Whole-genome identification of SOD gene family revealed the expansion of SOD in Chinese mitten crab, Eriocheir sinensis.

Superoxide dismutase (SOD) genes are essential components of the antioxidant defense system in crustacean. However, SOD genes have not been identified in Chinese mitten crab (Eriocheir sinensis). In this study, 6 SOD genes including 5 SOD1 and 1 SOD2 genes were identified through a comparative analysis in E.

Virtual reality-based cue exposure therapy reduces psychological craving in men with methamphetamine use disorder: a randomized controlled trial.

Reducing psychological craving is critical for preventing relapse in methamphetamine use disorder (MUD). This study aimed to evaluate the efficacy of virtual reality (VR)-based cue exposure therapy (CET) and cue exposure with aversion therapy (CETA) in reducing methamphetamine craving in men with MUD. In this randomized controlled trial, 89 men with MUD were assigned to three groups: VR-based cue exposure therapy (CET, n = 30), VR-based cue exposure combined with aversion therapy (CETA, n = 29), and neutral scenes (NS, n = 30).

Acenaphthylene-Fused Angular and Linear π-Extension of Acridone.

The direct functionalization of small heterocyclic molecules is an efficient strategy for constructing large heteroatom-doped polycyclic aromatic systems. However, due to the unique reactivity of acridone, π-extension on the benzene ring generally leads to the formation of angular-shaped acridone derivatives. In this study, we present the selective synthesis of both linear and angular π-extended acridone derivatives incorporating acenaphthylene units with intervening five-membered rings.

Advanced multi-label brain hemorrhage segmentation using an attention-based residual U-Net model.

Objective: This study aimed to develop and assess an advanced Attention-Based Residual U-Net (ResUNet) model for accurately segmenting different types of brain hemorrhages from CT images. The goal was to overcome the limitations of manual segmentation and current automated methods regarding precision and generalizability.

Materials And Methods: A dataset of 1,347 patient CT scans was collected retrospectively, covering six types of hemorrhages: subarachnoid hemorrhage (SAH, 231 cases), subdural hematoma (SDH, 198 cases), epidural hematoma (EDH, 236 cases), cerebral contusion (CC, 230 cases), intraventricular hemorrhage (IVH, 188 cases), and intracerebral hemorrhage (ICH, 264 cases).

Isolation and Molecular Characterization of Swine Parainfluenza Virus 5 from Piglets Co-Infected with PEDV.

Parainfluenza virus 5 (PIV5), now reclassified as , is a negative-sense, single-stranded RNA virus belonging to the genus of the family [...

Single-cell transcriptional landscape of peripheral myeloid cells in autoimmune diseases.

Myeloid cells are pivotal in autoimmune disorder development due to their varied immune response functions yet understanding them at the single-cell level in such conditions is limited. To address this gap, we analyzed 351,905 myeloid cells from 375 single-cell RNA sequencing samples covering 14 autoimmune diseases, which allowed us to classify myeloid cells into 13 distinct subsets with unique immunological profiles. Through pseudotime analysis, we identified a branching process leading to two intermediary inflammatory subtypes and observed dysregulation in eight co-expression modules crucial for monocyte function across autoimmune conditions.

Application of punch excision in the treatment of severe burn scars.

Introduction: This study aims to identify the therapeutic outcomes of punch excision in severe burn patients with extensive, excessive and long-lasting growth scars.

Methods: A retrospective comparative clinical observational study was conducted on patients with burn hypertrophic scars who were treated at the Department of Burn and Skin Wound Repair, First Hospital of Jilin University, between October 2022 and October 2024.

Results: A total of 49 patients with severe burn scars were included.

Differential gene expression in the intestines of Chinese mitten crabs with three carapace colors.

Background: Carapace color in Chinese mitten crab (Eriocheir sinensis) influences both commercial value and physiological traits, yet its molecular basis remains unclear. The intestine plays a key role in pigment absorption and metabolism, but its involvement in pigmentation has been understudied. This study aimed to investigate intestinal gene expression differences among red, white, and green carapace strains.

Synergistic Control of Mitochondrial Dynamics and Function by ERAD and Autophagy in Brown Adipocytes.

