Ethanol Infusion of the Vein of Marshall in Catheter Ablation of Persistent Atrial Fibrillation in Patients with Mitral Valve Replacement.

Background: The effectiveness of ethanol infusion of the vein of Marshall (EIVOM) for persistent atrial fibrillation (AF) in patients with mitral valve replacement (MVR) remains to be determined.

Objectives: This study investigated the effectiveness and safety of EIVOM in catheter ablation of persistent AF in patients with MVR.

Methods: This is a retrospective case-control study.

A Rare Intra-Atrial Cyst of Vascular Origin: Genetic Insights From a Case.

Background: Intra-atrial cysts are rare and often mistaken for neoplastic lesions. Vascular-origin cysts are even more uncommon. Limited genetic data hamper understanding of their pathogenesis and management.

Rapid activation of ARF6 after RAF inhibition augments BRAFV600E and promotes therapy resistance.

The intrinsic ability of cancer cells to evade death underpins tumorigenesis, progression, metastasis and the survival of drug-tolerant persister (DTP) cells. Herein, we discovered that when activated, the small GTPase ARF6 plays a central role in tumor survival by facilitating expression of the BRAF oncoprotein. Tumor-specific deletion caused a significant reduction in BRAF protein and MAPK signaling and prevented rapid tumor progression.

p22 prevents the oxidation of SERCA2a and stabilizes it in the heart.

Sarcoplasmic/endoplasmic reticulum (SR/ER) Ca ATPase 2a (SERCA2a) mediates Ca reuptake into the SR in cardiomyocytes. The inactivation or downregulation of SERCA2a leads to reduced contractility in the failing heart. Here we show that SERCA2a is regulated by p22, a heterodimeric partner of NADPH oxidases.

Winter microbial community structure and methane-cycling potential in constructed agricultural wetlands across regions and microhabitats.

Constructed wetlands are widely used to reduce nutrient loading to downstream waters, but they can also emit methane, a potent greenhouse gas. This trade-off between water quality benefits and climate impacts is driven by microbial processes that remain poorly understood in winter. We examined microbial community composition and methane-cycling potential in surface water samples from constructed wetlands in two agricultural regions of Sweden, focusing on the effects of emergent vegetation and environmental conditions.

Epigenetic control of tissue resident memory T cells.

Tissue-resident memory T cells (TRM) represent a heterogeneous population of T cells that exhibit both effector and memory functionalities. They express specific gene signatures that enable them to occupy tissues without recirculating, thus providing a first response against reencountered pathogens or antigens. TRM have been implicated in the pathogenesis of various diseases, including autoimmune disorders, infections, and cancers.

Kurarinone protects against renal injury and fibrosis after unilateral ureteral obstruction through enhancement of the Nrf-2 signaling pathway.

Background: Chronic kidney disease (CKD) is an epidemic with higher cardiovascular risk, and this pathology involves renal injury and fibrosis. Kurarinone (KAR) has anti-inflammatory and anticancer effects, which can regulate immune responses and macrophage polarization. This study aimed to investigate the effect of KAR on model-induced unilateral ureteral obstruction (UUO) renal injury and fibrosis.

Gender Differences in the Effects of Exercise Interventions on Alzheimer's Disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily characterized by memory loss, cognitive decline, and structural brain atrophy. Substantial sex differences have been observed in its incidence, clinical trajectory, and response to treatment. Women are disproportionately affected, exhibiting faster progression and more severe cognitive impairment.

Sestrin2 Regulates Mitochondrial Function and Autophagy via Nrf2/SIRT3 Signaling to Ameliorate Hypoxia/Reoxygenation-Induced Rat's Cardiomyocyte Injury.

Mitigating myocardial ischemia-reperfusion (I/R) injury poses a significant challenge, necessitating the exploration of novel therapeutic targets. Sestrin2 (Sesn2), a stress-induced protein, has emerged as a potential candidate for attenuating I/R injury, yet its precise mechanisms remain elusive. The role of Sesn2 was investigated using an in vitro model of H9C2 cardiomyocytes subjected to hypoxia-reoxygenation (H/R).

Extraction of xylo-oligosaccharides and carboxylated cellulose nanocrystals from corncob using stepwise treatment with ammonium persulfate.

