Low hemoglobin, albumin, lymphocyte, and platelet score increases symptomatic intracranial hemorrhage risk in thrombectomy patients.

Background: The HALP index, a composite biomarker integrating hemoglobin, albumin, lymphocyte, and platelet parameters, reflects both immunological competence and nutritional status. We therefore conducted this retrospective analysis to assess the correlation between HALP score and the risk symptomatic intracranial hemorrhage (sICH) risk in patients receiving mechanical thrombectomy (MT).

Methods: This retrospective study included patients with acute ischemic stroke due to anterior circulation large vessel occlusion who underwent MT between October 2019 and July 2024.

Characteristics and Outcomes of Fast Progressors Receiving Endovascular Treatment for Acute Large Vessel Occlusion: A Systematic Review and Meta-Analysis.

Introduction: Acute large vessel occlusion patients can be categorized into fast and slow progressors based on infarction growth rate (IGR) before endovascular treatment (EVT). However, the characteristics of fast progressors remain uncertain, and a comprehensive review investigating the adverse effects of fast IGR is needed.

Methods: A systematic search of studies published before March 24, 2025, was conducted using PubMed, Web of Science, Embase, and Cochrane Library following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.

Neurophysiological evidence of romantic love- and maternal love-specific vicarious risk and outcome processing during dynamic decision-making.

Vicarious decision-making is a fundamental to social interactions. Growing evidence suggests that the neural mechanisms underlying such decisions may vary according to interpersonal relationship types. However, the specific modulatory effects of romantic love on vicarious risk assessment and outcome evaluation during dynamic decision-making remain unclear.

Obesity-related alterations of intrinsic functional architecture: a resting-state fMRI study based on the human connectome project.

Background: Obesity, particularly in high-risk groups for food addiction, adversely impacts the brain's functional characteristics. However, its underlying neurobiological and molecular mechanisms remain elusive. The current study adopted a data-driven approach to investigate obesity-associated intrinsic functional architecture and neurotransmitter receptor patterns.

Association of biological age acceleration with poor outcome after endovascular thrombectomy.

Background: Accelerated aging is recognized as a risk factor for various chronic diseases and mortality. This study aimed to utilize phenotypic age to evaluate the role of biological age in clinical outcomes in ischemic stroke patients after endovascular thrombectomy (EVT).

Methods: We retrospectively enrolled patients from the prospectively maintained stroke registry admitted at 2 stroke centers in China.

A functional anatomical shift from the lateral frontal pole to dorsolateral prefrontal cortex in emotion action control underpins elevated levels of anxiety: partial replication and generalization of Bramson ., 2023.

Background: Emotion control represents a promising intervention target for mental disorders. In a recent study Bramson et al. (2023) demonstrate a functional-anatomical shift from the lateral frontal pole (FPl) to the dorsolateral prefrontal cortex (DLPFC) in anxious individuals during emotional action control.

Temporal variability-based alternations in dynamic functional networks in internet gaming disorder.

Background: Previous studies on resting-state functional connectivity (FC) in internet gaming disorder (IGD) have typically assumed that FC is static during the entire scan, neglecting the dynamic reorganization of brain networks. However, understanding the dynamic changes in functional networks is crucial for a comprehensive understanding of IGD, a complex and evolving disorder.

Methods: Resting-state fMRI data were collected from 269 participants (132 IGD subjects, male/female: 72/60, and 137 recreational game users (RGUs), male/female: 85/52).

Higher Neutrophil-Percentage-to-Albumin Ratio Was Associated with Poor Outcome in Endovascular Thrombectomy Patients.

Background And Purpose: The neutrophil percentage-to-albumin ratio (NPAR) is connected with all-cause mortality and stroke-related pneumonia. The purpose of this study was to assess the diagnostic efficacy of NPAR in predicting functional outcomes at 90 days after endovascular thrombectomy (EVT).

Methods: We retrospective analyzed consecutive patients who underwent EVT at Nanjing First Hospital from October 2019 to June 2024.

Infarct Growth Rate Predicts Early Neurological Improvement in Ischemic Stroke After Endovascular Thrombectomy.

