Correction to "ICG-Loaded PEG-Modified Black Phosphorus Nanosheets for Fluorescence Imaging-Guided Breast Cancer Therapy".

[This corrects the article DOI: 10.1021/acsomega.1c04909.

Comparing the diagnostic efficacy of [F]FDG PET/CT and [F]FDG PET/MRI in breast cancer recurrence: a systematic review and meta-analysis.

Purpose: This meta-analysis evaluates and compares the diagnostic accuracy of [F]FDG PET/CT and [F]FDG PET/MRI in detecting breast cancer recurrence.

Methods: A search was conducted across PubMed, Web of Science, and Embase databases up to June 10, 2025, to identify studies evaluating the diagnostic performance of [F]FDG PET/CT and/or [F]FDG PET/MRI in breast cancer recurrence. Sensitivity and specificity were calculated using the DerSimonian and Laird method with Freeman-Tukey double arcsine transformation.

Psychological Effects of 12 Weeks of Moderate-to-Vigorous Exercise on Men With Methamphetamine Use Disorder: A Randomized Controlled Trial.

Objectives: This study evaluated the psychological impact of moderate-to-vigorous aerobic exercise (MVE) on male methamphetamine (MA) use disorders (MUD) rehabilitation inpatients.

Methods: Hundred male MUD rehabilitation inpatients were randomized into 2 groups; the experimental group received the MVE intervention, and the control group received a low-to-moderate-intensity exercise intervention for 1 hour, 5 times a week for 3 months. Psychological assessment was performed using Symptom Checklist 90, and MA craving was assessed using the Virtual Reality Addiction Assessment System developed by Tsing Research Technology (http://www.

Oxidative Stress in Dry Eye Disease: A Bibliometric Analysis.

Purpose: To study the knowledge structure and evolution of oxidative stress in dry eye disease (DED) using bibliometrics and explore prospective anti-oxidative stress strategies for future clinical interventions.

Methods: The Web of Science Core Collection (WoSCC) was used as the data source to systematically retrieve and screen the research literature published between January 1, 1992, and December 31, 2024, related to oxidative stress research in DED. The data were then analyzed using VOSviewer, CiteSpace, and R package Bibliometrix to visualize the network of countries, organizations, journals, authors, and keywords related to oxidative stress in DED.

Residual-conditioned sparse transformer for photoacoustic image artifact reduction.

Photoacoustic tomography (PAT) combines the high spatial resolution of ultrasound imaging with the high contrast of optical imaging. To reduce acquisition time and lower the cost of photoacoustic imaging, sparse sampling strategy is often employed. Conventional reconstruction methods often produce artifacts when dealing with sparse data, affecting image quality and diagnostic accuracy.

Sudden rupture of recurrent rectal prolapse complicated by small intestine evisceration from anus: a case study.

Evisceration of the small intestine from the anus is a rare complication following rectal injury. In patients with recurrent rectal prolapse, delayed surgical intervention can lead to rectal wall thinning due to chronic ischemia, increasing the risk of rectal rupture and subsequent intrusion of the small bowel followed by antegrade intussusception. Since Bodie first described this condition in 1827, fewer than one hundred cases have been reported globally.

Sterilized protective immunity induced by DAM and DAM in mouse models for both VACV and MPXV.

The increasing prevalence of mpox calls for the development of safer and more accessible next-generation vaccines. Based on a structure-guided "two-in-one" immunogen design strategy, we have previously developed an innovative protein-based monkeypox virus (MPXV) vaccine, DAM (Double A35 and M1), which addresses the issues of imbalanced bioavailability associated with cocktail vaccines and elicits superior antiviral immunity with a safety profile. In this study, we iteratively designed two "four-in-one" chimeric immunogens, DAMs, using four MPXV antigens, M1, A29, A35, and B6.

An Engineered Soluble Single-Chain TCR Engager for KRAS-G12V Specific Tumor Immunotherapy.

T cell receptor (TCR) based immunotherapy is an attractive strategy to target a wide range of intra-tumoral antigens and elicit robust tumor cytotoxicity. However, engineering soluble TCR engagers that preserve physiological affinity is crucial for universal TCR drug development, yet remains challenging. In the present study, multiple TCR engagers featuring diverse architectures based on the KRAS-G12V specific 1-2C TCR in the context of HLA-A*11:01 is designed and evaluated.

