Exploring the psychological impact of long COVID: symptoms, mechanisms, and treatments.

Long COVID (LC) refers to a multisystem condition that persists after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). In addition to physical symptoms, the psychological impact is particularly pronounced. This review summarizes the manifestations, potential mechanisms, epidemiological characteristics, and current interventions related to psychological disorders in LC.

Atomistic Insights into Microwave-Induced Ice Melting and Interfacial Detachment on Absorbing Surfaces.

In response to the safety threats posed by ice and snow accumulation in extreme cold environments and the limitations of conventional deicing methods, this study focuses on enhancing microwave deicing efficiency through absorbing surfaces, aiming to address the current lack of atomistic understanding of electromagnetic-thermal-mechanical coupling mechanisms. Using molecular dynamics simulations, this work constructs an atomistic model consisting of an ice layer and a silicon carbide (SiC) absorbing layer to systematically explore the dynamics of ice melting and interfacial detachment under microwave irradiation. The results show that direct contact between the ice layer and the SiC layer accelerates melting by enhancing interfacial heat transfer and microwave absorption.

[Correlation between dietary patterns of pregnant women and weight changes in early pregnancy in Shenzhen from 2018 to 2021].

Objective: To understand the dietary pattern characteristics of pregnant women in early pregnancy and analyze the association between these dietary patterns and weight changes in early pregnancy.

Methods: Using the birth cohort of the China Birth Cohort Study(CBCS), we analyzed the early pregnancy information and food frequency questionnaire data of 3, 540 subjects who met the inclusion and exclusion criteria at the Shenzhen sub-center from July 2018 to January 2021. Dietary patterns were extracted using factor analysis.

Integrating Metabolomics and Gut Microbiota to Identify Key Biomarkers and Regulatory Pathways Underlying Metabolic Heterogeneity in Childhood Obesity.

Background/objectives: Individuals with childhood obesity exhibit significant metabolic heterogeneity, necessitating precise biomarkers for risk stratification and assessment. This multi-omics investigation characterizes metabolic and microbial signatures underlying divergent metabolic phenotypes in the context of pediatric obesity.

Methods: We analyzed 285 Chinese children (5-7 years) stratified into five groups: wasting (WAS, = 55), metabolically healthy/unhealthy and normal weight (MHWH, = 54; MUWH, = 67), and metabolically healthy/unhealthy obesity (MHO, = 36; MUO, = 73).

Predictive value of the hospital frailty risk score in perioperative complications of artificial hip and knee arthroplasty in elderly patients.

BackgroundAlthough artificial hip and knee arthroplasty has been widely used, the incidence of perioperative complications remains relatively high due to factors such as long operation time and large surgical incisions. However, the Hospital Frailty Risk Score (HFRS) clinical value for patients undergoing artificial hip and knee arthroplasty in China is not yet clear. This study aims to explore its clinical value in this population.

Behavioral adaptations of against pathogenic threats.

This review examines the behavioral adaptation mechanisms of in response to pathogenic bacterial threats, emphasizing their ecological significance. It systematically explores how mechanisms such as avoidance behavior, transgenerational learning, and forgetting enable to optimize its survival and reproductive strategies within dynamic microbial environments. detects harmful signals through chemosensation and initiates avoidance behaviors.

Exploration the therapeutic effects of sodium houttuyfonate combined with penicillin G on methicillin resistant infected wounds.

Background: Methicillin resistant (MRSA) is a Gram-positive bacterium that can cause local or systemic infectious diseases, and treatment for MRSA has become a major global health issue. Sodium houttuyfonate (SH) is a natural extract of Houttuynia cordata, which has antibacterial and anti-inflammatory effects. The aim of this study is to evaluate the antibacterial effect of SH combined with penicillin G (PNC) against MRSA and its potential beneficial effects in a rat model of MRSA wound infection, and to investigate its possible mechanism in combination with network pharmacology.

Characterization and Biocompatibility Assessment of 3D-Printed HA/PCL Porous Bionic Bone Scaffold: and Evaluation.

Objectives: This study aims to characterize a three-dimensional-printed hydroxyapatite (HA)/polycaprolactone (PCL) scaffold and assess its biocompatibility both and .

Methods: A bionic, porous HA/PCL scaffold was fabricated using 3D printing, and its microstructure, porosity, hydrophilicity, and mechanical properties were evaluated through scanning electron microscopy and various assays. Bone marrow mesenchymal stem cells (BMSCs) and vascular endothelial progenitor cells (VEPCs) were co-cultured with the scaffold, and their proliferation and osteogenic differentiation were assessed using the Cell Counting Kit-8, ALP assays, and alizarin red staining.

Analysis of elderly patients with inter-trochanteric fracture and failure of postoperative internal fixation.

ObjectiveThis study aims to compare the efficacy and safety of Proximal Femoral Nail Anti-Rotation (PFNA) versus Dynamic Hip Screw (DHS) in the treatment of intertrochanteric fractures (IF) in elderly patients. We specifically evaluate perioperative indicators, postoperative hip function, and the rate of internal fixation failure.Methods300 elderly IF patients treated in our hospital from July 2018 to May 2022 were divided into the PFNA group (n = 150), control group (n = 150), PFNA group treated with PFNA, and control group treated with mobility hip screw (DHS).

Epidemiological study of HPV infection in 24,588 rural women in Luonan, China.

Cervical cancer is a significant public health issue for women, with human papillomavirus (HPV) infection rates exhibiting regional variations throughout China. This study examined data from a cohort of 24,588 rural women who engaged in cervical cancer screening in Luonan County from 2021 to 2023, utilizing high-risk HPV (hrHPV) testing methodologies. The findings revealed an overall HPV positivity rate of 14.

