Powder Inhibition of Gas Explosion Research Progress and Development Trend.

The domestic and international research status was reviewed, analyzing the explosion characteristics of inert powders, active powders, and composite powder explosion suppressants from the perspectives of maximum explosion pressure and flame propagation properties. The explosion suppression mechanisms of powder suppressants were also summarized. Analysis found that the inert powder is mainly from the physical aspects of heat absorption, oxygen dilution, and the formation of physical barriers to inhibit gas explosions; the active powder is mainly from the chemical aspects of the capture of free radicals to interrupt the explosion chain reaction inhibition of gas explosions; the composite powder is through the physical-chemical aspects of synergistic inhibition of gas explosions.

Ecological distribution and metabolic potential of Marine Group II archaea in the Eastern Indian Ocean: Evidence for heterotrophic carbon fixation.

Marine Group II (MGII) archaea are globally distributed in oceanic waters, yet their ecological functions and metabolic potentials remain elusive due to the lack of pure culture. Here, we investigate the diversity, distribution, and metabolic potential of MGII archaea in the Eastern Indian Ocean using high-throughput sequencing and metagenomic analyses. We identified 37 MGII operational taxonomic units(OTUs), with surface and deep chlorophyll maximum (DCM) layers dominated by clade O1, O3, and P, and deeper waters by O4 and H, reflecting depth-specific ecological niches shaped by environmental gradients.

A comparative study on the PSE-like chicken breast meat protein isolate-sunflower oil emulsion stability, rheological properties and gel properties by different additions of l-Lysine.

In order to improve the emulsion gel properties of PSE (pale, soft, and exudative)-like chicken meat protein isolate (PPI), effect of different addition of l-lysine (L-Lys) on the emulsifying and gel properties of PPI-sunflower oil emulsion were studied by comparing control groups (pure PPI groups (PPI), only added L-Lys (Lys) and sunflower oil (SO)). Adding L-Lys to the PPI emulsion resulted in a decrease in particle size and uniform distribution, the stability of emulsion was increased, and the gel exhibited higher elastic (G'), better stability and more compact microstructure was formed. Especially when 0.

[Stem radial growth of dominant subalpine coniferous species and their responses to moisture variability in Northwest Yunnan, China].

The Hengduan Mountains region is sensitive to climate change. Although many dendrochronological studies have been conducted in this region, few researches examined seasonal variations of stem radial growth and their responses to environmental factors of subalpine coniferous tree species. We monitored stem radial variations of four dominant coniferous species .

Intra-annual stem radius growth and cell formation of two diffuse-porous tree species in a subtropical forest in Southwest China.

Studying tree growth and xylem formation is essential for understanding tree resilience to extreme droughts, which are expected to intensify with climate warming. However, researches on intra-annual stem growth and xylogenesis remain limited, particularly in moist subtropical forests. This study monitored the intra-annual stem radius growth and xylem formation of two diffuse-porous tree species, Stewartia pteropetiolata W.

Clinical Effect of Personalized Adjustable Mandibular Advancement Device on Obstructive Sleep Apnea.

Mandibular advancement devices are effective in treating mild or moderate obstructive sleep apnea (OSA), but such devices that are commonly used in clinical settings require further improvement. In this study, we evaluated the clinical effects of personalized adjustable mandibular advancement devices on mild or moderate OSA. Forty patients with mild or moderate OSA were randomly divided into experimental (personalized adjustable device) and control (traditional device) groups.

Magnetic Activation: A Novel Approach to Enhance Hydrogen Evolution Activity of CoSe@CNTs Heterostructured Catalyst.

The heterostructure strategy is currently an effective method for enhancing the catalytic activity of materials. However, the challenge that is how to further improve their catalytic performance, based on the principles of material modification is must addressed. Herein, a strategy is introduced for magnetically regulating the catalytic activity to further enhance the hydrogen evolution reaction (HER) activity for CoSe@CNTs heterostructured catalyst.

PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis.