Unlabelled: Mitochondrial quality control is essential for maintaining cellular energy homeostasis, particularly in brown adipocytes where dynamic mitochondrial remodeling supports thermogenesis. Although the SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) pathway and autophagy are two major proteostatic systems, how these pathways intersect to regulate mitochondrial integrity in metabolically active tissues remains poorly understood. Here, using adipocyte-specific genetic mouse models combined with high-resolution 2D and 3D ultrastructural imaging technologies, we reveal an unexpected synergy between SEL1L-HRD1 ERAD and autophagy in maintaining mitochondrial structure and function in brown adipocytes.

Efficacy and safety of Wuling capsule for the treatment of mild depression in patients with early Parkinson's disease in China: a randomized clinical trial.

Background: Depression is a prevalent non-motor symptom of Parkinson's disease (PD) that significantly impacts patients' quality of life. The Wuling capsule, a traditional Chinese medicine, is often utilized for treating depression, and this herbal medicine has been used to treat those PD patients with depression. This study aims to assess the efficacy and safety of Wuling capsule in treating mild depression in patients with early PD.

PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation.

Unlabelled: Porcine epidemic diarrhea virus (PEDV) leads to a high mortality in neonatal piglets and causes serious harm to the global swine industry. PEDV has been shown to exploit diverse strategies for antagonism of host innate immunity and promotion of self-replication. However, the underlying mechanisms involved in PEDV immunosuppression remain to be fully elucidated.

Comprehensive profiling of integrative conjugative elements (ICEs) in Mollicutes: distinct catalysts of gene flow and genome shaping.

Mollicutes, known as the simplest bacteria with streamlined genomes, were traditionally thought to evolve mainly through gene loss. Recent studies have highlighted their rapid evolutionary capabilities and genetic exchange within individual genomes; however, their evolutionary trajectory remains elusive. By comprehensive screening 1433 available Mollicutes genomes, we revealed widespread horizontal gene transfer (HGT) in 83.

The clinical outcomes of ultra-low-dose radiotherapy for primary conjunctival mucosa-associated lymphoid tissue lymphoma.

Purpose: To assess the treatment efficacy, long-term outcomes and ocular toxicity of ultra-low-dose radiotherapy (4 Gy) in managing conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma.

Methods: This study retrospectively analyzed 15 patients with conjunctival MALT lymphoma between 2020 and 2022, who received 4 Gy radiotherapy (RT) delivered in consecutive 2-Gy fractions. The long-term outcomes included response rate, response time, recurrences or progression, and RT-related toxic effects.

Evolving diagnosis and comorbidities of gaming disorder: Insights from psychiatry departments in five Chinese hospitals from 2018 to 2023.

Background And Aim: The 11th Revision of the International Classification of Diseases (ICD-11) recognizes gaming disorder (GD) as a behavioral addiction, but its implications for the clinical diagnostic practice of GD remain underexplored. This study examines the clinical diagnosis of GD since its inclusion in ICD-11 to understand trends in diagnosis rates in psychiatric departments and patient characteristics, particularly comorbidities.

Method: This multicenter, retrospective observational study was conducted in five large tertiary hospitals and mental health centers across four Chinese provinces.

Knockdown of TRIM65 Inhibits Neoangiogenesis in Proliferative Diabetic Retinopathy by Regulating miR29a-3p.

Introduction: High glucose-induced angiogenesis is the main component in Proliferative Diabetic Retinopathy (PDR) development. In PDR, ischemia and hypoxia have been identified as key stimuli that promote pathological neoangiogenesis by increasing Vascular Endothelial Growth Factor A (VEGFA). Furthermore, it has been demonstrated that TRIM65 knockdown in tumor cells reduces VEGFA expression.

Retraction notice to "The potential impact of digital economy on energy poverty in the context of Chinese provinces" [Heliyon 10 (2024) e30140].

[This retracts the article DOI: 10.1016/j.heliyon.

Bibliometric analysis of research trends on hyperbaric oxygen therapy in stroke from 2000 to 2022.

Background: Stroke primarily results from the interruption of cerebral blood flow. Hyperbaric oxygen therapy (HBOT), a noninvasive and promising therapeutic intervention, has been widely used to treat various ischemic and hypoxic conditions. Over the past two decades, extensive research has demonstrated HBOT's efficacy in reducing cerebral infarct volume, establishing it as a viable neuroprotective strategy.

Three-Dimensional Bicarbazole-Based Covalent Organic Frameworks as Efficient Yeager-Type Photocatalysts for HO Generation in a Two-Phase System.

