p22 prevents the oxidation of SERCA2a and stabilizes it in the heart.

Sarcoplasmic/endoplasmic reticulum (SR/ER) Ca ATPase 2a (SERCA2a) mediates Ca reuptake into the SR in cardiomyocytes. The inactivation or downregulation of SERCA2a leads to reduced contractility in the failing heart. Here we show that SERCA2a is regulated by p22, a heterodimeric partner of NADPH oxidases.

From Screening to Strategy: Targeted Carbapenem-Resistant Enterobacteriaceae (CRE) Infection Prediction After Endoscopic Retrograde Cholangiopancreatography (ERCP).

Background: Invariably, patients can be exposed to Carbapenem-resistant Enterobacteriaceae (CRE) through contaminated device during Endoscopic retrograde cholangiopancreatography (ERCP). We aimed to identify the risk factors and establish a model for predicting subsequent CRE infections in patients with CRE-positive bile screening after ERCP.

Methods: Patients underwent ERCP were performed with bile active screening of CRE.

Noise and artifact suppression in SQUID and wearable OPM-MEG: A systematic review of background, physiological, and Technical interference.

Magnetoencephalography (MEG) is a non-invasive imaging technique that captures neural activity with high spatio-temporal resolution. In recent years, novel wearable devices based on Optically Pumped Magnetometer (OPM) have emerged as a new driving force for advancing MEG due to their cost-effectiveness, portability, and mobility. In practical applications, MEG signals are frequently influenced by various interference sources, resulting in degradation of signal quality.

Case Report: A rare case of a giant sporadic non-ampullary duodenal adenoma that was safely and effectively resected using hybrid endoscopic submucosal dissection.

Background: As a rare condition, sporadic non-ampullary duodenal adenomas (SNADAs) are typically asymptomatic and diagnosed incidentally. It warrants treatment due to the high risk of malignant transformation. However, giant SNADAs, especially those treated using hybrid endoscopic submucosal dissection (ESD), are exceedingly rare, and to our knowledge, this condition has not been reported previously.

Integrating multi-omics data to optimize immunotherapy in endometrial cancer: a comprehensive study.

Immunotherapy represents a pivotal therapeutic modality in endometrial cancer (EC). Nevertheless, the efficacy of this treatment is limited to a subset of patients. The present investigation endeavors to amalgamate multi-omics data in order to elucidate the determinants impacting individual immune responsiveness and enhance the optimization of immunotherapy for EC.

Deciphering Seed Deterioration: Molecular Insights and Priming Strategies for Revitalizing Aged Seeds.

Seed deterioration is an inevitable process during storage, characterized by a gradual loss of germination capacity and eventual seed death, which poses challenges to seed longevity and the preservation of genetic resources. Understanding the molecular mechanisms driving seed aging and inherent resistance pathways, alongside developing innovative rejuvenation strategies for deteriorated seeds, is crucial for agricultural sustainability and germplasm banking. This review systematically examines (1) redox-regulated deterioration pathways involving reactive oxygen species (ROS) and macromolecular damage cascades, (2) anti-deterioration mechanisms mediated by the antioxidant system and macromolecular repair mechanisms, (3) genetic-epigenetic networks governing seed aging resistance, particularly ABA- and IAA-mediated signaling through ABI3/ABI5/LEC1 regulons, and (4) technological advances in seed priming that restore aged seeds via metabolic resetting and repair potentiation.

Engineering Physicochemical Properties of Nanofillers for High-Performance Composite Solid-State Electrolytes in Lithium Metal Batteries.

High-performance organic-inorganic composite solid-state electrolytes (OICSEs) are pivotal for advancing solid-state lithium metal batteries (SSLMBs), offering the potential for enhanced safety and higher energy density compared to conventional liquid electrolytes. This study systematically explores the influence of nanofiller physicochemical properties (particle size, specific surface area, and surface energy) on the electrochemical performance of polyethylene oxide (PEO)-based OICSEs. By optimizing these parameters, we developed a PEO/superhydrophobic SiO OICSE incorporating low surface energy SiO nanofillers with an optimized particle size of 7 nm and a high surface area of 300 m g.

Hydrothermal engineering of triple-scale corrosion resistance: Structural barrier, oxygen vacancy, and surface functionalization in Ce-NiCo-LDH coatings.

We report a hydrothermal engineering strategy to synergistically regulate structural barriers, oxygen vacancy-driven redox cycling, and surface functionalization in Ce-NiCo-LDH coatings for ultralong corrosion protection. Vertically aligned LDH nanosheets constructed a tortuous labyrinth barrier to physically impede corrosive species penetration. Oxygen vacancies acted as electron reservoirs to drive Ce/Ce redox cycling, enabling dynamic passivation repair via preferential Ce → Ce reduction at vacancy sites.

Growth hormone combined with estrogen improves intrauterine adhesion fibrosis by downregulating endometrial microbial citraconic acid to target β-catenin protein.

Intrauterine adhesions (IUAs) are a major cause of secondary infertility. This study aimed to investigate the therapeutic effects and mechanisms of combined recombinant rat growth hormone (rrGH) and estrogen therapy on endometrial fibrosis in IUA rats. Our findings revealed that IUA rats exhibited severe endometrial damage, heightened inflammatory responses, significant collagen deposition, and imbalances in various inflammatory and growth factors.

Clinical Pharmacology Overview of Tislelizumab in Patients With Advanced Tumors With a Focus on Racial Impact.

Tislelizumab, an anti-programmed cell death protein-1 monoclonal antibody, has demonstrated improved survival over the standard of care for multiple cancers. However, tislelizumab's effectiveness across different racial/ethnicity groups warrants further evaluation. This clinical pharmacology overview includes tislelizumab's pharmacokinetic properties, correlations with efficacy and safety, and immunogenicity, with a focus on racial impact.

Computational Modeling of Cardiac Electrophysiology with Human Realistic Heart-Torso Model.

The electrocardiogram (ECG) has long been considered the non-invasive gold standard in diagnosing heart diseases. However, its connection with the cardiac molecular biology remains somewhat unclear. Therefore, modeling the electrophysiological behavior of the heart provides an important theoretical complement to clinically observable data.

Predictive model for neonatal HBV infection risk in infants of HBV-infected mothers in China: an observational study.

Objective: In China, vertical transmission is the primary route of hepatitis B virus (HBV) transmission from mothers to their children. This study aimed to develop a predictive model for assessing the risk of HBV infection in newborns born to mothers with HBV infection. Additionally, the model was validated across subgroups based on child stage, gender, and race to facilitate the early identification of high-risk newborns and the development of personalized preventive measures.

Comparative evaluation of dulaglutide alone vs. dulaglutide combined with probiotics on cardiovascular risk factors in T2DM.

Objective: This randomized controlled trial aimed to compare the effects of dulaglutide alone versus dulaglutide combined with probiotics on cardiovascular risk factors, pancreatic beta-cell function, and gut microbiota in patients with type 2 diabetes mellitus (T2DM).

Methods: Sixty overweight/obese adults with T2DM (HbA1c 6.5-11%, BMI ≥ 24 kg/m²) were randomized to a control group (dulaglutide 1.