Impact of artificial liver plasma perfusion combined with plasma exchange therapy on clinical efficacy and short-term prognosis of hepatitis B virus-related acute-on-chronic liver failure with or without HIV infection.

Objective: To compare the effectiveness of plasma perfusion combined with plasma exchange (PP + PE) artificial liver support system in patients with hepatitis B virus-associated acute-on-chronic liver failure with and without HIV infection (HBV-ACLF/HIV(+) and HBV-ACLF/HIV(-), respectively) and to assess the clinical value and safety of the artificial liver support system.

Methods: This study involved 162 patients diagnosed with HBV-ACLF and hospitalized at Chengdu Public Health Clinical Medical Center from January 2020 to January 2025, in accordance with the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Acute-on-Chronic Liver Failure (2025 edition). Seventeen patients with tumors, severe underlying diseases, or other hepatitis virus infections were excluded.

Precision aerosol-jet micropatterning of liquid metal for high-performance flexible strain sensors.

Flexible wearable strain sensors are rapidly advancing non-invasive devices, while achieving both an ultra-low detection limit and wide sensing range concurrently presents a challenge. Herein, we propose a liquid metal (LM) strain sensors manufacturing strategy employing aerosol jet printing (AJP). Specially formulated LM ink is the key to enabling high-precision printing (12 μm) of LM via AJP, which is optimized by adjusting the concentration of polyvinylpyrrolidone and diethylene glycol.

Exploiting metabolic vulnerabilities to improve cancer therapeutics.

Over the past decade, our understanding of cancer metabolism has advanced significantly, revealing a complex and dynamic landscape of metabolic reprogramming that facilitates tumor progression and promotes therapeutic resistance. To survive under stressful conditions, cancer cells undergo crucial metabolic adaptations while also creating vulnerabilities that can be exploited for therapeutic purposes. Here, we discuss the evolving understanding of cancer cell metabolic adaptation in the tumor environment and the recent advances in identifying potential therapeutic mechanisms, including synthetic lethality, post-translational modifications (PTMs), as well as the interplay between metabolism and epigenetics.

Simple aberration elimination on a long-wave infrared metasurface by the germanium lens.

While achieving multifunctional integration of light wave phase, polarization, focusing, filtering, and more, metasurfaces often encounter challenges in ensuring optical imaging quality, including optical distortions like aberrations. This paper addresses the significant aberration challenges in far-field imaging of long-wave infrared metasurfaces by proposing the use of an infrared germanium lens point spread function (PSF) to optimize aberration phenomena in metasurface imaging. This study also demonstrated that the phase distribution of the metasurface unit cells achieved a complete coverage of 0-2, thereby validating the precise phase modulation capability of the designed metasurface.

Acute onset of spinal dural arteriovenous fistula and rapid progression to complete paraplegia: a case report and review of the literature.

Background: Spinal dural arteriovenous fistula usually has an insidious clinical course and is easily misdiagnosed. In some cases, acute exacerbation occurs following certain triggers, such as corticosteroid use and lumbar puncture. Here, we introduce a rare case of spinal dural arteriovenous fistula with acute onset, rapid progression, and no cause.

Construction and application of an efficient diesel degrading bacterial consortium for oily wastewater bioremediation.

The treatment of oil-contaminated wastewater represents a significant environmental challenge. In this study, five highly efficient diesel-degrading bacterial strains were successfully isolated from oily wastewater, which was designated as Pseudomonas sp. ZC1, Vibrio sp.

Multiscale Insights into the Counterion-Mediated Self-Assembly of CTA+ Micelles: Bridging Molecular Interactions and Mesoscopic Morphology.

As a cationic surfactant, the diverse self-assembly behaviors of cetyltrimethylammonium bromide (CTA) are influenced by the structure and type of counterions. However, related issues have not been systematically studied. Therefore, this paper employs multiscale simulations using density functional theory and coarse-grained molecular dynamics to simulate the interaction and dynamic behavior between CTA and different aromatic counterions.

Orthoplastic management of Gustilo-Anderson Type IIIB/C open tibial fractures: a consecutive 10-year series from China level I trauma center.