Photocatalytic reduction of oxygen to hydrogen peroxide (HO) represents an attractive solar-to-chemical conversion pathway. Nevertheless, it remains a significant challenge to achieve efficient HO photosynthesis while simultaneously mitigating photocorrosion of the catalysts owing to the presence of superoxide radicals (O) and the accumulation of photoexcited holes (h). In the present work, a 1,2,3,4-tetrahydroisoquinoline (THIQ)-water two-phase system was developed to achieve high-efficiency and durable production of HO by suppressing O intermediates and rapidly consuming h.

Characteristics of F-FAPI-04 PET/CT in patients with peritoneal metastasis and to predict treatment efficacy, a head-to-head comparison with F-FDG PET/CT.

Background: F-FAPI-04 PET/CT shows promise in detecting peritoneal metastases (PM), but its superiority over F-FDG PET/CT for lesion detection and predicting chemotherapy benefit remains unclear.

Purpose: To compare F-FAPI-04 and F-FDG PET/CT imaging features in PM and assess predictive value of F-FAPI-04 for chemotherapy efficacy.

Methods: 39 pathologically confirmed PM patients with digestive malignancies underwent concurrent F-FAPI-04 and F-FDG PET/CT.

Functional connectivity characteristics of epilepsy with anxiety: A resting-state functional near-infrared spectroscopy study.

Functional near-infrared spectroscopy (fNIRS) was applied to investigate the resting-state functional connectivity (RSFC) characteristics of the cerebral cortex in epileptic patients with and without anxiety. A total of 38 epileptic patients were recruited and divided into 2 groups according to the Generalized Anxiety Disorder 7-item score: epilepsy with anxiety (anxiety group) and epilepsy without anxiety (non-anxiety group). Resting-state fNIRS for 15 minutes was performed on each patient.

Leveraging deep learning and graph analysis for enhanced course recommendations in online education.

Online education growth requires the development of effective customized recommendation systems to improve student involvement and educational performance. This research, suggests new hybrid model based on Convolutional Neural Networks (CNNs) with graph analysis to improve online course recommendations by delivering more tailored suggestions to students. Our suggested process starts with extracting raw student and course data from a database which is preprocessed for training a CNN model.

Neutrophil-Camouflaged Stealth Liposomes for Photothermal-Induced Tumor Immunotherapy Through Intratumoral Bacterial Activation.

: , a tumor-resident bacterium colonizing breast cancer (BC), results in an immunosuppressive microenvironment and facilitates tumor growth and metastasis. This study aimed to develop a neutrophil-based liposome delivery system designed for dual-targeted elimination of tumor cells and , while simultaneously upregulating pathogen-associated molecular patterns and damage-associated molecular patterns to potentiate tumor immunotherapy. : The liposomes (PD/GA-LPs) loaded with the perylene diimide complex (PD) and gambogic acid (GA) were fabricated via the extrusion method.

Gender differences in problematic gaming among Chinese adolescents and young adults.

Background: This study aimed to evaluate the prevalence of problematic gaming among Chinese adolescents and young adults (CAYAs) and identify potential gender-specific risk variables.

Methods: 6,014 CAYAs were selected for this cross-sectional study using online convenience sampling. To evaluate their sociodemographic qualities, gaming practices, problematic gaming (as measured by the Video Game Dependency Scale), gaming motivations, and personality traits (as measured by the Chinese Big Five Personality Inventory abbreviated version), participants filled out a self-report questionnaire.

Exploring the relationship between cue-induced craving and withdrawal craving in MUD individuals based on a virtual-reality cue exposure paradigm.

Background: This study developed a virtual reality (VR) drug cue exposure paradigm for individuals with methamphetamine use disorder (MUD) to investigate the characteristics of withdrawal craving and cue-induced craving and their relationship.

Methods: A total of 150 male participants diagnosed with MUD completed questionnaires to assess their demographic characteristics and substance addiction profiles. Withdrawal craving for methamphetamine (MA) was measured using the visual analogue scale (VAS).

Genome-wide identification of heat shock protein 90 family in Larimichthys crocea and expression analysis in response to thermal stress and Vibrio parahaemolyticus infection.

Members of the heat shock protein 90 family (HSP90s) are evolutionarily conserved and play crucial roles in protein transport, immune regulation and antigen presentation. In this study, five hsp90s were identified from the genome of large yellow croaker (Larimichthys crocea) and analyzed using bioinformatics. All five identified hsp90s encode proteins with HATPase_c and HSP90 domains, and are mainly localized in the cytoplasm, mitochondria and endoplasmic reticulum.