CurveMark: Detecting AI-Generated Text via Probabilistic Curvature and Dynamic Semantic Watermarking.

Large language models (LLMs) pose significant challenges to content authentication, as their sophisticated generation capabilities make distinguishing AI-produced text from human writing increasingly difficult. Current detection methods suffer from limited information capture, poor rate-distortion trade-offs, and vulnerability to adversarial perturbations. We present CurveMark, a novel dual-channel detection framework that combines probability curvature analysis with dynamic semantic watermarking, grounded in information-theoretic principles to maximize mutual information between text sources and observable features.

20S-O-Glc-DM regulates fatty acid metabolism and mitochondrial function in the treatment of diabetes mellitus-associated MAFLD.

Background: The prevalence of diabetes mellitus-associated metabolic dysfunction-associated fatty liver disease (MAFLD) is on the rise, with over 90% of patients with Type 2 Diabetes Mellitus (T2DM) also suffering from MAFLD. Currently, there are no specific drugs available for the treatment of diabetes mellitus-associated MAFLD. Ginsenoside is commonly used to treat both MAFLD and diabetes.

Application of Raman spectroscopy and machine learning for determination of pro-toxicant activation in CYP2E1-expressing cells.

Developing a convenient, accurate, and cost-effective analytical method for the detection of Cytochrome P450 (CYP) mediated drug bioactivation remains a challenge. The present study proposes a method using Raman spectroscopy (RS) combined with machine learning algorithms to classify CYP2E1-expressing cells that were subjected to acetaminophen (APAP) metabolic activation. Raman spectra obtained from the cells were subjected to dimensionality reduction using principal component analysis (PCA), and machine learning algorithms were employed for further classification.

TUBB3/DTX LNPs Dry Powder Inhaler and an Efficient Delivery Device for Targeted Therapy of Lung Cancer.

Lung cancer is the most prevalent and deadly tumor globally, marked by drug resistance and a poor prognosis. Specialized formulations with strong lung targeting are currently lacking. Docetaxel (DTX) and TUBB3-siRNA represent chemotherapy and RNA interference (RNAi), two strategies for lung cancer treatment.

Microbiological spectrum and antibiotic susceptibility analysis of secretion from 308 cases of chronic dacryocystitis in north China.

Aim: To determine the microbiological agents and antibiotic susceptibility of chronic dacryocystitis in recent years to guide effective treatment strategies.

Methods: A total of 308 adult patients with chronic dacryocystitis were enrolled from January 2020 to September 2022 in Beijing Tongren Hospital. The 229 pus specimens were taken from the conjunctival sac, while 79 specimens were taken from the opened lacrimal sac during transnasal dacryocystorhinostomy (DCR) surgery.

[Case of stiff skin syndrome treated with acupuncture and cupping therapy].

Stiff skin syndrome is a very rare non-inflammatory reactive skin disease, characterized by skin sclerosis and limited joint mobility. The paper reports one case of child with stiff skin syndrome and treated with combined therapy of acupuncture and cupping. Acupuncture was used at the lateral line 1 of vertex (MS8) on the right side, Jiaji (EX-B2) of L to L, Huantiao (GB30), point, Juliao (GB29), Fengshi (GB31), Weizhong (BL40), and etc.

Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway.

Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) are linked to numerous chronic conditions, including cardiovascular disease, atherosclerosis, chronic kidney disease, and type II diabetes. Previous research identified the natural flavonoid diosmin, derived from Chrysanthemum morifolium, as a regulator of glucose metabolism. However, its effects on lipid metabolism and underlying mechanisms remained unexplored.

Overexpression of (P)RR in SHR and Renin-Induced HepG2 Cells Leads to Spontaneous Hypertension Combined with Metabolic Dysfunction-Associated Fatty Liver Disease.

Hypertension and metabolic dysfunction-associated fatty liver disease (MAFLD) are both common chronic diseases globally. Nearly half of patients with hypertension are complicated by MAFLD. The mechanisms of the bidirectional promotion between the two remain unclear.

