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Objectives: This study evaluated the psychological impact of moderate-to-vigorous aerobic exercise (MVE) on male methamphetamine (MA) use disorders (MUD) rehabilitation inpatients.
Methods: Hundred male MUD rehabilitation inpatients were randomized into 2 groups; the experimental group received the MVE intervention, and the control group received a low-to-moderate-intensity exercise intervention for 1 hour, 5 times a week for 3 months. Psychological assessment was performed using Symptom Checklist 90, and MA craving was assessed using the Virtual Reality Addiction Assessment System developed by Tsing Research Technology (http://www.qingtech.com.cn/AntiDrug/VrDrug). Two-factor repeated measures ANOVA was utilized to compare treatment differences between the 2 groups.
Results: There were better outcomes in the MVE group than in controls, mainly in terms of lower scores for compulsive symptoms ( < .05, η = .046), depression ( < .01, η = .061), and MA cravings ( < .05, η = .054). However, group × time interaction effects had no significant impact on somatization, interpersonal relationships, anxiety, hostility, paranoia, phobia, and psychoticism.
Conclusions: MVE helps reduce depression, compulsive symptoms, and MA cravings scores in adult men MUD rehabilitation inpatients. However, randomized double-blind trials are needed to validate this result further.
Trial Registration: ChiCTR2400080819.
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http://dx.doi.org/10.1177/29767342251352608 | DOI Listing |
Biol Psychiatry Cogn Neurosci Neuroimaging
September 2025
Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine and Psychology, Shanghai, China. Electronic address:
Background: Aberrant decision-making is a hallmark of substance use disorders (SUDs), often impeding recovery. While uncertainty, comprising risk and ambiguity, is central to real-world choices, its distinct effects in SUDs remain underexplored. This study disentangles risk and ambiguity to identify context-specific impairments in methamphetamine (MUD) and alcohol use disorders (AUD).
View Article and Find Full Text PDFTransl Psychiatry
August 2025
Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Reducing psychological craving is critical for preventing relapse in methamphetamine use disorder (MUD). This study aimed to evaluate the efficacy of virtual reality (VR)-based cue exposure therapy (CET) and cue exposure with aversion therapy (CETA) in reducing methamphetamine craving in men with MUD. In this randomized controlled trial, 89 men with MUD were assigned to three groups: VR-based cue exposure therapy (CET, n = 30), VR-based cue exposure combined with aversion therapy (CETA, n = 29), and neutral scenes (NS, n = 30).
View Article and Find Full Text PDFSubst Use Addctn J
August 2025
Chengdu Sport University, Chengdu, Sichuan Province, China.
Objectives: This study evaluated the psychological impact of moderate-to-vigorous aerobic exercise (MVE) on male methamphetamine (MA) use disorders (MUD) rehabilitation inpatients.
Methods: Hundred male MUD rehabilitation inpatients were randomized into 2 groups; the experimental group received the MVE intervention, and the control group received a low-to-moderate-intensity exercise intervention for 1 hour, 5 times a week for 3 months. Psychological assessment was performed using Symptom Checklist 90, and MA craving was assessed using the Virtual Reality Addiction Assessment System developed by Tsing Research Technology (http://www.
Eur Arch Psychiatry Clin Neurosci
June 2025
State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China.
Background: Patients with methamphetamine use disorder (MUD) are known to experience cognitive dysfunction. Our previous study was the first to demonstrate the negative impact of childhood maltreatment (CM) on cognitive function in MUD patients. Extensive research has highlighted the crucial role of brain-derived neurotrophic factor (BDNF) gene polymorphisms in cognitive function.
View Article and Find Full Text PDFRural Remote Health
June 2025
Wide Bay Hospital and Health Service, Bundaberg, Qld 4670, Australia.
Context: Necrotising fasciitis is a rapidly progressing, life-threatening soft tissue infection that carries a high morbidity and mortality, especially in susceptible populations.
Issue: During the La Niña spring-summer-autumn of 2021-2022, five male patients aged between 59 and 86 were admitted into the Hervey Bay Hospital (Queensland, Australia) intensive care unit (ICU) with necrotising fasciitis and multi-organ failure. All five patients had been in saltwater rivers within the local Fraser Coast area and either hunting for Scylla serrata (commonly known as green mud crabs), or descaling barnacles from their vessels.