Ethanol Infusion of the Vein of Marshall in Catheter Ablation of Persistent Atrial Fibrillation in Patients with Mitral Valve Replacement.

Background: The effectiveness of ethanol infusion of the vein of Marshall (EIVOM) for persistent atrial fibrillation (AF) in patients with mitral valve replacement (MVR) remains to be determined.

Objectives: This study investigated the effectiveness and safety of EIVOM in catheter ablation of persistent AF in patients with MVR.

Methods: This is a retrospective case-control study.

METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.

Adenomyosis, a prevalent gynecologic disorder affecting women of reproductive age, is characterized by the presence of ectopic endometrial tissue within the myometrium. The involvement and underlying mechanisms of ferroptosis in adenomyosis have not been fully elucidated. Recently, m6A RNA modification has been found to regulate various biological processes.

Working across religions, cultures, settings, and development: Protocol for wave 2 data collection with children and parents by the developing belief network.

The Developing Belief Network is a global research collaborative studying religious development in diverse social-cultural settings, with a focus on the intersection of cognitive mechanisms and cultural beliefs and practices in early and middle childhood. The current manuscript describes the study protocol for the network's second wave of data collection, which aims to further explore the development and diversity of religious cognition and behavior using a multi-time point approach. This protocol is designed to investigate three key research questions-how children represent and reason about religious and supernatural agents, how children represent and reason about religion as an aspect of social identity, and how religious and supernatural beliefs are transmitted within and between generations-via a set of eight tasks for children between the ages of 5 and 13 years and a survey completed by their parents/caregivers.

Electronically controlled deprotection chemistry for multiplex enzymatic DNA synthesis on a chip with single-base resolution.

Enzymatic deoxyribonucleic acid (DNA) synthesis (EDS) is an environmentally friendly approach capable of generating longer and more complex sequences than chemical synthesis, making it a promising next-generation technology for high-throughput single-stranded DNA production. However, precise sequence control at high throughput remains a key challenge. Here, we present a novel electronically controlled deprotection chemistry (ECDC) integrated with a hydrogel-primer modification system on-chip for efficient multiplexed EDS.

Indobufen Versus Aspirin Plus Clopidogrel in Patients After Coronary Stenting in Patients With Diabetes: A Post Hoc Analysis of the OPTION Trial.

Background: Despite increased risk of ischemic events in diabetes, the optimal anti-thrombotic strategy for secondary prevention has not been defined. We aimed to assess the efficacy and safety of optimal antiplatelet agents such as indobufen-based dual antiplatelet therapy (DAPT) in patients with diabetes after coronary stenting.

Methods: OPTION trial was a randomized, open-label, noninferiority, and multicentric study in China.

Salicylic acid regulates biosynthesis of floral fragrance (E)-β-farnesene via NPR3-WRKY1 module in chrysanthemum.

Floral fragrance is essential for the attraction of pollinators and responses to biotic and abiotic stresses. It also enhances the quality and economic value of plants. Phytohormones, acting as key signaling molecules, are crucial roles in regulating plant growth and development.

Exploring the psychological impact of long COVID: symptoms, mechanisms, and treatments.

Long COVID (LC) refers to a multisystem condition that persists after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). In addition to physical symptoms, the psychological impact is particularly pronounced. This review summarizes the manifestations, potential mechanisms, epidemiological characteristics, and current interventions related to psychological disorders in LC.

DFT Calculation-Assisted Design of Precursors for Nucleophilic 2-Amino Allyl Cations and Their Application in [3 + 2] Cycloaddition with Electron-Deficient Alkenes.

In this work, we developed nucleophilic 2-aminoallyl cations guided by DFT calculations. Computational insights enabled a comprehensive analysis of factors governing N-nucleophilicity and an accurate prediction of cycloaddition reactivity with electron-deficient alkenes. Notably, this study represents the first asymmetric [3 + 2] cycloaddition of amino-allyl cations with exocyclic double bonds, enabling the efficient synthesis of -pyrrolidines with excellent diastereoselectivities and enantioselectivities.

An attenuated African swine fever virus with deletions of the and genes offers complete protection against homologous challenge in pigs.