Measuring emotions triggered by fragrance through behavioral paradigms.

Intoduction: Fragrance has a positive impact on various aspects of people's emotions, experiences, and behaviors, such as product satisfaction, happiness, and comfort in daily life. While previous research has predominantly utilized physiological measurements or subjective evaluations, behavioral methods have been underexplored. This study aims to explore the measurement of emotional responses to fragrance through behavioral paradigms.

Combining promiscuous enzymes to construct a platform cell factory which yields flavonol 3-O-galactoside 6-O-acetates.

Promiscuous enzymes are distributed widely in nature. These promiscuous enzymes recognize multiple substrates and yield a variety of metabolites. Hence, the enzyme promiscuity is usually avoided to improve the specificity of metabolites.

Lamin A/C promotes HBV transcription by modulating histone modification associated with cccDNA minichromosome in an HBx-dependent manner.

Background: Chronic hepatitis B virus (HBV) infection remains a serious public health challenge, and primary treatment strategies are unable to cure HBV infection due to the persistence of HBV covalently closed circular DNA (cccDNA) in the nuclei of cells. The HBV X protein (HBx) plays a crucial role in regulating cccDNA transcription. Therefore, targeting HBx to identify host proteins that regulate cccDNA transcription could represent a curative approach.

Modulating Optoelectronic Performance Through Strategic Chlorine Substitution in Diketopyrrolopyrrole-Based Conjugated Polymers.

Chlorinated conjugated polymers offer a comparable and cost-effective alternative to fluorinated counterparts in organic electronics, yet a versatile and strategic regulation and optimization approach of their organic field-effect transistors (OFETs) performance remains underexplored. Herein, we report the rational design and synthesis of three chlorinated diketopyrrolopyrrole (DPP)-based copolymers (, , and ), and reveal the relationship between the molecular structure and OFETs performance. It was found that the reduction of chlorine in delivers attenuated hole mobilities of 0.

Therapeutic Strategies for Retention of Cranioplasty Titanium Mesh After Mesh Exposure.

Objective: This study seeks to explore the efficacy of utilizing dermal skin pieces as a potential alternative to mesh removal in cases of titanium mesh exposure after cranioplasty, with the goal of preserving the benefits of the rigid prosthesis.

Methods: This retrospective study analyzed patients who underwent treatment at the Department of Burns and Wound Repair Surgery of Zibo Central Hospital between January 2018 and November 2022 with the intention of preserving the titanium mesh. The treatment protocol involved initial wound bed management, including debridement of necrotic tissue and eradication of bacteria, followed by the augmentation of dermal thickness using a dermal pad to maintain the integrity of the titanium mesh.

Avenanthramide C from underutilized oat glumes exhibits dual anti-oxidant and anti-thrombotic effects in oxidative damage and thrombosis models.

Avenanthramides (Avns), particularly Avn-C, are unique phenolic compounds found in oats, known for their anti-oxidant and anti-inflammatory effects. This study evaluated Avn-C's bioactivity using oxidative damage models in HUVECs induced by -BOOH and thrombosis models in zebrafish induced by phenylhydrazine (PHZ). Avn-C exhibited potent antioxidant activity, with an IC value of 7.

Yeast Culture Supplementation Improves Meat Quality by Enhancing Immune Response and Purine Metabolism of Small-Tail Han Sheep ().

Yeast culture is widely used in ruminants to improve gut health, immunity, and productivity; however, its impact on meat quality remains unclear. This study aimed to investigate the effects of yeast culture supplementation in the basic diet on meat quality of Small-tail Han sheep. A total of 40 Small-tail Han sheep (17.

Hydroxy-Selenomethionine Supplementation During Gestation and Lactation Improve Reproduction of Sows by Enhancing the Antioxidant Capacity and Immunity Under Heat Stress Conditions.

