A Synergistic 3D-Printed Collar Transforms Radiofrequency Ablation Into Potent Thermal Immunotherapy for Lung Cancer.

Interventional thermal therapy, such as radiofrequency ablation (RFA), is a preferred therapy for non-small cell lung cancer (NSCLC) patients. However, part of some patients will still suffer from tumor recurrence due to incomplete ablation (e.g.

Solar-Driven Atmospheric Water Production Through Hierarchically Ordered Porous Carbon for Self-Sustaining Green Hydrogen Production.

Green hydrogen production by proton exchange membrane water electrolysis (PEMWE) powered by clean energy is a promising and environmentally friendly technology. However, it relies on a high-purity water source, which is limited in regions facing water scarcity. Here, a coupled self-sustaining solar-enabled system is reported that couples atmospheric water harvesting with PEM water electrolysis (AWH-PEMWE), offering a novel pathway for clean water generation and green hydrogen production.

Photocatalytic Aminative Suzuki-Miyaura C(sp)-N-C(sp) Cross-Coupling.

This study introduces a photoinduced Suzuki-Miyaura C(sp)-C(sp) coupling protocol in which the introduction of a nitrene reagent efficiently redirects the conventional C(sp)-C(sp) linkage toward a C(sp)-N-C(sp)-bridged architecture. A total of 432 reactions were conducted using a high-throughput screening strategy to identify the optimal parameters. This strategy exhibits mild conditions, convenient operation, and good functional group tolerance, meanwhile establishing a solid foundation for further developing novel catalytic systems of cross-coupling reactions.

Effects of α-amylase supplementation on production performance, blood metabolites, nutrient digestibility, and rumen fermentation parameters of Holstein dairy cows in late lactation.

Current research on dairy cows primarily focuses on peak lactation, with limited exploration of late lactation. This study investigated the effects of α-amylase supplementation on production performance, blood metabolites, nutrient digestibility, and rumen fermentation in late-lactation Holstein cows. Thirty cows (average milk yield: 37.

ALKBH5 regulates ACSL4 to sensitize erastin-induced ferroptosis via YTHDF2-dependent mA modification in hypoxic pulmonary hypertension.

Hypoxic pulmonary hypertension (HPH) is a common complication derived from chronic hypoxic lung diseases and is characterized by excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) and obvious pulmonary vascular remodeling (PVR). Despite recent advances, the clinical outcome is still unsatisfactory. Ferroptosis, a newly identified form of programmed cell death, has been reported to participate in cardiovascular disease progression; however, its role in HPH remains undefined.

Strategic energy-level modulation in porous heterojunctions: advancing gas sensing through Type-I to Type-II transitions.

To significantly enhance reaction efficiency of porous heterojunctions in various applications, precise engineering of customization heterostructures through energy-level modulation is indispensable. Herein, the preparation of a core-shell porous heterojunction, UiO-66@TDCOF, is reported. Taking advantage of adjustable structure of metal-organic frameworks (MOFs), the energy-level of UiO-66 core is tailored to precisely align with that of porphyrin-based covalent organic framework (denoted as TDCOF) shell.

Enhanced LDL uptake and PPARα signaling support OSCC cell survival under glutamine deprivation.

Oral squamous cell carcinoma (OSCC) urgently requires innovative therapeutic strategies due to its severity and stagnant five-year survival rate. Targeting glutamine metabolism, a promising approach, is hampered by tumor cells' profound metabolic plasticity. Through a series of experiments, we uncovered heterogeneous responses of OSCC cell lines to glutamine deprivation: While most cells maintained growth, HSC3 cells showed a marked reduction in proliferation.

GPR39 Activation Attenuates AngII-Induced Abdominal Aortic Aneurysm by Suppressing ETS-1 Mediated VEGF-A/VEGFR2 Signalling.

Abdominal aortic aneurysm (AAA), a vascular condition that endangers life, is typified by the progressive weakening and dilation of the aortic wall. In its pathogenic process, oxidative stress and angiogenesis assume crucial functions. This research explored the function of G protein-coupled receptor 39 (GPR39) in angiotensin II (AngII)-induced AAA in ApoE-/- mice and its underlying mechanisms.

Balancing Learning Plasticity and Memory Stability: A parameter space strategy for class-incremental learning.