Background And Purpose: The infarct growth rate (IGR) is a major modifier of the therapeutic effect of endovascular thrombectomy. The objective of this paper was to explore the utility of the IGR measured by perfusion the imaging in predicting early neurological improvement (ENI) of patients treated with EVT.

Methods: We reviewed consecutive large vessel occlusive stroke in the anterior circulation and treated by thrombectomy between October 2019 to July 2024.

Hypoxia tolerance and physiological coping strategies in fat greenling (Hexagrammos otakii).

Dissolved oxygen (DO) is necessary for fish survival and growth. This study investigated the hypoxia tolerance, hematological indexes, hepatic antioxidant capacity, and liver and gill morphological alternation of fat greenling during hypoxia stress. Changes in hematological parameters (cortisol, glucose, lactic acid, hemoglobin [Hb], hematocrit [Hct], and white blood cell [WBC], and red blood cell [RBC] numbers), hepatic antioxidant enzymes (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], catalase [CAT]), aminotransferase (AST), alanine aminotransferase (ALT) activities, and malondialdehyde (MDA) contents, and the histology of the liver and gill were evaluated under hypoxia stress and reoxygenation.

The Separation of Adult ADHD Inattention and Hyperactivity-Impulsivity Symptoms and Their Association with Problematic Short-Video Use: A Structural Equation Modeling Analysis.

Purpose: This study investigates the relationship between attention-deficit/hyperactivity disorder (ADHD) symptoms and problematic short-video use (PSVU) in adults, particularly focusing on the affective and cognitive processes that mediate this relationship. The research aims to clarify how different ADHD symptom domains, specifically inattention (IA) and hyperactivity-impulsivity (HI), contribute to PSVU.

Patients And Methods: The study recruited 563 Chinese college students (age: mean±SD = 19.

Determination of Stable Reference Genes for Gene Expression Analysis in Black Rockfish () Under Hypoxia Stress.

Background: Hypoxia triggers stress, leading to significant alterations in gene expression patterns, which in turn affect fish's growth and development. Real-time quantitative PCR (RT-qPCR) is a pivotal technique for assessing changes in gene expression. However, its accuracy is highly contingent upon the stable expression of reference genes.

Modulation of mitochondrial functions contributes to the protection of lamotrigine against Alzheimer's disease.

BackgroundOur previous studies have established that the broad-spectrum anti-epileptic drug lamotrigine (LTG) confers protection against cognitive impairments, synapse and nerve cell damage, as well as characteristic neuropathologies in APP/PS1 mice, a mouse model of Alzheimer's disease (AD). However, the precise molecular mechanisms responsible for this protective effect induced by LTG remain largely elusive.ObjectiveIn this study, we aimed to investigate the mechanisms underlying the beneficial effects of LTG against AD.

Early infarct growth rate is associated with symptomatic intracranial hemorrhage after endovascular thrombectomy.

Background: Time elapsed from stroke onset and baseline infarct volume is influential on endovascular thrombectomy (EVT) outcomes.

Objectives: This study aimed to explore the utility of early infarct growth rate (EIGR) measured by apparent diffusion coefficient (ADC) in predicting symptomatic intracranial hemorrhage (sICH) of ischemic stroke patients after EVT.

Methods: We retrospectively analyzed patients from the prospectively maintained stroke registry admitted between January 2019 and March 2023, presenting with large vessel occlusive stroke in the anterior circulation.

Alterations of gray matter asymmetry in internet gaming disorder.

Structural asymmetry is a subtle but pervasive property of the human brain, which has been found altered in various psychiatric and neurocognitive disorders. However, little is known regarding potential alterations of structural asymmetry underlying internet gaming disorder (IGD). Therefore, this study aimed to investigate the structural features of gray matter asymmetry in IGD.

Association between the serum glucose-to-potassium ratio and clinical outcomes in ischemic stroke patients after endovascular thrombectomy.

Background And Purpose: The baseline glucose-to-potassium ratio (GPR) is associated with poor outcomes in patients with acute brain injury and intracranial hemorrhage. However, the impact of serum GPR on clinical outcomes after endovascular thrombectomy (EVT) is unclear. This study aimed to evaluate the association between the GPR at admission and functional outcomes at 90 days after EVT.

Association between the atherogenic index of plasma and early neurological deterioration in mechanical thrombectomy patients.

