Safety evaluation for heavy vehicle drivers using extreme value model based on the multi-source sensing data.

Increasingly, the collection of multi-source sensing data from heavy vehicles through intelligent networked platforms has become prevalent for safety management and supervision. However, practical approaches for crash risk management and safety evaluation have not been fully developed to capitalize on this high-value driving data. This study proposed a safety evaluation framework for heavy vehicles using the extreme value modeling approach.

Fertility intentions among Chinese adults: a cross-sectional study using a national survey.

Background: The decline in fertility intentions has emerged as a critical demographic and policy challenge within China, particularly in light of the introduction of the three-child policy. This situation necessitates a thorough examination of the multiple underlying factors that contribute to individuals' decisions regarding family size. By analyzing these diverse influences, policymakers and stakeholders will be better equipped to design effective interventions aimed at addressing this urgent issue.

Lipidomic and transcriptomic profiling reveal alterations in the coexistence of gestational diabetes mellitus and preeclampsia impacting maternal and neonatal outcomes.

Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications, with the rising incidence of GDM and the pronounced heterogeneity of PE leading to an increased prevalence of their coexistence, presenting a unique and complex clinical condition. However, the disease characteristics and maternal-neonatal outcomes of this comorbidity remain largely unknown. In this study, we collected peripheral blood samples from 42 pregnant women, including pregnant controls without complications (Control, n = 10), GDM (n = 12), PE (n = 10), and those with coexistence of GDM and PE (PG, n = 10), as well as partial neonatal cord blood samples.

Drug Interaction Potential of Berberine Hydrochloride When Co-Administered with Tofacitinib and Filgotinib in Rats.

Propose: The co-treatment of ulcerative colitis with berberine hydrochloride (BBR), the Janus kinase(JAK) inhibitor Tofacitinib (TOFA), and Fligotinib (FIGA) is feasible and sophisticated in terms of mechanism. However, no studies have yet explored their interactions. This study aimed to establish a highly sensitive, specific, and reproducible HPLC-MS/MS method for investigating the pharmacokinetic interactions between BBR-TOFA and BBR-FIGA in rats.

A pH/MMP-9 smart dual-responsive liposome GBE@LP co-delivers and controls the release of GB1107/BMS1166/Enzalutamide for liver cancer immunotherapy.

Liver cancer is one of the malignant tumors with high morbidity and mortality worldwide and lacks effective clinical treatments. CD8 T cell-based immunotherapy is the most promising option for the treatment of liver cancer, but its application is severely limited by low infiltration and functional exhaustion of CD8 T cells in liver cancer tissues. To overcome this problem, in this study, pH/matrix metalloproteinase-9 (MMP-9) dual-responsive liposomes were constructed and co-loaded with a galectin-3 (Gal-3) inhibitor, GB1107, a programmed death receptor 1 (PD-1) inhibitor, BMS1166, and an androgen receptor (AR) antagonist, enzalutamide, for immunotherapy studies in liver cancer.

Exploring the impact zone at spiral tunnel entrances and exits: Analyzing the vehicle control process from invalidation to recovery under environmental perturbations.

At tunnel entrances and exits, rapid transition in cross-sections and abrupt lighting changes create a brief "environmental perturbation period," characterized by unstable vehicle dynamics until drivers regain control required by the new driving situation. During this period, the transition of vehicle control from invalidation to recovery is a critical zone for tunnel traffic safety. Different alignment radii may introduce unexpected perturbation to vehicle control in spiral tunnels with small-radius curves.

High-performance liquid chromatography-tandem mass spectrometry for simultaneous determination of 23 antidepressants and active metabolites in human serum and its application in therapeutic drug monitoring.

Introduction: The incidence and mortality rate from depression are increasing year by year, and depression has become the main cause of global health loss and disability. Currently, the treatment of depression mainly relies on drug intervention. However, the vast majority of antidepressants exhibit significant pharmacological variability, resulting in individual differences in steady-state blood drug concentrations even with the same dosing regimen among patients.

DeepSN-Net: Deep Semi-Smooth Newton Driven Network for Blind Image Restoration.

The deep unfolding network represents a promising research avenue in image restoration. However, most current deep unfolding methodologies are anchored in first-order optimization algorithms, which suffer from sluggish convergence speed and unsatisfactory learning efficiency. In this paper, to address this issue, we first formulate an improved second-order semi-smooth Newton (ISN) algorithm, transforming the original nonlinear equations into an optimization problem amenable to network implementation.

N-glycosylation of ephrin B1 modulates its function and confers therapeutic potential in B-cell lymphoma.

Given the pivotal role of the Eph-Ephrin signaling pathway in tumor progression, agonists or antagonists targeting Eph-Ephrin have emerged as promising anticancer strategies. However, the implications of glycosylation modifications within Eph-Ephrin and their targeted protein therapeutics remain elusive. Here, we identify that N-glycosylation within the receptor-binding domain (RBD) of ephrin B1 (EFNB1) is indispensable for its functional repertoire.

A cross-sectional safety evaluation approach using generalized extreme value models: A case of right-turn safety treatment.

There has been an increase in the use of the extreme value theory (EVT) approach for conflict-based crash risk estimation and its application such as conducting the evaluation of safety countermeasures. This study proposes a cross-sectional approach for evaluating the effectiveness of a right-turn safety treatment using a conflict-based EVT approach. This approach combines traffic conflicts of different sites at the same period and develops the generalized extreme value (GEV) models.

Laplacian Gradient Consistency Prior for Flash Guided Non-Flash Image Denoising.

