Effects of Dietary on Muscle Composition, Serum Biochemical Indicators, Antioxidant Capacity, Lipid Metabolism, and mTOR Signaling Pathway in Red Claw Crayfish ().

This study investigated the effects of dietary supplementation with varying levels (CK: 0.0 g/kg; RL: 0.1 g/kg; RM: 1.

JA Regulates Caffeine Biosynthesis in Tea Leaf for Resistance Against Fungal Infection and Antagonises With GA to Balance the Defence-Growth Trade-Off via CsDELLA-JAZ-MYC2-MYB184-TCS1 Module.

Caffeine is a defensive alkaloid primarily accumulated in tea leaves to defend against pathogens. But the regulatory mechanism for caffeine biosynthesis in response to fungal infection and the trade-off between specialised metabolite and plant growth remain elusive. Here, we report that jasmonic acid (JA)-regulated CsMYB184 is the key for caffeine biosynthesis in tea leaves.

Elucidating the therapeutic mechanisms of resveratrol in benign prostatic hyperplasia via an integrated strategy of network pharmacology, multi-omics and molecular biology.

Background: Benign prostatic hyperplasia (BPH) is a prevalent age-associated urological disorder marked by excessive proliferation of epithelial and stromal cells within the prostate. Resveratrol (Res), a naturally occurring polyphenol, has shown potential in treating various inflammatory and hyperproliferative disorders, yet its pharmacological mechanisms in BPH remain unclear.

Purpose: This study sought to comprehensively identify the therapeutic targets and signaling pathways underlying the protective effects of Res against BPH by combining network pharmacology, multi-omics analyses, molecular dynamics (MD), and experimental validation.

Efficient solar-to-thermal management on femtosecond laser composite fabrication of hierarchical Janus plates.

Photothermal conversion materials can efficiently convert solar energy into directly usable heat energy, thereby reducing carbon emissions. However, most photothermal conversion materials are complex to prepare and have a long cycle, and their photothermal performance is not ideal. These problems limit their practical application.

A dual-mode self-cleaning film for durable passive radiative cooling and solar heating.

Solar heating and radiative cooling offer sustainable pathways to address fossil energy demand. However, their single-mode operation and susceptibility to contamination restrict performance under varying daily and seasonal conditions. Herein, a superhydrophobic dual-mode thermal management film with combined cooling and heating features was developed.

Correction: Liu et al. Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy. 2025, , 43.

In the original publication [...

Dietary salt intake worsens the Th17-dependent inflammatory profile of patients with cirrhosis.

Background & AimsLiver cirrhosis is characterized by chronic inflammation and fibrosis, with Th17 cells playing a crucial role in its progression. Recent evidence suggests that dietary salt influences immune diseases by modulating Th17 differentiation. This study assessed the impact of dietary salt on Th17-driven inflammation in patients with compensated cirrhosis and explored its effects on liver injury in mouse models.

Non-traditional lipid parameters are independent predictors of the location, distribution, and stroke events of moderate-to-severe intracranial and extracranial atherosclerotic stenosis.

Objective: Moderate-to-severe stenosis has been identified as a significant risk factor for stroke recently. This study aims to investigate the relationship between non-traditional lipid parameters and the location and distribution of stenosis, as well as symptomatic events, in patients with moderate-to-severe intracranial atherosclerotic stenosis (ICAS) and extracranial atherosclerotic stenosis (ECAS).

Methods: This study analyzed correlation between non-traditional lipid parameters and moderate-to-severe ICAS and ECAS concerning stenosis location, distribution, and the presence or absence of symptoms.

Theoretical study of the breakdown of the Born-Oppenheimer approximation in the Cl(2P) + D2 (v = 0, j = 0 and 1) → DCl + D reaction.