The objective of this study was to determine whether hydroxy-selenomethionine (OH-SeMet) exerts better protective effects on sows against heat stress than sodium selenite (SeNa) or seleno-yeast (SeY). A total of 60 sows (Landrace × Yorkshire) were randomly allocated into the three groups and fed a base diet supplemented with SeNa, SeY, or OH-SeMet at 0.3 mg Se/kg under a heat stress condition for a reproductive cycle.

Design of a Novel Conditional Noise Predictor for Image Super-Resolution Reconstruction Based on DDPM.

Image super-resolution (SR) reconstruction is a critical task aimed at enhancing low-quality images to obtain high-quality counterparts. Existing denoising diffusion models have demonstrated commendable performance in handling image SR reconstruction tasks; however, they often require thousands-or even more-diffusion sampling steps, significantly prolonging the training duration for the denoising diffusion model. Conversely, reducing the number of diffusion steps may lead to the loss of intricate texture features in the generated images, resulting in overly smooth outputs despite improving the training efficiency.

Depth of Liver Invasion as a Novel Predictor for Outcome of Perihilar Cholangiocarcinoma.

The current American Joint Committee on Cancer (AJCC) pT classification was inaccurate in predicting prognosis for perihilar cholangiocarcinoma (pCCA). This study aimed to propose a novel classification based on the depth of liver invasion (DOLI) of pCCA. Patients who underwent major hepatectomy combined with caudate lobectomy for pCCA between January 2015 and June 2023 were reviewed retrospectively.

Hepatoprotective diterpenes from the nodes of .

Three new diterpenes, named pinusins D-F (-), were isolated from the Chinese medicine "" (the dried tuberculate or branched nodes of ), along with twelve known diterpenes. The structures of these new compounds were determined using detailed spectroscopic methods and ECD calculations. Compounds - displayed moderate hepatoprotective activity against HO-induced oxidative damage in HepG2 cells, while compounds - exhibited markedly enhanced efficacy -surpassing that of bicyclol (positive control).

Integrating radiomics and deep learning for enhanced prediction of high-grade patterns in stage IA lung adenocarcinoma.

Background: The presence of high-grade patterns (HGPs) often has a detrimental effect on prognosis. It is helpful to make individualized clinical treatment plans when preoperative recognition of the presence of HGPs becomes possible. So, this study aimed to develop a model based on preoperative computed tomography (CT) images to predict the presence of HPGs in invasive pulmonary non-mucinous adenocarcinoma.

Iron rust for efficient photocatalytic hydrogen evolution.

Iron (Fe) corrosion typically results in significant damage to Fe-based devices and structures. However, the corrosion products can be repurposed as active materials in electrocatalytic and photocatalytic reactions. In this study, we have strategically induced oxygen corrosion in Fe foams to synthesize cost-effective Fe rust cocatalysts (Orthorhombic FeOOH) for enhancing the photocatalytic hydrogen evolution reaction (HER), exemplifying the concept of "turning waste into treasure".

Contamination of aflatoxin B, deoxynivalenol and zearalenone in feeds in China from 2021 to 2024.

Background: This study was carried out to investigate the individual and combined contamination of aflatoxin B (AFB), deoxynivalenol (DON), and zearalenone (ZEN) in feeds in China between 2021 and 2024. A total of 23,003 feed samples, including 17,489 feedstuff samples and 5,514 complete feed samples, were collected from different provinces of China for mycotoxin analysis.

Results: The analyzed mycotoxins displayed considerably high contamination in the feed samples, with the individual contamination of AFB, DON, and ZEN were 20.

A Carboxylate-based Hydrophilic Organic Photovoltaic Catalyst with a Large Molecular Dipole Moment for High-Performance Photocatalytic Hydrogen Evolution.

Achieving ultrafast dissociation of photogenerated excitons and efficient charge transport within the photocatalyst is a fundamental issue. Additionally, enhancing the interaction between semiconductors and water is crucial for efficient photocatalytic water splitting. Herein, we synthesized a carboxylate-based hydrophilic polymer, hPTB7-Th.