Cascade Catalytic Nanozymes Induce Tumor Ca Overload and Ferroptosis by Reducing Energy Supply and Amplifying Oxidative Stress.

Nanozyme-mediated nanocatalytic therapy, by mimicking the activity of redox enzymes, generates highly toxic reactive oxygen species (ROS) within tumor cells, thereby opening a pathway for tumor-specific therapy. However, achieving satisfactory therapeutic outcomes with nanozymes remains challenging due to the inherent complexity of the tumor microenvironment (TME). In this context, we designed a two-dimensional layered double hydroxide (LDH) nanozyme loaded with Au nanoparticles, while incorporating bioactive Ca and Fe ions (denoted as MgCaFe-LDH@Au NSs) to target the specific needs of the TME.

Efficacy and safety of inetetamab plus pertuzumab and nab-paclitaxel as neoadjuvant therapy for HER2+ breast cancer: A single-arm multicenter phase II clinical trial.

The combination of inetetamab and vinorelbine has demonstrated survival benefits with an acceptable toxicity profile in HER2+ metastatic breast cancer (MBC) patients. This multicenter, single-arm, phase II trial further evaluates the efficacy of inetetamab combined with pertuzumab and nab-paclitaxel as neoadjuvant therapy. Treatment-naïve patients with HER2+ early-stage or locally advanced BC received four cycles of intravenous inetetamab (8 mg/kg loading dose, then 6 mg/kg for subsequent doses), intravenous pertuzumab (840 mg loading dose, then 420 mg for subsequent doses), and weekly nab-paclitaxel (125 mg/m).

Characterization of the intestinal microorganism in patients with congenital intestinal atresia: the preliminary exploration for establishment and influence of initial intestinal flora in newborns.

Purpose: This study aimed to analyze the differences in microbial composition between the proximal and distal intestinal segments of newborns with intestinal atresia, speculating about the mechanism underlying the initial establishment of neonatal intestinal flora. Additionally, differential metabolic pathways were explored to predict their potential effects on gravidas and fetuses.

Methods: The microbial characteristics of intestinal flora were assessed using 16SrRNA sequencing.

Unraveling breast cancer response to neoadjuvant chemotherapy through integrated genomic, transcriptomic, and circulating tumor DNA analysis.

Introduction: Neoadjuvant chemotherapy (NAC) is a standard treatment for breast cancer (BC) to shrink tumors and facilitate surgery. However, the molecular underpinnings of response to NAC and prognosis have not been well characterized.

Methods: We enrolled 73 stage II/III BC patients who received NAC followed by surgery.

Needling trigger points for treating myofascial pain syndrome: A systematic review and meta-analysis.

Background: Myofascial pain syndrome (MPS) is a widespread musculoskeletal disorder characterized by myofascial trigger points. Needling trigger points is one of the most common therapeutic interventions to treat MPS. However, it is unclear whether needling trigger points is superior to other non-pharmacological interventions.

ULST: U-shaped LeWin Spectral Transformer for virtual staining of pathological sections.

At present, pathological section staining faces several challenges, including complex sample preparation and stringent infrastructure requirements. Virtual staining methods utilizing deep neural networks to automatically generate stained images are gaining recognition. However, most current virtual staining techniques rely on standard RGB microscopy, which lacks spatial spectral information.

Rare large sigmoid hamartomatous polyp in an elderly patient with atypical Peutz-Jeghers syndrome: A case report.

Background: Peutz-Jeghers (PJ) syndrome (PJS) is a rare autosomal dominant genetic disease characterized by the association of intestinal polyposis, mucosal skin pigmentation, and cancer susceptibility. PJS patients have a significantly increased risk of malignant tumors in the gastrointestinal tract and extra-gastrointestinal tract, including various epithelial malignant tumors (colorectal cancer, gastric cancer, pancreatic cancer, breast cancer, and ovarian cancer, ). PJS is commonly seen in children and adolescents with multiple small intestinal polyps, often causing intussusception.

[Spherical measurement-based analysis of gradient nonlinearity in magnetic resonance imaging].

The gradient field, one of the core magnetic fields in magnetic resonance imaging (MRI) systems, is generated by gradient coils and plays a critical role in spatial encoding and the generation of echo signals. The uniformity or linearity of the gradient field directly impacts the quality and distortion level of MRI images. However, traditional point measurement methods lack accuracy in assessing the linearity of gradient fields, making it difficult to provide effective parameters for image distortion correction.

