One-step electrochemical conversion of propane to acetone of 96% purity.

Acetone is a crucial chemical and solvent with extensive industrial applications, traditionally synthesized from propane through multi-step processes that demand high temperatures and pressures. Here, we report a selective one-step conversion of propane to acetone using a heterogeneous electro-Fenton process (h-EFP) under mild conditions. In this process, concentrated ·OH radicals are generated in an iron/carbon hybrid cathode via a two-electron oxygen reduction reaction followed by HO conversion.

Unraveling α-synuclein and amylin co-aggregation: pathological insights and biomarker development for Parkinson's disease.

Patients with diabetes have a higher morbidity in Parkinson's disease (PD) than others, but the mechanism underlying this link remains controversial. The co-aggregation of α-synuclein (α-syn) and amylin has been hypothesized as a key contributor. Molecular interaction analysis and co-immunoprecipitation were conducted to assess the feasibility of co-aggregation.

TUBB3/DTX LNPs Dry Powder Inhaler and an Efficient Delivery Device for Targeted Therapy of Lung Cancer.

Lung cancer is the most prevalent and deadly tumor globally, marked by drug resistance and a poor prognosis. Specialized formulations with strong lung targeting are currently lacking. Docetaxel (DTX) and TUBB3-siRNA represent chemotherapy and RNA interference (RNAi), two strategies for lung cancer treatment.

Disease-associated loci share properties with response eQTLs under common environmental exposures.

Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To understand gene regulation across diverse environmental conditions and cellular contexts, we treated a broad array of human cell types with three environmental exposures . With single-cell RNA-sequencing data from 1.

Study on controlling 3D printed drug release rates based on model structural adjustment.

As an emerging technology, 3D printing facilitates the fabrication of complex preparations and enables controlled drug release. This study integrated semi-solid extrusion (SSE) and fused deposition modeling (FDM) to develop core-shell structured sustained-release tablets (CSRT) with varying release profiles, exploring how structural design influences release behavior. Propranolol hydrochloride was selected as the model drug.

Investigating the novel Escherichia coli bacteriophage Jgk1 as a potential antimicrobial agent.

Enterobacteriaceae are significant opportunistic pathogens in the environment, impacting both biological and human health. The rise in antibiotic-resistant strains has compelled the exploration of bacteriophages as alternative biological control agents. In this study, we isolated a bacteriophage JgK1 specific to Escherichia coli from environmental samples.

Bibliometric review on flexible pressure sensor design strategies.

Flexible pressure sensors have developed rapidly in recent years, with wide applications in wearable devices, healthcare, human-machine interaction, and other fields, showing great potential. Multiple cluster analyses of the relevant literature were performed using bibliometric methods to provide a comprehensive understanding of the research progress in this area. Additionally, the annual publication trends were analyzed, showcasing breakthrough technological developments in flexible pressure sensors.

Effects of polysaccharides and soy protein isolate on the gel properties and molecular structure of squid (Dosidicus gigas) surimi.

Background: Squid has characterized by high protein, low fat and no intermuscular bones, which makes it an ideal raw material for making surimi. However, the gel quality of squid surimi is inferior because of its high endogenous enzyme activity and low content of myosin and transglutaminase, which makes myofibrillar protein easy to be degraded and the degree of cross-linking of myosin heavy chain low. Although the cost of starch is low, its addition may lead to the reduction of protein content and the increase of heat of the gel product, and excessive addition may even reduce the quality of the product.

Disease-associated loci share properties with response eQTLs under common environmental exposures.

Many of the genetic loci associated with disease are expected to have context-dependent regulatory effects that are underrepresented in the transcriptomes of healthy, steady-state adult tissues. To understand gene regulation across diverse environmental conditions and cellular contexts, we treated a broad array of human cell types with three environmental exposures . With single-cell RNA-sequencing data from 1.

Tuning Interlayer Couplings and Stabilizing 2D Perovskite Lattices through Intercalation Chemistry.

