Lipid Metabolism and Immune Crosstalk in Fish Gut-Liver Axis: Insights from SOCS8 Knockout and Dietary Stress Models.

Metaflammation, a chronic immune response triggered by metabolic dysregulation, poses significant threats to gut-liver homeostasis in aquaculture species. To understand the progression of metaflammation, it is crucial to examine the role of SOCS8 deficiency in socs8 zebrafish, as this species may serve as a disease model for metabolic disorders due to the gradual dysregulation of immunity, metabolism, and the gut microbiota observed in them. This study examines the immune-metabolic crosstalk in grass carp, subjected to soybean meal-induced enteritis, and in socs8 zebrafish under genetic and dietary stress.

Ethanol Infusion of the Vein of Marshall in Catheter Ablation of Persistent Atrial Fibrillation in Patients with Mitral Valve Replacement.

Background: The effectiveness of ethanol infusion of the vein of Marshall (EIVOM) for persistent atrial fibrillation (AF) in patients with mitral valve replacement (MVR) remains to be determined.

Objectives: This study investigated the effectiveness and safety of EIVOM in catheter ablation of persistent AF in patients with MVR.

Methods: This is a retrospective case-control study.

The effect of the "Tears of Life" situational puzzle board game on death anxiety among nursing students: A randomized controlled trial.

Objectives: To examine the effects of death education using a situational puzzle board game versus reflective writing on nursing students' death anxiety, self-esteem and sense of meaning in life.

Background: Pre-clinical nursing students often exhibit high death anxiety due to limited clinical experience, potentially compromising future palliative care quality. Game-based learning shows promise in nursing education, warranting investigation for death education.

Mobile App-Assisted Self-Monitoring of Blood Glucose in Type 2 Diabetes in Ningbo, China: 12-Month Retrospective Cohort Study.

Background: Self-monitoring of blood glucose (SMBG) is recommended in clinical practice guidelines, including those in China, as part of patient education, self-management, and empowerment. With technological advancements, telecommunication technologies are now used for telemonitoring in health care. Mobile apps have become a practical tool for SMBG among patients with type 2 diabetes mellitus (T2DM).

Enhancing symptom control in postoperative middle-aged breast cancer patients through family support: A cross-sectional study utilizing latent profile analysis and latent interaction models.

Purpose: This study aimed to classify symptom types among young and middle-aged breast cancer survivors and compare differences in family resilience, family caring, and family function across these classifications.

Methods: A cross-sectional study was conducted with 432 young and middle-aged postoperative breast cancer survivors from a hospital in Liaoning Province, China. Symptom, family caring, family functioning, and family resilience scores were collected using convenience sampling.

Attention defines the context for implicit sensorimotor adaptation.

The sensorimotor system continuously uses error signals to remain precisely calibrated. We examined how attention influences this automatic and implicit learning process in humans (male and female). Focusing first on spatial attention, we compared conditions in which attention was oriented either towards or away from the visual feedback that defined the error signal.

Mechanism of xihuang pill inhibition of SLC7A11 deubiquitination through downregulation of the OTUB1 to promote ferroptosis in triple-negative breast cancer.

Ethnopharmacological Relevance: Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer (BC), is more sensitive to ferroptosis than other subtypes. Xihuang pill (XHP) has been extensively used in Chinese clinical practice as an adjuvant therapy for TNBC. However, the underlying mechanisms of XHP in TNBC treatment remain incompletely elucidated.

Domain driven mining of high activity anti-biofilm glycoside hydrolases in pathogenic bacteria.

Biofilm formation represents a critical antimicrobial resistance mechanism contributing to persistent chronic infections. Glycoside hydrolases encoded within the exopolysaccharide synthesis gene clusters of pathogenic bacteria play pivotal roles in biofilm formation and dispersal processes, making the mining of anti-biofilm glycoside hydrolases from pathogen genomes a promising therapeutic strategy. In this study, we established a systematic pipeline for screening anti-biofilm glycoside hydrolases from Klebsiella pneumoniae and Acinetobacter baumannii genomes.

