Deficiency of Ugcg in LSECs alleviates high-fat diet-induced MASLD.

Background: Hepatic glycosphingolipid biosynthesis is implicated in insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD). While UDP-glucose ceramide glucosyltransferase (UGCG) serves as the rate-limiting enzyme in glycosphingolipid synthesis, its cell-specific roles in MASLD pathogenesis remain undefined. Our study investigates the mechanistic contribution of LSEC-expressed UGCG to high-fat diet (HFD)-induced insulin resistance and MASLD progression.

Effectiveness of various exercise on neuropsychiatric symptoms among older adults with mild cognitive impairment or dementia: A systematic review and network meta-analysis.

Objective: To identify the comparative efficacy of exercise for reducing neuropsychiatric symptoms (NPS) among older adults with mild cognitive impairment (MCI) or dementia.

Methods: Ten databases were systematically searched from their inception to April 29, 2025, with the latest update in July 13, 2025. Randomized controlled trials (RCTs) and quasi-experimental studies evaluating the effectiveness of exercise on NPS in older adults with MCI or dementia were included.

Numerical simulation study on hydrogen leakage and explosion of hydrogen fuel cell buses.

This study explores the safety problems of hydrogen leakage and explosion in hydrogen fuel cell buses through Computational Fluid Dynamics simulations. The research investigates the diffusion behavior of hydrogen in the passenger cabin depending on the leakage position and flow rates, identifying a stratified, constant-concentration layer formed at the top of the cabin. Leakage near the rear wall of the vehicle provided the highest hydrogen concentration, while at higher flow rates, the diffusive process accelerated the spreading of flammable hydrogen concentrations.

Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions.

Background: Lactate has a beneficial effect on adult neurogenesis and has been identified as a mediator of lactylation of proteins. However, the regulatory role and function of histone lactylation in neurogenesis remain poorly understood. This study aimed to elucidate the relationship between lactate and the fate of neural stem cells (NSCs), and explore the role of histone lactylation in neurogenesis.

Research progress of mRNA vaccines for infectious diseases.

mRNA vaccines for infectious diseases prevent diseases by stimulating the body to produce specific immune responses through mRNA molecules encoding pathogenic proteins. Compared to traditional vaccines (e.g.

Interlayer Electronic Hybridization for Friction Control in MoSe/WS Heterostructures.

Van der Waals heterostructures, with atomically sharp interfaces and excellent optoelectronic properties, are prime building blocks for ultra-low-power nanoelectronics. Yet unavoidable interfacial friction in such micro/nanoscale stacks still throttles performance and reliability. Hybridized interlayer states are expected to flatten the sliding-energy landscape and curb frictional energy dissipation, yet their impact on friction remains unverified because electronic states and lateral forces are seldom measured in a directly comparable way.

Improved nitrogen removal from real mariculture effluent by halotolerant bacterial consortium SND223: Preparation, entrapping application, and mechanism.

This study developed a halotolerant composite bio-agent (SND223) containing Acinetobacter B2, B3, and Zobellella sp. MAD-44 (2:2:3) for saline aquaculture wastewater treatment. Optimised at carbon-to-nitrogen (C/N) 10, 150 r/m, and 30 °C, SND223 achieved complete ammonia (100 %) and high nitrate (97.

The impact of immune checkpoint inhibition on atherosclerosis in cancer patients.

The emergence of immune checkpoint inhibitors (ICIs) have provided a new perspective for cancer immunotherapy. Immune checkpoint inhibitors significantly improve the survival prognosis of patients with various advanced cancers by inhibiting immune checkpoint molecules, thereby releasing the suppression of T cells by tumor microenvironment, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1). Immune checkpoint inhibitor (ICI) therapy, while effective, gives rise to distinct immune-related adverse events (irAEs), including cardiovascular toxicities, necessitating focused research efforts to better understand and address these specific complications.

Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR-TKI resistance and metastasis.

The epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance is often linked to tumor metastasis, making control of metastasis crucial. Here, we identified a critical signaling hub responsible for cancer metastasis and resistance development: mitochondrial cristae remodeling and metabolic reprogramming, using an anoikis-resistant cell model and a mouse tail vein metastasis model. EGFR-TKI-resistant cells exhibited stronger anoikis resistance (AR) and mitochondrial metabolism compared with sensitive cells, making them more prone to metastasis.

Chromosome-level genome assembly of the Phoxinus lagowskii.

Phoxinus lagowskii is an economically important freshwater fish species native to China. In this study, a chromosome-level genome assembly of P. lagowskii was assembled using PacBio and Hi-C sequencing technologies.

Efficacy and Safety of Electroacupuncture Combined with Agomelatine Tablets Therapy in Treating Insomnia After Stroke.

Insomnia, a common complication following stroke, significantly impairs patients' clinical outcomes. Electroacupuncture (EA), an advanced acupuncture technique, has demonstrated efficacy in alleviating insomnia symptoms. Agomelatine (AT), a melatonin receptor agonist, is widely utilized for depression management.

Characterization of airborne microplastics and health risks in high-temperature urban streets: A case study of Nanjing city.

Microplastic pollution has become a global environmental issue, particularly pronounced in traffic-dense urban areas as the urbanization accelerates. Notably, under high temperatures (daily maximum temperature > 35 °C), the generation and diffusion of traffic-sourced microplastics may undergo significant variations, leading to a potentially higher exposure risk. While existing research has investigated microplastics in aquatic and terrestrial environments, systematic studies on traffic-sourced microplastics in urban streets remain scarce regarding their emission patterns, transport dynamics, and potential health impacts.

Designing Zwitterionic Peptide with Superhydrophilicity through Carboxyl-Amino Spacing Adjustment for Robust Antifouling Electrochemical Biosensing in Complex Biofluids.

The performance of electrochemical biosensors is severely compromised by biofouling in complex biofluids, underscoring the necessity to explore high-performance antifouling materials to construct robust nonfouling electrochemical biosensors. Here, the antifouling zwitterionic peptide CPPPP(D-Dap)(D-Dap)(D-Dap)(D-Dap) (CP(DDap)) was designed by adjusting the distance between the adjacent amino and carboxyl groups of the peptide, and it was further employed to fabricate antifouling electrochemical biosensors. Compared with traditional zwitterionic peptides, CP(DDap) exhibited not only superhydrophilicity but also higher structural rigidity and a smaller dipole moment, enabling it to achieve superior antifouling performance in complex biological media, while its unnatural characteristics endowed it with robust stability against hydrolysis by natural proteinase in biofluids.

Nanocarrier delivered dsRNA: an efficient method for controlling the malignant invasive golden apple snail (Pomacea canaliculata).

Pomacea canaliculata, commonly known as the golden apple snail, is one of the world's top 100 worst invasive alien species. Its widespread invasion has led to reduced agricultural yields, water pollution, and human health risks. While several control methods have been proposed, they often pose environmental and biodiversity risks.

Design and numerical simulation of a semi-cast-in-situ synthetic material sports surface on shock absorption performance optimization.

The persistent issue of moisture-induced "heave" in synthetic sports surfaces can affect athlete safety and surface performance. The objective of the study was to design an innovative synthetic material athletic track structure that mitigates adhesive failure between the synthetic layer and the cement base due to underground moisture. The new structure ensures field safety and meets biomechanical requirements for performance and shock absorption.

The impact of China's super urban agglomeration strategy on industrial pollution.

This study examines the relationship between industrial agglomeration and industrial pollution. The empirical results for the entire sample show that industrial pollution has a significant spatial spillover effect. Specifically, for every 1% point increase in industrial pollution in neighboring regions, industrial pollution in the region increases by 0.

Optimizing the Electronic Structure of Iron Oxides via Nonmetallic Dopants for Enhanced Peroxidase Mimetic Catalysis.

