Fault Diagnosis Method of Planetary Gearboxes Based on Multi-Scale Wavelet Packet Energy Entropy and Extreme Learning Machine.

As critical components of planetary gearboxes, gears directly affect mechanical system reliability when faults occur. Traditional feature extraction methods exhibit limitations in accurately identifying fault characteristics and achieving satisfactory diagnostic accuracy. This research is concerned with the gear of the planetary gearbox and proposes a new approach termed multi-scale wavelet packet energy entropy (MSWPEE) for extracting gear fault features.

Profiling characteristics of plasma exosomal miRNAs across cognitive stages: from normalcy to mild cognitive impairment and Alzheimer's disease.

The rising global prevalence of Alzheimer's disease (AD) and mild cognitive impairment (MCI) underscores the urgent need to elucidate their underlying pathogenic mechanisms. This study investigated the dynamic alterations of plasma-derived exosomal miRNAs across the cognitive spectrum from normal cognition (NC) through MCI to AD, and their potential pathogenetic implications. Here, we enrolled 10 AD patients, 9 MCI patients, and 10 normal cognitive (NC) patients rigorously diagnosed using amyloid PET imaging, cerebrospinal fluid biomarkers, and standardized neuropsychological assessments.

Comparison and prognostic analysis of focal segmental glomerulosclerosis patients with or without nephrotic syndrome at onset.

Background: Focal segmental glomerulosclerosis (FSGS) constituted one of the most common causes of end-stage kidney disease. We aimed to compare the presentation and prognosis for FSGS patients based on whether they met the criteria of nephrotic syndrome (NS) at disease onset.

Methods: Retrospective analysis of 291 treatment-naïve adult FSGS patients managed per clinical guidelines.

Curcumin-loaded polydopamine nanoparticles-based antioxidant scaffold promote spinal cord repair though dural-regulation of macrophage polarization.

Severe spinal cord injury (SCI) disrupts neuronal circulation and results in irreversible motor function loss. Treating SCI is a major challenge due to the limited regenerative capacity of axons and the inflammatory environment that hinders recovery. Macrophages play a dual role in SCI, with their polarization determining whether they exacerbate the injury or promote tissue repair.

High-strength chitosan-sericin cryogel with synergistically reinforced networks for hemostasis.

Developing chitosan-based hemostatic cryogels with simultaneously excellent mechanical properties and good biocompatibilities is still a challenge yet crucial for hemostasis of deep tissue bleeding. Typical approaches to enhancing the mechanical properties sacrifice biocompatibility of chitosan cryogels, thereby increasing the potential application risk. In this study, we develop a chitosan-sericin-ε-polylysine (CS-Ser-EPL) cryogel with synergistically reinforced networks achieved by physical and chemical crosslinking to address the limitations.

A highly scalable deep learning language model for common risks prediction among psychiatric inpatients.

Background: There is a lack of studies exploring the performance of Transformers-based language models in common risks assessment among psychiatric inpatients. We aim to develop a scalable risk assessment model using multidimensional textualized data and test the stability, robustness, and benefit of this approach.

Methods: In this real-world cohort study, a deep learning language model was developed and validated using first hospitalized cases diagnosed with schizophrenia, bipolar disorder, and depressive disorder between January 2016 and March 2023 in three hospitals.

Performance and Life Prediction of Recycled Concrete Against Sulfate Dry-Wet Cycle Corrosion.

To investigate the sulfate resistance of recycled concrete with composite admixtures under dry-wet cycling, a single-factor experimental design was first conducted to study the deterioration patterns of recycled concrete with single and composite admixtures (ground granulated blast furnace slag (GGBS) and fly ash) under sulfate attack. Based on the single-factor test results, orthogonal experiments were designed with composite admixtures as one influencing factor. Quantitative analysis was performed to determine the impact magnitude and significance of various factors on the sulfate resistance of recycled concrete at different corrosion ages.

Causal link between mental disorders and gastrointestinal diseases: a Mendelian randomization study.

Background: Observational research suggests that mental diseases may increase the risk of gastrointestinal diseases. However, the causal link between these conditions remains unclear. In this study, we conducted a two-sample Mendelian randomization (MR) analysis to investigate the causal associations between common mental diseases and the risk of gastrointestinal diseases.

Future Habitat Shifts and Economic Implications for Under Climate Change.

is a vital and unique traditional medicine native to the Tibetan Plateau (TP) and its adjacent regions. Its habitat has significantly diminished in recent years due to commercial harvesting and climate change. Although studies on the habitat of have been conducted, the impact of climate change on its future habitat and economy remains unclear.

Effects of Packet Loss on Neural Decoding Effectiveness in Wireless Transmission.

Background: In brain-computer interfaces, neural decoding plays a central role in translating neural signals into meaningful physical actions. These signals are transmitted to processors for decoding via wired or wireless channels; however, they are often subject to data loss, commonly referred to as "packet loss". Despite their importance, the effects of different types and degrees of packet loss on neural decoding have not yet been comprehensively studied.

Elevational dynamics of vegetation changes in response to climate change on the Tibetan plateau.

Understanding long-term vegetation dynamics is essential for assessing ecosystem responses to climate change, particularly in ecologically sensitive regions like the Tibetan Plateau. While numerous studies have analyzed vegetation changes on the Tibetan Plateau from 1982 to 2015 using remote sensing data, most have been limited by insufficient temporal coverage and low-resolution datasets, constraining the accuracy of trend detection and driver analysis. To address this gap, we utilize a high-resolution Normalized Difference Vegetation Index (NDVI) dataset, generated by merging GIMMS and SPOT data via the Extended Observation Time (EOT) algorithm, to investigate vegetation trends, breakpoints, and their climatic drivers over 34 years, with a specific focus on elevation effects.