Cognitive bridge between geometric and numerical learning in monkeys.

Educational research highlights strong developmental links between numerical and spatial cognition in humans, often shaped by cultural tools like the number line. However, emerging evidence suggests that these number-space connections may reflect our evolutionary history and emerge even in the absence of cultural tools. We examined how task-naïve monkeys learn spatial and numerical concepts over time.

c-di-GMP regulates bacterial NAD biosynthesis via targeting the transcriptional repressor NadR.

Unlabelled: As a near-ubiquitous bacterial second messenger, cyclic di-GMP (c-di-GMP) regulates a multitude of important biological processes. The regulatory effects of c-di-GMP on bacterial physiological processes are mediated through its interaction with various effector molecules, including mRNA riboswitches and proteins. Although c-di-GMP effector proteins have been widely reported, yet unknown c-di-GMP effectors in bacteria wait to be discovered, and the physiological roles of this second messenger still remain to be explored.

Effective strategies for teachers to guide children's art activities: based on a survey of children's art activities and teacher guidance, and an analysis of their correlation.

Providing effective strategic guidance for teachers to guide children's art activities and improving the quality and level of children's art activities is of great significance for children's mental development and subsequent development, as well as improving the quality of teacher teaching. We developed a children's art activity and teacher guidance observation table to collect art activity data from 538 children and guidance behavior data from 62 kindergarten teachers in 10 kindergartens in Chongqing, Sichuan, Hubei, Jiangxi, Jiangsu, and Shanghai. Then, we analyzed the differences in children's art activities and discussed the correlation between children's art activities and teachers' guidance.

Recurrent invasive liver abscess syndrome induced by with emerging drug resistance: a case report and literature review.

Background: Invasive liver abscess syndrome (ILAS) caused by hypervirulent (hvKp) is a life-threatening infection associated with high mortality, particularly when complicated by brain abscesses. The emergence of carbapenem-resistant hypervirulent (CR-hvKp) during treatment, driven by emerging resistance, poses significant therapeutic challenges.

Case Presentation: We describe a 70-year-old diabetic male with recurrent ILAS who developed sequential multi-organ infections, including urinary tract infection, bacteremia, lung abscess, and brain abscess.

Yorkie involves in immune response under hypoxia stress in Chinese mitten crab (Eriocheir sinensis).

Oxygen is essential for the survival of aquatic animals. Hypoxia constitutes a critical environmental stressor that fundamentally impacts immune homeostasis in aquatic crustaceans. However, the immune regulatory mechanisms of crustaceans under hypoxia stress require further exploration.

Multi-Scale Spatial Heterogeneity of Liver Fibrosis Evaluated by MR Elastography in Rat Models.

Background: While liver stiffness heterogeneity by MR elastography (MRE) is clinically important, whether MRE reflects multi-scale liver fibrosis heterogeneity and explains histopathological-MRE staging discordance remains unclear.

Purpose: To assess spatial heterogeneity of liver fibrosis at multiple scales using MRE, correlating with histopathology.

Study Type: Prospective.

[SETD1B gene related epilepsy and language delay: A case report and literature review].

Objective: To explore the clinical features and genetic etiology of a child with a SETD1B gene variant causing seizures and language delay.

Methods: A child with a SETD1B gene variant admitted to the Department of Pediatric Neurology at the Third Affiliated Hospital of Zhengzhou University in September 2022 was selected as the study subject. Clinical data of the child were collected, and peripheral blood samples from the child and her parents were obtained.

Online Bayesian Approximation based Uncertainty Aware Model for Ophthalmic Image Segmentation.