For flash guided non-flash image denoising, the main challenge is to explore the consistency prior between the two modalities. Most existing methods attempt to model the flash/non-flash consistency in pixel level, which may easily lead to blurred edges. Different from these methods, we have an important finding in this paper, which reveals that the modality gap between flash and non-flash images conforms to the Laplacian distribution in gradient domain.

Exploring the impact of right-turn safety measures on E-bike-heavy vehicle conflicts at signalized intersections.

A major safety hazard for e-bike riders crossing an intersection is encountering heavy vehicles turning right in the same direction, which often results in severe casualties. Recently, some cities in China have implemented right-turn safety improvement treatments (i.e.

Continuous and controllable synthesis of MnO adsorbents for HS removal at low temperature.

HS is an extremely noxious impurity generated from nature and chemical industrial processes. High performing HS adsorbents are required for chemical industry and environmental engineering. Herein, α-, γ-, and δ-MnO adsorbents with high sulfur capacity were synthesized through a continuous-flow approach with a microreactor system, achieving much higher efficiency than hydrothermal methods.

EFNB1 levels determine distinct drug response patterns guiding precision therapy for B-cell neoplasms.

The multi-omics data has greatly improved the molecular diagnosis of B-cell neoplasms, but there is still a lack of predictive biomarkers to guide precision therapy. Here, we analyzed publicly available data and found that B-cell neoplasm cell lines with different levels of EFNB1 had distinctive drug response patterns of inhibitors targeting SRC/PI3K/AKT. Overexpression of EFNB1 promoted phosphorylation of key proteins in drug response, such as SRC and STMN1, conferring sensitivity to SRC inhibitor and cytotoxic drugs.

TiO-PAA-SiO pearl chain blend modified polyvinylidene fluoride ultrafiltration membrane with excellent oil-water separation, anti fouling performance and durability.

In this work, a new type of composite nanoparticles, 'pearl chain', was developed by linking titanium dioxide and silicon dioxide by polyacrylic acid polymer chains, and the prepared TiO-PAA-SiO composite nanoparticles were analysed by SEM, Fourier transform infrared spectroscopy, x-ray photoelectron spectroscopy and thermogravimetric analysis, zeta potential, x-ray diffraction, etc. The success of this work was verified by the successful linking of TiO-PAA-SiO composite nanoparticles.TiO-PAA-SiO composite nanoparticles were analysed to verify the successful attachment of pearl chains.

PM induced liver lipid metabolic disorders in C57BL/6J mice.

PM can cause adverse health effects via several pathways, such as inducing pulmonary and systemic inflammation, penetration into circulation, and activation of the autonomic nervous system. In particular, the impact of PM exposure on the liver, which plays an important role in metabolism and detoxification to maintain internal environment homeostasis, is getting more attention in recent years. In the present study, C57BL/6J mice were randomly assigned and treated with PM suspension and PBS solution for 8 weeks.

Establishment of a primary renal lymphoma model and its clinical relevance.

Extranodal dissemination is an important feature of aggressive B-cell lymphoma. Owing to the lack of available animal models, the study on extranodal dissemination of lymphoma is greatly limited. Here, we identified a novel cell line, named MA-K, which originated from the Eμ-Myc;Cdkn2a cell line, named MA-LN in this study.

A Review of Research on the Effect of Temperature on the Properties of Polyurethane Foams.

Temperature is one of the main factors affecting the properties of polyurethane foams, and there are large differences in the mechanical properties of polyurethane foams at different temperatures. To understand the effect of temperature on the mechanical properties of polyurethane foams and to provide a theoretical basis for the application of polyurethane foams in extreme environments, this paper systematically describes the research on the effect of mold temperature, raw material temperature, and environmental temperature on the microstructure and mechanical properties of polyurethane foams in the formation and service stages of rigid polyurethane foams by domestic and foreign scholars, and summarizes the effect of temperature on the mechanical properties of polyurethane foams and the mechanism of action. A review of the literature shows that the effect of different temperatures on the mechanical properties of polyurethane foams can be summarized.

Responses of the Mushroom under Different CO Concentration by Comparative Proteomic Analyses.

Background: is a popular edible mushroom in East Asian markets. Research on the responses of under different carbon dioxide concentrations is limited.

Methods: Label-free LC-MS/MS quantitative proteomics analysis technique was adopted to obtain the protein expression profiles of fruiting body pileus collected under different carbon dioxide concentrations.

Entrepreneurial Intention and Delayed Job Satisfaction From the Perspective of Emotional Interaction: The Mediating of Psychological Capital.

The coronavirus disease 2019 (COVID-19) pandemic has exacerbated the labour shortage, and promoting entrepreneurship to spur job creation is one of the most effective strategies to address this problem. Entrepreneurs must lengthen their employment or start-up cycles due to COVID-19 normalisation. Consequently, the impact of career willingness to delay satisfaction on entrepreneurial ambition is investigated in this research an online survey in Jiangsu Province, China.

Dual effects of cardamonin/alpinetin and their acrolein adducts on scavenging acrolein and the anti-bacterial activity from Hayata as a spice in roasted meat.

Acrolein (ACR) is frequently produced by the thermal degradation of carbohydrates and amino acids and lipid peroxidation in the thermal processing of food. Long-term exposure to ACR can cause various chronic diseases. Here, we screened two high-temperature-resistant ACR inhibitors, cardamonin (CAR) and alpinetin (ALP), which can interconvert without any loss at 100 °C, and were obtained from Hayata (AKH).

Investigate the Influencing Factors of Industrial Design Platform Demand: From the Perspective of Emotional Interaction.

With the deep integration of industries brought about by big data technology, users' design needs are diversifying and individuating. Thanks to big data technology, users' diverse design needs can be precisely met. Meanwhile, big data can be used to realize emotional interaction for personalized design needs of users, resulting in a better user experience.