Assessing the impact of moxibustion on colonic mucosal integrity and gut microbiota in a rat model of cerebral ischemic stroke: insights from the "brain-gut axis" theory.

Objective: The aim of this study is to assess the impact of moxibustion on the colonic mucosal barrier and gut microbiota in a rat model of cerebral ischemic stroke (CIS).

Method: The CIS rat model was established using the modified Zea Longa suture method. Successfully modeled rats were randomly allocated into a model group and a moxibustion group, with a sham surgery group serving as the control.

In situ synthesis of silver nanoparticles on silk: producing antibacterial fabrics.

Herein, we explored an effective method for preparing silver nanoparticles (Ag NPs)-coated antibacterial silk fabrics. In particular, using amino acids and cellulose from silk as reducing agents and silver nitrate as a precursor, Ag NPs were synthesised in situ on the surface of silk without requiring additional reducing agents and catalysts. The surface morphology and chemical composition of the involved samples were characterised using techniques such as scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy.

Super Stable Coating Based on Ovalbumin and Tannic Acid for Hydrophilic and Antibacterial Functionalization of Polymer Materials.

Surface modification of polymer materials is crucial in the biomedical field, as it can endow materials with new properties, including high efficacy and durability and a low risk of infection. Here, we propose a simple, green, and reliable surface modification strategy using ovalbumin (OVA) and tannic acid (TA). The hydrogen bonds and hydrophobic interactions revealed between the OVA and TA molecules make the OVA/TA composite tenacious and stable.

Treatment of dye-containing wastewater using discarded animal blood-derived hemoglobin crystals.

Ever-expanding industrial and agricultural production has satisfied human needs but unfortunately causes serious environmental pollution. Pollutants such as dye-containing wastewater from the dye industry and animal blood waste from the meat industry impose heavy burdens on the environment and are difficult to treat. Here we demonstrate that hemoglobin crystals prepared from animal blood waste can effectively and selectively adsorb and remove organic pollutants from dye-containing wastewater.

Preventing inappropriate signals pre- and post-ligand perception by a toggle switch mechanism of ERECTA.

Dynamic control of signaling events requires swift regulation of receptors at an active state. By focusing on the Arabidopsis ERECTA (ER) receptor kinase, which perceives peptide ligands to control multiple developmental processes, we report a mechanism preventing inappropriate receptor activity. The ER C-terminal tail (ER_CT) functions as an autoinhibitory domain: Its removal confers higher kinase activity and hyperactivity during inflorescence and stomatal development.

Synthesis and Optoelectronic Characterizations of Conjugated Polymers Based on Diketopyrrolopyrrole and 2,2'-(thieno[3,2-b]thiophene-2,5-diyl)diacetonitrile Via Knoevenagel Condensation.

Conjugated polymers have attracted extensive attention as semiconducting materials in wearable and flexible electronics. In this study, we utilize atom-economical Knoevenagel reaction to construct two conjugated polymers, PTDPP-CNTT and PFDPP-CNTT, based on dialdehyde-thiophene/furan-flanked diketopyrrolopyrrole (DPP) and 2,2'-(thieno[3,2-b]thiophene-2,5-diyl)diacetonitrile (CNTT). The resulting polymers exhibited suitable highest occupied molecular orbital/lowest unoccupied molecular orbital (HOMO/LUMO) energy levels, small bandgaps, and broad UV-vis-NIR absorptions (≈400-1000 nm), endowing them with photothermal and balanced ambipolar semiconducting properties with hole and electron mobilities over 10 cmVs.

Belimumab versus telitacicept in sequential treatment after rituximab for refractory lupus nephritis: a real-world multicentre study.

Objective: Both belimumab and telitacicept are recognised blockers for B lymphocyte activation, both of which have been approved as add-on therapies for SLE in China. The aim of this study is to compare the efficacy of rituximab (RTX) followed by belimumab or telitacicept in a real-world cohort.

Methods: A total of 49 refractory lupus nephritis patients were enrolled from four independent centres, subsequently categorised into two treatment groups: belimumab group (n=35) and telitacicept group (n=14) based on their treatment following RTX.

A novel composite hydrogel matrix carrier guar gum@2-oxopropanoic acid sodium salt@konjac glucomannan for sensitive response to active mold and yeast.

The synergistic effect of natural guar gum (GG), konjac gum (KGM) and sodium 2-oxopropanoic acid sodium (2-OAS) to designed a novel physical cross-linked three-dimensional network structure GG@2-OAS@KGM as a carrier of active microorganisms for mold and yeast sensitive detection. At the ratio of 6:2:2 (w/w/w), GG@2-OAS@KGM possessed a uniform porous structure. After treatment for 120 h, the hydrogel exhibits higher water holding capacity (WHC, 71.

Comparations of efficacy and safety of rituximab, calcineurin inhibitors and cyclophosphamide in primary membranous nephropathy: a single-center retrospective analysis.

Background: To compare the efficacy and safety of rituximab (RTX), calcineurin inhibitor (CNI) and cyclophosphamide (CTX) plus glucocorticoids in the treatment of primary membranous nephropathy (PMN).

Methods: Totally 478 biopsy-proven PMN patients in single center were retrospectively included. After 1:1 propensity score matching (PSM), 258 patients were included in RTX, CNI or CTX group (86 patients in each group).

Efficacy and safety of 5-aminolevulinic acid photodynamic therapy in refractory genital lichen sclerosus.

Background: Genital lichen sclerosus (GLS) is a chronic inflammatory skin disease affecting the genital and anal areas. Treatment of refractory remains a challenge in clinical practice.

Objective: This study aimed to evaluate the efficacy and safety of 5-aminolevulinic acid photodynamic therapy (5-ALA PDT) for refractory GLS.