An innovative two-step ammonium persulfate (APS) process for corncob was proposed, utilizing the acidity of APS to produce xylo-oligosaccharides (XOS) and its oxidizing capability to generate carboxylated cellulose nanocrystals (cCNCs). Treatment with 0.5 % APS at 150 °C for 90 min resulted in a maximum XOS yield of 40.

KAT6A acetylation regulates AMPK function and hypertrophic remodeling in the heart.

Diets influence metabolism and disease susceptibility, with lysine acetyltransferases (KATs) serving as key regulators through acetyl-CoA. We have previously demonstrated that a ketogenic diet alleviates cardiac pathology, though the underlying mechanisms remain largely unknown. Here we show that KAT6A acetylation is crucial for mitochondrial function and cell growth.

H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer.

Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC) remains largely unknown.

Driver risk-level identification incorporating personality traits, demographic characteristics, and driving behaviors.

Objective: Human factors have a profound influence on the prevalence of vehicle crashes, particularly among high-risk drivers. This study aims to develop a driver risk-level identification method to effectively evaluate the safety of drivers and design training programs.

Methods: The personality traits of 50 drivers were quantitatively evaluated using the Symptom Checklist-90 scale, with parallel documentation of demographic information.

Effectiveness of Fu's subcutaneous needling on pain and physical function in patients with knee osteoarthritis: A systematic review and meta-analysis.

Objectives: This study aims to evaluate the efficacy of Fu's subcutaneous needling (FSN) for knee osteoarthritis (KOA) via a meta-analysis.

Methods: Randomized controlled trials (RCTs) of FSN for KOA were searched in PubMed, Cochrane Library, Embase, Web of Science, and other databases up to July 20, 2024. Stata 15.

Facet Selectivity of Carbon Dioxide Electroreduction to HCOOH on a Zn Catalyst.

Metallic zinc, regarded as the typical CO selectivity catalyst in CO electroreduction, can also exhibit HCOOH selectivity, but the real reasons for HCOOH selectivity remain somewhat unclear. Here, density functional theory calculations were initially employed to elucidate that the Zn(002) facet exhibited the most favorable adsorption energy for the critical HCOO* intermediate in HCOOH formation. Then, the Zn catalyst with a predominant (002) facet was prepared and exhibited a maximum HCOOH Faradaic efficiency of 90%, a partial current density of 40 mA cm and excellent stability without deactivation (<5% productivity change) during 20 h of operation.

Predictive value of atherogenic index of plasma in combination with diagonal earlobe crease in coronary heart disease.

Background: The atherogenic index of plasma (AIP) and diagonal earlobe crease (DELC) are correlated with the incidence of coronary heart disease (CHD). Nevertheless, the role of AIP and DELC in the characterization and prediction of CHD remains underexplored.

Methods: This study enrolled a total of 1,378 patients suspected to be indicative of CHD, all of whom were admitted to Chengde Central Hospital between September 2021 and August 2024.

Acupuncture for arousal combined with repetitive transcranial magnetic stimulation promotes functional reorganization of brain regions in patients with a minimally conscious state: study protocol for a randomized controlled trial.

Introduction: The minimally conscious state (MCS) is one of the common and serious complications of stroke patients. Its incidence is higher than that of other types of consciousness disorders. The prolonged monitoring and comprehensive management of patients with MCS imposes substantial socioeconomic burden, creating multifaceted challenges for healthcare systems and considerable strain on familial resources.

An artificial intelligence model integrating culprit lesion diagnosis and risk assessment for acute coronary syndrome.

Background: An integrated machine learning (ML) approach capable of both diagnosing acute coronary syndrome (ACS, encompassing myocardial infarction and unstable angina) and predicting future ACS risk within defined optimal timeframes remains an unmet need in cardiovascular risk stratification.

Methods: We conducted a multicentre cohort study in China between January 2012 and December 2021. The derivation cohort (cohort 1+ cohort 2), consisting of a training, validation, and independent external test set, retrospectively included 1854 patients from four hospitals who underwent coronary computed tomography angiography (CCTA) and received a definitive diagnosis of ACS or chronic coronary syndromes (CCS) within 7 days.