The robust segmentation of different targets in multiple modality images is challenging due to factors such as low contrast, variations in target size and shape, and interference from diseases, which may lead to segmentation ambiguity. In addition, the assessment of the reliability of artificial intelligence is crucial for its clinical application. This paper proposes the Online Bayesian approximation based Uncertainty-aware Network (OBU-Net) for robust ophthalmic image segmentation.

Resilience of coastal human-environment composite systems of the 21st century maritime silk road: Theory, model, and spatial patterns.

Under the dual pressures of global climate change and intensified anthropogenic activities, enhancing the resilience of coastal human-environment composite systems (CHECS) to natural hazards has become imperative for alleviating the escalating tensions between resource-environment constraints and socioeconomic development. Resilience, as an inherent property of such systems, plays a crucial role in disaster risk reduction and the maintenance of ecological security. In this context, the resilience of CHECS serves as a key indicator of sustainable development potential.

Assessing current status and exploring influencing factors and mechanisms of mothers' discharge readiness for premature infants: A cross-sectional analysis using structural equation modeling.

Background: Prematurity remains a global health challenge, with preterm infants' immaturity placing significant caregiving demands on mothers.

Objectives: This study aimed to assess mothers' discharge readiness for preterm infants and explore influencing factors using structural equation modeling to inform discharge preparation plans.

Design: Cross-sectional study.

Predictive value of sudden cardiac death risk stratification for outcomes of catheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy.

Background: Prediction models for sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) incorporate factors that influence outcomes of catheter ablation (CA) of atrial fibrillation (AF).

Objective: This study aimed to investigate the outcomes of CA of AF in patients with HCM stratified by SCD risk.

Methods: Of the 23,904 patients who underwent CA of AF, 417 patients with HCM were screened.

Cross-sectional and longitudinal associations of circulating bile acids and dementia: a systematic review.

Bile acids (BAs) may contribute to dementia by regulating neuroinflammation and influencing gut-brain axis signaling, especially in Alzheimer's disease (AD). However, their alterations in dementia development are rather complex and their impact on dementia risk remains inconclusive. To provide a comprehensive understanding of these associations, we systematically reviewed cross-sectional and longitudinal studies on circulating BAs and dementia.

Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish.

Perfluorodecanesulfonate (PFDS), a long-chain polyfluoroalkyl substance (PFAS), is widely detected in aquatic environments and increasingly recognized for its environmental persistence and bioaccumulative potential; however, its immunotoxicity remains poorly understood in aquatic biota. In this study, early life stage zebrafish (Danio rerio) were exposed to environmentally relevant concentrations of PFDS and PFOS for 120 h to better characterize the adverse effects of PFDS on aquatic organisms. Additionally, the toxicological differences between PFDS and PFOS at the same exposure concentrations were compared, as PFDS is a known substitute for PFOS.

A systematic survey of type I secretion systems and their substrate proteins in .

Type I secretion systems (T1SSs) and the substrates have not been investigated extensively in , despite their potential significance. In this research, we screened the comprehensive list of T1SSs, observed their evolution and transcriptional regulation, predicted the substrates and explored their sequence and structural properties. In total, 61 sets of T1SSs were captured from the genomes of 26 representative strains covering the known species and subspecies.

Versatile Design of Metal Aerogels for Environmental Remediation: An Overview.

As one of the latest members in the aerogel family, metal aerogels (MAs) appear to be promising materials entirely structured from nanosized metals. The combined attributes of nanometals and aerogels render them a special class of porous materials with vast potential in diverse fields. Growing environmental concerns have spurred interest in MAs for environmental remediation.

Standardized diversity estimation uncovers global distribution patterns and drivers of stream insects.

Freshwater insect biodiversity is under global threat from anthropogenic stressors, yet the roles of natural and anthropogenic drivers remain unclear. Here, we examine 783 river basins to map the global diversity and explore the effects of sampling bias, natural, and anthropogenic factors on four major taxa: Ephemeroptera, Plecoptera, Trichoptera and Odonata (EPTO). About 62% of basins were under-sampled, especially in the Global South.