Efficiently enhancing the activity and selectivity of targeted nanozymes is a challenging task, primarily due to the inherent structural stability and heterogeneous atomic composition of traditional nanozymes. Herein, theoretical design is carried out to select Fe-based oxides (FO) nanozymes with high peroxidase (POD)-like activity by incorporating different nonmetallic atoms (N, P, S, and B). Among these dopants, B emerged as a superior candidate because it could effectively tune the adsorption energies of *OH intermediates and *HO, thereby endowing the nanozymes with superior POD-like performance.

Structure-guided expansion strategy unveils potent allosteric SHP2 inhibitors with synergistic efficacy against AML through MCL-1 co-targeting.

SHP2, an oncogenic phosphatase pivotal in RAS-MAPK, PI3K-AKT, and JAK-STAT signaling, represents a compelling therapeutic target in malignancies driven by its hyperactivation. While allosteric inhibitors like SHP099 have overcome historical challenges of orthosteric agents by stabilizing SHP2's autoinhibited conformation, opportunities remain to enhance potency, selectivity, and clinical utility. Here, we report a structure-guided expansion strategy leveraging detailed profiling of the tunnel-shaped allosteric pocket to design next-generation inhibitors.

The effect of medroxyprogesterone acetate plus conjugated equine estrogens on lipoprotein(a) and apolipoprotein concentrations in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.

Objective: The influence of medroxyprogesterone acetate plus conjugated equine estrogens (MPA/CEE) on apolipoproteins and lipoprotein(a) levels has been vastly studied with inconsistent results. These inconsistencies could be attributed to several factors, such as the characteristics of the included participants and dosage and duration of intervention, among others. This study was conducted to determine the impact of MPA/CEE on the lipoprotein(a) and apolipoprotein concentrations in the postmenopausal women through a systematic review and meta-analysis of randomized controlled trials (RCTs).

Dynamic eIF3-S6 Phase Separation Switch Instructed by mA Modification Drives the Molting of Locusts.

Molting is critical for the development and growth of insects. A central juncture in molting is the periodic and coordinated regulation of molting-responsive mRNAs, which are essential for degrading the old cuticle and forming a new one. Knowledge is lacking of how molting-responsive molecules function cooperatively and timely.

[A large family of Nascimento form of syndromic X-linked intellectual developmental disorder caused by large segment deletion of the gene: a case report and literature review].

This article reports the clinical features and gene mutation types of a large family with Nascimento form of syndromic X-linked intellectual developmental disorder (MRXSN), involving 9 individuals across 3 generations, and a literature review was conducted. In this family, 9 individuals had similar manifestations including mental retardation and unusual facies, and 4 of them had passed away. Genetic testing showed that the proband had the deletion of exons 2-3 of the gene, which was inherited from the mother.

[Effects of and gene polymorphisms on plasma concentrations and toxicity following high-dose methotrexate therapy in children with acute lymphoblastic leukemia].

Objectives: To investigate the effects of methylenetetrahydrofolate reductase () rs1801133 and γ-glutamyl hydrolase () rs11545078 gene polymorphisms on plasma concentrations and toxicity following high-dose methotrexate (MTX) therapy in children with acute lymphoblastic leukemia (ALL).

Methods: Children with ALL treated at the Xuzhou Children's Hospital of Xuzhou Medical University from January 2021 to April 2024 were selected for this study. Genotypes of rs1801133 and rs11545078 were determined using multiplex polymerase chain reaction.

Colletotridemin A and Three New Botrydial Sesquiterpenoids From Fungus Colletotrichum dematium.

One new bicyclic sesterterpene, colletotridemin A (1), and three new botrydial sesquiterpenoids (3-5), along with 11 identified compounds (2, 6-15) separated from the plant-associated fungus Colletotrichum dematium. Electronic circular dichroism (ECD) and spectroscopic analyses (NMR and HR-ESI-MS) were conducted to characterize the structures and their absolute configurations. All compounds were assessed for their α-glucosides and cytotoxic activities.