The objective of Continual Learning(CL) is to maintain both the learning plasticity and memory stability of a model, allowing it to continuously acquire new knowledge over time while ensuring robust retention of previously learned knowledge. However, existing CL methods primarily focus on memory stability, preventing catastrophic forgetting (CF) of knowledge from earlier tasks, while overlooking efficient learning of new tasks. In this paper,we propose a parameter-space decomposition method to Balanced Learning Plasticity and Memory Stability (BLPMS), dividing the model into sub-networks for each task by parameter isolation, further decomposing each sub-network into task-general and task-specific parameter spaces.

Phase transitions in retrofitting urban drainage systems: a computational framework for adaptation-sustainability trade-offs.

Climate change is compelling nations to invest heavily in retrofitting urban drainage systems (UDSs). However, limited information can lead to inefficient resource allocation, exacerbating the redundancy-efficiency dilemma. Traditional decision-making methods, such as multi-objective optimization, fail to capture the nonlinear evolution of adaptation, as they are constrained by static scenarios and lack the flexibility to accommodate multiple adaptation pathways.

Sweetened beverage intake and incident gastroesophageal reflux disease in a prospective cohort study.

Purpose: Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder with rising prevalence globally. Emerging evidence suggests that dietary factors, including the intake of sweetened beverages, may influence the risk of GERD. Uncertainty surrounds the relationship between various sweetened beverage kinds and GERD incidents, though.

Failure to Restore Normal Trochlear Orientation Does Not Affect Postoperative Patella-Related Outcomes in Robotic-Assisted Functional Alignment Total Knee Arthroplasty.

Background: This study evaluated the restoration of trochlear orientation following primary functional alignment (FA) total knee arthroplasty (TKA) using an image-based robotic-assisted system and investigated the relationship between trochlear orientation and clinical outcomes.

Methods: This retrospective study included 110 robotic-assisted TKAs performed between September 2021 and October 2023. The average age of this cohort was 67 ± 8.

Crosstalk of glutamine metabolism between cancer-associated fibroblasts and cancer cells.

Glutamine (Gln), a critical metabolic substrate, fuels the uncontrolled proliferation of cancer cells. Cancer-associated fibroblasts (CAFs), essential components of the tumor microenvironment, facilitate tumor progression by supplying Gln to cancer cells and driving drug resistance through metabolic reprogramming. This review highlights the key processes of Gln uptake, transport, and catabolism and explores the metabolic crosstalk between CAFs and cancer cells.

Mineralized collagen-enhanced bone cement: A prospective, randomized controlled trial in total knee arthroplasty.

Total knee arthroplasty (TKA) is a common procedure for end-stage osteoarthritis (OA). Traditional polymethylmethacrylate (PMMA) bone cement used in TKA has limitations, including lack of osteointegration and higher modulus than bone. We developed a novel bone cement, mineralized collagen (MC)-PMMA, to address these issues.

Effects of Postpartal Relative Body Weight Change on Production Performance, Serum Biomarkers, and Fecal Microbiota in Multiparous Holstein Cows.

This study aimed to determine effects of postpartal relative body weight change (PRBWC) on production performance, serum biomarkers, and the relation between PRBWC and gastrointestinal microbiota. A total of 59 multiparous cows participated in this research. Every cow's PRBWC was calculated by the following equation: PRBWC = (BW - BW)/BW × 100%, in which BW refers to body weight on Day 21 post-calving and BW refers to body weight on the day of parturition.

Delayed effects of the relative humidity on the outpatient visits of dry eye disease in Shanghai, China: effect modification by green and blue space.

Background: Few studies have examined the influence of relative humidity (RH) on dry eye disease (DED), particularly in the context of the urban environment. The objective of this study was to investigate the influence of RH on the frequency of outpatient visits for DED among patients residing in diverse urban settings.

Methods: Data pertaining to outpatient visits, together with data on the DED, meteorological factors and air pollutants in Shanghai for the period 2019-2023, were retrieved.

Higher Neutrophil-Percentage-to-Albumin Ratio Was Associated with Poor Outcome in Endovascular Thrombectomy Patients.

Background And Purpose: The neutrophil percentage-to-albumin ratio (NPAR) is connected with all-cause mortality and stroke-related pneumonia. The purpose of this study was to assess the diagnostic efficacy of NPAR in predicting functional outcomes at 90 days after endovascular thrombectomy (EVT).

Methods: We retrospective analyzed consecutive patients who underwent EVT at Nanjing First Hospital from October 2019 to June 2024.

