Upregulation of EMP3 in acute myeloid leukemia: a study based on data mining, RT-qPCR and immunohistochemistry.

Background: Epithelial Membrane Protein 3 (EMP3) has been associated with multiple malignancies, but its expression patterns and clinical significance in acute myeloid leukemia (AML) remain poorly characterized.

Methods: Public datasets were integrated to assess EMP3 mRNA expression levels in AML patients versus healthy donors, with validation performed using reverse transcription quantitative PCR (RT-qPCR). Protein expression was accessed through immunohistochemistry.

Lycium Barbarum Polysaccharides Protects Zebrafish Larvae From Nonylphenol-Induced Neurodevelopmental Disorders via the p38/5-HT1A/Wnt/β-Catenin Pathway.

Severe contamination with nonylphenol (NP) poses exposure risks and potential health problems for humans. However, direct evidence linking NP exposure to neurodevelopmental disorders in infants and young children remains limited, and the underlying mechanisms of such effects are unclear. Furthermore, neurodevelopmental disorders are characterized by their far-reaching impacts and lack of effective cures, emphasizing an urgent need to develop drugs targeting the treatment of these disorders.

Safety and immunogenicity of novel live attenuated type 1 and type 3 oral poliomyelitis vaccines in healthy adults in the USA: a first-in-human, observer-masked, multicentre, phase 1 randomised controlled trial.

Background: Reducing the risks of vaccine-derived polioviruses and vaccine-associated paralytic poliomyelitis motivated the development of novel types 1 and 3 oral poliovirus vaccines (nOPV1 and nOPV3, respectively), designed to have similar safety and immunogenicity and improved genetic stability (to reduce risk of reversion to neurovirulence) relative to types 1 or 3 Sabin-strain OPVs. We aimed to assess the safety and immunogenicity of nOPV1 and nOPV3 in healthy adults.

Methods: We did a first-in-human, observer-masked, multicentre, phase 1 randomised controlled trial in healthy adults at four centres in the USA.

Sodium Alginate Hydrogel Sponges Embedded with M2 Macrophages: An Adoptive Cell Therapy Strategy for Accelerated Diabetic Wound Healing.

Hydrogels possess advantages for providing a moist wound environment and enabling drug or cell delivery. Wound healing is a complex, multistage process where macrophages play a pivotal role; they influence inflammation resolution, anti-inflammatory cytokine production, angiogenesis, and extracellular matrix remodeling. Combining hydrogel materials with adoptive M2 macrophages offers a promising adoptive cell therapy approach to accelerate healing.

The response characteristics of 10 kV typical distribution transformers under high-altitude electromagnetic pulse.

High-altitude electromagnetic pulses (HEMP) have the potential to inflict substantial harm on the distribution system through coupling with overhead lines. This study investigates HEMP-induced conduction effects on 10 kV distribution transformers through theoretical analysis and test validation. Transmission line theory was employed to analyze the coupling environment of overhead lines under HEMP.

Identification of novel angiotensin I-converting enzyme inhibitory peptides from walnut ( Dode) protein hydrolysates and their vascular endothelial protective properties: and studies.

The objective of this study was to explore novel functional peptides derived from walnut protein isolate (WPI) that exhibited gastrointestinal stability, angiotensin I-converting enzyme (ACE1) inhibitory activity, and endothelial protective properties. Among the 81 detected peptides, 36 peptides with Glu, Leu, Pro, and Asp as the predominant residues were predicted to exhibit ACE1 inhibitory activity. Four promising peptides (TLEPT, TLEPN, VYLEQ, and VLSPQ) were selected for further evaluation based on predicted bioactivity and abundance.

Environmental risk management and innovation: The impact of patent insurance pilots on clean technology development.

Green transformation has become a global consensus, promoting green technology innovation of heavy polluting enterprises has become a key issue to promote sustainable development. We take implementation of patent insurance pilot policy as an exogenous shock, and constructs a multi-period double difference model based on the data of A-share listed companies in the heavy pollution industry from 2008 to 2023 to empirically test impact of patent insurance pilot on enterprises' green technology innovation. The findings show that the patent insurance pilot significantly enhance green technology innovation level of heavy pollution enterprises.

The PARP1-EXD2 axis orchestrates R-loop resolution to safeguard genome stability.