Lysozyme and dandelion extract alleviate tearing eye disease by reducing inflammation and oxidative stress through canine corneal fibroblast model established.

Tearing around the eyes was a common health problem in dogs and cats. The alleviating effects of lysozyme and dandelion extract on inflammatory reaction of canine corneal fibroblasts induced by lipopolysaccharide (LPS) were systematically investigated. Based on inflammatory model established, inflammatory factors (IL-6, IL-8, IL-10, TNF-α) and oxidative stress indicators (SOD, CAT, GSH, MDA) were utilized to evaluate inflammatory response.

Self-Assembled Homogeneous Heterobimetallic-Oxide Interfaces Enable Synergistic Hydrogen Evolution Passivation for Durable Acidic Zn-Mn Batteries.

Acidic Zn-Mn batteries hold promising prospects in large-scale energy storage owing to their higher discharge voltage and capacity. However, the challenge of developing long-term acidic Zn-Mn batteries still remains due to Zn anode instability in acidic media arising from the inevitable proton corrosion and hydrogen evolution reaction (HER). Herein, we report self-assembled homogeneous heterobimetallic-oxide interfaces on the Zn anode surface via a multi-cation (Cu, In, and Sn) synergistic regulation strategy to achieve >85.

The Predictive Value of Real-World Cardiologist Performance (RWCP) Score in Atrial Fibrillation Recurrence Risk After Radiofrequency Ablation.

Objective: To explore the predictive value of Real-world Cardiologist Performance (RWCP) score for atrial fibrillation (AF) recurrence risk after radiofrequency catheter ablation (RFCA).

Methods: Patients with nonvalvular AF who underwent first-time RFCA at Luoyang Central Hospital affiliated to Zhengzhou University between October 2021 and June 2023 were included in this study. Detailed ablation data were exported from CARTO®3 system (Biosense Webster, USA), based on which, four parameters, including discharge time proportion, Catheter Contact Force Stability (C3-FOT proportion), Ablation Index Consistency (SURPOINT/TOP-4 proportion) and fragmented points proportion, were calculated.

Efficacy of artificial intelligence-based FFR technology for coronary CTA stenosis detection in clinical management of coronary artery disease: a systematic review.

Coronary computed tomography angiography (CCTA) integrated with artificial intelligence (AI) technology, particularly AI-based fractional flow reserve (FFR) assessment, has emerged as a crucial tool in the diagnosis and treatment of coronary artery disease (CAD). Recent advances in AI technology have demonstrated promising applications of AI-based FFR in detecting coronary stenosis through CCTA. Current evidence suggests that AI-FFR offers significant advantages in diagnostic accuracy and clinical utility, potentially enhancing the efficiency of CAD management.

PCPE-YOLO with a lightweight dynamically reconfigurable backbone for small object detection.

In the domain of object detection, small object detection remains a pressing challenge, as existing approaches often suffer from limited accuracy, high model complexity, and difficulty meeting lightweight deployment requirements. In this paper, we propose PCPE-YOLO, a novel object detection algorithm, specifically designed to address these difficulties. First, we put forward a dynamically reconfigurable C2f_PIG module.

Differential regulation of FADS2 by EZH2 reveals a metabolic vulnerability in ovarian cancer treatment.

Background: Ovarian cancer (OC) is the most aggressive and lethal gynaecological cancer and is characterised by abnormal lipid metabolism. Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2). It functions as a tumour promoter through both canonical H3K27me3 modification and noncanonical mechanisms.

Dynamic Co(II)/Co(III) Cycle Driven by Outer- and Inner-Sphere Electron Transfer for Sustained Peroxymonosulfate Activation.

In the realm of transition metal (M) activated peroxymonosulfate (PMS), sluggish reduction kinetics of M often lead to the rapid deactivation of catalytic centers, posing a significant challenge for commercialization of homogeneous advanced oxidation processes (AOPs). We report a pioneering elucidation of a distinct Co(II)/Co(III) cycling mechanism within electrochemically enhanced PMS-AOPs, utilizing Co(II) as a model catalyst. Remarkably, this cycling process predominantly unfolds in the anodic region, rather than the cathodic, revealing a novel aspect of electrochemical modulation.