In this study, we have employed the time-independent close-coupling method for comprehensive calculation of the state-to-state cross sections for the Cl(2P) + D2(v = 0, j = 0 and 1) reaction, including all couplings arising from the nonzero electronic orbital and spin angular momenta of the chlorine atom. The optimization of homonuclear exchange symmetry is incorporated in our calculation. The theoretical results clearly reveal the breakdown of the Born-Oppenheimer (BO) approximation, which is similar to that observed in the Cl + H2 reaction.

Discovery of metabolic biomarkers for distinguishing LAA and SVO subtypes of acute ischemic stroke.

Acute ischemic stroke (AIS) subtypes exhibit distinct pathophysiological mechanisms. While current classification methods predominantly depend on neuroimaging, there remains a critical need for sensitive biomarkers to complement imaging and enhance early subtype identification in clinical settings. This study employed metabolomics to identify such biomarkers.

TNF-α modulates cell proliferation via SOX4/TGF-β/Smad signaling in benign prostatic hyperplasia.

Benign prostatic hyperplasia (BPH) is an age-related condition in men with a poorly defined etiology. Chronic inflammation is increasingly recognized as a key contributor to BPH progression; however, the underlying mechanisms remain incompletely understood. This study aimed to elucidate the role of a TNF-α-induced inflammatory microenvironment in regulating BPH progression.

Exploring the Impact of Constipation on Mental Health and Non-Motor Symptoms in Parkinson's Disease Patients: A Clinical and Mendelian Randomization Approach.

Background And Aims: Parkinson's disease (PD) patients frequently experience constipation and non-motor symptoms, significantly affecting their quality of life. Although constipation is common, its causal relationship with mental health issues, such as anxiety and depression, remains underexplored. This study aims to investigate the association between constipation severity, non-motor symptoms, and mental health outcomes in PD patients.

Femtosecond Laser Atomic-Nano-Micro Fabrication of Biomimetic Perovskite Quantum Dots Films toward Durable Multicolor Display.

Perovskite quantum dots (QDs) have emerged as revolutionary materials for next-generation display technologies due to their tunable bandgaps, high color purity, and low-cost fabrication. However, challenges persist in outdoor display applications, including poor stability, inadequate weatherability designs, and multicolor integration difficulties. This study proposes a bioinspired "atomic-nano-micro" fabrication strategy based on femtosecond laser direct writing (FsLDW).

Kirigami-Inspired Breathable Smart Contact Lens for Wireless Monitoring of Corneal Hypoxia and Microenvironment.

Severe corneal dysfunctions caused by corneal hypoxia and microenvironmental imbalance threaten hundreds of millions of people's eye health, leading to neovascularization, keratitis, and even vision loss, particularly among contact lens wearers. However, there are no accessible digital tools for wearable and continuous monitoring of corneal oxygen and microenvironment status. Here, a kirigami-inspired breathable smart contact lens for wireless monitoring of corneal hypoxia and microenvironment is presented.

Safety of Surgery within 24 h following Colonoscopy for Colorectal Cancer: A Retrospective Propensity Scores Matched Analysis.

Introduction: In clinical practice, clinicians often perform repeat colonoscopy before colorectal cancer (CRC) surgery to accurately assess tumor location, size, and the presence of other underlying lesions. No previous study has reported the safety of the interval from colonoscopy to laparoscopic CRC surgery on surgical outcomes. The purpose of this study was to evaluate the safety of the interval from colonoscopy to laparoscopic CRC surgery on surgical outcomes using propensity score matching (PSM).

US Food and Drug Administration's Advancing Real-World Evidence Program: Initial Experience.

Advances in the availability and analysis of real-world data (RWD) have enabled the generation of robust real-world evidence (RWE) to support regulatory decision making by the US Food and Drug Administration. Realizing the full potential of RWE in a regulatory environment requires cross-discipline expertise and collaboration to increase confidence in RWE-based approaches. The FDA's Advancing RWE Program was established to address this need by providing a new option for regulatory interactions on RWE-based approaches.

WGCNA analysis and identification of key genes in tobacco in response to different nitrogen levels.

