mitochondrial complex I intermediate assembly (MCIA) complex is required for building the membrane arm module.

Alleviates Liver Steatosis and Steatohepatitis by Increasing Fibroblast Growth Factor 21 Sensitivity.

The gut microbiota is a newly identified contributor to the development of non-alcoholic fatty liver disease (NAFLD). Previous studies of (), a species of that is common in the human intestinal tract, have demonstrated that it can alleviate liver steatosis and steatohepatitis. Fibroblast growth factor 21 (FGF21) has long been considered as a biomarker of NAFLD, and recent studies have shown the protective effect of FGF21 analogs on NAFLD.

Catalytic valorization of biomass for furfuryl alcohol by novel deep eutectic solvent-silica chemocatalyst and newly constructed reductase biocatalyst.

Chemoenzymatic cascade catalysis using deep eutectic solvent-silica heterogeneous catalyst and reductase biocatalyst was constructed for synthesizing furfuryl alcohol from biomass in one-pot manner. A novel heterogeneous catalyst B:LA-SG(SiO) was firstly prepared by immobilizing deep eutectic solvent Betaine:Lactic acid on silica with sol-gel method using tetraethyl orthosilicate as silicon source. High furfural yield (45.

Valorisation of corncob into furfuryl alcohol and furoic acid via chemoenzymatic cascade catalysis.

Heterogeneous tin-based sulfonated graphite (Sn-GP) catalyst was prepared with graphite as carrier. The physicochemical properties of Sn-GP were captured by FT-IR, XRD, SEM and BET. Organic acids with different pKa values were used to assist Sn-GP for transforming corncob (CC), and a linear equation (Furfural yield  = - 7.

FGF21/adiponectin ratio predicts deterioration in glycemia: a 4.6-year prospective study in China.

Background: The fibroblast growth factor (FGF) 21-adiponectin pathway is involved in the regulation of insulin resistance. However, the relationship between the FGF21-adiponectin pathway and type 2 diabetes in humans is unclear. Here, we investigated the association of FGF21/adiponectin ratio with deterioration in glycemia in a prospective cohort study.

Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes.

Although obesity occurs in most of the patients with type 2 diabetes (T2D), a fraction of patients with T2D are underweight or have normal weight. Several studies have linked the gut microbiome to obesity and T2D, but the role of gut microbiota in lean individuals with T2D having unique clinical characteristics remains unclear. A metagenomic and targeted metabolomic analysis is conducted in 182 lean and abdominally obese individuals with and without newly diagnosed T2D.

Updating and interaction of polycomb repressive complex 2 components in maize (Zea mays).

The information on core components in maize polycomb repressive complex 2 (PRC2) are updated at a genome-wide scale, and the protein-protein interaction networks of PRC2 components are further provided in maize. The evolutionarily conserved polycomb group (PcG) proteins form multi-subunits polycomb repressive complexes (PRCs) that repress gene expression via chromatin condensation. In Arabidopsis, three distinct PRC2s have been identified, each determining a specific developmental program with partly functional redundancy.