Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5.

Okanin is a natural product with few known biological activities. Its anti-cancer effects and the underlying mechanisms are investigated. It is found that okanin inhibits cancer cell growth (25-50 µm) with minimal effects on non-cancerous colorectal cells except at much higher doses (i.

Transferring the 5Ns chromosome into wheat genetic background to enhance powdery mildew resistance.

Disease resistance is crucial for minimizing agricultural inputs and safeguarding food supply to solve world hunger. The genetic diversity of wild relatives provides a valuable resource for enhancing the disease resistance and yield of crops such as common wheat (Triticum eastivum). Psathyrostachys huashanica (2n = 2x = 14, NsNs) is a valuable wild germplasm for wheat improvement because of its resistance to various diseases and abiotic stresses.

Automated generation of easy-assembly off-axis three-mirror imaging systems based on few-shot machine learning.

Integrated processing is an effective approach to reduce the assembly difficulty of off-axis reflective imaging systems. However, existing design methods for the easy assembly of off-axis reflective systems generally face specific design requirements, resulting in varying design processes and insufficient generalizability. This study proposes an automated generation method for easy-assembly off-axis three-mirror imaging systems, utilizing a support vector regression (SVR) model inspired by few-shot machine learning principles.

Fertility intentions among Chinese adults: a cross-sectional study using a national survey.

Background: The decline in fertility intentions has emerged as a critical demographic and policy challenge within China, particularly in light of the introduction of the three-child policy. This situation necessitates a thorough examination of the multiple underlying factors that contribute to individuals' decisions regarding family size. By analyzing these diverse influences, policymakers and stakeholders will be better equipped to design effective interventions aimed at addressing this urgent issue.

Design and realization of a low-drive bionic frog robot.

This paper presents the design and fabrication of a compact underdriven bionic frog robot, which is inspired by the locomotion stance of a frog. The robot's hind legs were ingeniously built using an underdriven associative 8-bar linkage mechanism with a single motor drive to mimic the swimming motion of a frog. To enhance the robot's biomechanics and locomotor capabilities, the robot's shell was designed to mimic biological features and adjust buoyancy.

Three New Physalins from L. var. (Mast.) Makino.

L. var. (Mast.

Impact of low nitrate nitrogen availability on nutrient removal and microbial community structure in a denitrifying phosphorus removal (DPR) system.

Combining partial nitrification and anammox with denitrifying phosphorus removal (DPR) is considered a promising strategy for nitrogen and phosphorus removal. However, the low nitrate nitrogen availability (produced from anammox) in the side-stream DPR system could affect nutrient removal and the competition between denitrifying phosphate-accumulating organisms (DPAOs) and denitrifying glycogen-accumulating organisms (DGAOs). In this study, the nitrogen and phosphorus removal performance, microbial structure shifts, and key functional groups in a DPR reactor were investigated under long-term nitrate-limited conditions.

Acetamiprid mediates cognitive dysfunction through the gut-brain axis: Synaptic damage and immune-mediated blood-brain barrier dysfunction.

Acetamiprid is a widely used neonicotinoid pesticide that can increase the risk of inducing nervous system diseases. Considering the increased exposure to acetamiprid and its impact on cognitive function, further clarification is needed. Therefore, we used a mouse model of drinking water to evaluate the effects of acetamiprid on cognitive dysfunction and the possible underlying mechanisms.

Retraction Notice to: circRAPGEF5 Contributes to Papillary Thyroid Proliferation and Metastatis by Regulation miR-198/FGFR1.

[This retracts the article DOI: 10.1016/j.omtn.

Research progress on the effect of neutrophil elastase and its inhibitors in respiratory diseases.

Neutrophil elastase is a serine protease secreted by neutrophils that plays a crucial role in the onset and progression of various respiratory diseases. The imbalance between neutrophil elastase and its endogenous inhibitors can contribute to the onset and progression of respiratory diseases such as chronic obstructive pulmonary disease, cystic fibrosis, bronchiectasis, and acute respiratory distress syndrome. The excessive release of neutrophil elastase contributes to multiple pathophysiological processes, such as disruption of the alveolar-capillary barrier, oxidative stress and inflammatory responses, autophagy, and apoptosis.