Rapid Bacterial Identification through Multiplexed Nucleic Acid Detection on a Digital Microfluidic Platform for Enhanced Clinical Intervention against Infections.

Bacterial infections often lead to severe health consequences owing to their ability to infiltrate multiple anatomical sites, including the bloodstream, respiratory tract, and digestive tract, posing substantial diagnostic and therapeutic challenges. Consequently, a rapid and versatile detection method capable of identifying a broad spectrum of bacterial pathogens is urgently required to facilitate precise antibiotic prescriptions. Addressing this need, we introduce MiND-DMF (Multibacterial Infection Nucleic Acid Detection on a Digital Microfluidic Platform), a cost-effective digital microfluidic platform tailored for multiplexed bacterial detection.

Electroacupuncture alleviates damage to myopic RGCs probably through lncRNA-XR_002789763.1-mediated mitophagy.

Background: Mitophagy is closely related to the regulation of retinal ganglion cell (RGC) structure and function. Our previous study suggested that long noncoding RNAs (lncRNAs) can cause damage to myopic RGCs. However, whether electroacupuncture (EA) treatment can delay myopia progression through lncRNA-mediated mitophagy in RGCs is currently unknown.

Long COVID facts and findings: a large-scale online survey in 74,075 Chinese participants.

Background: Research on long COVID in China is limited, particularly in terms of large-sample epidemiological data and the effects of recent SARS-CoV-2 sub-variants. China provides an ideal study environment owing to its large infection base, high vaccine coverage, and stringent pre-pandemic measures.

Methods: This retrospective study used an online questionnaire to investigate SARS-CoV-2 infection status and long COVID symptoms among 74,075 Chinese residents over one year.

Micropeptide hSPAR regulates glutamine levels and suppresses mammary tumor growth via a TRIM21-P27KIP1-mTOR axis.

mTOR plays a pivotal role in cancer growth control upon amino acid response. Recently, CDK inhibitor P27KIP1 has been reported as a noncanonical inhibitor of mTOR signaling in MEFs, via unclear mechanisms. Here, we find that P27KIP1 degradation via E3 ligase TRIM21 is inhibited by human micropeptide hSPAR through its C-terminus (hSPAR-C), causing P27KIP1's cytoplasmic accumulation in breast cancer cells.

Case report: A successful case of targeted immunotherapy for locally advanced pancreatic cancer under non-surgical conditions.

Introduction: Locally advanced pancreatic cancer (LAPC) is a borderline unresectable malignancy that presents significant treatment challenges. The management of LAPC remains a complex issue, particularly in patients who are not eligible for surgical resection.

Case: Here, we report the case of a 60-year-old woman diagnosed with LAPC through pathological biopsy who subsequently underwent targeted immunotherapy following the failure of a gemcitabine, oxaliplatin, and S-1 (G&S) chemotherapy regimen.

Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression.

Black phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions in cancer treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol-functionalized BP (BP-PEG) nanosheets in breast cancer models. Using immunocompetent mouse models-including 4T1 orthotopic BALB/c mice and MMTV-PyMT transgenic mice, it is found that BP-PEG significantly inhibits tumor growth and metastasis without directly inducing cytotoxicity in tumor cells.

Plasma-based transcriptomic non-coding signature for predicting relapse in pediatric acute lymphoblastic leukemia.

Pediatric Acute Lymphoblastic Leukemia (ALL) is the most common malignant tumor of the hematological system in children, and its relapse after treatment has consistently been a significant factor hindering prognosis. This study aimed to develop a blood-based non-invasive method for predicting relapse in children with ALL. Two cohorts of pediatric ALL patients were analyzed.

Three-dimensional kinematic analysis can improve the efficacy of acupoint selection for post-stroke patients with upper limb spastic paresis: A randomized controlled trial.

Background: China is seeing a growing demand for rehabilitation treatments for post-stroke upper limb spastic paresis (PSSP-UL). Although acupuncture is known to be effective for PSSP-UL, there is room to enhance its efficacy.

Objective: This study explored a semi-personalized acupuncture approach for PSSP-UL that used three-dimensional kinematic analysis (3DKA) results to select additional acupoints, and investigated the feasibility, efficacy and safety of this approach.