Erythropoiesis and megakaryopoiesis are stringently regulated by signaling pathways. However, the precise molecular mechanisms through which signaling pathways regulate key transcription factors controlling erythropoiesis and megakaryopoiesis remain partially understood. Herein, we identified heat shock cognate B (HSCB), which is well known for its iron-sulfur cluster delivery function, as an indispensable protein for friend of GATA 1 (FOG1) nuclear translocation during erythropoiesis of K562 human erythroleukemia cells and cord-blood-derived human CD34+CD90+hematopoietic stem cells (HSCs), as well as during megakaryopoiesis of the CD34+CD90+HSCs.

Investigating the Influence of Fluctuating Humidity and Temperature on Creep Deformation in High-Performance Concrete Beams: A Comparative Study between Natural and Laboratorial Environmental Tests.

To investigate the influence of temperature and humidity variations on creep in high-performance concrete beams, beam tests were conducted in both natural and laboratory settings. The findings indicate that the variations in creep primarily stem from temperature changes, whereas humidity changes have little influence on fluctuations in both basic creep and total creep. The influence of humidity on creep is more strongly reflected in the magnitude of creep.

Clinical characteristics and targeted therapy of different gene fusions in non-small cell lung cancer: a narrative review.

Background And Objective: Lung cancer is the most fatal malignant tumor in the world. Since the discovery of driver genes, targeted therapy has been demonstrated to be superior to traditional chemotherapy and has revolutionized the therapeutic landscape of non-small cell lung cancer (NSCLC). The remarkable success of tyrosine kinase inhibitors (TKIs) in patients with epidermal growth factor receptor () mutations and anaplastic lymphoma kinase () fusions has shifted the treatment from platinum-based combination chemotherapy to targeted therapy.

Inhibition of phosphoinositide‑3 kinases γ/δ ameliorates pulmonary granuloma by rescuing Treg function in a sarcoidosis model.

Sarcoidosis is a multisystem inflammatory disease characterized by the development of Th1/Th17/regulatory T cells (Tregs)-related non-caseating granulomas. Phosphoinositide-3 kinases δ/γ (PI3Kδ/γ) play an important role in the maintenance of effective immunity, especially for Tregs homeostasis and stability. In the present study, superoxide dismutase A (SodA) stimulation was used to establish the sarcoidosis mouse model.

Boldine promotes stemness of human urine-derived stem cells by activating the Wnt/β-catenin signaling pathway.

Human urine-derived stem cells (hUSCs) process self-renewal and multilineage differentiation ability. Due to their non-invasive and easily available clinical source, hUSCs represent a promising alternative source of mesenchymal stem cells (MSCs) for application potential in cytotherapy. However, technical limitations, such as stemness property maintenance, have hindered hUSCs' clinical application.

Detection of tomato water stress based on terahertz spectroscopy.

China's tomato cultivation area is nearly 15 thousand km, and its annual tomato output is about 55 million tons, accounting for 7% of its total vegetable production. Because of the high drought sensitivity of tomatoes, water stress inhibits their nutrient uptake, leading to a decrease in tomato quality and yield. Therefore, the rapid, accurate and non-destructive detection of water status is important for scientifically and effectively managing tomato water and fertilizer, improving the efficiency of water resource utilization, and safeguarding tomato yield and quality.

SDEGen: learning to evolve molecular conformations from thermodynamic noise for conformation generation.

Generation of representative conformations for small molecules is a fundamental task in cheminformatics and computer-aided drug discovery, but capturing the complex distribution of conformations that contains multiple low energy minima is still a great challenge. Deep generative modeling, aiming to learn complex data distributions, is a promising approach to tackle the conformation generation problem. Here, inspired by stochastic dynamics and recent advances in generative modeling, we developed SDEGen, a novel conformation generation model based on stochastic differential equations.

Detection Method for Tomato Leaf Mildew Based on Hyperspectral Fusion Terahertz Technology.

Leaf mildew is a common disease of tomato leaves. Its detection is an important means to reduce yield loss from the disease and improve tomato quality. In this study, a new method was developed for the multi-source detection of tomato leaf mildew by THz hyperspectral imaging through combining internal and external leaf features.