Detecting Deleterious Recessive Variants in Large Yellow Croaker Using Data from 7337 Individuals.

In diploid organisms, deleterious recessive alleles represent a significant component of genetic mutations and often result in lethal effects when in a homozygous state. Large yellow croaker (Larimichthys crocea), a critical marine aquaculture species in China, has shown signs of inbreeding depression due to its limited natural distribution along the coasts of Fujian, Guangdong, and Zhejiang provinces, combined with intensive artificial propagation practices. Identifying loci with deleterious recessive homozygous genotypes is therefore crucial for sustainable industry development.

Genetic Differentiation and Selection Signatures Revealed by Two Successive Genomic Selection of Large Yellow Croaker Against Parasite .

The large yellow croaker is one of the most important marine aquaculture species in China, yet its intensive farming industry faces challenges from various pathogens, particularly white spot disease caused by Cryptocaryon irritans. This study aimed to address the issue of white spot disease through genetic breeding. We implemented two consecutive generations of genomic selection (GS) of large yellow croaker against , resulting in three continuous generations for subsequent analyses.

Novel nomograms for predicting overall survival and cancer-specific survival in invasive lobular carcinoma of the breast.

Purpose: Currently, the clinical diagnosis and treatment for invasive lobular carcinoma of the breast (ILC) often draw on the treatment approaches used for invasive ductal carcinoma (IDC), despite significant differences between the two. Studies evaluating the risk and prognosis of ILC are limited; thus, our goal was to construct a predictive model for the prognosis of ILC.

Methods: Clinical data of patients diagnosed with unilateral primary ILC from 2010 to 2015 were acquired from the SEER database.

A lightweight and efficient gesture recognizer for traffic police commands using spatiotemporal feature fusion.

In response to the demand for efficient and accurate recognition of traffic police gestures by driverless vehicles, this paper introduces a novel traffic police gesture recognition framework (Novel Traffic Police Gesture Recognizer, NTPGR). Initially, keypoints related to traffic police gestures are extracted using the Efficient Progressive Feature Fusion Network (EPFFNet), followed by feature modeling and fusion to enable the recognition network to better learn the temporal characteristics of gestures. Additionally, a convolution network branch and a hybrid attention branch are incorporated to further extract skeleton information from the traffic police gesture data, assign different temporal weights to key frames, and enhance the focus on important channels.

Homocapsaicin II induce ferroptosis in colorectal cancer cells via cholesterol-centrosome amplification-multipolarity axis.

Ethnopharmacological Relevance: Homocapsaicin II (Hp II), a natural product abundantly found in Capsicum annuum L., is a structural analog of capsaicin. Traditionally, capsaicin is utilized for managing digestive disorders and analgesic applications.

Integrating scRNA-seq to explore offspring neurodevelopmental toxicity induced by Cyfluthrin exposure during pregnancy: A fate decision for NSCs.

Cyfluthrin is a widely used insecticide, and studies have shown that its exposure during pregnancy is associated with neurobehavioral abnormalities in offspring, but the mechanism of toxicity is unknown. In this study, we observed the neurodevelopmental toxicity of Cyfluthrin in rat offspring of different ages due to pregnancy exposure, which manifested a series of impairments such as persistent cognitive impairment, neuronal loss in hippocampal tissues, synaptic damage, and altered expression of neurodevelopmental-related factors. Hippocampal scRNA-seq in neonatal rats showed specific cellular responses to prenatal Cyfluthrin exposure.

Non-covalent binding of non-steroidal anti-inflammatory drugs to antibiotics: preparation, characterization, physicochemical properties and study of single crystals of tolfenamic acid-enrofloxacin drug-drug salt and their antibacterial and anti-inflammatory activities.