R-loops, comprising an RNA-DNA hybrid and a displaced single-stranded DNA, are dynamic three-stranded nucleic acid structures that, when dysregulated, can disrupt transcription and replication, undermining genome integrity and contributing to human pathologies. Here we identify exonuclease 3'-5' domain-containing 2 (EXD2) as a pivotal R-loop resolvase. We demonstrate that EXD2, through direct interaction with poly(ADP-ribose) (PAR) polymers synthesized by R-loop-bound and activated PAR polymerase 1 (PARP1), is recruited to R-loops, where it undergoes acetylation by the acetyltransferase CREB-binding protein at K416.

Effects of Acupuncture Combined with Conventional Rehabilitation Training for Patients with Post-Stroke Dysphagia: A Randomized Controlled Trial.

Objective: Stroke is a significant global public health challenge. Evidence suggests that acupuncture contributes to the treatment and rehabilitation of post-stroke dysphagia (PSD), effectively improving swallowing function and enhancing patients' quality of life. This study aimed to examine the effects of acupuncture combined with conventional rehabilitation training (CRT) on swallowing function, neurotransmitter levels, nutritional status, and swallowing-related quality of life in patients with PSD.

Core construction establishment for Ruchengbaimao tea based on SSR markers.

Germplasm collection and conservation requires many efforts and resources. Core collection construction could both conserve genetic diversity and improve conservation efficiency. This study investigated the genetic diversity of tea plants [Camellia sinensis (L.

Graft-growth of Cobalt-based Prussian blue analogs on bamboo for indoor formaldehyde removal.

Formaldehyde is a common indoor organic pollutant and primarily emitted from materials such as artificial panels and wall coatings, posing significant risks to human health. Therefore, it is of practical significance to develop novel materials for efficient removal of indoor formaldehyde. Prussian blue analogs (PBA), which possess desirable properties such as high tunability, multifunctionality, large specific surface area, and environmental friendliness, show great potential in formaldehyde removal applications.

Combined effect of fasting blood glucose and serum uric acid on nonalcoholic fatty liver disease.

Background: This study sought to investigate the independent and synergistic impacts of fasting blood glucose (FBG) and serum uric acid (SUA) levels on non-alcoholic fatty liver disease (NAFLD) in participants with and without type 2 diabetes mellitus (T2DM).

Method: A total of 12,430 participants (mean age: 54.34 ± 15.

Fabrication of Periodic Arrays of Highly Oriented Plasmonic Heterotrimers via Site-Specific Sequential Colloidal Assembly.

Plasmonic nanoarrays show applications in biosensors, nanolasers, and photodetectors, but precisely organizing and orienting nanoparticle (NP) trimers on substrates remains a grand challenge. Here, we present a self-assembly strategy to arrange metallic NPs with distinct diameters into centimeter-scale arrays of highly oriented linear trimers by modulating the balance between capillary forces and coordination-electrostatic interactions. We achieved an 88% yield of plasmonic trimers with ±10° orientation uniformity across 1 cm substrates by optimizing the ionic strength of the NP solutions.

Prognostic value of serum C-reactive protein in idiopathic multicentric Castleman disease and construction of a prognostic model for patients.

Background: Idiopathic Multicentric Castleman disease (iMCD) is a type of the rare lymphoproliferative diseases. C-reactive protein (CRP) is a well-recognized biomarker of inflammation, frequently exhibits elevated levels in individuals diagnosed with iMCD. However, its prognostic value of this factor in iMCD remains uncertain.

Predictors for recurrent ischemic stroke in patients with watershed infarct induced by intracranial artery stenosis.

Background And Purpose: Symptomatic intracranial artery stenosis (sICAS) is strongly associated with an elevated risk of recurrent ischemic stroke, yet the underlying risk factors remain elusive. In this present study, we aimed to investigate the risk factors and predictive value of imaging features for recurrent ischemic stroke in patients with watershed infarction caused by ICAS.

Methods: We prospectively collected clinical information and imaging data from patients with watershed infarction caused by ICAS.

Genomic mutation and Clinicopathological features of KRAS wild-type tumors in Chinese cohort with pancreatic adenocarcinoma.

This study aims to elucidate the genomic and clinicopathological characteristics of pancreatic ductal adenocarcinoma (PDAC) in Chinese patients with KRAS wild-type (WT) tumors. Analysis of 869 PDAC patients revealed that 164 tumors (19 %) were KRAS WT, with a predominance of TP53 mutations (32 %), followed by AHNAK (12 %), CTNNB1 (6 %), and BRAF (5 %). These tumors exhibited a higher prevalence of DNA damage response gene mutations, lower levels of tumor antigens CA-199, CA-125, and CEA, and with a similar trend in mutant-allele tumor heterogeneity and tumor mutational burden.

