Indobufen Versus Aspirin Plus Clopidogrel in Patients After Coronary Stenting in Patients With Diabetes: A Post Hoc Analysis of the OPTION Trial.

Background: Despite increased risk of ischemic events in diabetes, the optimal anti-thrombotic strategy for secondary prevention has not been defined. We aimed to assess the efficacy and safety of optimal antiplatelet agents such as indobufen-based dual antiplatelet therapy (DAPT) in patients with diabetes after coronary stenting.

Methods: OPTION trial was a randomized, open-label, noninferiority, and multicentric study in China.

An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure.

Background: Endogenous retroviruses (ERVs) occupy >8% of the human genome. Aberrant resurgence of ERVs has been implicated recently in several critical pathologies. However, the possible incidence and role of ERV resurgence in heart failure (HF), a leading cause of global morbidity and mortality, remain unexplored.

[Expressions of PRMT5 and DKK3 proteins in prostate cancer tissue correlate to biochemical recurrence after radical prostatectomy].

Objective: To investigate the relationship of the expression levels of protein arginine methyltransferase 5 (PRMT5) and Dickkopf-related protein 3 (DKK3) in the PCa tissue with biochemical recurrence (BR) of the malignancy after radical surgery.

Methods: This study included 105 cases of PCa diagnosed in our hospital from January 2016 to December 2020 and, according to BR within 3 years after surgery, we divided them into a BR (n = 22) and a non-BR group (n = 83). We detected the expressions of PRMT5 and DKK3 in the prostate tissues of the patients by immunohistochemistry, analyzed the correlation of the expression levels of PRMT5 and DKK3 using the Spearman method, and conducted a multivariate analysis of postoperative BR of the malignancy using the Cox multivariate regression model.

Macrophage NADPH oxidase inhibition by ultralow-dose dextromethorphan alleviates DSS-induced inflammation and colitis.

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal tract with limited treatment options and no definitive cure. Emerging evidence implicates NADPH oxidase (Nox) in IBD pathogenesis, but the specific subtype involved and its therapeutic potential remain unclear. To assess the efficacy of dextromethorphan (DM), a potent Nox2 inhibitor, we employed a dextran sulfate sodium (DSS)-induced chronic colitis model in mice.

Machine Learning and Deep Learning Hybrid Approach Based on Muscle Imaging Features for Diagnosis of Esophageal Cancer.

: The rapid advancement of radiomics and artificial intelligence (AI) technology has provided novel tools for the diagnosis of esophageal cancer. This study innovatively combines muscle imaging features with conventional esophageal imaging features to construct deep learning diagnostic models. : This retrospective study included 1066 patients undergoing radical esophagectomy.

Recent advances in biosynthesis and regulation of strawberry anthocyanins.

Cultivated strawberry ( × ) is a kind of Rosaceae fruit crops grown worldwide. It is popularly consumed for its attractive color, juicy flesh, and nutrient content. The rich anthocyanin in strawberry fruits is responsible for its coloration.

Muscle-Driven prognostication in gastric cancer: A multicenter deep learning framework integrating Iliopsoas and erector spinae radiomics for 5-Year survival prediction.

This study developed a 5-year survival prediction model for gastric cancer patients by combining radiomics and deep learning, focusing on CT-based 2D and 3D features of the iliopsoas and erector spinae muscles. Retrospective data from 705 patients across two centers were analyzed, with clinical variables assessed via Cox regression and radiomic features extracted using deep learning. The 2D model outperformed the 3D approach, leading to feature fusion across five dimensions, optimized via logistic regression.

High doses of the galactooligosaccharides, 2'-fucosyllactose alleviate immunodeficiency in vitro and in vivo.

Purpose: Galactooligosaccharides (GOS) are widely added to infant formula milk powder. One of these, 2'-fucosyllactose (2'-FL), has many potential applications. This study investigated the immunomodulatory effects of GOS and 2'-FL, alone or in combination, on RAW 264.

Chlorogenic acid alleviates intrauterine growth retardation-induced intestinal damage in piglets.

Objectives: Intestinal disorder is a crucial contributor to growth lag, decreased disease resistance and increased perinatal morbidity and mortality in newborns suffering from intrauterine growth retardation (IUGR). This study was conducted to investigate the protective effects of chlorogenic acid (CGA) on IUGR-induced intestinal damage using weaned piglets as a model.