A Mendelian randomization study on the causal association of circulating cytokines with diabetic nephropathy.

Background: Circulating cytokines were reported to be related to diabetic nephropathy (DN) in observational studies. However, the causal relationship between them remains unknown. This study aimed to investigate the causal relationship between DN and circulating cytokines with genetic data in the frame of Mendelian Randomization (MR).

Integrating Subacute Ruminal Acidosis, Lipopolysaccharide, and Trained Immunity: A Comprehensive Review.

Subacute ruminal acidosis (SARA) has emerged as a prevalent digestive disorder that significantly affects the overall health of ruminants, with notable links to various inflammatory diseases. Throughout the progression of SARA, elevated lipopolysaccharide (LPS) levels in the rumen play a crucial role in initiating the innate immune response. In this review, we evaluate the recent insights into the pathways associated with SARA-induced inflammatory responses, with a specific focus on LPS.

A novel CRISPR-Cas9 nickase-mediated rolling circle amplification (CRIRCA) technique for gene identification and quantitative analysis of extrachromosomal DNA.

Introduction: Extrachromosomal DNA (ecDNA) plays an important role in the initiation and progression of cancerous tumors. Although Circle-seq and other genetic technologies can be utilized for ecDNA analysis, they fail to provide multi-dimensional information from ecDNA, which is time-consuming and laborious.

Objectives: Herein, by combining the netlike rolling circle amplification (NRCA) with CRISPR, we developed a novel CRISPR-Cas9 nickase-mediated RCA (CRIRCA) technology that can meet the clinical analysis needs of ecDNA.

Comparison of the Efficacy of Three Intervention Schemes for Postpartum Pelvic Floor Muscle Hypertonia.

Purpose: To investigate the effects of three treatment regimens on postpartum pelvic floor muscle hypertonia.

Methods: One hundred sixty-five patients with postpartum pelvic floor muscle hypertension treated in a maternal and child health hospital from December 2023 to June 2024 were selected as the research participants. According to the random number table method, they were divided into group A, group B, and group C, with 55 cases in each group.

Multi-omics profiling of dairy cattle oxidative stress identifies hindgut-derived Phascolarctobacterium succinatutens exhibiting antioxidant activity.

An imbalance between oxidative and antioxidant processes in the host can lead to excessive oxidation, a condition known as oxidative stress (OS). Although changes in the hindgut microbiota have been frequently linked to OS, the specific microbial and metabolic underpinnings of this association remain unclear. In this study, we enrolled 81 postpartum Holstein cows and stratified them into high oxidative stress (HOS, n = 9) and low oxidative stress (LOS, n = 9) groups based on the oxidative stress index (OSi).

Robotic-assisted total knee arthroplasty provides better joint line and posterior condylar offset restoration than conventional total knee arthroplasty: a retrospective study of radiological outcomes.

To evaluate the radiologic outcomes between robot-assisted total knee arthroplasty (raTKA) and conventional total knee arthroplasty (cTKA), focusing on joint line height (JLH) and posterior condylar offset (PCO). This retrospective study analyzed 200 patients who underwent TKA from April 2020 to October 2024. In this study, a total of 200 patients were included, 79 raTKA patients matched with cTKA patients were divided into raTKA group and cTKA group.

Manipulation of Oxygen Tension in Damaged Regions via Hypoxia-Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration.

Disruption of low oxygen tension homeostasis during intervertebral disc degeneration inhibits endogenous stem cell viability and function, posing a challenge for endogenous regeneration. Here, to achieve sustained hypoxia manipulation, constructed hypoxia-inducible interpenetrating polymer network (IPN) hydrogel microspheres (HIMS) are constructed by microfluidics to integrate the hypoxic system with a stabilizing network. The IPN is synthesized through a two-step polymerization process, consisting of rapid photo-crosslinked gelatin methacrylate anhydride (GM) polymer I and slow enzyme-crosslinked vanillin-grafted gelatin (GV) polymer II.

Endothelial MICU1 protects against vascular inflammation and atherosclerosis by inhibiting mitochondrial calcium uptake.

Mitochondrial dysfunction fuels vascular inflammation and atherosclerosis. Mitochondrial calcium uptake 1 (MICU1) maintains mitochondrial Ca2+ homeostasis. However, the role of MICU1 in vascular inflammation and atherosclerosis remains unknown.