Background: Research on open tibiofibular fractures is limited. We compared clinical outcomes of Gustilo-Anderson type IIIB/C open tibial fractures using orthopedic and orthoplastic approaches, and identified poor prognosis predictors.

Materials And Methods: The clinical data of 746 patients with Gustilo-Anderson type IIIB/C open tibial fractures (420 and 326 treated using the orthopedic and orthoplastic approach, respectively) were retrospectively analyzed.

Diagnostic Accuracy of [F]-DCFPyL PSMA PET/CT in Intermediate-Risk Prostate Cancer Undergoing Radical Prostatectomy: Is Pelvic Lymph Node Dissection Still Necessary?

Purpose: Pelvic lymph node dissection (PLND) remains standard for nodal staging in prostate cancer (PCa), yet its benefit in intermediate-risk PCa is controversial. Traditional imaging and nomograms often lack accuracy, resulting in unnecessary PLND. Prostate-specific membrane antigen positron emission tomography/CT (PSMA PET/CT) is a promising alternative.

Retraction Notice to: circRAPGEF5 Contributes to Papillary Thyroid Proliferation and Metastatis by Regulation miR-198/FGFR1.

[This retracts the article DOI: 10.1016/j.omtn.

Automatic Mode-Matching Method for MEMS Gyroscope Based on Fast Mode Reversal.

Processing errors can result in an asymmetric stiffness distribution within a microelectromechanical system (MEMS) disk resonator gyroscope (DRG) and thereby cause a mode mismatch and reduce the mechanical sensitivity and closed-loop scale factor stability. This paper proposes an automatic mode-matching method that utilizes mode reversal to obtain the true resonant frequency of the operating state of a gyroscope for high-precision matching. This method constructs a gyroscope control system that contains a drive closed loop, sense force-to-rebalance (FTR) closed loop, and quadrature error correction closed loop.

Preparation and Properties of Magnetically Responsive Graphene/Boron Nitride/Iron Oxide Filler Composite Epoxy Resin Materials.

In this paper, magnetically responsive graphene/boron nitride/iron oxide fillers were prepared by growing iron oxide on the surface of graphene/boron nitride fillers via liquid-phase reaction. By adding the composite filler into the epoxy resin and utilising magnetic field-assisted curing, the composites were prepared to effectively improve the thermal conductivity of the composites while maintaining the insulating properties. The thermal conductivity of the composite filler is 2.

A novel bispecific integrin α5β1/αv antibody reprograms the Myc-regulated basal phenotype of prostate cancer with natural killer cell-mediated tumor elimination.

Integrin α5β1 and αv crosstalk in chemotaxis and clonogenic survival of prostate cancer cells is abrogated by a bispecific α5β1/αv antibody (BsAbα5β1/αv), which uniquely induces internalization and lysosomal degradation of target integrins. We hypothesized that the BsAbα5β1/αv inactivates pathological mechanosignaling pathways that correlate with integrin expression from patient samples. Mechanistic studies indicate that the BsAbα5β1/αv uniquely reverses YAP, beta-catenin and FAK nuclear localization compared to monospecific integrin α5β1 and αv antibody controls in basal-type androgen-receptor negative prostate cancer cells.

First-in-human PET imaging and evaluation of melanin-targeted [F]DMPY2 in malignant melanoma patients.

Early diagnosis and accurate malignant melanoma (MM) staging are significant and decisive in clinical practice. [F]DMPY2 is a promising PET tracer with high affinity and selectivity for melanin. The study aims to investigate the biodistribution and radiation dosimetry in healthy volunteers, and the potential clinical application of [F]DMPY2 in MM patients.

Assessing predictive probability of success for future clinical trials.

Data-driven decision-making is crucial in drug development, with the predictive probability of success (PoS) being a key quantitative tool. PoS estimates the likelihood of success of a future trial based on the same or surrogate endpoint(s) of interest, utilizing information from interim analyses, or completed historical studies. While it has been extensively studied and broadly applied in clinical practice, there is a growing need of a unified approach for PoS that can effectively incorporate information from surrogate endpoints and multiple historical studies.

