Intermittent pneumatic compression therapy for patients after arthroscopic release of post-traumatic elbow stiffness: A randomised controlled trial.

ObjectiveTo evaluate the efficacy of intermittent pneumatic compression therapy after arthroscopic release for post-traumatic elbow stiffness.DesignRandomised controlled trial.SettingSingle-centre trial conducted in Shanghai Sixth People's Hospital, Shanghai, China.

Resident Macrophage-Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor-Associated Nephrotoxicity.

Immune checkpoint inhibitors (ICIs) transform cancer therapy but are often associated with immune-related adverse events, including ICI-associated nephrotoxicity (ICI-AN). The mechanisms driving ICI-AN remain poorly understood, limiting diagnostic and therapeutic progress. This study integrates imaging mass cytometry, transcriptomics, and murine models to investigate the cellular and molecular mechanisms driving ICI-AN.

Plastic additive bisphenol S induces depression by promoting AZU1/CTSD proteins to mediate plasma-related proteins and metabolites: A comprehensive multi-omics analysis.

Background: The role of bisphenol S (BPS) in the pathogenesis of depression still unclear, particularly regarding its underlying mechanisms and causality.

Methods: In this study, network toxicology approaches were employed to explore the mechanisms underlying BPS-induced depression, and Mendelian randomization (MR) was utilized to validate the causal relationship between BPS-targeted proteins and depression. Clinical datasets were further analyzed to corroborate the identified proteins.

StMYB308L and its regulatory role in flavonoid biosynthesis pathways in potato.

Background: The potato (Solanum tuberosum L.) is a globally significant tuber crop, and colored potatoes, as a unique cultivar of potato, have garnered considerable attention from scholars in recent years.

Result: StMYB308L, belonging to R2R3-MYB, is 804 bp in length and encodes 267 amino acids, which are locatized in the nucleus.

Comparison and prognostic analysis of focal segmental glomerulosclerosis patients with or without nephrotic syndrome at onset.

Background: Focal segmental glomerulosclerosis (FSGS) constituted one of the most common causes of end-stage kidney disease. We aimed to compare the presentation and prognosis for FSGS patients based on whether they met the criteria of nephrotic syndrome (NS) at disease onset.

Methods: Retrospective analysis of 291 treatment-naïve adult FSGS patients managed per clinical guidelines.

Case Report: Achieving ankle joint stability through early intervention in an 8-year-old with congenital fibular hemimelia.

Introduction: Congenital Fibular Hemimelia (CFH), also known as congenital absence of the fibula, has an incidence of approximately 5.7-20 cases per million live births. Clinically, it manifests as partial or complete absence of the fibula, accompanied by tibial shortening and bowing, ball-and-socket or dish-shaped ankle joints, and tarsal anomalies.

A study on the effectiveness and safety of interventional embolization using drug-loaded microspheres in combination with sorafenib and envafolimab for intermediate and advanced renal cell carcinoma.

Objective: To investigate the effectiveness and safety of drug-loaded microsphere interventional embolization (D-TAE) in conjunction with sorafenib and envafolimab in the management of intermediate and advanced renal carcinoma.

Methods: 120 cases of intermediate and advanced renal cell carcinoma cured in the Oncology Department of our hospital from January 2022 to December 2023 were selected. Individuals in the combination group received D-TAE paired with sorafenib and envafolimab.

Normative isokinetic knee strength values and prediction models in non-athletic Chinese adults.

Background: Establishing normative isokinetic muscle strength values and prediction models for knee joints in non-athletic healthy Chinese adults aids in clinical assessments, diagnosis, and rehabilitation. However, there has been limited research on these normal reference values, particularly involving large sample cohorts. Therefore, this study aimed to develop normative reference values and predictive models for knee joint isokinetic muscle strength across different age groups and genders in non-athletic healthy Chinese adults.

Optimization of Ultrasonic-Enzymatic-Assisted Extraction of Flavonoids from Sea Buckthorn ( L.) Pomace: Chemical Composition and Biological Activities.

Sea buckthorn pomace (SBP) is a rich source of flavonoid compounds with potential healthy properties. This study optimized ultrasonic-enzymatic-assisted extraction (UEAE) of flavonoids from SBP and investigated its chemical composition and biological activities. Under the optimal conditions (pectinase addition of 1500 U/g, ultrasonic power of 300 W, ethanol concentration of 48%, liquid-solid ratio of 34:1, extract temperature of 50 °C, and extraction time of 28 min), the yield of SBP flavonoid extracts (SBFEs) was 21.

of negatively regulates drought tolerance in rice.

MADS-box transcription factors are important regulators of plant abiotic stress response. Despite the exceptional drought tolerance of , research on the MADS-box transcription factors governing simulate drought stress in this species are limited. In this study, overexpressing in rice resulted in reduced drought tolerance.

Predicting diabetic kidney disease with serum metabolomics and gut microbiota.

This study aims to identify biomarkers for reliably predicting diabetic kidney disease (DKD), systematically characterize serum metabolites and gut microbiota in DKD patients, and investigate the correlation between differential serum metabolites and gut microbiota. From September 2021 to January 2023, 90 subjects were recruited: 30 with DKD, 30 with type 2 diabetes mellitus (T2DM), and 30 normal controls (NCs). Serum metabolites, including 180 different metabolites, were analyzed using untargeted metabolomics UPLC-MS/MS, and gut microbiota were assessed via 16S rRNA sequencing.

The impact of intradialytic elastic band exercise on physical and cognitive abilities in patients on maintenance hemodialysis: a randomized controlled trial.

Exercise benefits patients on maintenance hemodialysis (MHD) by addressing complications and dysfunctions. Elastic band exercise is cost-effective, but its safety, efficacy, and feasibility during dialysis are not well-established. The aim of this study is to investigate the physical and mental effects of intradialytic elastic band exercise in patients on MHD.