Background: Nitrogen (N) supply directly impacts growth and quality in flue-cured tobacco. To decipher molecular responses to N gradients, we integrated transcriptomics and weighted gene co-expression network analysis (WGCNA) on leaves from four N treatments: 0 (inherent soil fertility), 60 (low), 105 (standard), and 150 kg/hm (high).

Results: Phenotypic analysis revealed dose-dependent increases in leaf nitrogen content with higher N application, accompanied by excessive vegetative growth and delayed maturity at 150 kg/hm.

Incidence of major urological cancers in patients on dialysis: a systematic review and meta-analysis.

Background: Studies have demonstrated an elevated risk of urological malignancies in individuals undergoing dialysis, which consequently leads to unfavorable prognoses and diminished quality of life for patients with end-stage kidney disease. Nevertheless, the absence of standardized recommendations for cancer screening and limited utilization of conventional screening methods within the dialysis population remain prevalent issues.

Methods: A meta-analysis was conducted on cohort studies published prior to June 2024, aiming to quantify the cancer risk among individuals undergoing dialysis.

All-Season Passive Thermal Management Film with Multifunctionality for Efficient Radiative Cooling and Solar Heating.

Thermal radiation management is an important aspect of thermal engineering and plays a crucial role in various industrial and environmental applications. However, either cooling or heating devices alone can exacerbate all-season consumption during hot summers or cold winters. We have designed a dual-mode thermal management device that can switch modes by a pull-out method, with femtosecond laser-induced graphene (LIG) on the surface of a polyimide membrane as the heating surface and a SiO hollow microsphere coating as the cooling surface.

Antiviral Therapy-Induced Changes in Long Non-Coding RNA Expression Profiles in Umbilical Cord Blood and Placental Tissues of Hepatitis B Virus-Infected Pregnant Women.

Background: Hepatitis B virus (HBV) is a major global health concern, with maternal-fetal transmission being the primary route of transmission, which can lead to chronic HBV infection in newborns. Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation and immune responses, but their involvement in HBV transmission during pregnancy remains unclear. This study aimed to assess the impact of tenofovir disoproxil fumarate (TDF)-based antiviral therapy on lncRNA expression profiles and immune signaling pathways in umbilical cord blood and placental tissues and to identify potential therapeutic targets for preventing intrauterine HBV infection.

The Impact of Increasing Subjective Economic Inequality on Prosocial Behavior Development: The Longitudinal Mediating Effect of Trust and Moderating Effect of Socioeconomic Status.

While the adverse effects of economic inequality on prosocial behavior have been well-documented, the dynamic processes and underlying mechanisms during emerging adulthood remain equivocal. Whether this relation is consistent across different socioeconomic status groups also awaits to be unveiled. To address these gaps, this three-year longitudinal study shed light on the developmental nature of subjective economic inequality, trust, as well as prosocial behavior, and the nuance within such associations across low- and high-socioeconomic status groups.

Rapid detection of the c.235delC mutation based on CRISPR-Cas13a combined with lateral flow dipstick.

Hereditary hearing loss, an auditory neuropathy disorder, is characterized by its high prevalence and significant impact on the quality of life of those affected. In Chinese populations, the most prevalent gap junction beta-2 () mutation hotspot is c.235delC.

CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier.

: Cathartic colon (CC) is a type of slow-transit constipation caused by a patient's long-term use of irritating laxatives. Probiotics play a crucial role in managing constipation. : This study aims to identify probiotics that can alleviate CC and explore their specific mechanisms of action.

Nitric oxide enhances copper tolerance by regulating cell wall composition and copper transporting-related transcripts in cotton roots.

Little is known about nitric oxide (NO)-mediated cotton plants' response to copper (Cu) stress and the underlying tolerance mechanism. It was hypothesized that NO can alleviate Cu toxicity to cotton roots by regulating the root cell wall composition and the transcription of Cu ion transporting-related genes. Cu stress significantly increased NO synthase (EC 1.