 (Poaceae, Bambusoideae), a new combination supported by morphological and molecular evidence.

Morphological characteristics and phylogenetic analyses clearly revealed that should be a member of the genus , rather than , and is a distinct species close to and . Morphologically, it differs from all the other known species by internodes initially with white pubescent, culm leaf auricles absent and triangularly subulate sheath blades, characteristics that are unusual in this genus. And this morphological distinction warrants recognition of as a new combination of .

[Research progress on NCOA4-mediated ferritinophagy and related diseases].

Nuclear receptor co-activator 4 (NCOA4) acts as a selective cargo receptor that binds to ferritin, a cytoplasmic iron storage complex. By mediating ferritinophagy, NCOA4 regulates iron metabolism and releases free iron in the body, thus playing a crucial role in a variety of biological processes, including growth, development, and metabolism. Recent studies have shown that NCOA4-mediated ferritinophagy is closely associated with the occurrence and development of iron metabolism-related diseases, such as liver fibrosis, renal cell carcinoma, and neurodegenerative diseases.

Differential analysis of brain functional network parameters in MHE patients.

Resting-state functional magnetic resonance imaging, using blood-oxygen-level-dependence signal data and graph theory, was employed to explore brain functional network parameter changes in 32 MHE patients and 21 healthy controls. The Gretna software package and spm8 are used to preprocess and process the data in matlab2012b to calculate the global efficiency (Eg), local efficiency (El), nodal degree (nodal De), nodal clustering coefficient (nodal Cp), nodal shortest path length (nodal Lp), and nodal betweenness (nodal Be) as brain functional network characteristic parameters. The BrainNet View soft is used to draw network maps and present surface-based data.

[Spherical measurement-based analysis of gradient nonlinearity in magnetic resonance imaging].

The gradient field, one of the core magnetic fields in magnetic resonance imaging (MRI) systems, is generated by gradient coils and plays a critical role in spatial encoding and the generation of echo signals. The uniformity or linearity of the gradient field directly impacts the quality and distortion level of MRI images. However, traditional point measurement methods lack accuracy in assessing the linearity of gradient fields, making it difficult to provide effective parameters for image distortion correction.

Immunogenicity of monkeypox virus surface proteins and cross-reactive antibody responses in vaccinated and infected individuals: implications for vaccine and therapeutic development.

Background: The monkeypox virus (MPXV) has raised global health concerns due to its widespread transmission. This study evaluated the MPXV immunogenic antigens and the impact of vaccinia virus (VACV) vaccination and MPXV infection on cross-reactive antibody responses to conserved proteins from representative MPXV strains that reflected the evolutionary trajectory.

Methods: Phylogenetic analyses were first conducted to reveal the evolutionary trajectory of MPXV from 1970 to 2024.

Genome-wide identification of the AAAP gene family and expression analysis under tissue-specific expression in five legumes.

Amino acid/auxin permease (AAAP) is a transcription factor with a highly conserved amino acid region that regulates physiological processes and development in many plants and responds to various abiotic stresses. In this study, a genome-wide analysis of five legumes (Phaseolus vulgaris, Medicago truncatula, Lotus japonicus, Glycine max, and Cicer arietinum) identified 74, 106, 87, 147, and 70 AAAP genes, respectively. In addition, chromosomal localisation, phylogenesis, conserved motifs, gene structure, and gene replication analyses were performed on AAAP genes.

The role of mycobacteremia screening in enhancing non-tuberculous mycobacteria detection in hospitalized persons with HIV.

Among hospitalized severely immunocompromised persons with HIV (PWH), non-tuberculous mycobacteria (NTM) may be under-diagnosed due to non-specific symptoms undifferentiable with other opportunistic infections. To evaluate the prevalence of NTM mycobacteremia and how screening for mycobacteremia assistant with identification of NTM infections, this study retrospectively analyzed 1,136 hospitalized PWH with CD4 counts <200 cells/μL, who underwent mycobacteremia screening at a tertiary hospital in Nanjing, China, between July 2018 and December 2023. The prevalence of non-tuberculous mycobacteremia was 5.

Effect of organizational change on employee innovation performance: A dual mediation model.

Affected by the COVID-19 pandemic and the international development pattern, the international environment has undergone profound changes. Enterprises, as the main body of activities on the front line of production and operation and the main battlefield of market competition, are facing various risk challenges. In both domestic and international markets, these challenges are becoming increasingly complex for businesses to navigate.