Facing the future of transit ridership: shifting attitudes towards public transit and auto ownership among transit riders during COVID-19.

Unlabelled: Public transit agencies face a transformed landscape of rider demand and political support as the COVID-19 pandemic recedes. We explore people's motivations for returning to or avoiding public transit a year into the pandemic. We draw on a March 2021 follow-up survey of over 1,900 people who rode transit regularly prior to the COVID-19 pandemic in Toronto and Vancouver, Canada, and who took part in a prior survey on the topic in May 2020.

Application of Machine Learning Algorithms to Predict Acute Kidney Injury in Elderly Orthopedic Postoperative Patients.

Objective: There has been a worldwide increment in acute kidney injury (AKI) incidence among elderly orthopedic operative patients. The AKI prediction model provides patients' early detection a possibility at risk of AKI; most of the AKI prediction models derive, however, from the cardiothoracic operation. The purpose of this study is to predict the risk of AKI in elderly patients after orthopedic surgery based on machine learning algorithm models.

Copper nanoclusters-based fluorescent sensor array to identify metal ions and dissolved organic matter.

In recent years, the prevention and control of water pollution has received extensive attention. There is a need to develop simple and effective strategies for the rapid detection of metal ions and dissolved organic matter (DOM) in order to improve water quality. To this end, the first copper nanoclusters (CuNCs)-based fluorescent sensor array was done to identify 12 metal ions (Pb, Fe, Cu, Cd, Cr, Co, Ni, Zn, Ag, Fe, Hg, and Al) and DOM (humic substances, lipids, fatty acids, amino acids, and lignans).

Syngeneic bone marrow transplantation in combination with PI3K inhibitor reversed hyperglycemia in later-stage streptozotocin-induced diabetes.

Background: Type 1 diabetes (T1D) is a multiple factor autoimmune disease characterized by T cell-mediated immune destruction of islet β cells. Autologous hematopoietic stem cell transplantation (AHSCT) has been a novel strategy for patients with new-onset T1D, but not for those with a later diagnosis. Disturbance of regulatory T cells (Tregs) likely contributes to poor response after transplantation in later-stage T1D.

New Drimane Sesquiterpenes and Polyketides from Marine-Derived Fungus sp. TW58-16 and Their Anti-Inflammatory and -Glucosidase Inhibitory Effects.

Marine fungi-derived natural products represent an excellent reservoir for the discovery of novel lead compounds with biological activities. Here, we report the identification of two new drimane sesquiterpenes ( and ) and six new polyketides (-), together with 10 known compounds (-), from a marine-derived fungus sp. TW58-16.

Eliminating barriers to nighttime activity participation: the case of on-demand transit in Belleville, Canada.

Unlabelled: Demand-responsive technologies are rapidly changing the transportation landscape. The City of Belleville, Ontario has recently replaced its evening and nighttime fixed route bus service with an on-demand transit (ODT) service. Preliminary reports have found a 300% increase in nighttime bus ridership since the implementation of this service, yet to fully understand the social return on the investment in on-demand services, we must also quantify whether and for whom these new services have enabled time savings and increased levels of activity participation.

Overexpressed miR-335-5p reduces atherosclerotic vulnerable plaque formation in acute coronary syndrome.

Background: Acute coronary syndrome (ACS) may induce cardiovascular death. The correlation of mast cells related microRNAs (miRs) with risk of ACS has been investigated. We explored regulatory mechanism of miR-335-5p on macrophage innate immune response, atherosclerotic vulnerable plaque formation, and revascularization in ACS in relation to Notch signaling.

Organic carbon in a seepage face of a subterranean estuary: Turnover and microbial interrelations.

Subterranean estuaries, the mixing zone between terrestrial groundwater and coastal seawater, are important biogeochemical hotspots. In the present study, organic carbon cycling and related drivers, including the characterization of different organic carbon pools and sediment microbial community, were investigated in a subterranean estuary seepage face. Within the first 20 cm depth seepage face sediments, both production and removal of dissolved organic carbon (DOC) were observed, mainly driven by heterotrophic microbes.