Research Methods & Procedures: In total, 24 normal birth weight weaned piglets and 24 IUGR weaned piglets were fed either a basal diet or a basal diet plus 1 g/kg CGA from 26 to 47 days of age.

Selectivity Descriptors of Glycerol Valorization over 10-Member Ring Zeolites.

The shift to renewable feedstocks is essential for developing "smart drop-in" technologies to produce synthetic fuels and chemicals, playing a crucial role in industrial decarbonization. Herein, zeolite-catalyzed glycerol valorization offers a mature way to create higher-value chemicals. This study aims to identify the key factors influencing process efficiency by examining the reaction mechanisms of glycerol valorization using 10-membered ring zeolites: ZSM-5 (MFI, 3D), MCM-22 (MWW, 2D), and ZSM-22 (TON, 1D), each with unique topologies and channel structures.

Fabrication of polydopamine-altered PCL/PLGA nanofibrous scaffolds on cerium to enhance cytocompatibility, microbial inhibition, and improved osteogenic properties for tissue regeneration in orofacial treatment.

Biodegradable scaffolds have significant potential for directed tissue regeneration in craniofacial and oral applications and bone regeneration. We designed an innovative cerium-altered/collagen-clacked polycaprolactone/poly-lactic-co-glycolic acid (PC/PL) electrospun scaffolds (PC/PL-PD-Ce-CL) to address the deficiencies of existing scaffold materials regarding osteogenic and antimicrobial characteristics. Novel scaffolds were developed by electrospinning a fundamental PCL/PLGA matrix, impregnating in situ reduction with cerium nanoparticles (CeNPs), applying a polydopamine coating, and clacking with collagen.

Effect of Dietary Energy Levels on the Reproductive Performance in Breeding Pigeons, and Growth Performance and Intestinal Health in Squabs.

The present study evaluated the effect of different dietary energy levels on reproductive performance in breeding pigeons, as well as growth performance and intestinal health in squabs. In total, 180 pairs of 12-month-old White King breeding pigeons were randomly assigned to five dietary treatments, each with six replicates of six pairs of birds, and fed diets containing 11.60, 11.

The relationship between parental phubbing and bullying behavior in middle school students: the mediating role of family closeness and negative emotions.

Purpose: This study examined the mediating role of family closeness and negative emotions in the relationship between parental phubbing and bullying behavior in middle school students.

Methods: A survey was conducted on 1281 middle school students using the Parental Phubbing Scale, Family closeness Scale, Negative Emotion Scale, and Bullying Behavior Questionnaire.

Results: (1) Parental phubbing was significantly and positively related with bullying behavior in middle school students; (2) Parental phubbing was related with bullying behavior in middle school students through the separate mediating effects of family closeness and negative emotions, as well as their sequential chain mediating effect.

Separation of MnWO and NaWSiO Phases Boosts Oxidative Coupling of Methane.

The oxidative coupling of methane (OCM) is an attractive approach for methane transformations, but achieving a satisfactory combination of activity and selectivity remains challenging, even with the promising Mn-NaWO/SiO catalyst. Herein, we demonstrate that nanoscale separation of Mn-based and NaWO-based phases results in a highly efficient catalyst, achieving a remarkable 79% selectivity for C-C hydrocarbons at a 32% CH conversion at 775 °C, outperforming most previously reported catalysts. Our studies reveal that MnWO phases with adjustable surface Mn/W ratios and redox activities are more effective for the selective activation of O, thereby enhancing the OCM of CH.

Aditus ad antrum patency on CT as a predictor of tympanoplasty outcomes in chronic otitis media.

To evaluate the prognostic significance of aditus ad antrum patency, as determined by computed tomography (CT), on the surgical outcomes in patients with chronic suppurative otitis media (CSOM). This study analyzed CSOM patients who had tympanoplasty at a tertiary hospital from 2015 to 2019. Patient demographics, operative reports, preoperative CT scans and outcomes were reviewed.

On-chip Mach-Zehnder interferometer for 1550 nm laser frequency stabilization.

Low-noise stable lasers have broad applications in metrology, spectroscopy, communication, and quantum physics. Here we demonstrate locking a semiconductor laser to an on-chip silicon nitride Mach-Zehnder interferometer (MZI) using the Pound-Drever-Hall (PDH) stabilization technology. After locking, the frequency noise of the laser is suppressed by up to 37 dB, and the relative stability reaches 3 10 at a gate time of 1 ms, showing an order of magnitude improvement compared to a free-running operation.

