The effect of medroxyprogesterone acetate plus conjugated equine estrogens on lipoprotein(a) and apolipoprotein concentrations in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.

Objective: The influence of medroxyprogesterone acetate plus conjugated equine estrogens (MPA/CEE) on apolipoproteins and lipoprotein(a) levels has been vastly studied with inconsistent results. These inconsistencies could be attributed to several factors, such as the characteristics of the included participants and dosage and duration of intervention, among others. This study was conducted to determine the impact of MPA/CEE on the lipoprotein(a) and apolipoprotein concentrations in the postmenopausal women through a systematic review and meta-analysis of randomized controlled trials (RCTs).

Retraction: MicroRNA-377-3p targeting MMP-16 inhibits ovarian cancer cell growth, invasion, and interstitial transition.

[This retracts the article DOI: 10.21037/atm-20-8027.].

Deep Learning-Guided Quantitative Analysis Establishes Optimized BRAF V600E Immunohistochemical Criteria for Colorectal Cancer: A Multiplatform Validation Study.

Accurate detection of BRAF V600E mutation is critical for guiding therapeutic strategies. Unlike other solid tumors, colorectal cancer (CRC) lacks reliable immunohistochemical (IHC) interpretation criteria. This study aimed to establish CRC-specific IHC criteria through quantitative analysis.

Determination of optimal dietary calcium levels under different zinc sources in Jing Tint 6 layer chicks from hatch to day 14.

An experiment was conducted to investigate the optimal dietary calcium (Ca) levels in Jing Tint 6 layer chicks fed different sources of zinc (Zn). A total of 1440 day-old birds with similar body weight (38 ± 0.5 g) were selected and divided into 10 groups with 6 replicates per group, each containing 24 chicks.

Assessment of the combined response of heavy metals and human pathogens to different additives during composting of black soldier fly manure.

The bioconversion of black soldier fly (BSF) is a new model of livestock manure resourcing. However, the biochemical properties of BSF manure are unstable and direct application can be harmful to crops. Therefore, the effect of additives (biochar, humic acid and tea residue) on the removal of heavy metals and pathogens from BSF compost was investigated.

Future Habitat Shifts and Economic Implications for Under Climate Change.

is a vital and unique traditional medicine native to the Tibetan Plateau (TP) and its adjacent regions. Its habitat has significantly diminished in recent years due to commercial harvesting and climate change. Although studies on the habitat of have been conducted, the impact of climate change on its future habitat and economy remains unclear.

Association between secondhand smoke exposure and osteoporosis risk in postmenopausal women: a cross-sectional analysis of NHANES data.

Background: This study aimed to investigate the association between smoke exposure and the risk of osteoporosis in postmenopausal women in the United States, using data from the National Health and Nutrition Examination Survey (NHANES).

Methods: A cross-sectional analysis was conducted using NHANES data from 2005 to 2010, 2013 to 2014, and 2017 to 2018. The study population consisted of postmenopausal women aged 18 years and older.

Elevational dynamics of vegetation changes in response to climate change on the Tibetan plateau.

Understanding long-term vegetation dynamics is essential for assessing ecosystem responses to climate change, particularly in ecologically sensitive regions like the Tibetan Plateau. While numerous studies have analyzed vegetation changes on the Tibetan Plateau from 1982 to 2015 using remote sensing data, most have been limited by insufficient temporal coverage and low-resolution datasets, constraining the accuracy of trend detection and driver analysis. To address this gap, we utilize a high-resolution Normalized Difference Vegetation Index (NDVI) dataset, generated by merging GIMMS and SPOT data via the Extended Observation Time (EOT) algorithm, to investigate vegetation trends, breakpoints, and their climatic drivers over 34 years, with a specific focus on elevation effects.

genus: a comprehensive review of its botany, ethnomedicinal values, phytochemistry, pharmacology, toxicology and clinical studies.

Background: The genus, comprising 66 species in the Boraginaceae family, has a history of ethnomedicinal use for various ailments. This review focuses on the botany, traditional uses, phytochemistry, pharmacology, toxicology, clinical studies, cultivation, and commercial potential of the genus, with the goal of enhancing current research and applications.

Methods: Literatures related to species were compiled using keywords such as "," "traditional use," "chemical constituents," and "bioactivity" from scientific databases, including "China Knowledge Resource Integrated Databases (CNKI)," "Flora of China," "Google Scholar," "Hunan Library," "Plants of the World Online," and "Web of Science" and so on.

Effect of Hemp Seed Oil on Milk Performance, Blood Parameters, Milk Fatty Acid Profile, and Rumen Microbial Population in Milk-Producing Buffalo: Preliminary Study.

Vegetable oils rich in unsaturated fatty acids have been shown to improve animal health and enrich milk with functional fatty acids in various studies. This study investigates the effects of dietary supplementation with hemp seed oil (HSO), a native vegetable oil from the "longevity village" of Bama (Guangxi, China), on the milk performance, milk fatty acid composition, blood indicators, and rumen bacterial community of milk-producing buffalo. Seventeen healthy, four-year-old, crossbred, milk-producing buffaloes with the same parity (three), as well as similar body weights (BW = 580 ± 25 kg), number of days producing milk (DIM, 153 ± 10 d), and milk yields (8.