Real-time frame-registered resonant fluorescence scanning laser ophthalmoscopy for quantifying static and dynamic cellular properties in the mouse retina: publisher's note.

This publisher's note contains a correction to Opt. Lett.50, 1329 (2025)10.

Flexible Pressure Sensors for Optimizing Pressure Garment Therapy in Periarticular Scar Treatment: Preclinical and Clinical Applications.

Pressure garment therapy is a common strategy for controlling hypertrophic scars; however, insufficient pressure due to reduced elasticity or joint movement limits its effectiveness around joints. The FlexiForce B201 pressure sensor offers precise pressure measurements, thereby demonstrating a promising solution. This study used a Bama pig scar model with an untreated group, a pressure garment group, and a pressure monitoring group that was treated with FlexiForce B201 sensors and pressure garments.

Change and significance of connexin 43 in saliva extracellular vesicles from oral lichen planus patients.

Objectives: This study aims to explore whether Connexin 43 (Cx43) in salivary extracellular vesicles (EVs) can serve as a biomarker for diagnosing oral lichen planus (OLP), an inflammatory oral mucosal disorder.

Design: The study assessed disease activity in OLP patients using the reticulum-erosion-ulcer disease activity score. Saliva EVs were isolated and purified with an EV Enrichment Kit.

Effects of long-term low-dose 2.45 GHz microwave electromagnetic radiation on vulnerable organs in humans: a retrospective study based on patients receiving microwave diathermies in the Department of Rehabilitation Medicine.

Purpose: To retrospectively observe the effects of long-term low-dose 2.45 GHz microwave electromagnetic radiation on human vulnerable organs.

Methods: This single-center, retrospective cohort study investigated patients who received long-term (20-100 times of microwave therapy within three months) low-dose (≤20 W) microwave therapy in our department five years ago.

Carbohydrate polymer-functionalized metal nanoparticles in cancer therapy: A review.

Metal nanoparticles have been emerged as promising candidates in cancer therapy because of their large surface area, optical properties and ROS generation. Therefore, these nanoparticles are able to mediate cell death through hyperthermia, photothermal therapy and ROS-triggered apoptosis. The various metal nanoparticles including gold, silver and iron oxide nanostructures have been exploited for the theranostic application.

Real-time frame-registered resonant fluorescence scanning laser ophthalmoscopy for quantifying static and dynamic cellular properties in the mouse retina.

Fluorescence labeling offers excellent contrast for cell imaging within living mouse eyes. High-speed, high-resolution imaging with a large field of view (FOV) is always desirable. A high-speed scanning laser ophthalmoscopy (SLO) system has been developed, equipped with real-time desinusoiding correction and frame registration for fluorescence imaging of mouse retinas.

Optimized Ni(II)-doping in Co(III)-based layered double hydroxides towards electrochemical oxygen evolution catalysis.

An OER catalyst showing both high activity and stability in promoting oxygen evolution is important for its practical application in electrochemical water-splitting. Here, we report the screening of such a catalyst by optimizing the Ni(II)-doping in Co(III)-based layered double hydroxides (LDHs). Such LDH samples tailored with Ni(II)-doping are prepared by an oxidative intercalation reaction where brucite-like Ni(II)Co(II)(OH) (0 ≤ ≤ 0.

Mobile-based in-home telerehabilitation compared with in-hospital face-to-face rehabilitation for elderly patients after total hip arthroplasty in China's level 1 trauma center: a noninferiority randomized controlled trial.

Background: Telerehabilitation is gaining popularity in European and American countries, but whether it can be successfully implemented in China still lacks support from clinical studies.

Objective: This trial aimed to determine if a home-based telerehabilitation method is clinically noninferior to standard in-hospital face-to-face rehabilitation for elderly patients with total hip arthroplasty (THA) in China.

Methods: This multicenter randomized controlled trial was conducted from January 2021 to June 2022 at The First Rehabilitation Hospital in Shanghai, Shanghai Jiao Tong University affiliated Sixth People's Hospital and Shanghai Tongji University affiliated Tenth People's Hospital.

The StbHLH47 transcription factor negatively regulates drought tolerance in potato (Solanum tuberosum L.).

Background: Drought stress is a major environmental constraint affecting crop yields. Plants in agricultural and natural environments have developed various mechanisms to cope with drought stress. Identifying genes associated with drought stress tolerance in potato and elucidating their regulatory mechanisms is crucial for the breeding of new potato germplasms.

Ginkgolic acid inhibits Ebola virus transcription and replication by disrupting the interaction between nucleoprotein and VP30 protein.

The Ebola virus, a filovirus, has been responsible for significant human fatalities since its discovery. Despite extensive research, effective small-molecule drugs remain elusive due to its complex pathogenesis. Inhibition of RNA synthesis is a promising therapeutic target, and the VP30 protein plays a critical role in this process.

Transcriptome sequencing and screening of anthocyanin related genes in purple potato tubers (Solanum tuberosum L.).

Background: Pigmented potatoes (Solanum tuberosum L.) are rich in anthocyanin, which have antioxidantiy and play an important role in health and medical. Nevertheless, the regulation mechanism of anthocyanins in purple potato at different growth stages remain unclear.

Does Early Continuous Passive Motion Improves Effectiveness of Physical Therapy After Arthroscopic Release of Elbow Contracture: A Prospective Randomized Trial.

Objective: The aim of the study is to investigate the effectiveness of early continuous passive motion combined with physical therapy compared to physical therapy alone as the rehabilitation protocol after the release of elbow contracture.

Design: In this randomized controlled trial, 61 patients were randomly assigned to two groups (31 in the early continuous passive motion with physical therapy group vs. 30 in the physical therapy group).