Reduced Peak Myocardial Work Efficiency With Coronary Flow Velocity Reserve Predicts Significant Coronary Artery Stenosis in Chronic Coronary Syndrome.

Background: Identification of significant coronary artery stenosis (CAS) in patients with chronic coronary syndromes (CCS) is crucial for clinical management. Myocardial work (MW) is a new noninvasive method reflecting myocardial metabolism and has been applied in myocardial ischemia. We aimed to explore the value of global MW during vasodilator stress echocardiography in detecting significant CAS.

DHCR7 Promotes Liver Metastasis of Pancreatic Cancer Through PI3K-Akt Signaling Pathway.

Pancreatic cancer (PC) is associated with dismal clinical outcomes, largely due to the high prevalence of liver metastasis (LM) at diagnosis or post-resection. Despite its clinical significance, the molecular drivers of LM in PC remain poorly characterized, and few validated biomarkers or therapeutic targets are currently available. Our study identifies 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme in cholesterol biosynthesis, as significantly upregulated in PC tissues and closely correlated with LM progression.

Downregulated miR-199a-3p in Preeclamptic Placenta-derived Exosomes from Cord Blood Hinders VEGF-induced Fetal Glomerular Dysplasia Through Inhibiting Akt1(S473) Phosphorylation via Targeting PHLPP2.

Background: Preeclampsia is amultisystem disorder involving in inflammatory responses and metabolic dysfunction of maternal-fetal circulation. Recently, researchers found it threatens renal health of offspring in adulthood. Growing evidence indicated chronic kidney disease is associated with glomeruli deficiencies during intrauterine development.

Dual-scale chemical ordering for cryogenic properties in CoNiV-based alloys.

The mechanical properties of metallic materials often degrade under harsh cryogenic conditions, posing challenges for low-temperature infrastructures. Here we introduce a dual-scale atomic-ordering nanostructure, characterized by an exceptionally high number density of co-existing subnanoscale short-range ordering (approximately 2.4 × 10 m) and nanoscale long-range ordering (approximately 4.

Electronic structure modulation of Zn-doped FeNiS nanosheet arrays for alkaline overall water splitting.

Water electrolysis comprises two half-reactions-the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER)-each involving multiple elementary steps. The development of bifunctional electrocatalysts that are simultaneously efficient for both HER and OER remains a significant challenge, as different steps often require distinct catalytic properties. Pentlandite-type materials ((Fe,Ni)S) have emerged as promising candidates for water splitting due to their intrinsic bifunctional activity.

Development of a Clinical Management Pathway for Perioperative Nutritional Risk in Elderly Patients with Hip Fractures.

Objective: The nutritional challenges faced by elderly patients with hip fractures during the perioperative period are significantly associated with clinical outcomes. This study aims to develop a clinical management pathway tailored for elderly hip fracture patients at nutritional risk during the perioperative period, with the objectives of enhancing patient management precision, reducing the duration of hospitalization, and minimizing associated healthcare costs.

Methods: Based on the perioperative time sequence, nursing process framework, and the five-step principle of nutritional diagnosis and treatment, literature review, Delphi method, and priority graph method were employed to determine the content and hierarchical weight indicators of the clinical management pathway for this patient population.

SP1-Mediated Glycolytic Reprogramming Promotes Tumorigenesis and Progression in Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy, commonly progressing from pancreatic intraepithelial neoplasia (PanIN). However, the molecular alterations in PanIN lesions and their contribution to PDAC progression remain poorly defined. Here, using laser capture microdissection-based proteomics of patient tissues, early metabolic remodeling and upregulation of the transcriptional factor specificity protein 1 (SP1) in PanIN lesions are identified, which persisted into the PDAC stage.

STING inhibits LINE-1 retrotransposition through sorting ORF1p to lysosomes for degradation.

The cyclic dinucleotide sensor stimulator of interferon (IFN) genes (STING) is known for its critical role in interferon and inflammatory responses. In addition, STING also has functions independent of interferon induction. In this study, we report that STING restricts the mobilization of the cellular retrotransposon long interspersed nuclear element 1 (LINE-1) independent of cGAS and interferon induction.

Manipulation of Topology by Electric Field in Breathing Kagome Lattice.

Magnetic kagome lattices have attracted much attention because the interplay of band topology with magnetism and electronic correlations give rise to various exotic quantum states. A common structural distortion in the kagome lattice is the breathing mode, which can significantly influence the magnetism and band characteristics. However, the control of breathing mode and the associated topological phenomena remain rarely explored.