Two-dimensional (2D) organic-inorganic hybrid lead halide perovskites are promising semiconductors for optoelectronics, spintronics, and ferroelectrics due to their versatile structural and physical properties enabled by a variety of organic spacer cations. While previous research has focused on new spacer cations for templating 2D perovskite structures and influencing their properties, the intercalation of functional molecules within the organic layers has been less explored. Here, we demonstrate the intercalation of iodine within the organic sublattice as an effective tool to tune interlayer electronic interactions and stabilize 2D perovskite structures that would otherwise not form.

The effects of tennis on depressive symptoms and pro-social behaviors in university students: the mediating role of appreciative social support.

Aims: This research aimed to explore the impact of tennis on depressive symptoms and pro-social behaviors among college students, while also delving into the intermediary function of social support navigation.

Materials And Methods: Utilizing a suite of psychological evaluations and social support instruments, the study compared the levels of depressive symptoms and pro-social behaviors between collegiate tennis athletes and their non-athlete peers.

Results: The findings revealed an inverse relationship between the duration of tennis engagement and the presence of depressive symptoms ( = -0.

Two-dimensional organic-inorganic hybrid perovskite quantum-well nanowires enabled by directional noncovalent intermolecular interactions.

Layered 2D semiconductors, when grown into 1D nanowires, can exhibit excellent optical and electronic properties, promising for nanoscale optoelectronics and photonics. However, rational strategies to grow such nanowires are lacking. Here, we present a large family of quantum-well nanowires made from 2D organic-inorganic hybrid metal halide perovskites with tunable well thickness, organic spacer cations, halide anions, and metal cations, achieved by harnessing directional nonvalent intermolecular interactions present among certain spacer cations.

Association of Dietary Live Microbe Intake With Mortality: Results From the National Health and Nutrition Examination Survey, 1999-2018.

Background: The association between dietary intake of live microbes and mortality remains unclear.

Objective: This study aims to investigate the relationship between dietary live microbial intake and all-cause and cause-specific mortality among adults in the United States.

Design: This is a cross-sectional study of adults aged 20 years or older who participated in the 1999-2018 National Health and Nutrition Examination Survey.

Upper limit of ice content at the lunar south pole as revealed by the Earth-based SYISR-FAST bistatic radar system.

An increasing amount of evidence indicates that lunar water ice exists in permanently shadowed regions at the poles and will soon become an important resource for lunar exploration. However, the water ice content and distribution are still uncertain. We report a new 70-cm-wavelength radar image of the lunar south pole obtained by an Earth-based bistatic radar system consisting of the Sanya incoherent scatter radar (SYISR) and the five-hundred-meter aperture spherical radio telescope (FAST).

The diversity pattern of soil bacteria in the rhizosphere of different plants in mountain ecosystems.

Research on the composition and diversity of rhizosphere microbial communities of different plant species can help to identify important microbial functional groups or functional potentials, which is of great significance for vegetation restoration and ecological reconstruction. To provide scientific basis for the management of mountain ecosystem, the diversity pattern of rhizosphere bacterial community was investigated using 16 S rRNA high-throughput sequencing method among different host plants (Cirsium japonicum, Artemisia annua, Descurainia sophia, Lepidium apetalum, Phlomis umbrosa, and Carum carvi) in Tomur Peak National Nature Reserve, China. The results showed that the richness and diversity of rhizosphere bacteria were highest in Descurainia sophia, and lowest in Lepidium apetalum.

Screening of Potential Angiotensin-Converting Enzyme-Inhibitory Peptides in Squid () Skin Hydrolysates: Preliminary Study of Its Mechanism of Inhibition.

Background: Hypertension has been identified as a significant risk factor for cardiovascular disease. Given the prevalence of the adverse effects of angiotensin-converting enzyme-inhibitory (ACEI) drugs, natural and effective alternatives to these medications need to be identified.

Methods: An investigative study was conducted to assess the ACEI capacity and structural characteristics of enzymatic hydrolysates with varying molecular weights derived from squid skin.

ARF4-mediated intracellular transport as a broad-spectrum antiviral target.