Study on the effects of Massa Medicata Fermentata with different formulations on the intestinal microbiota and enzyme activities in mice with spleen deficiency constipation.

Objective: This study aims to explore the therapeutic mechanism of Massa Medicata Fermentata (MMF) with different formulations on spleen deficiency constipation in mice by analyzing gastrointestinal hormones, D-xylose, intestinal microbiota, and intestinal enzyme activities.

Methods: A spleen deficiency constipation model was established using an oral administration of Sennae Folium decoction combined with controlled diet and water intake. After successful model establishment, the mice with spleen deficiency constipation were treated with MMF S1, S2, S3.

Gut protects against fat deposition by enhancing secondary bile acid biosynthesis.

Gut microbiome is crucial for lipid metabolism in humans and animals. However, how specific gut microbiota and their associated metabolites impact fat deposition remains unclear. In this study, we demonstrated that the colonic microbiome of lean and obese pigs differentially contributes to fat deposition, as evidenced by colonic microbiota transplantation experiments.

Gastrointestinal microbiota and metabolites responses to dietary cereal grains in an adult pig model.

Corn (C), wheat (W), and paddy rice (PR) are important energy sources and are commonly used in feed production for swine. This study mainly focuses on the variation and regularities of microbiota and metabolites in the gastrointestinal tract (GIT) of pigs in response to C, W, and PR. A total of 18 pigs were allotted into three dietary groups with six replicated pigs and received diets containing C, W, or PR as the sole energy source, respectively.

The Role of Iron in Intestinal Mucus: Perspectives from Both the Host and Gut Microbiota.

Although research on the role of iron in host immunity has a history spanning decades, it is only relatively recently that attention has been directed toward the biological effects of iron on the intestinal mucus layer, prompted by an evolving understanding of the role of this material in immune defense. The mucus layer, secreted by intestinal goblet cells, covers the intestinal epithelium, and given its unique location, interactions between the host and gut microbiota, as well as among constituent microbiota, occur frequently within the mucus layer. Iron, as an essential nutrient for the vast majority of life forms, regulates immune responses from both the host and microbial perspectives.

Determination of optimal dietary calcium levels under different sources of zinc in Jing tint 6 layer chicks from 15 to 42 d of age.

An experiment was conducted to investigate the optimal dietary calcium (Ca) levels in Jing Tint 6 layer chicks fed different sources of zinc (Zn). The diets were formulated using 2 different Zn sources: organic Zn (80 mg/kg Zn as HMZn) and inorganic Zn (80 mg/kg Zn as sulfate). For each Zn source, 5 diets were formulated to contain Ca levels of 0.

Assessment of Non-Phytate Phosphorus Requirements of Chinese Jing Tint 6 Layer Chicks from Hatch to Day 42.

We aimed to estimate the non-phytate phosphorus (NPP) requirements of Chinese Jing Tint 6 layer chicks. We randomly allocated 720 birds to five treatments with six cages of 24 birds each, feeding them a corn-soybean diet containing 0.36%, 0.

Using mobile phone big data to discover the spatial patterns of rural migrant workers' return to work in China's three urban agglomerations in the post-COVID-19 era.

Knowing how workers return to work is a key policymaking issue for economic recovery in the post-COVID-19 era. This paper uses country-wide time-series mobile phone big data (comparing monthly and annual figures), obtained between February 2019 and October 2019 and between February 2020 and October 2020, to discover the spatial patterns of rural migrant workers' (RMWs') return to work in China's three urban agglomerations (UAs): the Beijing-Tianjin-Hebei Region, the Yangtze River Delta and the Pearl River Delta. Spatial patterns of RMWs' return to work and how these patterns vary with location, city level and human attribute were investigated using the fine-scale social sensing related to post-pandemic human mobility.

Ferrous-sucrose complex supplementation regulates maternal plasma metabolism and the fecal microbiota composition and improves neonatal immunity and placental glucose transportation by activating the EGF/PI3K/AKT signaling pathways in sows.

Pregnancy is a dynamic state involving rapid physiological changes in metabolism, affecting the health and development of the offspring. During pregnancy, the placenta constitutes a physical and immunological barrier to provide fetal nutrition through the maternal blood and prevent the exposure of the fetus to dangerous signals. Metabolic changes in the plasma, the fecal microbiota profile, and functional regulation in the placenta were studied in sows supplied with a ferrous-sucrose complex (FeSuc) from late gestation to parturition.

Dynamic changes in butyrate levels regulate satellite cell homeostasis by preventing spontaneous activation during aging.

The gut microbiota plays a pivotal role in systemic metabolic processes and in particular functions, such as developing and preserving the skeletal muscle system. However, the interplay between gut microbiota/metabolites and the regulation of satellite cell (SC) homeostasis, particularly during aging, remains elusive. We propose that gut microbiota and its metabolites modulate SC physiology and homeostasis throughout skeletal muscle development, regeneration, and aging process.