Study on postoperative survival prediction model for non-small cell lung cancer: application of radiomics technology workflow based on multi-organ imaging features and various machine learning algorithms.

Objective: This study aims to construct an effective prediction model for the two-year postoperative survival probability of patients with non-small cell lung cancer (NSCLC). It particularly focuses on integrating radiomics features, including the erector spinae and whole-lung imaging features, to enhance the accuracy and stability of prognostic predictions.

Materials And Methods: The study included 37 NSCLC patients diagnosed and surgically treated at the First Affiliated Hospital of Anhui Medical University from January 2020 to December 2021.

Effects of Resveratrol on Redox Status, Jejunal Injury, and Mitochondrial Function in Intrauterine Growth-Retarded Weaned Piglets.

This study investigated the effects of resveratrol (RSV) on redox status, jejunal injury, and mitochondrial function in intrauterine growth-retarded (IUGR) weaned piglets. In total, 12 male normal birth weight (NBW) newborn piglets and 24 male IUGR newborn piglets were selected. They were weaned at 26 days of age and then divided into three treatments in a three-week trial: (1) NBW piglets fed a basal diet; (2) IUGR piglets fed a basal diet; (3) IUGR piglets fed a basal diet supplemented with 300 mg/kg RSV.

A Comparison of the Diagnostic Value of Multiorgan Point-of-care Ultrasound between High-risk and Medium-to-low-risk Pulmonary Embolism Cases.

Objective: This study aimed to explore the diagnostic value of multiorgan (heart, lungs, blood vessels) point-of-care ultrasound (PoCUS) in patients with high-risk and medium-to-low-risk pulmonary embolism (PE).

Methods: Clinical data of 92 patients with suspected PE, admitted to Hangzhou TCM Hospital affiliated with Zhejiang Chinese Medical University from July 2021 to June 2023, were retrospectively analyzed. According to hemodynamic status, patients were divided into the high-risk (n=28) and the medium-to-low-risk groups (n=64).

Long non-coding RNA XR008038 promotes the myocardial ischemia/reperfusion injury development through increasing the expressions of galectin-3.

Background: Myocardial ischemia/reperfusion (I/R) injury is a common pathophysiological change after myocardial reperfusion therapy. Recent research confirmed that long non-coding RNA (IncRNAs) played an important role in many cardiovascular diseases. This study was carried out to explore the role of lncRNA XR008038 in the I/R progression.

Indobufen-based dual antiplatelet therapy in patients with multivessel coronary disease undergoing drug-eluting stent implantation insight from the OPTION trial.

Background: It remains unclear whether indobufen-based dual antiplatelet therapy (DAPT) preserves ischemic protection while limiting bleeding risk in patients with multivessel coronary disease (MVD). This study aimed to investigate the efficacy and safety of indobufen-based DAPT in patients with MVD.

Methods: Patients in the OPTION trial were stratified based on the presence of MVD.

Analysis of the role of PANoptosis in intervertebral disk degeneration via integrated bioinformatics analysis and experimental validation.

Intervertebral disc degeneration (IVDD) is an age-related orthopedic degenerative disease characterized by recurrent episodes of lower back pain, and death of nucleus pulposus cells (NPCs) has been identified as a key factor in the pathophysiological process of IVDD episodes. Recent studies have shown that " PANapoptosis ", a newly characterized form of cell death, has emerged as an important factor contributing to the development of several diseases. However, studies on the specific mechanisms of its role in the development of IVDD are lacking.

Comparison of the effects of transperitoneal and retroperitoneal robot-assisted partial nephrectomy.

Objective: To compare the effects of transperitoneal and retroperitoneal approaches for robotic assisted partial nephrectomy (RAPN) in patients with renal cell carcinoma (RCC).

Methods: We conducted a retrospective cohort study on RAPN at Affiliated Hospital of Jiangsu University. Between September 2020 and February 2024, the included patients underwent either transperitoneal approach or retroperitoneal approach.

Extraction, Characterization, and Antioxidant Activity of Polysaccharides.

Herein, the ultrasound-assisted extraction conditions affecting the yield of EUPS ( polysaccharide) were analyzed using a Box-Behnken response surface design. The alleviation effect of EUPS on diquat-induced oxidative stress in mice was also studied. A maximum EUPS yield of 2.