Host factors that are involved in modulating cellular vesicular trafficking of virus progeny could be potential antiviral drug targets. ADP-ribosylation factors (ARFs) are GTPases that regulate intracellular vesicular transport upon GTP binding. Here we demonstrate that genetic depletion of ARF4 suppresses viral infection by multiple pathogenic RNA viruses including Zika virus (ZIKV), influenza A virus (IAV) and SARS-CoV-2.

Judgment of Social Traits and Emotions of "Neutral" Avatars.

With the rapid advance of technology, human interactions with virtual avatars in simulated social environments are becoming increasingly common. The aim of the current study was to examine users' perception of social traits and emotions of "neutral," expressionless avatars using an open-source collection. These avatars represented different ethnicities, genders, and occupations via visual features including skin tone, facial structure, and apparel.

Identification and characterization of playing a positive role in the abiotic stress resistance of Chinese chestnut via an integrated strategy.

Chinese chestnut ( Blume) is an important economic forest tree species and mainly cultivated in mountainous areas and wastelands, subjecting it to various abiotic stresses. The protein phosphatase 2C (PP2C) genes contributes largely to stress responses in plants. However, the characteristics and functions of genes in remain unknown.

[Characterization of host factors and upon Zika virus infection by construction of gene knockout mice].

The effects of host factors ADP-ribosylation factor 4 (ARF4) and ADP-ribosylation factor 5 (ARF5) upon Zika virus (ZIKV) infection were characterized by construction of gene knockout mice via CRISPR-Cas9. Firstly, and genes were modified by the CRISPR-Cas9 system and then microinjected into the fertilized eggs of C57BL/6JGpt mice. Fertilized eggs were transplanted to obtain or knockout (ARF4KO or ARF5KO) mice, and / double knockout mice were achieved by the mating between ARF4KO and ARF5KO mice (ARF4KO/ARF5KO).

Effects of heat-moisture extrusion on the structure and functional properties of protein-fortified whole potato flour.

The aim of this study was to explore the effects of twin-screw extrusion combined with exogenous protein on interaction between starch and protein of the compound potato powder thereby contributing to better structural characterization and functional properties of whole potato flour lack of gluten. The results showed that the heat-moisture extrusion increased the relative crystallinity of starch. Meanwhile, the exogenous protein introduced (-SH) under the action of extrusion to form (-S-S-) in the compound system and furtherly promoted the construction of the network structure of the protein.

Cell type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating cultures.

Identifying the molecular effects of human genetic variation across cellular contexts is crucial for understanding the mechanisms underlying disease-associated loci, yet many cell types and developmental stages remain underexplored. Here, we harnessed the potential of heterogeneous differentiating cultures (HDCs), an in vitro system in which pluripotent cells asynchronously differentiate into a broad spectrum of cell types. We generated HDCs for 53 human donors and collected single-cell RNA sequencing data from over 900,000 cells.

AO-DETR: Anti-Overlapping DETR for X-Ray Prohibited Items Detection.

Prohibited item detection in X-ray images is one of the most essential and highly effective methods widely employed in various security inspection scenarios. Considering the significant overlapping phenomenon in X-ray prohibited item images, we propose an anti-overlapping detection transformer (AO-DETR) based on one of the state-of-the-art (SOTA) general object detectors, DETR with improved denoising anchor boxes (DINO). Specifically, to address the feature coupling issue caused by overlapping phenomena, we introduce the category-specific one-to-one assignment (CSA) strategy to constrain category-specific object queries in predicting prohibited items of fixed categories, which can enhance their ability to extract features specific to prohibited items of a particular category from the overlapping foreground-background features.

The Exploration of Ink Formulations in Binder Jet 3D Printing Drugs.

The application of binder jet 3D printing technology in the pharmaceutical field is developing rapidly. The properties of the ink are very important, affecting the stability of the ejection and the precision of the finished product, but there is a great lack of research on pharmaceutical inks. This study used solvents and excipients commonly used in pharmaceuticals to quantify the printability of inks using printability value theory, while using an ink-jet printing and observation platform to analyze the droplet ejection state of different composition inks from microscopic level.