Background And Purpose: Atherogenic index of plasma (AIP) is a newly identified as marker of lipid metabolism and glucose metabolism, showing significant predictive value in individuals with cardiovascular disease. This study aimed to explore the correlation between AIP and early neurological deterioration (END) in ischemic stroke patients after mechanical thrombectomy (MT).

Methods: Patients with anterior circulation large artery occlusive stroke who underwent MT were retrospectively enrolled from 2 stroke center in China.

Long-term hypoxia-induced physiological response in turbot Scophthalmus maximus L.

Hypoxia affects fish's survival, growth, and physiological metabolism processes. In this study, turbot plasma glucose and cortisol contents, hepatic glycolysis (hexokinase [HK], phosphofructokinase [PFK], pyruvate kinase [PK]) and lipolysis (fatty acid synthetase [FAS], lipoprotein lipase [LPL]) enzyme activities, anti-oxidant enzyme (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GSH-Px]) activities, malondialdehyde (MDA), lactate and glycogen contents, gill histological parameters (lamellar length [SLL], width [SLW], interlamellar distance [ID]), respiratory frequency (RF), the proportion of the secondary lamellae available for gas exchange (PAGE), and hifs (hif-1α, hif-2α, hif-3α) expression were determined during long-term hypoxia and reoxygenation. Results showed that long-term hypoxia (3.

Salvianolic acid A alleviates HO-induced endothelial oxidative injury via miR-204-5p.

Oxidative stress induced endothelial dysfunction plays a particularly important role in promoting the development of cardiovascular diseases (CVDs). Salvianolic acid A (SalA) is a water-soluble component of traditional Chinese medicine Salvia miltiorrhiza Bunge with anti-oxidant potency. This study aims to explore the regulatory effect of SalA on oxidative injury using an in vitro model of HO-induced injury in human umbilical vein endothelial cells (HUVECs).

Solid-liquid redistribution and degradation of antibiotics during hydrothermal treatment of sewage sludge: Interaction between biopolymers and antibiotics.

Waste activated sludge serves an important reservoir for antibiotics within wastewater treatment plants, and understanding the occurrence and evolution of antibiotics during sludge treatment is crucial to mitigate the potential risks of subsequent resource utilization of sludge. This study explores the degradation and transformation mechanisms of three typical antibiotics, oxytetracycline (OTC), ofloxacin (OFL), and azithromycin (AZI) during sludge hydrothermal treatment (HT), and investigates the influence of biopolymers transformation on the fate of these antibiotics. The findings indicate that HT induces a shift of antibiotics from solid-phase adsorption to liquid-phase dissolution in the initial temperature range of 25-90 °C, underscoring this phase's critical role in preparing antibiotics for subsequent degradation phases.

The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit.

Background: The involvement of specific basal ganglia-thalamocortical circuits in response inhibition has been extensively mapped in animal models. However, the pivotal nodes and directed causal regulation within this inhibitory circuit in humans remains controversial.

Objective: The main aim of the present study was to determine the causal information flow and critical nodes in the basal ganglia-thalamocortical inhibitory circuits and also to examine whether these are modulated by biological factors (i.

Relationship Between Liver Fibrosis and Increased Risk of Symptomatic Intracranial Hemorrhage in Ischemic Stroke Patients Undergoing Mechanical Thrombectomy.

Background: Liver fibrosis has been reported to be associated with hematoma expansion and mortality in patients with intracerebral hemorrhage. This study aimed to detect the association between liver fibrosis and symptomatic intracranial hemorrhage (sICH) in ischemic stroke after mechanical thrombectomy (MT).

Methods: We retrospectively included patients with large artery occlusion in the anterior circulation and treated with MT at a single stroke center.

Wavelength-Controlled Photoconductance Polarity Switching via Harnessing Defects in Doped PdSe for Artificial Synaptic Features.

Optoelectronic synapses are currently drawing significant attention as fundamental building blocks of neuromorphic computing to mimic brain functions. In this study, a two-terminal synaptic device based on a doped PdSe flake is proposed to imitate the key neural functions in an optical pathway. Due to the wavelength-dependent desorption of oxygen clusters near the intrinsic selenide vacancy defects, the doped PdSe photodetector achieves a high negative photoresponsivity of -7.