African swine fever (ASF) has caused a devastating pandemic among domestic and wild swine, leading to significant economic losses in the global swine industry. Recombinant live-attenuated vaccines are a potential option for the control of ASF. However, safe and effective vaccines against the ASF virus (ASFV) are not yet commercially available, and thus, additional vaccine candidates still need to be developed.

17β-trenbolone increases circulating myeloid-derived MMP8 in CSDS-induced mice and drives depressive tendencies to social threat.

Chronic psychosocial stress is a major risk factor for major depressive disorder (MDD). The impact of 17β-trenbolone (17-TB), an anabolic steroid and potential environmental endocrine disruptor, on stress responses and mood states in mammals is unclear. In this study, we explored how 17-TB interacts with chronic social defeat stress (CSDS) to drive neuroinflammatory cascades and behavioral abnormalities in mice.

A fusion ORF3a-E subgenomic RNA involved in SARS-CoV-2 infection efficacy by influencing cellular protein synthesis.

Subgenomic RNAs (sgRNAs) are discontinuous transcription products of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that are involved in viral gene expression and replication, but their exact functions are still being studied. Here, we report the identification of a nested ORF3a-sgRNA, the fusion ORF3a-E-sgRNA, which is involved in the infection process of SARS-CoV-2. This sgRNA encodes both ORF3a and E and can be detected throughout the viral life cycle in SARS-CoV-2-infected cells with high copy numbers.

Epidemiological characteristics and environmental contamination of monkeypox in Beijing's Chaoyang district: Field evidence from 2023 to 2024.

Objectives: The mpox outbreak in Beijing's Chaoyang District after late May 2023, this study aims to evaluate the epidemiological characteristics and environmental contamination of this outbreak.

Methods: A field investigation was conducted to evaluate the epidemiological characteristics of mpox cases and their living environments in Chaoyang District, Beijing, between May 2023 and May 2024. Laboratory testing, epidemiological description, and statistical analysis were conducted subsequently.

Leveraging data analytics to revolutionize cybersecurity with machine learning and deep learning.

The exponential growth of digital technologies has brought about a surge in the complexity and frequency of cyber-attacks, necessitating robust cyber security measures. This study introduces an innovative approach to cyber security data analysis by leveraging Convolutional Neural Network (CNN) technology. The primary objective is to explore the potential of CNNs in accurately and efficiently detecting and classifying cyber security threats.

Targeting hematopoietic progenitor kinase 1 (HPK1) for tumor immunotherapy: advances in small molecule inhibitors.

Hematopoietic progenitor kinase 1 (HPK1), also known as MAP4K1, is a hematopoietic-specific serine/threonine kinase and a member of the MAP4K family of mammalian Ste20-associated protein kinases, which share a highly similar protein structure, and play important roles in the regulation of cell survival, cell migration, apoptosis and autophagy. HPK1 is a negative regulator of T-cell, B-cell and dendritic cell-mediated immune responses, and HPK1 kinase deficiency increases cytokine secretion and enhances T-cell signaling, viral clearance and tumor growth inhibition. Thus, HPK1 may be implicated in the development and progression of human malignant tumors and is a potent target for anti-tumor immunotherapy.

Chromium picolinate alleviates heat stress-induced breast muscle glucose and lipid metabolism disorders in broiler chickens.

To date, extensive research has shown that heat stress disturbs glucose and lipid metabolism in broiler chickens. Recent evidence suggests that chromium supplementation influences metabolic regulation, particularly in glucose and lipid homeostasis in mammals. This study aimed to evaluate the effects of chromium picolinate supplementation on glucose and lipid metabolism in the breast muscle of broiler chickens under chronic heat stress.

Solvent-Driven Precise Control of Stacking Configurations in Covalent Organic Frameworks for High-Efficiency Photocatalysis.

Two-dimensional covalent organic frameworks (2D COFs) have emerged as promising photocatalysts due to their high surface areas and precisely tunable physicochemical properties. However, it remains a significant challenge to precisely control over interlayer stacking configurations in 2D COFs, which critically influence charge carrier transport and consequently determine catalytic efficiency. In this study, we demonstrate a solvent-driven strategy to precisely regulate the interlayer stacking configurations of metal-incorporated 2D COFs, successfully achieving both AA eclipsed (COF-TD-AA) and ABC staggered (COF-TD-ABC) configurations.

Photocatalytic Formamide Synthesis from Plastic Waste and Ammonia via C─N Bond Construction Under Mild Conditions.