High quantum yield copper nanoclusters integrated with nitrogen-doped carbon dots for off-on ratiometric fluorescence sensing of S and Zn.

Pursuing nanomaterials with high fluorescence quantum yields is of great significance in the fields of bioimaging, medical diagnosis, and food safety monitoring. This work reports on orange-emitting aggregation-induced emission (AIE) copper nanoclusters (Cu NCs) integrated with blue-emitting nitrogen-doped carbon dots (N-CDs), which enables highly sensitive detection of S and Zn ions through an off-on ratiometric fluorescence method. The highly emissive Cu NCs was doped by Ce with a high quantum yield of 51.

Mechanistic Study on the Influence of Wax on Hydrate Formation Process.

To manage the interactions between wax and hydrate formation, a comprehensive understanding of the system's thermodynamics and flow characteristics is essential. Wax and hydrates coexist under low-temperature and high-pressure conditions, mutually influencing each other both thermodynamically and kinetically. This study focused on two main aspects: how wax affects the rate of hydrate formation in the oil-water system and how hydrate formation influences the thermodynamics of wax crystal precipitation.

Risk factors associated with intraoperative persistent hypotension in pancreaticoduodenectomy.

Background: Intraoperative persistent hypotension (IPH) during pancreaticoduodenectomy (PD) is linked to adverse postoperative outcomes, yet its risk factors remain unclear.

Aim: To clarify the risk factors associated with IPH during PD, ensuring patient safety in the perioperative period.

Methods: A retrospective analysis of patient records from January 2018 to December 2022 at the First Affiliated Hospital of Nanjing Medical University identified factors associated with IPH in PD.

Knockout of the delta11-desaturase SfruDES1 disrupts sex pheromone biosynthesis, mating and oviposition in the fall armyworm, Spodoptera frugiperda.

Moth insects rely on sex pheromones for long distance attraction and searching for sex partners. The biosynthesis of moth sex pheromones involves the catalytic action of multiple enzymes, with desaturases playing a crucial role in the process of carbon chain desaturation. However, the specific desaturases involved in sex pheromone biosynthesis in fall armyworm (FAW), Spodoptera frugiperda, have not been clarified.

Insights into the Efficient Release of the Polyacrylamide Drag Reducer via a pH-Responsive Inverse Polymer Emulsion.

The enormous demand for petroleum consumption has resulted in the shortage of fossil resources, prompting the need to explore unconventional reservoirs. Polyacrylamide emulsion drag reducers are capable of inhibiting the turbulence of fracturing fluids for enhancing the reservoir stimulation results, but the poor dissolution efficiency of polyacrylamide emulsion drag reducers is the primary limitation to their large-scale application. Here, a pH-responsive ionic liquid surfactant, oleic acid/cyclohexanediamine (HOA/HMDA), is synthesized by using oleic acid (HOA) and cyclohexanediamine (HMDA).

Photocontrollable DNA Walker-Based Molecular Circuit for the Tunable Detection of MicroRNA-21 Using Metal-Organic Frameworks as Label-Free Fluorescence Tags.

Tunable detection of microRNA is crucial to meet the desired demand for sample species with varying concentrations in clinical settings. Herein, we present a DNA walker-based molecular circuit for the detection of miRNA-21 (miR-21) with tunable dynamic ranges and sensitivity levels ranging from fM to pM. The phosphate-activated fluorescence of UiO-66-NH metal-organic framework nanoparticles was used as label-free fluorescence tags due to their competitive coordination effect with the Zr atom, which significantly inhibited the ligand-to-metal charge transfer.

[Optimization of three-dimensional culture conditions of L02 cells with response surface methodology based on VitroGel system].

Objective: This study optimizes three-dimensional(3D)culture conditions of L02 cells using response surface methodology(RSM) based on the VitroGel system to construct the hepatocytes model in vitro.

Methods: L02 cells were 3D cultured by the VitroGel system. The appropriate level of three key factors(concentration of inoculated cells, culture time and dilution degree of the hydrogel) was determined by single-factor experiment, and the optimal conditions of 3D culture of L02 cells based on the VitroGel system were determined by RSM.

Evaluation of Porcine Psoas Major as a Scaffold Material for Engineered Heart Tissues.

Decellularized porcine myocardium is commonly used as scaffolding for engineered heart tissues (EHTs). However, structural and mechanical heterogeneity in the myocardium complicate production of mechanically consistent tissues. In this study, we evaluate the porcine psoas major muscle (tenderloin) as an alternative scaffold material.

d-Penicillamine@Ag/Cu Nanocluster-Based Fluorescent Nanoneuron for Logic Screening Phosphonate-Type Organophosphate Pesticides and Steganographically Encrypting Information.

Organophosphate pesticides are used in agriculture due to their high effectiveness and low persistence in eradicating insects and pests. However, conventional detection methods encounter the limitation of undesired detection specificity. Thus, screening phosphonate-type organophosphate pesticides (OOPs) from their analogues, phosphorothioate organophosphate pesticides (SOPs), remains a challenge.

Early outcomes, associated factors and predictive values of clinical outcomes of tandospirone in generalized anxiety disorder: a post-hoc analysis of a randomized, controlled, multicenter clinical trial.

Objective: To examine the early outcomes, associated factors and predictive values of clinical outcomes of different tandospirone doses in patients with a generalized anxiety disorder (GAD).

Methods: This was a posthoc analysis of "a randomized, controlled multicenter clinical trial of the efficacy and safety of different doses of tandospirone on GAD". A total of 274 patients with GAD were included and randomized into the high-dose (tandospirone 60 mg/d) and low-dose (tandospirone 30 mg/d) groups for a 6-week treatment.