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Online education growth requires the development of effective customized recommendation systems to improve student involvement and educational performance. This research, suggests new hybrid model based on Convolutional Neural Networks (CNNs) with graph analysis to improve online course recommendations by delivering more tailored suggestions to students. Our suggested process starts with extracting raw student and course data from a database which is preprocessed for training a CNN model. The purpose of this CNN model is to identify essential characteristics from student records and educational performance data and course information for predicting student course selection probabilities. The proposed model then defines the students as the fundamental entities of a graph network while behavioral and educational relationships create the edges between them. The application of graph analysis serves to detect behavioral patterns among students while predicting new possible relationships through solutions to cold start problems. This goal is achieved by applying the link prediction technique on the constructed graph. The generated course recommendations result from combining information derived from CNN models and graph analysis techniques. Experimental results based on 12,898 students from the Islamic Azad University E-Campus Tehran, Iran validated this hybrid approach through better performance than traditional methods which yielded precision at 0.8336 and F1-Score at 0.3347 thus confirming its ability to provide precise relevant course recommendations.
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http://dx.doi.org/10.1038/s41598-025-02156-y | DOI Listing |
J Nephrol
September 2025
Department of Internal Medicine, Faculty of Medicine, Universidad de Antioquia, Carrera 73 # 53-93, Medellín, Colombia.
Background: Acute kidney injury (AKI) is a common complication in patients affected by COVID-19 and has been strongly associated with increased mortality. However, its independent contribution remains debated. This study aimed to evaluate the independent association using a directed acyclic graph-based approach.
View Article and Find Full Text PDFPLoS One
September 2025
Information Technologies and Programming Faculty, ITMO University, Saint Petersburg, Russia.
In the paper we consider the well-known Influence Maximization (IM) and Target Set Selection (TSS) problems for Boolean networks under Deterministic Linear Threshold Model (DLTM). The main novelty of our paper is that we state these problems in the context of pseudo-Boolean optimization and solve them using evolutionary algorithms in combination with the known greedy heuristic. We also propose a new variant of (1 + 1)-Evolutionary Algorithm, which is designed to optimize a fitness function on the subset of the Boolean hypercube comprised of vectors of a fixed Hamming weight.
View Article and Find Full Text PDFBioinformatics
September 2025
Centre National de Recherche en Génomique Humaine, Institut François Jacob CEA Université Paris-Saclay.
Motivation: Graph Neural Network (GNN) models have emerged in many fields and notably for biological networks constituted by genes or proteins and their interactions. The majority of enrichment study methods apply over-representation analysis and gene/protein set scores according to the existing overlap between pathways. Such methods neglect knowledges coming from the interactions between the gene/protein sets.
View Article and Find Full Text PDFBrief Bioinform
August 2025
College of Pharmacy, Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, P. R. China.
Drug-induced hepatotoxicity (DIH), characterized by diverse phenotypes and complex mechanisms, remains a critical challenge in drug discovery. To systematically decode this diversity and complexity, we propose a multi-dimensional computational framework integrating molecular structure analysis with disease pathogenesis exploration, focusing on drug-induced intrahepatic cholestasis (DIIC) as a representative DIH subtype. First, a graph-based modularity maximization algorithm identified DIIC risk genes, forming a DIIC module and eight disease pathogenesis clusters.
View Article and Find Full Text PDFJ Pharm Anal
August 2025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
P-glycoprotein (P-gp) is a transmembrane protein widely involved in the absorption, distribution, metabolism, excretion, and toxicity (ADMET) of drugs within the human body. Accurate prediction of P-gp inhibitors and substrates is crucial for drug discovery and toxicological assessment. However, existing models rely on limited molecular information, leading to suboptimal model performance for predicting P-gp inhibitors and substrates.
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