Photocatalytic upcycling of polyethylene terephthalate (PET) waste into value-added chemicals represents a sustainable route for plastic valorization. However, previous studies have solely focused on generating oxygenated compounds through intramolecular C─O bond transformations. Achieving heteroatom-containing important chemicals via intermolecular coupling reactions is still challenging.

Anti-Swelling Dual-Network Zwitterionic Conductive Hydrogels for Flexible Human Activity Sensing.

Conventional conductive hydrogels are susceptible to swelling in aquatic environments; which compromises their mechanical integrity; a limitation that poses a potential challenge to their long-term stability and application. In this study, a zwitterionic ion-conductive hydrogel was fabricated from polyvinyl alcohol (PVA), acrylic acid (AA), and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SMBA), forming a dual-network structure. A copolymer of zwitterionic SBMA and AA formed the first network, and PVA formed the second network by repeated freeze-thawing.

Transcriptomic Identification of Key Genes Responding to High Heat Stress in Moso Bamboo ().

Moso bamboo (), the most widely distributed bamboo species in China, is valued for both its shoots and timber. This species often faces challenges from high-temperature stress. To cope with this stress, Moso bamboo has evolved various adaptive mechanisms at the physiological and molecular levels.

Preparation of a Nanomaterial-Polymer Dynamic Cross-Linked Gel Composite and Its Application in Drilling Fluids.

During the process of oil and gas drilling, due to the existence of pores or micro-cracks, drilling fluid is prone to invade the formation. Under the action of hydration expansion of clay in the formation and liquid pressure, wellbore instability occurs. In order to reduce the wellbore instability caused by drilling fluid intrusion into the formation, this study proposed a method of forming a dynamic hydrogen bond cross-linked network weak gel structure with modified nano-silica and P(AM-AAC).

Myopic-Net: Deep Learning-Based Direct Identification of Myopia Onset and Progression.

Purpose: Identifying and monitoring the onset and progression of myopia (myopia onset and progression [MOP]) based on the changes in anatomical structures in fundus retinal images has significant clinical application prospects. For this purpose, we tested the performance of deep neural networks.

Methods: We established a deep neural network, called Myopic-Net, to detect anatomical changes owing to the MOP from a pair of retinal images collected during different fundoscopies.

Negative Modulation of Maternal Iodine Deficiency and Excess on Milk Lipid Synthesis and Secretion in Lactating Rats.

Iodine is an essential micronutrient for developmental processes in the early stages; however, data on the effect of maternal iodine nutrition on milk lipids are limited. We aimed to explore the effect of inadequate and excessive iodine intake on milk lipid metabolism and its mechanisms preliminarily. Rats were treated with different concentrations of potassium iodide water to construct animal models of iodine deficiency and excess.

Catalytic refining lignin into toluene over atomically dispersed Cu/Ni dual sites.

Lignin refining still suffers from great challenges of selective depolymerization and cleavage of stubborn C‒C linkages. Here, a robust atomically dispersed Cu/Ni-SA@HNC catalyst is fabricated for super-selective hydrogenolysis of lignin and model compounds via an unusual "preferential C-C bond cleavage in β-O-4 linkages" pathway, affording toluene in yield up to 75.7% from β-O-4 model compounds, and up to 33.

Trajectory Planning for Patch Clamp in a Highly Constrained Cerebrovascular Environment.

The patch-clamp technique is the gold standard for electrophysiologists' research into the cellular and molecular biological mechanisms underlying mental activities at the animal level. During the procedure, micropipette trajectory planning plays a significant role in the in vivo patch clamp. However, the high constraint between the cerebral environment and the micropipette's movement, as well as the absence of comprehensive 3D spatial information, make planning its trajectory incredibly challenging.

Peri-implant diseases triggered by oral microdysbiosis: pathogenesis and precision intervention strategies.

Peri-implant disease is a chronic infection-induced inflammation condition affecting tissues around dental implants, categorized into peri-implant mucositis and peri-implantitis. Oral microbial dysbiosis plays an important role in this disease. Currently, researchers face three challenges in establishing the pathogenic link between peri-implant disease and microdysbiosis: (1) elucidating the underlying molecular mechanisms; (2) Clarifying causal links between host and microbiome; and (3) Identifying secondary microbial changes during disease progression.