To improve the physicochemical properties and biological activities of the nonsteroidal anti-inflammatory drug tolfenamic acid (TA) and the fluoroquinolone enrofloxacin (ENR). Based on the previous experience of our group in designing and synthesizing quinolone pharmaceutical co-crystals/salts single crystals by non-covalent bonding to improve their physicochemical properties, a drug-drug salt single crystal of tolfenamic acid-enrofloxacin was prepared for the first time using TA and ENR(TA-ENR, CHFNO·CHClNO·CHN). Single-crystal X-ray diffraction (SCXRD) analysis indicated that TA and ENR interacted predominantly through charge-assisted hydrogen bonds (CAHBs) within non-covalent bonds to form asymmetric units.

Differential responses of the intestine and liver transcriptome to high levels of plant proteins in diets for large yellow croaker ().

Large yellow croaker is an economically important carnivorous marine aquaculture fish in China with high protein requirements. Current fish meal - based feeds face issues like high cost and resource depletion, while plant protein sources have potential but also controversies. To explore this, a 120 - day feeding trial was conducted with a standard commercial feed (CF) and a modified feed (PF) where 70% of fish meal was replaced by plant protein.

Study on the spectrum-effect correlation of phytoestrogenic activity of total flavonoids from Cynomorii Herba.

Ethnopharmacological Relevance: Cynomorii Herba (CH), a traditional Chinese medicine, contains total flavonoids with potential phytoestrogenic activity, but the specific active components and mechanisms of action remain unclear.

Aim Of The Study: To investigate the active components and mechanisms responsible for the phytoestrogenic activity of Cynomorii Herba Total Flavonoids (CHTF).

Materials And Methods: A comprehensive fingerprint analysis of CHTF from 12 different regions was conducted using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) technology.

Polyvinyl pyrrolidone/carboxymethyl chitosan hydrogel loaded with Paris polyphylla var. yunnanensis extracellular vesicles promotes wound healing.

Wound healing presents a persistent challenge, particularly in enhancing tissue regeneration and mitigating inflammation. Conventional wound dressings often fall short in providing adequate protection against microbial infections and do not fully support the regenerative processes necessary for effective healing. In this study, extracellular vesicles (PPEVs) were successfully isolated from Paris polyphylla var.

A hybrid network based on multi-scale convolutional neural network and bidirectional gated recurrent unit for EEG denoising.

Electroencephalogram (EEG) signals are time series data containing abundant brain information. However, EEG frequently contains various artifacts, such as electromyographic, electrooculographic, and electrocardiographic. These artifacts can change EEG waveforms and affect the accuracy and reliability of neuroscientific studies.

Immune regulation differences in Large yellow croaker with varied resistance to Cryptocaryon irritans infection.

Large yellow croaker (Larimichthys crocea) is one of the main marine aquaculture species in China, but has faced considerable losses due to Cryptocaryon irritans infection. In this study, we successfully established a C. irritans-susceptible population of large yellow croaker by genomic selection technology.

Application of selection Index for enhancing resistance to and in large yellow croaker.

Despite the high cost of genotyping and the limited economic return per individual that restricts the use of genome selection technology in aquatic species breeding, integrating multiple traits in a selection index can reduce costs and present a promising direction for fish breeding. The aim of this study was to evaluate the feasibility and performance of breeding for dual resistance traits against and in large yellow croaker, using a selection index approach. A candidate stock population from the resistance strain (GS3) of the F2 generation ( = 560) was genotyped using a 55 K SNP array.

Tianxiangdan (TXD) alleviates myocardial ischemia reperfusion-induced ferroptosis through the activation of estrogen receptor alpha (ERα).

Tianxiangdan (TXD), a traditional Chinese herbal remedy, demonstrates efficacy in mitigating myocardial ischemia-reperfusion (I/R)-induced damage. This study employed network pharmacology to evaluate the therapeutic targets and mechanisms of TXD in treating I/R. High-performance liquid chromatography-mass spectrometry (HPLC-MS) identified 86 compounds in TXD.