A Single Carbon Microyarn-Based Integrated Wearable Textile Sweat Sensor Built into a Hook-and-Loop Fastener.

By fusing wearable sweat sensors for on-body sweat monitoring with textiles for daily wear, wearable textile sweat sensors (WTSSs) demonstrate the distinctive capability to monitor perspiration in real time while engaging in daily activities. However, previous WTSSs mainly focused on "weave-in-textile" or "print-on-textile" ones, which are permanently immobilized on specific regions of specific types of textiles prior to use and, accordingly, cannot be used in some specific routine circumstances (e.g.

Prediction of vulnerability to mental health symptoms in children with congenital ectopia lentis: development and validation of a prediction model.

Objective: To evaluate mental health among children with congenital ectopia lentis (CEL) and to develop an effective nomogram for predicting risk of mental health symptoms in CEL.

Methods: In total, 48 children with CEL and 50 control subjects aged 7-18 years old were enrolled in this study. Participants were required to complete the Children's Depression Inventory (CDI) and the Screen for Child Anxiety Related Emotional Disorders (SCARED) questionnaire to screen depressive and anxiety symptoms.

Comparative Study of Bu/Cy/ATG and Flu/Cy/ATG Conditioning Regimens for Unrelated Donor Hematopoietic Stem Cell Transplantation in Severe Aplastic Anemia.

Unrelated donor hematopoietic stem cell transplantation (URD-HSCT) is a curative option for severe aplastic anemia (SAA), but the optimal conditioning regimen remains unclear. This retrospective study compares Busulfan/Cyclophosphamide/Anti-thymocyte globulin (Bu/Cy/ATG) and Fludarabine/Cyclophosphamide/Anti-thymocyte globulin (Flu/Cy/ATG) protocols to identify the best regimen for SAA patients. We retrospectively analyzed the clinical outcomes of 107 SAA patients who underwent URD-HSCT with Flu/Cy/ATG (n = 63) or Bu/Cy/ATG (n = 44) between November 2012 and December 2022.

Solvent-Mediated Charge Transfer Regulation of Inner Core Clusters in Hybrid Copper(I)-Based Halides for High-Efficiency X-Ray Scintillation.

Cu(I)-based metal halides have gained significant interest as scintillators. However, their X-ray luminescence efficiency is mainly determined by the competition between radiative organic ligands and nonradiative metal cluster-centered charge transfer. How to regulate their charge transfer to enhance radiative emission is an intractable challenge.

circADARB1 enhances ZEB1 expression in an mA-dependent manner to promote the invasion and migration of nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC) is an aggressive head and neck malignancy, with invasion and metastasis as the primary drivers of poor prognosis. Although various molecular mechanisms underlying NPC invasion and metastasis have been reported, the overall regulatory network remains unclear, particularly the role of circRNA-mediated regulation, which has not been systematically investigated. In this study, we identified circular RNA circADARB1 as a key regulator of epithelial-mesenchymal transition (EMT) in NPC.

Continuous Graph Learning-Based Self-Adaptation for Multi-Stream Concept Drift.

Concept drift, characterized by changes in data distribution over time, has always been an inevitable problem in nonstationary data stream environments. Multistream scenarios are particularly complex due to the potential alteration of interstream correlations, posing significant challenges in addressing concept drift across multiple streams. Most existing adaptation methods target single-stream data, with limited research on multistream.

Therapeutic Strategies for Retention of Cranioplasty Titanium Mesh After Mesh Exposure.

Objective: This study seeks to explore the efficacy of utilizing dermal skin pieces as a potential alternative to mesh removal in cases of titanium mesh exposure after cranioplasty, with the goal of preserving the benefits of the rigid prosthesis.

Methods: This retrospective study analyzed patients who underwent treatment at the Department of Burns and Wound Repair Surgery of Zibo Central Hospital between January 2018 and November 2022 with the intention of preserving the titanium mesh. The treatment protocol involved initial wound bed management, including debridement of necrotic tissue and eradication of bacteria, followed by the augmentation of dermal thickness using a dermal pad to maintain the integrity of the titanium mesh.