Comparing the diagnostic efficacy of [F]FDG PET/CT and [F]FDG PET/MRI in breast cancer recurrence: a systematic review and meta-analysis.

Purpose: This meta-analysis evaluates and compares the diagnostic accuracy of [F]FDG PET/CT and [F]FDG PET/MRI in detecting breast cancer recurrence.

Methods: A search was conducted across PubMed, Web of Science, and Embase databases up to June 10, 2025, to identify studies evaluating the diagnostic performance of [F]FDG PET/CT and/or [F]FDG PET/MRI in breast cancer recurrence. Sensitivity and specificity were calculated using the DerSimonian and Laird method with Freeman-Tukey double arcsine transformation.

Reserve of global constructive work for early diagnosis of myocardial ischemia and risk stratification in chronic coronary syndrome.

Background: In chronic coronary syndrome (CCS), assessing myocardial ischemia is difficult due to its variable severity. Myocardial mechanical parameters are helpful in ischemia detection. This study investigates the use of non-invasive myocardial work (MW) for ischemia detection and risk assessment in CCS patients.

Generation and Annihilation of Local Magnetic Moments by an Electric Field.

Electric field control of magnetism is highly desirable for designing next-generation spintronic devices. However, the switching effect of local magnetic moments using an external electric field has rarely been demonstrated. Here, we discover a unique magnetoelectric coupling mechanism that is independent of spin-orbit coupling and enables the electric field control of local magnetic moments via a switchable breathing mode.

Diagnostic Accuracy of Self-Reported Questionnaires for Detecting Periodontitis Across Multiple Cultures and Geographic Locations: A Systematic Review and Meta-Analysis.

Objective: To evaluate self-reported questionnaires' intrinsic validity and diagnostic accuracy for detecting periodontitis across diverse cultural and geographic contexts.

Materials And Methods: Electronic searches were conducted in PubMed, Embase and the Cochrane Library until 4 March 2025. Studies included those using the Centers for Disease Control and Prevention and the American Academy of Periodontology (CDC/AAP) criteria or the 2017 World Workshop classifications as reference standards and reporting the diagnostic accuracy of self-reported questionnaire items.

Interface-Engineered 2H-MoS/MXene Heterostructures for High-Performance Ammonium-Ion Hybrid Supercapacitors.

Aqueous ammonium-ion hybrid supercapacitors (AAHSCs) have received significant interest due to their environmental friendliness and excellent electrochemical performance. 2D transition metal carbides and nitrides (MXenes) are promising cathode candidates for AAHSCs owing to their high conductivity and redox activity. However, their tendency to restack severely limits ion accessibility and rate performance.

A photocatalytic and superhydrophobic self-cleaning nanocellulose-based membrane based on Cu-MOF for highly efficient oil/water separation, the removal of dyes and anti-biofouling towards sewage remediation.

Multifunctional superhydrophobic nanocellulose-based membranes for self-cleaning, oil/water separation, photocatalytic degradation, and anti-biofouling are in great demand for sewage treatment. This demand led to the in situ deposition of Cu-MOF micro/nanoparticles on the surface of CB membranes, followed by stearic acid (STA) modification to provide excellent superhydrophobicity, which enables effective oil/water separation, photocatalytic degradation, and anti-biofouling. The CB/Cu-MOF/STA membranes created in this manner demonstrated good superhydrophobicity with a water contact angle of 160 ± 2° and superoleophobicity with an oil contact angle of 0°.

The impact of preoperative biliary drainage on bile colonization of patients undergoing pancreaticoduodenectomy.

Background: Preoperative biliary drainage (PBD) may be performed for jaundiced patients with periampullary tumors. This study aimed to evaluate the impact of PBD on biliary microbiome and perioperative complications in patients undergoing pancreaticoduodenectomy (PD).

Methods: This retrospective study enrolled 323 patients who underwent PD between March 2018 and March 2024.

Synthesis and characterization of celecoxib peroxide: crystal structure, theoretical analysis, thermochemistry and bond dissociation energy.

Celecoxib peroxide (systematic name: 4-{5-[4-(hydroperoxymethyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}benzenesulfonamide), CHFNOS, a compound identified in destruction experiments and the long-term storage of the active pharmaceutical ingredient (API) celecoxib, was synthesized and characterized using a variety of techniques, including NMR (H and C), UV, IR, MS and single-crystal X-ray diffraction (SC-XRD). Powder XRD and thermal differential scanning calorimetry/thermogravimetry (DSC/TG) techniques were also employed to further elucidate the features of the crystal. The structure analysis revealed that the molecule is disordered, with the peroxide O atoms distributed over two sites with occupancies of 0.

Alkaline Amino Acids for Salt Reduction in Surimi: A Review.

Surimi products are popular due to their high protein and low fat content. However, traditional processing methods rely on high concentrations of salt (2-3%) to maintain texture and stability, contributing to excessive sodium intake. As global health trends advance, developing green and low-salt technologies while maintaining product quality has become a research focus.

Multimodal prediction based on ultrasound for response to neoadjuvant chemotherapy in triple negative breast cancer.

Pathological complete response (pCR) can guide surgical strategy and postoperative treatments in triple-negative breast cancer (TNBC). In this study, we developed a Breast Cancer Response Prediction (BCRP) model to predict the pCR in patients with TNBC. The BCRP model integrated multi-dimensional longitudinal quantitative imaging features, clinical factors and features from the Breast Imaging Data and Reporting System (BI-RADS).

Comparison of Radiofrequency Ablation and High Ligation Stripping for Varicose Veins: A Retrospective Analysis.

Background: To compare the clinical efficacy, postoperative complications, and quality-of-life (QoL) outcomes of ultrasound-guided radiofrequency ablation (RFA) combined with tributary phlebectomy and foam sclerotherapy versus high ligation and stripping (HLS) combined with tributary phlebectomy.

Methods: We retrospectively analyzed 2,740 patients (1,588 women; mean age 59.01 ± 12.

Non-traditional lipid parameters are independent predictors of the location, distribution, and stroke events of moderate-to-severe intracranial and extracranial atherosclerotic stenosis.

Objective: Moderate-to-severe stenosis has been identified as a significant risk factor for stroke recently. This study aims to investigate the relationship between non-traditional lipid parameters and the location and distribution of stenosis, as well as symptomatic events, in patients with moderate-to-severe intracranial atherosclerotic stenosis (ICAS) and extracranial atherosclerotic stenosis (ECAS).

Methods: This study analyzed correlation between non-traditional lipid parameters and moderate-to-severe ICAS and ECAS concerning stenosis location, distribution, and the presence or absence of symptoms.

A multifunctional dicyanoisophorone-based fluorescent probe for Zn and pyrophosphate detection: Practical applications in water, living sprout, and cell imaging.

Zinc ions (Zn) and pyrophosphate (PPi) play pivotal roles in biological systems, with their dynamic concentrations being closely linked to various physiological and pathological processes, making them essential biomarkers for disease diagnosis and health assessment. The development of highly sensitive and selective in situ detection technologies is crucial for elucidating their biological functions. This study introduces an advanced near-infrared fluorescent sensor, DHP, constructed by integrating the molecular framework of dicyanoisophorone (DCI) derivatives with di(thiophen-2-yl)ethyl amide moieties.

Solvent Exchange Strengthening Interpenetrating Dual-Network Organohydrogels with Anti-icing Durability and Friction Resistance.

Developing mechanically robust hydrogels with low ice adhesion and anti-icing durability in low-temperature environments (≤ -20 °C) remains a persistent challenge. In this study, a dual-network organohydrogel (PAD) was synthesized through a facile one-pot copolymerization of acrylamide (AM), and [2-(Methacryloyloxy)-ethyl]-trimethylammonium chloride (DML) dissolved in poly-(vinyl alcohol) (PVA) aqueous solution, followed by solvent exchange in a mixed solvent of dl-1,2-Isopropylideneglycerol-(ACM) and water (HO). This unique solvent exchange enhances chain entanglement within the interpenetrating dual networks and establishes robust hydrogen bonding interactions.

Spi1 aggravates neuropathic pain by modulating Clec7a-mediated neuroinflammation and microglial phagocytosis.

Background: Microglia are essential in mediating responses to nerve injury, with neuroinflammation and engulfment of interneuron inhibitory synapses driving heightened neuronal excitability and pain hypersensitivity. Spi1 is the main regulator of microglial homeostasis in the central nervous system. However, its function in neuropathic pain remains unclear.